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p38 Signaling Mediates Naringin-Induced Osteogenic Differentiation of Porcine Metanephric Mesenchymal Cells

Chinese Journal of Integrative Medicine 2024年第9期30卷 818-825页

作者： JI Peng-cheng XIE Yuan-sheng GUO Wen-kai FU Bo chen xiang-mei Chinese PLA Medical School Beijing100853China Department of Nephrology First Medical Center of Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing100853China School of Medicine Nankai UniversityTianjin300071China

Objective:To explore the potential of metanephric mesenchymal cells(MMCs)for osteogenesis and naringin’s ability to enhance this process and its molecular ***:Porcine MMCs at 70 days of gestation were used as tool cells,cultured in osteogenic induction medium,identified by immunocytochemistry *** potential of porcine MMCs and naringin’s ability to enhance this process was tested by detecting changes in cell viability,alkaline phosphatase(ALP)activity,the expression of runt-related transcription factor 2(Runx2),osteopontin(OPN)and osteocalcin(OCN),and the formation of mineralized nodules,and the application of the p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of ***:Immunocytochemical staining showed that the cells were Vimentin and Six2(+),E-cadherin and CK-18(−).Naringin can activate the p38 signaling pathway to enhance the osteogenesis of porcine MMCs by increasing cell viability,ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).The application of p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of naringin,manifested by decreased ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).Conclusion:Naringin,the active ingredient of Chinese herbal medicine Rhizoma Drynariae for nourishing Shen(Kidney)and strengthening bone,enhances the osteogenic differentiation of renal MMCs through the p38 signaling pathway.

关键词： metanephric mesenchymal cells naringin osteogenesis differentiation

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A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 754-761页

作者： Xiao-hong PAN Ying-xue chen mei-xiang xiang Geng XU Jian-an WANG Department of Cardiology the Seeond Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent(PES) in ST-segment elevation myocardial infarction(STEMI) patients.A systematic literature search was conducted to identify all randomized clinical trials in mortality,recurrent myocardial infarction(rMI),repeat revascularization(RR),and stent thrombosis(ST).A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent(BMS).The pooled repeat revascularization rate was 5.7% in PES group,significantly lower than 10.0% in BMS group with an odds ratio(OR) of 0.56,95% confidence interval(CI) [0.44,0.72](P<0.00001).No significant difference was found between PES and BMS groups in mortality at one year after the indexing procedure(3.9% vs.5.1%,OR 0.88,95% CI [0.63,1.21],P=0.42).Similarly,rMI rate did not differ significantly between the two groups(3.4% vs.4.1%,OR 0.80,95% CI [0.56,1.13],P=0.21).PES was also associated with the comparable pooled rate of definite stent thrombosis with BMS(2.3% vs.2.4%,OR 0.81,95% CI [0.52,1.26],P=0.35).The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety.

关键词： Myocardial infarction Paclitaxel-eluting stent Bare-metal stent Meta-analysis

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A Scheme for Generating Cluster States via Raman Interaction

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Communications in Theoretical Physics 2007年第1期47卷 53-58页

作者： YANG Rong-Can LI Hong-Cai LIN Xiu HUANG Zhi-Ping chen mei-xiang School of Physics and Optoelectronics Technology Fujian Normal University Fuzhou 350007 China

A scheme for generating cluster states via Raman interaction is proposed. In the scheme, we firstly prepare cluster states of multi-cavities with information encoded in the coherent states and then generate cluster states of multiatoms, which encode the information in the ground states of A-type atoms. The advantages of our scheme are that the atomic spontaneous radiation can be efficiently reduced since the cavity frequency is largely detuned from the atomic transition frequency and the Hadamard gate operation of the coherent states is replaced by measuring the coherent states.

关键词： cluster states Raman interaction A-type three-level atom coherent states

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慢性肾脏病患者的膳食评估

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解放军医学杂志 2024年第8期49卷 946-951页

作者：黄惠王倩骆雅咏唐正淳刘芳张睿敏董哲毅陈香美广东药科大学临床医学院广东广州510006 解放军总医院第一医学中心肾脏病医学部/肾脏疾病全国重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室北京100853 成都中医药大学基础医学院四川成都611137

慢性肾脏病(CKD)常用的膳食评估方法包括24 h膳食回顾(24-h DR)/3 d膳食回顾(3DDR)、食物频率问卷(FFQ)、饮食记录及基于氮动态平衡估计膳食蛋白摄入量。由于亚洲人群CKD患者较多,且对其采用FFQ方法进行的相关研究很少,因此,建立适合中... 详细信息

慢性肾脏病(CKD)常用的膳食评估方法包括24 h膳食回顾(24-h DR)/3 d膳食回顾(3DDR)、食物频率问卷(FFQ)、饮食记录及基于氮动态平衡估计膳食蛋白摄入量。由于亚洲人群CKD患者较多,且对其采用FFQ方法进行的相关研究很少,因此,建立适合中国CKD人群的FFQ十分重要。本文针对CKD膳食评估方法的优缺点和研究现状,以及建立FFQ的内容和步骤进行综述,旨在为改良中国CKD患者的FFQ提供参考。

关键词：慢性肾脏病膳食评估 24 h膳食回顾食物频率问卷

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Effect of short neuropeptide F signaling on larval feeding in Mythimna separata

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Insect Science 2024年第2期31卷 417-434页

作者： mei-mei Li Qi Yang Li-Hui chen Yan-Ying Li Jun-xiang Wu xiang-Li Xu State Key Laboratory of Crop Stress Biology in Arid Areas College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi ProvinceChinaand School of Agricultural Sciences Jiangxi Agricultural UniversityNanchangChina

Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the *** short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity of physiological functions,especially in functions related to feeding in insects,it is a molecular target for pest ***,an sNPF and 2 sNPFRs were identified and cloned from *** analysis revealed that the sNPF and its receptors had a highly conserved RLRFamide C-terminus and 7 transmembrane domains,*** sNPF and its receptor genes were distributed across larval periods and tissues,but 2 receptors had distinct expression *** starvation-induced assay elucidated that sNPF and sNPFR expression levels were downregulated under food deprivation and recovered with subsequent *** interference knockdown of sNPF,sNPFR1,and sNPFR2 by injection of double-stranded RNA into larvae not only suppressed food consumption and increased body size and weight,but also led to decrease of glycogen and total lipid contents,and increase of trehalose compared with double-stranded green fluorescent protein ***,molecular docking was performed on the interaction mode between sNPFR protein and its ligand sNPF based on the 3-dimensional models constructed by AlphaFold;the results indicated that both receptors were presumably activated by the mature peptide *** results revealed that sNPF signaling played a considerably vital role in the feeding regulation of *** and represents a potential control target for this pest.

关键词： feeding regulation Mythimna separata pest control target RNA interference short neuropeptide F sNPF receptors

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Icariin ameliorates learning and memory function via improving cerebral glucose metabolism disorder in APP/PS1/Tau triple transgenic Alzheimer disease mice

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中国药理学与毒理学杂志 2018年第9期32卷 704-705页

作者： ZHANG Ying YAN Fei chen mei-xiang JIN Hai NIE Jing SHI Jing-shan JIN Feng Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Institute of Digestive Diseases of Affiliated Hospital Zunyi Medical University Zunyi 563006 China

OBJECTIVE To investigate the protective effect of icariin(ICA) on learning and memory function in APP/PS1/Tau triple transgenic Alzheimer disease mice(3×Tg-AD mice),and then to explore whether its mechanism is related to the improvement of brain glucose metabolism *** Three-month-old male 3 ×Tg-AD mice were randomly divided into three groups(n=10):3×Tg group,3×Tg+ICA low-dose group(30 mg·kg-1) and 3×Tg + ICA high-dose group(60 mg·kg-1).Age-matched male wild type(WT) mice were randomly divided into two groups(n=10):WT control group and WT+ICA60 mg·kg-1 *** in vehicle(0.5% Tween-80 in distilled water) was given orally once a day for five months in the 3×Tg+ICA groups.3×Tg and WT control group were given an equal volume *** water maze was used to detect the learning and memory function of *** glucose metabolism in 3×Tg mice was observed by 18 F-FDG microPET imaging *** staining and HE staining were used to evaluate the survival neurons in hippocampus of *** oxidase assay was used to detect glucose contents in cortex of *** protein expression of APP,Aβ1-40,Aβ1-42 and glucose transporter 1(GLUT1),and the phosphorylation level of tau protein at multiple sites in hippocampus were detected by Western *** Behavioral examination revealed a profound decrease learning and memory function,accompanied by a decrease in number of neuronal cells in 3×Tg-AD ***,the cerebral18 F-FDG uptake rate per gram tissue was reduced and the glucose contents in the cortex were increased in 3×Tg-AD *** addition,Western blotting analysis showed that the expression of APP,Aβ1-40,Aβ1-42 proteins and the levels of tau protein phosphorylation at Ser199/202 and PHF-1(Ser396/404) sites were increased significantly,followed by a decrease of GLUT1 expression in hippocampus of 3×Tg-AD *** of these changes in behavioral functions,neuronal loss and related protein expression were reversed when mice were treated with

关键词： icariin Alzheimer disease glucosemetabolism glucose transporter 1

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Frost heaving and crack initiation characteristics of tunnel rock mass in cold regions under low-temperature degradation

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Journal of Mountain Science 2024年第8期21卷 2844-2854页

作者： chen Wenhua xiang Tian School of Civil Engineering Beijing Jiaotong UniversityBeijing 202303China

Water freezing in rock fractures causes volumetric expansion and fracture development through frost *** study introduces a novel analytical model to investigate how uneven freezing force and surrounding rock pressure influence fracture initiation,based on mass conservation,elasticity,and water-ice phase transition principles.A model for rock fracture initiation considering freezing temperature,uneven freezing expansion,in-situ stress,and lateral pressure was proposed based on fracture *** for stress intensity factors were developed and validated using the phase field *** effects of rock elastic modulus anisotropy and critical fracture energy density on fracture initiation were also *** results show that the values of KI and KII exhibit an upward trend as the freezing temperature,uneven expansion,in-situ stress,and lateral pressure *** uneven freezing expansion has the most significant influence on KI and KII values among these *** the uneven freezing expansion coefficient increases to 0.5,the fracture initiation mode shifts from tensile fracture to shear *** the lateral pressure coefficient increases to 1,the fracture initiation mode shifts from tensile fracture to shear *** elastic modulus anisotropy causes fractures to propagate in a clockwise direction,forming a'butterfly'*** fracture energy density an isotropy causes counterclockwise deviation in propagation direction,resulting in branching paths and an'H'-shaped pattern.

关键词： Rock fractures Fracture water Uneven freezing expansion Phase field method Initiation angle Anisotropy

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Effects of the properties of Mg(OH)_(2)precursor on the hydrothermal synthesis of magnesium oxysulfate whiskers

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Particuology 2024年第9期92卷 13-23页

作者： Thanayos Boonrit mei Yang Guangwen chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China

Magnesium oxysulfate(MOS)whiskers are commonly synthesized through a dissolution-precipitation mechanism,wherein Mg(OH)_(2)dissolves to form Mg(OH)64−,followed by reactions with SO_(4)^(2−)and H_(2)O to yield MOS ***,the impact of Mg(OH)_(2)precursor properties on the formation process of MOS whiskers has been insufficiently explored,and sector-like and needle-like morphologies were both observed in previous *** this study,we systematically investigated how the properties of Mg(OH)_(2)precursors influenced the crystalline structure and morphology of MOS *** various experimental conditions,MgSO_(4)·5Mg(OH)_(2)·2H_(2)O(152MOS)whiskers were consistently obtained,regardless of Mg(OH)_(2)morphology and *** size of Mg(OH)_(2)emerged as a critical factor in shaping the morphology of 152MOS ***-sized Mg(OH)_(2)(≤106±37 nm)favored the formation of sector-like whiskers,while larger-sized Mg(OH)_(2)(≥206±98 nm)encouraged the development of needle-like *** distinction was attributed to the slower dissolution rate exhibited by larger-sized Mg(OH)_(2),maintaining a smaller number of 152MOS nuclei and promoting the growth of needle-like whiskers instead of the aggregation of 152MOS nuclei into sector-like *** addition,the effects of the molar ratio of Mg^(2+)to SO_(4)^(2−)and hydrothermal temperature were also *** average length and diameter of the needle-like whiskers prepared with Mg(OH)_(2)of 331±145 nm under optimized conditions were 77±32 and 0.39±0.10μm,*** study presented an effective strategy for controlling the morphology of 152MOS whiskers.

关键词： Magnesium oxysulfate whiskers Morphology control Precursor Microreactor

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社会经济因素对中国内地地区血液透析发病率的影响

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中国血液净化 2024年第5期23卷 347-350页

作者：李思晨赵德龙邢增辉刘超蔡广研陈香美孙雪峰解放军总医院肾脏病医学部、肾脏疾病全国重点实验室、国家慢性肾病临床医学研究中心北京100853

目的明确影响中国内地地区血液透析(hemodialysis,HD)发病率的社会经济因素。方法从2012—2021年国家医疗服务与质量安全报告和中国统计年鉴中,分别提取2011—2020年中国内地31个省级地区(不含港澳台地区)的HD发病率数据和社会经济数据,... 详细信息

目的明确影响中国内地地区血液透析(hemodialysis,HD)发病率的社会经济因素。方法从2012—2021年国家医疗服务与质量安全报告和中国统计年鉴中,分别提取2011—2020年中国内地31个省级地区(不含港澳台地区)的HD发病率数据和社会经济数据,以2011年人均国内生产总值(gross domestic product,GDP)水平分为低(<3.0万元)、中等(≥3.0万元且<8.0万元)和高(≥8.0万)3组,分析影响HD发病率的危险因素;检索文献对比不同国家地区的慢性肾脏病(chronic kidney disease,CKD)患病率。结果不同年份和不同人均GDP组别影响HD发病率:HD发病率在低和中等人均GDP组,2020年高于2011年(t=3.736,P=0.002;t=12.898,P<0.001);10年间低和中等人均GDP组HD发病率的增长率高于高人均GDP组(F=5.573,P=0.009;F=0.733,P=0.024);乡村城镇人口比例、每千人口医疗卫生机构床位数、每千人口卫生技术人员和人均收入是影响HD发病率的独立相关因素(β=-0.172,0.232,0.225,-0.348;P=0.008,0.002,0.011,0.004);中国内地地区的CKD 3~5期患病率较全球平均水平低下(2.21 pmp比8.10 pmp)。结论伴随社会经济发展的医疗服务能力的增长,增加HD发病率;高人均GDP地区的HD发病率增长速度较低中人均GDP地区显著延缓。

关键词：血液透析发病率社会经济

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青风藤活性成分对糖尿病db/db小鼠氧化应激、炎症反应及免疫功能的影响

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河北中医药学报 2024年第4期39卷 1-7页

作者：刘均广冯智丽李猛高钰周晓红陈香美高维娟承德医学院病理生理学教研室河北承德067000 河北中医药大学/河北省心脑血管病中医药防治研究重点实验室石家庄050091 中国人民解放军总医院第一医学中心肾脏病医学部北京100853

目的:探讨青风藤活性成分对糖尿病(diabetes mellitus,DM)db/db小鼠肾脏的保护作用及其机制研究。方法:30只6周龄雄性db/db小鼠随机分为模型组(等体积生理盐水),阳性组(195 mg/kg/d羟苯磺酸钙),盐酸青藤碱(Sinomenine Hydrochloride,SH... 详细信息

目的:探讨青风藤活性成分对糖尿病(diabetes mellitus,DM)db/db小鼠肾脏的保护作用及其机制研究。方法:30只6周龄雄性db/db小鼠随机分为模型组(等体积生理盐水),阳性组(195 mg/kg/d羟苯磺酸钙),盐酸青藤碱(Sinomenine Hydrochloride,SH)低、中、高剂量组(31.2、62.4、124.8 mg/kg/d SH)5组,同时选取6只同周龄db/m小鼠设为对照组(等体积生理盐水),每日1次,定时灌胃给药,连续6 w。于12 w末观察各组小鼠一般情况,检测尿微量白蛋白(mAlb)、血肌酐(SCr)和血尿素氮(BUN)水平;试剂盒检测肾组织匀浆中丙二醛(MDA)、还原型谷胱甘肽(GSH)和超氧化物歧化酶(SOD)的水平;Luminex多因子检测技术测定血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)的含量;ELISA法检测血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)及补体蛋白3(C3)的水平;苏木精-伊红(HE)和过碘酸-雪夫(PAS)染色观察肾脏组织病理形态变化;透射电镜观察肾脏超微结构的改变。结果:与模型组比较,阳性组和SH低、中、高剂量组小鼠mAlb、SCr和BUN水平均降低(P<0.05);肾组织匀浆中MDA水平降低(P<0.05),GSH水平和SOD活性均升高(P<0.05);血清中TNF-α、IL-1β、IL-6、IgG、IgM、IgA和补体C3水平均降低(P<0.05),IL-10水平升高(P<0.05);镜下肾小球损伤及肾小管上皮水肿情况均有所改善,肾组织损伤减轻。结论:青风藤活性成分对DM db/db小鼠的肾脏具有保护作用,其作用机制可能与改善氧化应激反应,缓解炎症反应及提高免疫功能有关。

关键词：青风藤糖尿病db/db小鼠氧化应激炎症反应免疫功能

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