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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults

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Biomedical and Environmental Sciences 2023年第1期36卷 1-9页

作者： ZHAO Hui QIU Xia LI Hua Zi cui jia jia SUN Yong Ye Department of Nutrition and Food Hygiene School of Public HealthQingdao UniversityQingdao 266071ShandongChina State Key Laboratory of Bioactive Seaweed Substances Qingdao Bright moon Seaweed Group Co.LtdQingdao 266400ShandongChina Department of Medical Imaging Haici Hospital Affiliated to Medical College of Qingdao UniversityQingdao 266071ShandongChina

Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese *** A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD *** The multivariable adjusted odds ratio(95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888(2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index(BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose-response analysis indicated a linear positive correlation between UHR and the risk of *** UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.

关键词： Serum uric acid HDL-cholesterol The UHR index Inflammation Nonalcoholic fatty liver disease

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Synthesis, Structure and Decarboxylative Behavior of a Nitro-coordinated Potassium Compound

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Chinese Journal of Structural Chemistry 2019年第3期38卷 362-368页

作者： LI Dong-Mi cui jia-jia YAO jia-Xin LI Zhao-Hao ZHAO Bang-Tun College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-oriented Porous Materials Luoyang Normal University

A novel nitro-coordinated potassium compound [K(Htdc)(H_2O)]_n(tdc = 3-nitro-thiophene-2,5-dicarboxylate), has been synthesized and characterized. The complex with a two-dimensional(2D) layer structure contains an infinite K-O ladder-shaped chain, which is connected through carboxyl and unusual nitro-coordination of Htdc– anion. Then the 2D layers are further extended by intermolecular hydrogen-bonding to form a three-dimensional(3D) supramoleculalr network. Variable temperature powder X-ray diffractions, thermogravimetric analysis and nuclear magnetic resonance studies exhibit that the compound has a thermal-induced decarboxylative behavior.

关键词： crystal structure coordination mode two-dimensional compound decarboxylative behaviour

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M2型巨噬细胞通过Ac2-26极化调节对急性心力衰竭大鼠血流动力学与心肌线粒体损害的影响研究

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现代免疫学 2024年第1期44卷 17-25页

作者：韩明磊刘振崔佳佳侯永兰金卫东新乡医学院附属第四临床学院心血管内科新乡453000

为探究膜联蛋白A1(Annexin A1,ANXA1)拟肽Ac2-26对急性心力衰竭(acute heart failure,AHF)模型大鼠的血流动力学与心肌线粒体损伤的影响及作用机制,将研究对象分为对照组、模型组和Ac2-26组(每组15只大鼠),模型组和Ac2-26组大鼠构建AHF... 详细信息

为探究膜联蛋白A1(Annexin A1,ANXA1)拟肽Ac2-26对急性心力衰竭(acute heart failure,AHF)模型大鼠的血流动力学与心肌线粒体损伤的影响及作用机制,将研究对象分为对照组、模型组和Ac2-26组(每组15只大鼠),模型组和Ac2-26组大鼠构建AHF模型,且Ac2-26组静脉输注Ac2-26,对照组和模型组静脉输注等体积生理盐水,1次/d,连续14 d。彩色多普勒超声仪检测各组大鼠的血流动力学指标变化;H-E染色观察各组大鼠的心肌组织病理学损伤情况;TUNEL染色观察各组大鼠心肌细胞的凋亡情况;透射电子显微镜观察各组大鼠的心肌线粒体结构;线粒体分离试剂盒分离各组大鼠心肌组织线粒体,JC-1染色观察线粒体膜电位变化;免疫组织化学染色观察各组大鼠心肌组织巨噬细胞标志物CD68、M1型巨噬细胞标志物iNOS与M2型巨噬细胞标志物CD206的表达;实时荧光定量PCR检测各组大鼠心肌组织中TNF-α、IL-6、TGF-β、IL-10及重组人精氨酸酶1(Arginase 1,Arg-1)的mRNA相对表达量;Western blotting检测各组大鼠心肌组织中IL-10、Arg-1和CD206的蛋白表达水平。与模型组比较,Ac2-26组大鼠左心室收缩压(left ventricular systolic pressure,LVSP)与+左心室内压最大上升速率(maximum increase rate of left ventricular pressure,+LV dp/dtmax)均升高,左心室舒张末压(left ventricular end-diastolic pressure,LVEDP)与-左心室内压最大下降速率(maximum decrease rate of left ventricular pressure,-LV dp/dtmax)均下降,心率(heart rate,HR)升高;心肌组织中心肌细胞数较多,细胞间隙缩小,炎症细胞和巨噬细胞浸润现象明显减轻;TUNEL染色阳性率下降,心肌细胞线粒体损伤减轻、结构相对完整,线粒体膜电位升高;心肌组织中iNOS阳性表达减少,而CD68和CD206的阳性表达均增加;TNF-α、IL-6的mRNA相对表达量均下调,TGF-β、IL-10和Arg-1的mRNA相对表达量均上调;同时,IL-10、Arg-1和CD206的蛋白表达水平也均上调。由此,Ac2-26可以改善AHF大鼠的血流动力学状态,减轻心肌细胞线粒体的损伤,该作用可能与促进巨噬细胞向抑炎性M2型极化有关。

关键词：心力衰竭 Ac2-26 巨噬细胞血流动力学线粒体损伤

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Universal dynamic scaling and Contact dynamics in quenched quantum gases

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Frontiers of physics 2024年第2期19卷 213-220页

作者： jia-Nan cui Zhengqiang Zhou Mingyuan Sun School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Lab of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

Recently universal dynamic scaling is observed in several systems,which exhibit a spatiotemporal self-similar scaling behavior,analogous to the spatial scaling near phase *** latter one arises from the emergent continuous scaling *** by this,we investigate the possible relation between the scaling dynamics and the continuous scaling symmetry in this *** derive a theorem that the scaling invariance of the quenched Hamiltonian and the initial density matrix can lead to the universal dynamic *** is further demonstrated both in a two-body system analytically and in a many-body system *** the latter one,we calculate the dynamics of quantum gases quenched from the zero interaction to a finite interaction via the non-equilibrium high-temperature virial expansion.A dynamic scaling of the momentum distribution appears in certain momentum-time windows at unitarity as well as in the weak interacting ***,this universal scaling dynamics persists approximately with smaller scaling exponents even if the scaling symmetry is fairly *** findings may offer a new perspective to interpret the related *** also study the Contact dynamics in the BEC−BCS ***,the half-way time displays a maximum near unitarity while some damping oscillations occur on the BEC side due to the dimer state,which can be used to detect possible two-body bound states in experiments.

关键词： dynamic scaling Contact dynamics quantum gases cold atom quench dynamics virial expansion continuous scaling symmetry

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Mutual Information Maximization via Joint Power Allocation in Integrated Sensing and Communications System

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China Communications 2024年第2期21卷 129-142页

作者： jia Zhu Junsheng Mu Yuanhao cui Xiaojun Jing School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ISAC, we propose a design scheme based on spectrum sharing, that is,to maximize the mutual information(MI) of radar sensing while ensuring certain communication rate and transmission power constraints. In the proposed scheme, three cases are considered for the scattering off the target due to the communication signals,as negligible signal, beneficial signal, and interference signal to radar sensing, respectively, thus requiring three power allocation schemes. However,the corresponding power allocation schemes are nonconvex and their closed-form solutions are unavailable as a consequence. Motivated by this, alternating optimization(AO), sequence convex programming(SCP) and Lagrange multiplier are individually combined for three suboptimal solutions corresponding with three power allocation schemes. By combining the three algorithms, we transform the non-convex problem which is difficult to deal with into a convex problem which is easy to solve and obtain the suboptimal solution of the corresponding optimization problem. Numerical results show that, compared with the allocation results of the existing algorithms, the proposed joint design algorithm significantly improves the radar performance.

关键词： coexistence communications multicarrier radar mutual information spectrum sharing

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Triple signal amplification electrochemical sensing platform for Hg^(2+) in water without direct modification of the working electrode

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 157-167页

作者： Liuyin Hu jiahua cui Tao Lu Yalin Wang Jinping jia School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China International Copper Association Ltd.Shanghai 200020China

An ultrasensitive electrochemical biosensor to detect trace Hg^(2+)in environmental samples was developed utilizing nanogold-decorated magnetic reduced graphene oxide(MrGO-AuNPs),exonuclease III-assisted target cycle(Exo Ⅲ-ATC)and hybridization chain reaction(HCR)synergistic triple signal *** MrGO-AuNPs is a superior carrier for capture DNA(cDNA)and acts as magnetic media for automatic separation and *** innovative utilization of the magnetism and improved sensing efficiency obviates the need for direct modification and repeated polishing of the working ***,the three DNA hairpins(cDNA,methylene blue(MB)labeled HP1 and HP2)further contribute to biosensor specificity and *** cDNA captures Hgt,it activates Exo Ⅲ-ATC due to the formation of a sticky end in the DNA stem via thymine-Hig-thymidine(T-Hg^(2+)-T),this leads to the hydrolysis of self-folded DNA by Exo Ⅲ-ATC to form"key"DNA(kDNA).The kDNA subsequently initiates HCR,resulting in massive super-sandwich structures(kDNA-[HP1/HP2])carrying signaling molecules on MrGO-AuNPs,and this overall structure serves as a signal probe(SP).Leveraging magnetic adsorption,the SP was automatically adsorbed onto the magneto-glass carbon electrode(MGCE),generating an amplified *** biosensor's detection limit(LOD)was 3.14 pmol/L,far below the limit of 10 nmol/L for mercury in drinking water set by the US *** biosensor also showed excellent selectivity when challenged by interfering ions,and the results of its application in actual samples indicate that it has good potential for practical applications in environmental monitoring.

关键词： Electrochemical sensing Hg^(2+) Amplification Graphene Hybridization chain reaction Exonuclease Ⅲ

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Glutamate oxidase-integrated biomimetic Fe_(3)O_(4) hybrids as cascade nanozymes for glutamate detection

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Particuology 2024年第5期88卷 192-200页

作者： Peikun Li Yanchao Wang Xiuyan Luo Zixin Geng jiahui jia Ruirui Wang jiandong cui Hongjie Bian Shiru jia State Key Laboratory of Food Nutrition and Safety Laboratory of Industrial Fermentation MicrobiologyMinistry of EducationTianjin University of Science and TechnologyTianjin300457China Sports Department Hebei University of Science and TechnologyShijiazhang050000China Research Center for Fermentation Engineering of Hebei College of Bioscience and BioengineeringHebei University of Science and TechnologyShijiazhang050000China

Herein,a new nanozyme/natural enzyme hybrid biosensor was established for ultrasensitive l-glutamic acid(L-Glu)*** Fe_(3)O_(4) nanoparticles with peroxidase-like activity and stability was used as a nanozyme and carrier for immobilizing l-Glutamate oxidase(GLOD)through Schiffff base reaction to construct a chem-enzyme cascade *** resultant Fe_(3)O_(4)-GOLD exhibited a wide linear range(10−500μM)and a low detection limit of 6.03μM for L-Glu ***,the Fe_(3)O_(4)-GOLD exhibited excellent pH stability,thermal stability,reusability and storage *** repeated nine cycles,Fe_(3)O_(4)-GOLD still retained 70%of its initial ***,Fe_(3)O_(4)-GOLD maintained 50%of its initial activity after storage for 20 days,while free GLOD only retained 20%of its initial *** strategy of integrating biomimetic Fe 3 O4 and natural enzymes for cascade catalysis makes it possible to design an efficient and stable chemo-enzyme composite catalysts,which are promising for applications in biosensing and biomimetic catalysis.

关键词： Fe_(3)O_(4) nanozyme GLOD Chemo-enzymes Glutamate detection

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High-rate lithium-ion battery performance of a ternary sea urchin-shaped CoNiO_(2)@NiP_(6)Mo_(18)/CNTs composites

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Journal of Energy Chemistry 2024年第9期96卷 516-525页

作者： Li-ping cui Shuang Sun Kai Yu Shu Zhang Mei-lin Wang jia-jia Chen Bai-bin Zhou Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy MaterialsXiamen UniversityXiamen 361005FujianChina

Bimetallic oxides are attractive anode materials for lithium-ion batteries(LIBs)due to their large theoretical ***,the low conductivity,short cycle life,and poor rate capability are the bottlenecks for their further *** overcome above issues,the basket-like polymolybdate(NiP_(6)Mo_(18))and carbon nanotubes(CNTs)were uniformly embedded on the urchin-shaped CoNiO_(2)nanospheres to yield a ternary composites CoNiO_(2)@NiP_(6)Mo_(18)/CNTs via electrostatic *** multi-level morphology of urchin spinules accelerates the diffusion rate of Li^(+);CNT improves the conductivity and enhances cycle stability of the material;and heteropoly acid contributes more redox activity ***,CoNiO_(2)@NiP_(6)Mo_(18)/CNTs as an anode of LIBs exhibits a high initial capacity(1396.7 mA h g^(−1)at 0.1 A g^(−1)),long-term cycling stability(750.2 mA h g^(−1)after 300 cycles),and rate performance(450.3 mA h g^(−1)at 2 A g^(−1)),which are superior to reported metallic oxides anode of *** density functional theory(DFT)and kinetic mechanism suggest that CoNiO_(2)@NiP_(6)Mo_(18)/CNTs delivers an outstanding pseudocapacitance and rapid Li^(+)diffusion behaviors,which is due to the rich surface area of the urchin-like CoNiO_(2)with the uniform embeddedness of NiP_(6)Mo_(18)and *** study provides a new idea for optimizing the performance of bimetallic oxides and developing high-rate lithium-ion battery composites.

关键词： Bi-metal oxides Transition metal oxides Polyoxometalates Nanocomposite LIBs

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Translational regulation of DNA repair systems by eIF3a in cancer chemotherapeutic response

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中国药理学与毒理学杂志 2016年第10期30卷 1050-1051页

作者： CHEN Juan cui jia-jia ZHANG jian-ting ZHOU Hong-hao LIU Zhao-qian YIN Ji-ye Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South University Hunan Key Laboratory of Pharmacogenetics Department of Pharmacology and Toxicology Indiana University School of Medicine IU Simon Cancer Center Indiana University School of Medicine

OBJECTIVE To investigate the role of e IF3a in the regulation of DNA repair pathways in cancer chemotherapeutic *** Immunohistochemistry was used to determine the expression of e IF3a in lung and breast cancer tissues followed by association analysis of e IF3a expression with patient′s response to *** overexpression and RNA interference knockdown of e IF3a were carried out in NIH3T3and H1299 cell lines,respectively,to determine the effect of altered e IF3a expression on cellular response to chemotherapeutic drugs by using MTT *** DNA repair capacity of these cells was evaluated by using host-cell reactivation,NHEJ and HR ***-time reverse transcriptase PCR and Western Blot analyses were carried out to determine the effect of e IF3a on the DNA repair genes by using cells with altered e IF3a *** e IF3a expression associates with response of lung and breast cancer patients to platinum and anthracycline.e IF3a knockdown or overexpression,respectively,increased and decreased the cellular resistance to cisplatin and anthracycline anticancer drugs,DNA repair activity,and expression of NER and NHEJ DNA repair *** e IF3a plays an important role in regulating the expression of NER and NHEJ DNA repair proteins which,in turn,contributes to cellular response to DNA-damaging anticancer drugs and patients′response to platinum and anthracycline chemotherapy.

关键词： eIF3a DNA repair translation regulation platinum anthracycline cancer chemotherapy

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Structure attack on full-round DBST

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Frontiers of Computer Science 2024年第4期18卷 223-225页

作者： Chenhao jia Qing LING Ting WU Tingting cui School of Cyberspace Hangzhou Dianzi UniversityHangzhou 310018China Hangzhou Innovation Institute Beihang UniversityHangzhou 310052China Key Laboratory of Cryptologic Technology and Information Security(Ministry of Education) Shandong UniversityQingdao 266237China

1 Introduction Block cipher is one of the most important part of symmetric cipher,which has been widely used in the field of computer communication and information system *** order to meet the increasing demand for ensuring secure data transmission in Internet of Things(IoT)environment,lightweight block ciphers have become more and more important due to their easy software implementation,low resource consumption,ease of standardization and high ***,in order to satisfy the constraints of resource-limited devices,lightweight block ciphers strive to achieve a balance between the cost of software and hardware implementation,efficiency,and ***,sometimes the security of lightweight block ciphers might be challenged due to the simplified ***,it is meaningful to study the type of simplified lightweight block ciphers.

关键词： hardware computer simplified

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