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Tunning the bandgap of MnO_(2)homojunction by building active high-index facet to achieve rapid electron transfer for enhanced photocatalytic sterilization

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Journal of Materials Science & Technology 2024年第1期168卷 265-275页

作者： Tao Zhang Bo Li Chaofeng Wang Shuilin Wu Shengli Zhu hui Jiang Yufeng Zheng Zhaoyang Li Zhenduo Cui Yu Zhang Paul K chu Xiangmei Liu Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science and Engineering Hubei UniversityWuhan 430062China School of Health Science&Biomedical Engineering Hebei University of TechnologyTianjin 300401China School of Materials Science&Engineering Peking UniversityBeijing 100871China School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Physics Department of Materials Science and Engineering and Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Photocatalysis has been a research hotspot in recent years,and the design and modification of photocat-alysts have been the key *** methods for designing photocatalysts,including constructing heterojunctions and homojunctions,have been developed on the basis of *** this study,two homojunctions of manganese dioxide(MnO_(2)),including a high-index crystal plane homojunction and a general homojunction,are prepared using a stepwise hydrothermal *** a capping agent,the high-index crystal surface of the MnO_(2)is *** is found that the electron transport efficiency be-tween the two components of the homojunction with high-index planes is higher and the adsorption capacity of the oxygen is stronger,which leads to higher photocatalytic *** addition,the newly designed high-index homojunction is used for the treatment of bacterial infections,and it kills Staphy-lococcus aureus(***)and Escherichia coli(***)at rates of 99.95%±0.04%and 99.31%±0.25%,*** also has excellent therapeutic effects on mouse wounds,which implies superb practical application *** work provides a new strategy for the improved design of homojunctions and the application of photocatalytic materials.

关键词： Photocatalysis Homojunction Bandgap High-index facet Antibacterial

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第1期15卷 42-51页

作者： Qing-Quan LI Miao BI Song YANG Qing-Yuan WU Yi-hui DING Xin-Yong SHEN Xiao-Ting SUN Meng-chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease

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Chinese Medical Journal 2024年第4期137卷 502-504页

作者： hui Liu Shunying Zhao Haiming Yang Jinrong Liu hui Xu Xiaolei Tang Yuelin Shen Xiaoyan Zhang Xiaohui Wen Yuhong Zhao Ping chu huimin Li Department of Second Respiratory Medicine National Clinical Research Center for Respiratory DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Office of Scientific Research Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

To the Editor:Chronic granulomatous disease(CGD)is an inherited primary immunodeficiency disease characterized by recurrent life-threatening bacterial or fungal infection and tissue granuloma formation.^([1])Pulmonary infection is the most frequent manifestation,affecting nearly 80%of patients,[2]and remains the major cause of morbidity and mortality in patients with *** of the pathogenic microorganisms responsible for first-episode pulmonary infection provide information on the spectrum of infection in patients with CGD,help guide the empirical choice of antibiotics or antifungal therapy,and contribute to the early identification and management of *** is the commonest causative agent of pulmonary infection,but the distribution of other pathogens varies among countries.^([2–5])Few studies have investigated the etiology of pulmonary infection in CGD in a large cohort in China.

关键词： granuloma infection mortality

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Risk factors associated with intraoperative persistent hypotension in pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1582-1591页

作者： Xing-Jun Wang Xi-Chen Xuan Zhao-chu Sun Shi Shen Fan Yu Na-Na Li Xue-chun chu hui Yin You-Li Hu Department of Anesthesia and Perioperative Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain *** To clarify the risk factors associated with IPH during PD,ensuring patient safety in the perioperative *** A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in *** factors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas *** was defined as sustained mean arterial pressure30 min despite additional deoxyepinephrine and fluid *** Among 1596 PD patients,661(41.42%)experienced *** logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](P<0.001),longer surgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(P<0.01),and greater blood loss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(P<0.01).A novel finding was the association of arterial blood Ca^(2+)<1.05 mmol/L with IPH(OR:2.03,95%CI:1.65-2.50)(P<0.001).CONCLUSION IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).

关键词： Risk factors Pancreaticoduodenectomy Perioperative period Intraoperative persistent hypotension Retrospective cohort study

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电动汽车电池温度一致性与驾驶行为关联特性研究

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中国公路学报 2024年第3期37卷 216-230页

作者：张晖李少鹏丁乃侃武汉理工大学智能交通系统研究中心湖北武汉430063 武汉理工大学交通信息与安全教育部工程研究中心湖北武汉430063

为实现融合车辆运行状态的电池温度不一致性的精准评估诊断,设计并开展电动汽车自然驾驶试验,利用长周期、精细化的车辆运行数据,从微观运行片段的角度探究了电池温度一致性与驾驶行为的关联特性。通过驾驶人踩/松踏板的驾驶行为将车辆... 详细信息

为实现融合车辆运行状态的电池温度不一致性的精准评估诊断,设计并开展电动汽车自然驾驶试验,利用长周期、精细化的车辆运行数据,从微观运行片段的角度探究了电池温度一致性与驾驶行为的关联特性。通过驾驶人踩/松踏板的驾驶行为将车辆运行过程划分为A、B、C、D四类微观片段。分别针对4类片段,通过计算最大信息系数(Maximum Information Coefficient, MIC)得到了各驾驶行为参数与探针温度变异系数(Variation Coefficient of Probe Temperature, VCPT)的相关性,利用随机森林模型分析了驾驶行为参数对VCPT的重要性及影响机理,利用数据分组统计计算了驾驶行为参数对VCPT的量化影响效应。研究结果表明:驾驶行为参数与电池温度一致性具有弱相关性,且其对电池温度一致性的影响是非线性且非单调的;总体上车速类参数与电池温度一致性的相关性强于加速度和踏板类参数;对VCPT回归预测最重要的4项驾驶行为参数中,4类片段下均包含最大车速,B、C、D三类片段下均包含最大负向加速度;相比于高车速和高车速波动,高减速度驾驶行为引起的温度不一致性增幅是最显著的,4类片段下VCPT促进效应最显著的驾驶行为参数分别是最大负向加速度、平均负向加速度、最大负向加速度、车速标准差,其参数值85%分位点以上对应的VCPT均值比15%分位点以下的分别大9.44%、20.36%、13.05%、16.37%。研究结果可以支撑基于驾驶场景自适应阈值的电池温度不一致性评估诊断方法的提出,进而提高电动汽车电池安全预警准确率。

关键词：汽车工程电池安全最大信息系数电池温度一致性电动汽车驾驶行为

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Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

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Military Medical Research 2024年第1期11卷 148-151页

作者： hui-Juan Duan Hong-Qian chu Ting-Ming Cao Guang-Ming Dai Na Tian Gang Sheng Zhao-Gang Sun Beijing Key Laboratory in Drug Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China

Dear Editor,The tuberculin skin test(TST)reagents have continuously improved,with the ESAT6-CFP10(EC)test having recently been introduced,but are seldom based on the direction of the delayed-type hypersensitivity(DTH)*** studies only partially showed the infiltration and activation of immune cells and the production of cytokines of the skin induration[1,2],and lack the detailed measurements of cell proportions and gene expression in the DTH ***,in this study,we revealed the comprehensive characteristics of DTH by single-cell RNA sequencing(scRNA-seq)in the guinea pig tuberculosis(TB)model[Experimental Animal Welfare Ethics Committee,Beijing Tuberculosis and Thoracic Tumor Research Institute(2021-064)].

关键词： Tuberculin skin test Delayed-type hypersensitivity Single-cell RNA sequencing

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Efficacy of Moxifloxacin against Mycobacterium abscessus in Zebrafish Model in vivo

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Biomedical and Environmental Sciences 2020年第5期33卷 350-358页

作者： NIE Wen Juan XIE Zhong Yao GAO Shan TENG Tian Lu ZHOU Wen Qiang SHANG Yuan Yuan JING Wei SHI Wen hui WANG Qing Feng HUANG Xue Rui CAI Bao Yun WANG Jun WANG Jing GUO Ru GE Qi Ping NIE Li hui HAN Xi Qin DU Ya Dong chu nai hui Tuberculosis Department Beijing Chest Hospital affiliated to Capital Medical UniversityBeijing 101149China Beijing Chest Hospital affiliated to Capital Medical University Beijing 101149China

Objective Moxifloxacin(MFX)shows good in vitro activity against Mycobacterium abscessus and can be a possible antibiotic therapy to treat *** infection;however,other studies have shown a lower or no *** aimed to evaluate MFX activity against *** using zebrafish(ZF)model in *** A formulation of *** labeled with CM-Dil was micro-injected into *** curves were determined by recording dead ZF every *** were lysed,and colony-forming units(CFUs)were *** dissemination and fluorescence intensity in ZF were *** rates of MFX and azithromycin(AZM,positive control)were determined and *** Significantly increased survival rate was observed with different AZM ***,increasing MFX concentration did not result in a significant decrease in ZF survival *** significant differences in bacterial burdens by CFU loads were observed between AZM and MFX groups at various *** fluorescence intensity in ZF was significantly correlated with AZM ***,with increasing MFX concentration,fluorescence intensity decreased slightly when observed under fluorescence *** rates at various concentrations were comparable between the MFX and AZM groups,with no significant *** MFX showed limited efficacy against *** in vivo using ZF *** activity in vivo needs to be confirmed.

关键词： Mycobacterium abscessus Moxifloxacin Azithromycin Zebrafish

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终止结核病流行须加强结核分枝杆菌潜伏感染高危人群筛查和预防性治疗的管理

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中国防痨杂志 2022年第3期44卷 209-214页

作者：马艳陆伟高磊初乃惠周林成诗明中国中医科学院中医临床基础医学基础所北京100700 江苏省疾病预防控制中心南京210009 中国医学科学院病原生物学研究所北京100730 北京市结核病胸部肿瘤研究所/首都医科大学附属北京胸科医院结核一科北京101149 中国疾病预防控制中心结核病预防控制中心患者关怀部北京102206 中国防痨协会北京100710

当前,全球结核病发病率下降缓慢,给实现终止结核病目标带来了严峻的挑战。2020年估算全球结核分枝杆菌潜伏感染人群近20亿,在无预防性治疗干预情况下,其中有5%~10%的感染者在一生中会发展为活动性结核病,在结核病高危人群中发病率更高... 详细信息

当前,全球结核病发病率下降缓慢,给实现终止结核病目标带来了严峻的挑战。2020年估算全球结核分枝杆菌潜伏感染人群近20亿,在无预防性治疗干预情况下,其中有5%~10%的感染者在一生中会发展为活动性结核病,在结核病高危人群中发病率更高。世界卫生组织在全球范围内号召推广结核分枝杆菌潜伏感染(LTBI)的预防干预,以实现结核病发病率快速下降的目标。笔者就LTBI流行和预防性治疗的现状、高危人群发病风险、筛查方法、干预和管理建议等进行论述,为制定我国LTBI干预和管理策略及措施提供参考。

关键词：分枝杆菌,结核传染病潜伏期诊断预防和防护用药

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High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells

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World Journal of Stem Cells 2024年第2期16卷 176-190页

作者： Yu-Su Wang Wen-hui chu Jing-Jie Zhai Wen-Ying Wang Zhong-Mei He Quan-Min Zhao chun-Yi Li Institute of Antler Science and Product Technology Changchun Sci-Tech UniversityChangchun 130000Jilin ProvinceChina College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118Jilin ProvinceChina School of Life Science Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Oral Implantology Hospital of StomatologyJilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Cartilage defects are some of the most common causes of *** lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral *** studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral *** To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral *** We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM *** sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the *** weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee *** The defects were successfully repaired by applying the *** highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem *** Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.

关键词： Osteochondral defect repair Mesenchymal stem cells Extracellular matrix Decellularization Antler stem cells Reserve mesenchymal cells Xenogeneic

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耐药肺结核患者氟喹诺酮类药物耐药情况及影响因素

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中国防痨杂志 2021年第9期43卷 905-909页

作者：石文卉初乃惠北京市结核病胸部肿瘤研究所/首都医科大学附属北京胸科医院结核一科 101149

目的分析耐药肺结核患者对氟喹诺酮类药物的耐药情况及影响因素。方法采用回顾性研究方法,选取2015年1月至2020年12月于首都医科大学附属北京胸科医院确诊并住院治疗的988例耐药肺结核患者作为研究对象。研究对象均经痰液标本分枝杆菌... 详细信息

目的分析耐药肺结核患者对氟喹诺酮类药物的耐药情况及影响因素。方法采用回顾性研究方法,选取2015年1月至2020年12月于首都医科大学附属北京胸科医院确诊并住院治疗的988例耐药肺结核患者作为研究对象。研究对象均经痰液标本分枝杆菌培养阳性,并经菌种鉴定为结核分枝杆菌,均进行了药物敏感性试验(简称"药敏试验"),证实对异烟肼、利福平、利福喷丁、利福布丁、乙胺丁醇、氯法齐明、阿米卡星、丙硫异烟胺、克拉霉素、卡那霉素、卷曲霉素、链霉素等药物中任意一种或一种以上药物耐药。采用比例法药敏试验对氧氟沙星、左氧氟沙星、莫西沙星等进行耐药检测。分析不同特征研究对象对氟喹诺酮类药物的耐药情况,并采用多因素logistic回归模型分析耐药肺结核患者出现氟喹诺酮类药物耐药的影响因素。结果988例研究对象中,对氟喹诺酮类药物耐药者有431例,耐药率为43.62%。氟喹诺酮类药物耐药者中年龄<18岁者占0.93%(4/431)、初治患者占17.86%(77/431)、北京地区居住者占14.62%(63/431),均明显高于氟喹诺酮类药物敏感者[分别占3.05%(17/557)、36.98%(206/557)、31.42%(175/557)],差异均有统计学意义(χ^(2)值分别为6.154、43.453、37.508,P值均<0.05);利福平耐药者占94.66%(408/431),明显高于氟喹诺酮类药物敏感者[84.38%(470/557)],差异有统计学意义(χ^(2)=25.968,P<0.01);有氟喹诺酮类药物用药史者占3.81%(15/431),与氟喹诺酮类药物敏感者相比[2.98%(15/557)],差异无统计学意义(χ^(2)=0.465,P=0.495)。多因素logistic回归分析显示,利福平耐药[OR(95%CI)=2.704(1.585~4.615)]、有氟喹诺酮类药物用药史[OR(95%CI)=2.661(1.210~5.854)]是耐药肺结核患者发生氟喹诺酮类药物耐药的危险因素;而初治[OR(95%CI)=0.402(0.283~0.571)]及居住在北京[OR(95%CI)=0.411(0.289~0.585)]是耐药肺结核患者发生氟喹诺酮类药物耐药的保护因素。结论耐药肺结核患者对氟喹诺酮类药物的耐药率较高;复治、利福平耐药、有氟喹诺酮类药物用药史和非北京地区居住患者发生氟喹诺酮类药物耐药的风险增高。

关键词：结核肺抗药性喹诺酮类危险因素横断面研究

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