Clinical implications of microRNAs in liver cancer stem cells

作     者：Stella Chai Stephanie Ma 

作者机构：Department of Clinical Oncology Li Ka Shing Faculty of Medicine The University of Hong Kong State Key Laboratory for Liver Research Li Ka Shing Faculty of Medicine The University of Hong Kong 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2013年第32卷第8期

页      面：419-426页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Research Grant Council-General Research Fund (HKU 760911M and HKU 773412M) Research Grant Council-Collaborative Research Fund (CUHK8/CRF/11R, HKU3/ CRF/11R and HKU7/CRF/09) the University of Hong Kong Strategic Research Theme in Cancer 

主　　题：肝干细胞 microRNA 临床意义 肝癌 miRNAs 肝细胞癌 表达模式 小RNA 

摘      要：The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications.