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Journal of Innovative Optical Health Sciences 2012年第2期5卷 25-33页

作者： christine m.n.yow RICKY W.K.WU ZHEnG HUAnG medical Laboratory Science Department of Health Technology Informatics Hong Kong Polytechnic University Hong Kong SARChina Department of Radiation Oncology University of Colorado Denver COUSA mOE Key Laboratory of OptoElectronic Science and Technology for medicine Fujian normal University FuzhouChina

nasopharyngeal carcinoma(nPC)is a prevalent cancer in some areas of southern *** explore the potential of photodynamic therapy(PDT)for the treatment of nPC,a small molecule prodrug 5-aminolevulinic acid(ALA)and its methyl ester(mAL)mediated PDT was studied in *** results showed that human nPC cells were sensitive to both ALA-and mAL-mediated ***,ALA was more effective than mAL,possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin(PpIX)in nPC *** ALA nor mAL caused any significant *** ALA-based PDT might be a useful modality in the treatment ofnPC.

关键词： Aminolevulinic acid methylaminolevulinate nasopharyngeal carcinoma photodynamic therapy

An in vitro investigation of photodynamic efficacy of FosPeg■ on human colon cancer cells

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 86-93页

作者： Ricky W.K.Wu Ellie S.m.Chu Zheng Huang malini C.Olivo David C.W.Ip christine m.n.yow medical Laboratory Science Department of Health Technology&Informatics Hong Kong Polytechnic UniversityHKSARChina Department of medical Science Tung Wah CollegeHKSARChina College of Photonic&Electronic Engineering Fujian normal University Fuzhou China University of Colorado Denver Cancer Center COUSA Department of Pharmacy National University of SingaporeSingapore

Photodynamic therapy(PDT)is a novel therapeutic approach for combating various *** involves the administration of a photosensitizer which generates singlet oxygen after light ***■ is the liposomal formulation of *** this in vitro study,the photodynamic efficacy of FosPeg■ on a human colon cancer cell line(HT29)was investigated via studying the cellular uptake of FosPeg■,FosPeg■ PDT mediated photocytotoxicity and the cell death mechanism were ***■ PDT demonstrated its antitumor effect in a drug and light dose-dependent manner in HT-29 *** dose(LD50)was achieved with 0.4g/mL of drug and 3 J/cm^(2) of light ***■ PDT triggered apoptotic cell death via activating caspase cascade and regulating cell cycle *** conclusion,FosPegr-PDT is an effective measure to combat human colon cancer cells.

关键词： FosPeg■ HT-29 apoptosis caspase-3

Photodynamic therapy of cancer-Challenges of multidrug resistance

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 14-26页

作者： Zheng Huang Yih-Chih Hsu Li-Bo Li Luo-Wei Wang Xiao-Dong Song christine m.n.yow Xia Lei Ali I.musani Rong-Cheng Luo Brian J.Day mOE Key Laboratory of OptoElectronic Science and Technology for medicine Fujian Normal University FuzhouP.R.China College of Engineering and Applied Science University of Colorado Denver COUSA Department of medicine national Jewish Health COUSA Department of Bioscience Technology Center for nanotechnology and Institute of Biomedical Technology Chung Yuan Christian University TaoyuanTaiwan TCm-Integrated Cancer Center Southern medical University GuangzhouP.R.China Department of Gastroenterology&Endoscopy Changhai Hospital Second Military Medical University ShanghaiP.R.China Department of Urologic Surgery Tongji Medical College of Huazhong University of Science&TechnologyWuhanP.R.China Department of Health Technology Informatics Hong Kong Polytechnic University Hong Kong SARP.R.China Department of Dermatology Daping Hospital Third Military Medical UniversityChongqingP.R.China

Photodynamic therapy(PDT)of cancer is a two-step drug device combination modality,which involves the topical or systemie administration of a photosensitizer followed by light ilumnination of cancer *** the presence of oxygen molecules,the light illmnination of photosensitizer(PS)can lead to the generation of cytotoxic reactive oxygen species(ROS)and consequently destroy *** to many other anticancer therapies,PDT is also subject to intrinsic cancer resistance mediated by mutidrug resistance(mDR)*** paper will review the recent progress in understanding the interaction between mDR transporters and PS *** strategies that can be used in a clinical setting to owercome or bypass mDR will also be discussed.

关键词： Photodynamic therapy photosensitizer multidrug resistance cancer

The role of retinoic acid in the commitment to meiosis

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Asian Journal of Andrology 2021年第6期23卷 549-554页

作者： Rachel L Gewiss m christine Schleif michael D Griswold School of molecular Biosciences and Center for Reproductive Biology Washington State UniversityPullmanWA 99164USA

male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid *** review focuses on the role of retinoic acid(RA)in meiosis,as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and ***,we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8(STRA8)and mEIOSIn,which are responsive to RA and are critical for *** assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.

关键词： meiosis retinoic acid spermatogenesis testis

Uncovering the effect of poly(ethylene-co-vinyl alcohol)molecular weight and vinyl alcohol content on morphology,antifouling,and permeation properties of polysulfone ultrafiltration membrane:thermodynamic and formation hydrodynamic behavior

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Frontiers of Chemical Science and Engineering 2023年第10期17卷 1484-1502页

作者： Sania Kadanyo christine n.matindi Derrick S.Dlamini nozipho n.Gumbi Yunxia Hu Zhenyu Cui Jianxin Li State Key Laboratory of Separation membranes and membrane Processes National Center for International Joint Research on Membrane Science and TechnologyTiangong UniversityTianjin 300387China School of materials Science and Engineering Tiangong UniversityTianjin 300387China Institute for nanotechnology and Water Sustainability College of ScienceEngineering and TechnologyUniversity of South Africa Science CampusFlorida 1710South Africa University of California Los Angeles(UCLA)Department of Civil&Environmental EngineeringUCLA California NanoSystems Institute and UCLA Institute of the Environment&SustainabilityLos AngelesCA 90095USA

Various hydrophilic poly(ethylene-co-vinyl alcohol)(EVOH)were used herein to precisely control the structure and hydrodynamic properties of polysulfone(PSF)***,to prepare pristine PSF and PSF/EVOH blends with increasing vinyl alcohol(VOH:73%,68%,56%),the non-solvent-induced phase separation(nIPS)technique was *** glycol was used as a compatibilizer and as a porogen in n,*** and ultrasonic separation kinetic measurements were also carried out to develop an ultrafiltration membrane *** extracted membrane properties and filtration capabilities were systematically compared to the proposed ***,the addition of EVOH led to an increase in the rheology of the *** resulting membranes exhibited a microporous structure,while the finger-like structures became more evident with increasing VOH *** PSF/EVOH behavior was changed from immediate to delayed segregation due to a change in the hydrodynamic ***,the PSF/EVOH32 membranes showed high hydrophilicity and achieved a pure water permeability of 264 L·m^(–2)·h^(–1)·bar^(–1),which was higher than that of pure PSF membranes(171 L·m^(–2)·h^(–1)·bar^(–1)).In addition,PSF/EVOH32 rejected bovine serum albumin at a high rate(>90%)and achieved a significant restoration of ***,from the thermodynamic and hydrodynamic results,valuable insights into the selection of hydrophilic copolymers were provided to tailor the membrane structure while improving both the permeability and antifouling performance.

关键词： polysulfone blend modification ultrafiltration membrane formation hydrodynamics poly(ethyleneco-vinyl alcohol)copolymer

Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 41-57页

作者： christine C. nguyen Cody n. Hugie molly L. Kile Tala navab-Daneshmand Department of Environmental Sciences Oregon State University Corvallis OR 97331 USA School of Chemical Biological and Environmental Engineering Oregon State University Corvallis OR 97331 USA School of Biological and Population Health Sciences Oregon State University Corvallis OR 97331 USA

Antibiotic resistance in human pathogens can proliferate under selective pressures. Heavy metals in environmental reservoirs may contribute to selecting antibiotic-resistant strains. To determine the associations between heavy metals and antibiotic resistance, a literature review was conducted to systematically collect and categorize evidence for co-occurrence of resistance to heavy metals and antibiotics within human pathogenic bacteria in water, wastewater, and soil. In total, 42 publications adhered to inclusion criteria. Across the reservoirs, zinc and cadmium were the most commonly observed heavy metals associated with resistance to antibiotics. Pseudomonas aeruginosa and Escherichia coli were the most commonly studied bacteria with reported co-occurrence of resistance to several heavy metals and antibiotic classes. As co-selecting agents, prevalence of heavy metals in the environment can proliferate resistance to heavy metals and antibiotics through co-resistance and crossresistance mechanisms. In comparing different reservoirs, soils and sediments harbor higher heavy metal and antibiotic resistances compared to water environments. Additionally, abiotic factors such as pH can affect the solubility and hence, the availability of heavy metals to bacterial pathogens. Overall, our review demonstrates heavy metals act as co-selecting agents in the proliferation of antibiotic resistance in human pathogens in multiple environmental reservoirs. more studies that include statistical data are needed to further describe the exposure-response relationships between heavy metals and antibiotic resistance in different environmental media. moreover, integration of culturebased and molecular-based methods in future studies are recommended to better inform our understanding of bacterial co- and cross-resistance mechanisms to heavy metals and antibiotics.

关键词： Zinc Cadmium Copper Lead E. coli P. aeruginosa

Using Statistical Downscaling to Quantify the GCm-Related Uncertainty in Regional Climate Change Scenarios: A Case Study of Swedish Precipitation

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Advances in Atmospheric Sciences 2006年第1期23卷 54-60页

作者： Deliang CHEn christine ACHBERGER Jouni R■IS■nEn Cecilia HELLSTRm Earth Sciences Centre Gothenburg UniversityGothenburgSweden Laboratory for Climate Studies/National Climate CenterChina Meteorological AdministrationBeijingChina Earth Sciences Centre Gothenburg UniversityGothenburgSweden Department of Atmospheric Sciences University of HelsinkiFinland

There are a number of sources of uncertainty in regional climate change scenarios. When statistical downscaling is used to obtain regional climate change scenarios, the uncertainty may originate from the uncertainties in the global climate models used, the skill of the statistical model, and the forcing scenarios applied to the global climate model. The uncertainty associated with global climate models can be evaluated by examining the differences in the predictors and in the downscaled climate change scenarios based on a set of different global climate models. When standardized global climate model simulations such as the second phase of the Coupled model Intercomparison Project （CmIP2） are used, the difference in the downscaled variables mainly reflects differences in the climate models and the natural variability in the simulated climates. It is proposed that the spread of the estimates can be taken as a measure of the uncertainty associated with global climate models. The proposed method is applied to the estimation of global-climate-model-related uncertainty in regional precipitation change scenarios in Sweden. Results from statistical downscaling based on 17 global climate models show that there is an overall increase in annual precipitation all over Sweden although a considerable spread of the changes in the precipitation exists. The general increase can be attributed to the increased large-scale precipitation and the enhanced westerly wind. The estimated uncertainty is nearly independent of region. However, there is a seasonal dependence. The estimates for winter show the highest level of confidence, while the estimates for summer show the least.

关键词： Statistical downscaling global climate model climate change scenario uncertainty

Practical Considerations and Limitations of Using Leaf and Canopy Temperature measurements as a Stomatal Conductance Proxy:Sensitivity across Environmental Conditions,Scale,and Sample Size

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Plant Phenomics 2024年第2期6卷 416-432页

作者： Ismael K.mayanja christine H.Diepenbrock Vincent Vadez Tong Lei Brian n.Bailey Department of Biological Systems Engineering University of CaliforniaDavisDavisCAUSA Department of Plant Sciences University of CaliforniaDavisDavisCAUSA French national Research Institute for Sustainable Development(IRD) UMR DIADEUniversity of MontpellierMontpellierFrance

Stomatal conductance(gs)is a crucial component of plant physiology,as it links plant productivity and water loss through *** gs indirectly through leaf temperature(Tl)measurement is common for reducing the high labor cost associated with direct gs ***,the relationship between observed Tl and gs can be notably affected by local environmental conditions,canopy structure,measurement scale,sample size,and gs itself.

关键词： environmental temperature conditions canopy sample proxy scale leaf across conductance

Effects of Saccharomyces cerevisiae or boulardii yeasts on acute stress induced intestinal dysmotility

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World Journal of Gastroenterology 2016年第48期22卷 10532-10544页

作者： christine West Andrew m Stanisz Annette Wong Wolfgang A Kunze mcmaster Brain-Body Institute St. Joseph’s Healthcare Department of Biology McM aster University Department of Psychiatry and Behavioural neurosciences Mc Master University

AIm To investigate the capacity of Saccharomyces cerevisiae(S. cerevisiae) and Saccharomyces boulardii(S. boulardii) yeasts to reverse or to treat acute stress-related intestinal *** Adult Swiss Webster mice were stressed for 1 h in a wire-mesh restraint to induce symptoms of intestinal dysmotility and were subsequently killed by cervical dislocation. Jejunal and colon tissue were excised and placed within a tissue perfusion bath in which S. cerevisiae, S. boulardii, or their supernatants were administered into the lumen. Video recordings of contractility and gut diameter changes were converted to spatiotemporal maps and the velocity, frequency, and amplitude of propagating contractile clusters(PCC) were measured. motility pre- and post-treatment was compared between stressed animals and unstressed controls. RESULTS S. boulardii and S. cerevisiae helped to mediate the effects of stress on the small and large intestine. Restraint stress reduced jejunal transit velocity(mm/s)from 2.635 ± 0.316 to 1.644 ± 0.238, P nd jejunal transit frequency(Hz) from 0.032 ± 0.008 to 0.016 ± 0.005, P nt stress increased colonic transit velocity(mm/s) from 0.864 ± 0.183 to 1.432 ± 0.329, P nd frequency to a lesser degree. Luminal application of S. boulardii helped to restore jejunal and colonic velocity towards the unstressed controls; 1.833 ± 0.688 to 2.627 ± 0.664, P nd 1.516 ± 0.263 to 1.036 ± 0.21, P n the stressed gut, but was most apparent in the jejunum. S. cerevisiae increased PCC velocity in the stressed jejunum from 1.763 ± 0.397 to 2.017 ± 0.48, P = 0.0031 and PCC frequency from 0.016 ± 0.009 to 0.027 ± 0.007, P n PCC velocity from 1.647 ± 0.187 to 1.038 ± 0.222, P n of S. boulardii or S. cerevisiae supernatants also helped to restore motility to unstressed values in similar capacity. COnCLUSIOn The

关键词： Intestine Saccharomyces cerevisiae Saccharomyces boulardii Restraint stress motility

memory access optimization for particle operations in computational fluid dynamics-discrete element method simulations

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Particuology 2023年第7期78卷 97-110页

作者： Deepthi Vaidhynathan Hariswaran Sitaraman Ray Grout Thomas Hauser christine m.Hrenya Jordan musser Computational Science Center National Renewable Energy LaboratoryUnited States Research Computing University of ColoradoBoulderUnited States Chemical and Biological Engineering University of ColoradoBoulderUnited States Computational Science and Engineering National Energy Technology LaboratoryUnited States

Computational Fluid Dynamics-Discrete Element method is used to model gas-solid systems in several applications in energy,pharmaceutical and petrochemical *** performance bot-tlenecks often limit the problem sizes that can be simulated at industrial *** data structures used to store several millions of particles in such large-scale simulations have a large memory footprint that does not fit into the processor cache hierarchies on current high-performance-computing platforms,leading to reduced computational *** paper specifically addresses this aspect of memory access bottlenecks in industrial scale *** use of space-flling curves to improve memory access patterns is described and their impact on computational performance is quantified in both shared and distributed memory parallelization *** morton space flling curve applied to uniform grids and k-dimensional tree partitions are used to reorder the particle data-structure thus improving spatial and temporal locality in *** performance impact of these techniques when applied to two benchmark problems,namely the homogeneous-cooling-system and a fluidized-bed,are *** optimization techniques lead to approximately two-fold performance improvement in particle focused operations such as neighbor-list creation and data-exchange,with~1.5 times overall improvement in a fluidization simulation with 1.27 million particles.

关键词： CFD-DEm memory access optimization Spatial reordering Performance optimization