Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease

作     者：Hui Liu Shunying Zhao Haiming Yang Jinrong Liu Hui Xu Xiaolei Tang Yuelin Shen Xiaoyan Zhang Xiaohui Wen Yuhong Zhao Ping Chu Huimin Li 

作者机构：Department of Second Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Office of Scientific ResearchBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2024年第137卷第4期

页      面：502-504页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100202[医学-儿科学] 10[医学] 

基　　金：supported by a grant from the Respiratory Research Project of the National Clinical Research Center for Respiratory Diseases(No.HX2X-202103) 

主　　题：granuloma infection mortality 

摘      要：To the Editor:Chronic granulomatous disease(CGD)is an inherited primary immunodeficiency disease characterized by recurrent life-threatening bacterial or fungal infection and tissue granuloma formation.^([1])Pulmonary infection is the most frequent manifestation,affecting nearly 80%of patients,[2]and remains the major cause of morbidity and mortality in patients with *** of the pathogenic microorganisms responsible for first-episode pulmonary infection provide information on the spectrum of infection in patients with CGD,help guide the empirical choice of antibiotics or antifungal therapy,and contribute to the early identification and management of *** is the commonest causative agent of pulmonary infection,but the distribution of other pathogens varies among countries.^([2–5])Few studies have investigated the etiology of pulmonary infection in CGD in a large cohort in China.