Efficacy of Moxifloxacin against Mycobacterium abscessus in Zebrafish Model in vivo
Efficacy of Moxifloxacin against Mycobacterium abscessus in Zebrafish Model in vivo作者机构:Tuberculosis DepartmentBeijing Chest Hospital affiliated to Capital Medical UniversityBeijing 101149China Beijing Chest Hospital affiliated to Capital Medical UniversityBeijing 101149China
出 版 物:《Biomedical and Environmental Sciences》 (生物医学与环境科学(英文版))
年 卷 期:2020年第33卷第5期
页 面:350-358页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 0830[工学-环境科学与工程(可授工学、理学、农学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100706[医学-药理学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学]
基 金:supported by Beijing Hospital Authority Youth Programme[QML20171602] Tongzhou District’s Two Supreme Talent[YH201911] Key Laboratory of Capital Medical University Open Research Project and Beijing Tuberculosis&Thoracic Tumor Research Institute Cultivation Project 13th Five National Major Scientific and Technological Projects[2017ZX09304009]
主 题:Mycobacterium abscessus Moxifloxacin Azithromycin Zebrafish
摘 要:Objective Moxifloxacin(MFX)shows good in vitro activity against Mycobacterium abscessus and can be a possible antibiotic therapy to treat *** infection;however,other studies have shown a lower or no *** aimed to evaluate MFX activity against *** using zebrafish(ZF)model in *** A formulation of *** labeled with CM-Dil was micro-injected into *** curves were determined by recording dead ZF every *** were lysed,and colony-forming units(CFUs)were *** dissemination and fluorescence intensity in ZF were *** rates of MFX and azithromycin(AZM,positive control)were determined and *** Significantly increased survival rate was observed with different AZM ***,increasing MFX concentration did not result in a significant decrease in ZF survival *** significant differences in bacterial burdens by CFU loads were observed between AZM and MFX groups at various *** fluorescence intensity in ZF was significantly correlated with AZM ***,with increasing MFX concentration,fluorescence intensity decreased slightly when observed under fluorescence *** rates at various concentrations were comparable between the MFX and AZM groups,with no significant *** MFX showed limited efficacy against *** in vivo using ZF *** activity in vivo needs to be confirmed.