Photodynamic therapy of cancer-Challenges of multidrug resistance
作者机构：MOE Key Laboratory of OptoElectronic Science and Technology for MedicineFujian Normal University FuzhouP.R.China College of Engineering and Applied Science University of Colorado DenverCOUSA Department of Medicine National Jewish HealthCOUSA Department of Bioscience Technology Center for Nanotechnology and Institute of Biomedical Technology Chung Yuan Christian UniversityTaoyuanTaiwan TCM-Integrated Cancer Center Southern Medical UniversityGuangzhouP.R.China Department of Gastroenterology&Endoscopy Changhai HospitalSecond Military Medical University ShanghaiP.R.China Department of Urologic SurgeryTongji Medical College of Huazhong University of Science&TechnologyWuhanP.R.China Department of Health Technology Informatics Hong Kong Polytechnic UniversityHong Kong SARP.R.China Department of DermatologyDaping Hospital Third Military Medical UniversityChongqingP.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2015年第8卷第1期
页 面：14-26页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 0702[理学-物理学] 10[医学]
主 题：Photodynamic therapy photosensitizer multidrug resistance cancer
摘 要：Photodynamic therapy(PDT)of cancer is a two-step drug device combination modality,which involves the topical or systemie administration of a photosensitizer followed by light ilumnination of cancer *** the presence of oxygen molecules,the light illmnination of photosensitizer(PS)can lead to the generation of cytotoxic reactive oxygen species(ROS)and consequently destroy *** to many other anticancer therapies,PDT is also subject to intrinsic cancer resistance mediated by mutidrug resistance(MDR)*** paper will review the recent progress in understanding the interaction between MDR transporters and PS *** strategies that can be used in a clinical setting to owercome or bypass MDR will also be discussed.
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