Rationally designed monoamine oxidase A-activatable AIE molecular photosensitizer for the specific imaging and cellular therapy of tumors

作     者：Yingcai Hu Sheng-Yan Yin Wei Liu Zuhao Li Yun Chen Jishan Li 

作者机构：State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China 

出 版 物：《Aggregate》 (聚集体（英文）)

年 卷 期：2023年第4卷第2期

页      面：163-172页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：NSFC,Grant/Award Number:21775035 Natural Science Foundation of Hunan Province,Grant/Award Numbers:2020SK2096,2021JJ31137 

主　　题：aggregation-induced emission cellular therapy fluorescence imaging photosensitizer target-activatable 

摘      要：Due to both the requirements of repeated complex organic synthesis and tedious biochemical verification experiments for the screening of new photosensitizers,the development of a satisfactory photosensitizer with excellent photosensitivity and highly specific response ability is still a great challenge for the accurate imaging localization and the precise photodynamic therapy(PDT)of ***,under the help of theoretical calculations,a high-efficient target-activatable aggregation-induced emission(AIE)molecular photosensitizer,TPE-TThPy,is rationally designed and synthesized by the conjugation of tetraphenylethylene(TPE,which is used as the electron donor)and tetrahydropyridine(ThPy,which can be converted to methylpyridine salts as the electron acceptor)using thiophene(T)as the π-*** TPE-TThPy molecule exhibits not only good cellular uptake and mitochondrial targeting ability but also ultra-high monoamine oxidase A(MAO-A)response specificity and excellent photosensitivity when oxidized under the action of *** specifically imaging ability and cellular PDT performance of the MOA-A-activatable AIE photosensitizer of TPE-TThPy is demonstrated by using different cell lines and mouse tumor *** successful development of this MOA-A-activatable AIE photosensitizer also provides insight for the development of single-molecule PDT therapeutic drugs with excellent photosensitivity and highly specific targeting-response ability.