检索结果-南通市图书馆

cT检查提高感染性纵隔炎与胸骨切开心脏手术术后正常改变的鉴别诊断能力

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第4期 503-503页

作者：金莹莹 B.Foldyna M.Mueller c.D.Etz c.luecke J.Haunschild I.Hoffmann Department of Diagnostic and Interventional Radiology University of Leipzig-Heart Center

摘要目的确认心脏术后感染性纵隔炎相关的独立cT参数,提高急性炎症与正常术后改变的鉴别诊断。方法本回顾性、观察性队列研究评价胸骨切开心脏术后病人的胸部

关键词：纵隔炎胸骨后感染性 cT 心脏手术鉴别诊断

心肌梗死样急性心肌炎病人心脏MRI T1和T2 maps的纹理分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第1期 104-104页

作者： B.Baessler c.luecke J.Lurz K.Klingel M.V.Roeder S.D.Waha 王佳佳 Department of Radiology University Hospital of Cologne

摘要目的探讨心脏MRI T和Tmaps的纹理分析对梗死样急性心肌炎的潜在诊断价值。材料与方法这项前瞻性研究纳入了2012年8月—2015年5月从Magnetic Reso-

关键词：急性心肌炎 MRI T1 T2 maps 心肌梗死纹理分析

Exercise immunology:Novel insights

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： David c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune system.Questions were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when ill.could MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby

The value of the INFEcTIONS scoring system in identifying bacterial infections among patients presenting at the emergency department of a middle-income country:A pilot study

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Traumatology 2024年第2期27卷 77-82页

作者： Dooshanveer c.Nuckchady Department of Internal Medicine Victoria HospitalCandosMauritius

Purpose:To investigate which scoring system is the most accurate tool in predicting mortality among the infected patients who present to the emergency department in a middle-income country,and to validate a new scoring system to predict bacterial infections.Methods:This was a retrospective,single-center study among patients who were admitted via the emergency department of a public hospital.All patients who were started on antibiotics were included in the study,while patients agedcluded.Data collected includeding patients'demographics,vital signs and basic laboratory parameters like white blood cell count and creatinine.The sensitivity and specificity of different scoring systems were calculated as well as their negative and positive predictive values.Logistic regression was used to derive a novel early warning system for bacterial infections.The area under the receiver operating characteristic(AUROc)was computed for each scoring model.Results:In total,109 patients were included in this study.The quick sequential organ failure assessment(qSOFA),search out severity and rapid acute physiology score had the highest AUROc(≥0.89)for predicting mortality,while qSOFA and universal vital assessment were the simplest scoring systems with an AUROc>0.85;however,these scoring systems failed to predict whether patients were truly infected.The INFEcTIONS(short for impaired mental status,not conscious,fast heart rate,elevated creatinine,high temperature,on inotrope,low oxygen,high neutrophils and high sugar)model reached an AUROc of 0.88 to more accurately predict the infectious state of a patient.conclusions:Middle-income countries should use the qSOFA or universal vital assessment score to identify the sickest patients in emergency department.The INFEcTIONS score may help recognize patients with bacterial infections,but it should be further validated in multiple countries prior to widely use.

关键词： Prognosis Mortality Bacterial infection INFEcTIONS scoring system Sequential organ failure assessment Prediction

Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and Technological Enterprise(cREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive function.While heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and function.Methods:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,respectively.In a separate trial,blended ice was ingested before and during exercise as a cooling strategy.Data were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging techniques.Results:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive hyperthermia.Executive function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital cortex.conversely,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural perturbations.conclusion:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

A toast to a zebrafish germ cell induction cocktail

在线全文

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2024年第6期67卷 1314-1315页

作者： Mary c.Mullins Department of cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGcs)at phenomenal rates.This major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

Non-coding RNAs in exercise immunology:A systematic review

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsch Melina Heimer Boris Schmitz Frank c.Mooren Department of Rehabilitation Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall health.While strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical exercise.Two combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise”.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental data.Studies were eligible if they reported on exercise-based interventions in healthy humans.After duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative synthesis.Six studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also identified.Results were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between studies.Evaluation criteria were defined as“validated”with 100%of≥3 independent studies showing identical direction of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared plausible.For endurance exercise,15 miRNAs were categorized as validated,wit

关键词： Immune system Inflammation MicroRNA ncRNA Physical exercise

Artificial intelligence analysis of videos to augment clinical assessment:an overview

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 717-718页

作者： David c.Wong Stefan Williams University of Leeds Leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical medicine.Observation of movement is particularly important for the neurologist.conditions such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic ways.In some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of speech.The clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to treatment.However,that practice depends upon a limited resource of experienced experts.In addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第1期19卷 75-79页

作者： christa c.Huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming years.While therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are lacking.Recently,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively studied.Exosomes,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell communication.Exosomes are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral sclerosis.Accordingly,the exosomes derived from the patients are an invaluable source of disease biomarkers.On the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological diseases.This review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative disorders.We also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic efficacy.Finally,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy