Efficacy of Moxifloxacin against Mycobacterium abscessus in Zebrafish Model in vivo

作     者：NIE Wen Juan XIE Zhong Yao GAO Shan TENG Tian Lu ZHOU Wen Qiang SHANG Yuan Yuan JING Wei SHI Wen Hui WANG Qing Feng HUANG Xue Rui CAI Bao Yun WANG Jun WANG Jing GUO Ru GE Qi Ping NIE Li Hui HAN Xi Qin DU Ya Dong CHU Nai Hui NIE Wen Juan;XIE Zhong Yao;GAO Shan;TENG Tian Lu;ZHOU Wen Qiang;SHANG Yuan Yuan;JING Wei;SHI Wen Hui;WANG Qing Feng;HUANG Xue Rui;CAI Bao Yun;WANG Jun;WANG Jing;GUO Ru;GE Qi Ping;NIE Li Hui;HAN Xi Qin;DU Ya Dong;CHU Nai Hui

作者机构：Tuberculosis DepartmentBeijing Chest Hospital affiliated to Capital Medical UniversityBeijing 101149China Beijing Chest Hospital affiliated to Capital Medical UniversityBeijing 101149China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第5期

页      面：350-358页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100706[医学-药理学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Beijing Hospital Authority Youth Programme[QML20171602] Tongzhou District’s Two Supreme Talent[YH201911] Key Laboratory of Capital Medical University Open Research Project and Beijing Tuberculosis&Thoracic Tumor Research Institute Cultivation Project 13th Five National Major Scientific and Technological Projects[2017ZX09304009] 

主　　题：Mycobacterium abscessus Moxifloxacin Azithromycin Zebrafish 

摘      要：Objective Moxifloxacin(MFX)shows good in vitro activity against Mycobacterium abscessus and can be a possible antibiotic therapy to treat *** infection;however,other studies have shown a lower or no *** aimed to evaluate MFX activity against *** using zebrafish(ZF)model in *** A formulation of *** labeled with CM-Dil was micro-injected into *** curves were determined by recording dead ZF every *** were lysed,and colony-forming units(CFUs)were *** dissemination and fluorescence intensity in ZF were *** rates of MFX and azithromycin(AZM,positive control)were determined and *** Significantly increased survival rate was observed with different AZM ***,increasing MFX concentration did not result in a significant decrease in ZF survival *** significant differences in bacterial burdens by CFU loads were observed between AZM and MFX groups at various *** fluorescence intensity in ZF was significantly correlated with AZM ***,with increasing MFX concentration,fluorescence intensity decreased slightly when observed under fluorescence *** rates at various concentrations were comparable between the MFX and AZM groups,with no significant *** MFX showed limited efficacy against *** in vivo using ZF *** activity in vivo needs to be confirmed.