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clinical implications of microRNAs in liver cancer stem cells

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chinese Journal of cancer 2013年第8期32卷 419-426页

作者： Stella chai Stephanie Ma Department of clinical Oncology Li Ka Shing Faculty of Medicine The University of Hong Kong State Key Laboratory for Liver Research Li Ka Shing Faculty of Medicine The University of Hong Kong

The prognosis of patients diagnosed with hepatocellular carcinoma (Hcc) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and Hcc tissues or between liver cancer stem cells (cScs) and non-cSc subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver cScs and highlights the need for further investigations of the role of miRNAs in regulating liver cSc subsets for possible future clinical applications.

关键词：肝干细胞 microRNA 临床意义肝癌 miRNAs 肝细胞癌表达模式小RNA

Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

New patterns of localized excitations in (2+1)-dimensions:The fifth-order asymmetric Nizhnik-Novikov-Veselov equation

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communications in Theoretical Physics 2024年第8期76卷 11-18页

作者： Jianyong Wang Yuanhua chai Department of Mathematics and Physics Quzhou UniversityQuzhou 324000China Physics group Jiangshan Middle School of Zhejiang ProvinceQuzhou 324000China

By applying the mastersymmetry of degree one to the time-independent symmetry K_(1), the fifth-order asymmetric Nizhnik-Novikov-Veselov system is derived. The variable separation solution is obtained by using the truncated Painlevé expansion with a special seed solution. New patterns of localized excitations, such as dromioff, instanton moving on a curved line, and tempo-spatial breather, are constructed. Additionally, fission or fusion solitary wave solutions are presented,graphically illustrated by several interesting examples.

关键词： asymmetric Nizhnik-Novikov-Veselov system localized excitations truncated Painlevéexpansion

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黄土地区设诱导缝地铁车站地震响应特性研究

地震工程学报 2025年第1期47卷 91-103页

作者：权登州柴少波王玉铃卜永红王毅红长安大学建筑工程学院陕西西安710061

诱导缝已在我国地铁车站建设中广泛应用,但其地震响应规律尚不明确。以西安黄土地区地铁车站建设为背景,在前期研究基础上建立黄土场地-设诱导缝地铁车站动力相互作用三维数值模型,研究不同频谱特性及不同峰值加速度地震波作用下黄土场... 详细信息

诱导缝已在我国地铁车站建设中广泛应用,但其地震响应规律尚不明确。以西安黄土地区地铁车站建设为背景,在前期研究基础上建立黄土场地-设诱导缝地铁车站动力相互作用三维数值模型,研究不同频谱特性及不同峰值加速度地震波作用下黄土场地中设诱导缝地铁车站的加速度响应和损伤演化过程。结果表明:(1)诱导缝同侧结构加速度反应基本一致,但其两侧结构的加速度反应有显著差异,质量较大一侧结构的峰值加速度较大;随着地震强度增大,土-结构动力相互作用更剧烈,地铁车站结构损伤程度不断加深,损伤范围逐渐扩大,且在低频成分丰富的地震波作用下其结构损伤更加严重;(2)诱导缝断面处结构损伤面积相对较大,容易出现局部破坏。研究结果将为黄土地区地铁\,地下结构诱导缝的地震响应进一步研究和工程设计提供参考。

关键词：黄土地区诱导缝地铁车站地震损伤数值模拟

A user-selected uplink power control algorithm in the two-tier femtocell network

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Science china(Information Sciences) 2015年第4期58卷 51-62页

作者： chai XiaoMeng XU Xu ZHANg ZhongShan Institute of Advanced Network Technology and New Services University of Science and Technology Beijing

In two-tier femtocell networks, the frequency reuse among cells leads to cross-tier interference(cTI),the primary constraint to system performance improvement. In order to alleviate the impact of cTI, we propose a user-selected power control algorithm based on the non-cooperative game theory in consideration of user diversity gain. In the proposed scheme, the macro-user with high channel gain and the femto-user with low channel gain at the macro base station are scheduled to be "active" in one slot but to be "opposite" in next slot in order to achieve an optimal overall performance. Numerical results show that the proposed scheme is capable of outperforming the traditional stochastic schedule strategy by more than 30% improvement in terms of average macrocell capacity. Furthermore, an obvious performance gain in the percentage femtocells beyond its signal-to-interference-and-noise ratio(SINR) target can also be achieved by executing the macrocell link-quality-protection strategy.

关键词： power control game theory user-selected femtocell macrocell capacity

Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin chai Yan Sun Yan gao Department of computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:computational Thinking(cT)ability,visual presentation aesthetics,and code *** them,the assessment of cT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch computational Thinking(cT) visual aesthetic static analysis integration policy machine learning

Influence of fly ash fineness and shape on the porosity and permeability of blended cement pastes

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International Journal of Minerals,Metallurgy and Materials 2010年第6期17卷 683-690页

作者： Theerawat Sinsiri Prinya chindaprasirt chai Jaturapitakkul School of civil Engineering Suranaree University of Technology Department of civil Engineering Khon Kaen University Department of civil Engineering King Mongkut's University of Technology Thonburi

The effects of the fineness and shape of fly ash on the porosity and air permeability of cement pastes were investigated. Pulverized coal combustion （Pcc） fly ash and fluidized bed coal combustion （FBc） fly ash classified into three different finenesses were used. River sand with particle size distribution similar to that of fly ash was also used for comparison. Portland cement was replaced with fly ash and ground sand at the dosages of 0, 20wt%, and 40wt%. A water-to-binder ratio （w/b） of 0.35 was used throughout the experiment. The results show that the porosity and air permeability of the pastes are influenced by the shape, fineness, and replacement level of fly ash. The porosity and air permeability of FBc fly ash pastes are higher than those of Pcc fly ash pastes. This is due to the higher irregular shape and surface of FBc fly ash compared to the spherical shape and relatively smooth surface of Pcc fly ash. The porosity increases with the increase in fly ash replacement level and decreases with the increase in its fineness. The permeability of Pcc fly ash pastes decreases with the increase in replacement level and fineness, while for FBc fly ash, the permeability increases with the increase in replacement level. Decreases in porosity and permeability are due to a combined effect of the packing of fine particles and the reaction of fly ash.

关键词： cement fly ash coal combustion porosity permeability

control synthesis of linear distributed parameter switched systems

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Journal of Systems Engineering and Electronics 2015年第3期26卷 565-572页

作者： Leping Bao Shumin Fei Lin chai School of Automation Southeast University Department of Automation Taiyuan Institute of Technology

The control synthesis for switched systems is extended to distributed parameter switched systems in Hilbert space. Based on semigroup and operator theory, by means of multiple Lyapunov method incorporated average dwell time approach, sufficient con- ditions are derived in terms of linear operator inequalities frame- work for distributed parameter switched systems. Being applied to one dimensional heat propagation switched systems, these lin- ear operator inequalities are reduced to linear matrix inequalities subsequently. In particular, the state feedback gain matrices and the switching law are designed, and the state decay estimate is explicitly given whose decay coefficient completely depends on the system＇s parameter and the boundary condition. Finally, two numerical examples are given to illustrate the proposed method.

关键词： distributed parameter switched systems multiple Lya-punov method stabilization linear operator inequalitie average dwell time.

Development of dynamic slip model for a shear crack

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Earthquake Engineering and Engineering Vibration 2010年第1期9卷 1-7页

作者： Juin-Fu chai Tsung-Jen Teng center for Research on Earthquake Engineering

The objective of this paper is to develop a dynamic slip model for a shear crack under constant stress drop. This crack problem is formulated by a traction boundary integral equation （BIE） in the frequency domain and then solved by the hyper-singular boundary element method as well as the regularization technique proposed in this paper. Based on the spectral integral form of the kernel function, the unbounded term can be isolated and extracted from the hyper-singular kernel function by using the method of subtracted and added back in wave number domain. Finally, based on the inverse transformation from the frequency domain to the time domain, the time histories of crack opening displacement under constant stress drop can be determined. Three rupture models （simultaneous rupture model, symmetric bilaterally-propagating model and unilaterally propagating model） with specified time histories of stress drop are considered in this paper. Even though these three models will cause the same final slip shapes because of the same constant stress drop, the associated slip time functions differ significantly from each other during the rupture process.

关键词： dynamic rupture model traction boundary element method (BIE) hyper-singular boundary element method (HBEM) regularization technique