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中国化学快报：英文版 2023年第2期34卷 403-406页

作者： Hui Liang Xiaoyu Liu Liting Tang Zafar Mahmood Zeduan Chen Guowei Chen Shaomin Ji Yanping Huo School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconverted emission is preferred for most of the practical applications, but developing a NIR-to-blue TTA upconversion system is a challenging task in photochemistry. In this work, a thermally activated delayed fluorescence(TADF) material with intense visible-to-NIR absorption is demonstrated that shows a longer triplet state lifetime(32 μs) and high triplet state energy(E_(T)= 1.55 e V). For the first time, a heavy atomfree NIR(λ_(ex)> 650 nm) to blue(λ_(em)photosensitizer(PS) and a large anti-Stokes shift(0.88 e V) along with moderate upconversion yield was achieved. Our work provides the solution and guidance for the future development of purely organic heavy atom-free NIR activating TTA upconversion system for a wide array of applications.

关键词： Heavy atom-free Triplet state photosensitizer TTA-upconversion

Rationally designed monoamine oxidase A-activatable AIE molecular photosensitizer for the specific imaging and cellular therapy of tumors

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聚集体(英文) 2023年第2期4卷 163-172页

作者： Yingcai Hu Sheng-Yan Yin Wei Liu Zuhao Li Yun Chen Jishan Li State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Due to both the requirements of repeated complex organic synthesis and tedious biochemical verification experiments for the screening of new photosensitizers,the development of a satisfactory photosensitizer with excellent photosensitivity and highly specific response ability is still a great challenge for the accurate imaging localization and the precise photodynamic therapy(PDT)of tumors.Herein,under the help of theoretical calculations,a high-efficient target-activatable aggregation-induced emission(AIE)molecular photosensitizer,TPE-TThPy,is rationally designed and synthesized by the conjugation of tetraphenylethylene(TPE,which is used as the electron donor)and tetrahydropyridine(ThPy,which can be converted to methylpyridine salts as the electron acceptor)using thiophene(T)as the π-bridge.This TPE-TThPy molecule exhibits not only good cellular uptake and mitochondrial targeting ability but also ultra-high monoamine oxidase A(MAO-A)response specificity and excellent photosensitivity when oxidized under the action of MAO-A.The specifically imaging ability and cellular PDT performance of the MOA-A-activatable AIE photosensitizer of TPE-TThPy is demonstrated by using different cell lines and mouse tumor models.The successful development of this MOA-A-activatable AIE photosensitizer also provides insight for the development of single-molecule PDT therapeutic drugs with excellent photosensitivity and highly specific targeting-response ability.

关键词： aggregation-induced emission cellular therapy fluorescence imaging photosensitizer target-activatable

Photoswitchable semiconducting polymer dots with photosensitizer molecule and photochromic molecule loading for photodynamic cancer therapy

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Journal of Innovative Optical Health Sciences 2022年第6期15卷 17-29页

作者： Lu Guo Bo Xu Haobin Chen Ying Tang Department of Gastroenterology The First Hospital of Jilin University Changchun 130021P.R.China Department of Urology The First Hospital of Jilin University Changchun 130021 P.R.China Department of Biomedical Engineering School of Basic Medical Sciences Central South University Changsha 410013P.R.China

Photodynamic therapy(PDT)is a new and rapidly developing treatment modality for dinical cancer therapy.Semiconductor polymer dots(Pdots)doped with photosensitizers have been successfully applied to PDT,and have made progress in the field of tumor therapy.However,the problems of severe photosensitivity and limited tisue penetration depth are needed to be solved during the implementation process of PDT.Here we developed the Pdots doped with photosensitizer molecule Chlorin e6(Ce6)and photochromic molecule 1,2-bis(2,4-dimethy1-5 phenyl-3-thiophene)-3,3,4,5-hexafuoro-1-cyclopentene(BTE)to construct a photoswitchable nanoplatform for PDT.The Ce6-BTE-doped Pdots were in the green region,and the tissue penetration depth was increased compared with most Pdots in the blue region.The reversible conversion of BTE under different light irradiation was utilized to regulate the photodynamic effect and solve the problem of photosensitivity.The prepared Ce6-BTE-doped Pdots had small size,excellent optical property,efficient ROS generation and good photoswitchable ability.The cellular uptake,cytotoxicity,and photodynamic effect of the Pdots were detected in human colon tumor cells.The experiments in vitro indicated that Ce6-BTE-doped Pdots could exert excellent photodynamic effect in ON state and reduce photosensitivity in OFF state.These results demonstrated that this nanoplatform holds the potential to be used in clinical PDT.

关键词： Photodynamic therapy semiconductor polymer dots photosensitizer tumor therapy

Orthogonal Aza-BODIPY–BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 128-140页

作者： Dongliang Yang Liguo Sun Lei Xue Xiaorui Wang Yanling Hu Jinjun Shao Ling Fu Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM)School of Physical and Mathematical Sciences Nanjing Tech University(NanjingTech)Nanjing 211816 P.R.China Department of Radiology Binzhou Medical University Hospital Yantai 264100 P.R.China

Photodynamic antibacterial therapy shows great potential in bacterial infection and the reactive oxygen species(ROS)production of the photosensitizers is crucial for the therapeutic e®ect.Introducing heavy atoms is a common strategy to enhance photodynamic performance,while dark toxicity can be induced to impede further clinical application.Herein,a novel halogen-free photosensitizer Aza-BODIPY-BODIPY dyad NDB with an orthogonal molecular conguration was synthesized for photodynamic antibacterial therapy.The absorption and emission peaks of NDB photosensitizer in toluene were observed at 703 nm and 744 nm,respectively.The°uorescence(FL)lifetime was measured to be 2.8 ns in toluene.Under 730 nm laser illumination,the ROS generation capability of NDB was 3-fold higher than that of the commercial ICG.After nanoprecipitation,NDB NPs presented the advantages of high photothermal conversion e±ciency(39.1%),good photostability,and excellent biocompatibility.More importantly,in vitro antibacterial assay conrmed that the ROS and the heat generated by NDB NPs could extirpate methicillin-resistant S.aureus e®ectively upon exposure to 730 nm laser,suggesting the potential application of NDB NPs in photo-initiated antibacterial therapy.

关键词： photosensitizer photodynamic therapy antibacterial therapy.

Membrane-targeting amphiphilic AIE photosensitizer for broad-spectrum bacteria imaging and photodynamic killing of bacteria

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中国化学快报:英文版 2023年第9期34卷 183-187页

作者： Haining Zhang Chaojun He Limin Shen Wenjun Tao Jianhui Zhu Jinzhao Song Ziyong Li Jun Yin Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyang 471934China Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

An amphiphilic AIE photosensitizer has been successfully developed,which allows for easily inserting into the bacterial membranes.Binding experiments with phospholipid preliminary demonstrates its membrane specificity.As expected,it is proved to possess a broad-spectrum bacterial staining performance and photodynamic antibacterial activity toward S.aureus and E.coli.

关键词： Photodynamic therapy Aggregation-induced emission photosensitizer Membrane-targeting Singlet oxygen Broad-spectrum Bacteria imaging

photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment

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Nano-Micro Letters 2021年第2期13卷 246-261页

作者： Huanyu Yang Renfa Liu Yunxue Xu Linxue Qian Zhifei Dai Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityNo.95 Yongan RoadXicheng DistrictBeijing 100050People’s Republic of China Department of Biomedical Engineering College of EngineeringPeking UniversityNo.5 Yiheyuan RoadHaidian DistrictBeijing 100871People’s Republic of China

Patients with pancreatic cancer(PCa)have a poor prognosis apart from the few suitable for surgery.Photodynamic therapy(PDT)is a minimally invasive treatment modality whose efficacy and safety in treating unresectable localized PCa have been corroborated in clinic.Yet,it suffers from certain limitations during clinical exploitation,including insufficient photosensitizers(PSs)delivery,tumor-oxygenation dependency,and treatment escape of aggressive tumors.To overcome these obstacles,an increasing number of researchers are currently on a quest to develop photosensitizer nanoparticles(NPs)by the use of a variety of nanocarrier systems to improve cellular uptake and biodistribution of photosensitizers.Encapsulation of PSs with NPs endows them significantly higher accumulation within PCa tumors due to the increased solubility and stability in blood circulation.A number of approaches have been explored to produce NPs co-delivering multi-agents affording PDT-based synergistic therapies for improved response rates and durability of response after treatment.This review provides an overview of available data regarding the design,methodology,and oncological outcome of the innovative NPs-based PDT of PCa.

关键词： Photodynamic therapy photosensitizer Nanoparticle Pancreatic cancer Combined therapy

Synthesis and Characterization of Novel Schiff Base for Enhanced Dye-Sensitized Solar Cell Photo-Response Mechanism

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Crystal Structure Theory and Applications 2024年第2期12卷 11-20页

作者： Raphael Shadai Oguike Hanatu Akanagn Omolara Oni Corrosion Protection and Materials Science Laboratory Chemistry Department Abubakar Tafawa Balewa University Bauchi Nigeria

The efficient photo-response mechanism is one of the key factors in the commercialization of dye-sensitized solar cells in a bid to satisfy renewable energy demands. Progress in green technology has put solar energy on the front burner as a provider of clean and affordable energy for a sustainable society. We report the synthesis of a novel Schiff base with optical transparency in the visible and near IR region of the solar spectrum that can find application in the DSSCs photo-response mechanism. The synthesized crystal exhibited features that could handle some of the shortcomings of dye-sensitized solar cells which include wide band solar spectrum absorption and capability for swift charge transfer within the photoelectrodes. The synthesized Schiff base was characterized using x-ray diffractometer, UV/Visible spectrometer, Frontier transmission infrared spectrometer and conductometer. XRD data revealed the grown crystal to have an average crystallite size of 2.08 nm with average microstrain value of about 269.43. The FT-IR recorded transmission wave ѵ (CO) at 1207.7 cm−1 while dominant wave occurred at ѵ1654.9 and ѵ1592.3 cm−1 relating to ѵ (CN) stretching and ѵ (NH) bending respectively were observed. The IR spectrum revealed the bonding species and a probable molecular structure of 2,6-bis(benzyloxy)pyridine. The UV/Visible spectra convoluted to maximum peak within the near IR region suggesting that 2,6-bis(benzyloxy)pyridine can absorb both the visible and near IR region while its electrical conductivity was determined to be 4.58 µS/cm. The obtained result of the present study revealed promising characteristics of a photosensitizer that can find application in the photo-response mechanism of DSSCs.

关键词： Dye-Sensitized Solar Cell Schiff Base photosensitizer Optical Transparency Benzil Pyridine

Advances in photosensitizer-related design for photodynamic therapy

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 668-686页

作者： Zhaojie Zhou Ling Zhang Zhirong Zhang Zhenmi Liu College of Polymer Science and Engineering Sichuan UniversityChengdu 610015China West China School of Pharmacy Sichuan UniversityChengdu 610041China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041China

Photodynamic therapy(PDT)is highly effective in treating tumors located near body surface,offering strong tumor suppression and low damage to normal tissue nearby.PDT is also effective for treating a number of other conditions.PDT not only provide a precise and selective method for the treatment of various diseases by itself,it can also be used in combination with other traditional therapies.Because PDT uses light as the unique targeting mechanism,it has simpler and more direct targeting capability than traditional therapies.The core material of a PDT system is the photosensitizer which converts light energy to therapeutic factors/substances.Different photosensitizers have their distinct characteristics,leading to different advantages and disadvantages.These could be enhanced or compensated by using proper PDT system.Therefore,the selected type of photosensitizer would heavily influence the overall design of a PDT system.In this article,we evaluated major types of inorganic and organic PDT photosensitizers,and discussed future research directions in the field.

关键词： Photodynamic therapy photosensitizer Tumour treatment Combination therapy Porphyrin

Fabrication of AQ2S/GR composite photosensitizer for the simulated solar light-driven degradation of sulfapyridine

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Environmental Science and Ecotechnology 2021年第4期8卷 1-9页

作者： Shuang-Yang Zhao Cheng-Xin Chen Jie Ding Shan-Shan Yang Ya-Ni Zang Xu-Dong Qin Xin-Lei Gao Zhao Song Nan-Qi Ren State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Harbin Institute of Technology National Engineering Research Center of Water Resources Co. LtdHarbin150090China Guangdong Yuehai Water Investment Co. LtdShenzhen518021China UNSW Water Research Center School of Civil and Environmental EngineeringThe University of New South WalesSydneyNSW2032Australia

Chlorination has been intensively investigated for use in water disinfection and pollutant elimination due to its efficacy and convenience;however,the generation and transportation of chlorine and hypochlorite are energy-consuming and complicated.In this study,a novel binary photosensitizer consisting of anthraquinone-2-sulfonate(AQ2S)and graphene was synthesized via a p-p stack adsorption method;this compound could allow for the chlorination of organic pollutants using on-site chlorine generation.In this photosensitive degradation process,sulfapyridine(SPY)was selected as a model pollutant and was decomposed by the reactive species(Cl2-,Cland O2-)generated during the photosensitive oxidation of chloride.The synthesized AQ2S/graphene exhibited superior activity,and the degradation rate of SPY was over 90%after 12 h of visible light irradiation with a kinetic constant of 0.2034h1.Results show that 20 mg AQ2S/GR at a 21%weight percentage of AQ2S in a pH 7 SPY solution with 1 mol/L Clachieved the highest kinetics rate at 0.353 h1.Free radical trapping experiments demonstrated that Cl2-and O2-were the dominant species involved in SPY decomposition under solar light.The reusability and stability of this composite were verified by conducting a cycle experiment over five successive runs.The capacity of photodegradation still remained over 90%after these 5 runs.The current study provides an energyefficient and simple-operational approach for water phase SPY control.

关键词： photosensitizer AQ2S Visible-light-driven Free radicals trapping Reusability

Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

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Journal of Innovative Optical Health Sciences 2016年第2期9卷 25-30页

作者： Valeriya S.Maryakhina Vyacheslav V.Gun'kov Orenburg State University 13 Pobedy st. Orenburg 460018Russia

In this paper,the mathematical model of distribution of the injected compound in biological liquid flow has been described.It is considered that biological liquid contains a few phases such as water,peptides and cells.The injected compound(for example,photosensitizer)can interact with peptides and cells.At the time,viscosity of the biological liquid depends on pathology present in organism.The obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of tumors.It is obtained that the curves do not have monotonic nature.There is a sharp curves decline in the first few seconds after injection.Intensivity of curves rises after decreasing.It is especially pronounced for wavelength 590 nm and 580 nm(near the"transparency window"of biological tissues).Time of inflection point shifts from 8.4 s to 6.9 s for longer wavelength.However,difference between curves is little for di®erent viscosity means of the biological liquid.Thus,additional pathology present in organism does not impact to the results of in vivo biomedical investigations.

关键词： Fluorescence diffusion biomedical diagnostics photosensitizer viscosity