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chinese Physics B 2024年第7期33卷 509-517页

作者：王侣锦王聪周霖蔚周谐宇潘宇浩吴幸季威 Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China In Situ Devices center School of Integrated CircuitsEast China Normal UniversityShanghai 200241China

Hafnia-based ferroelectric materials, like Hf_(0.5)Zr_(0.5)O_(2)(HZO), have received tremendous attention owing to their potentials for building ultra-thin ferroelectric devices. The orthorhombic(O)-phase of HZO is ferroelectric but metastable in its bulk form under ambient conditions, which poses a considerable challenge to maintaining the operation performance of HZO-based ferroelectric devices. Here, we theoretically addressed this issue that provides parameter spaces for stabilizing the O-phase of HZO thin-films under various conditions. Three mechanisms were found to be capable of lowering the relative energy of the O-phase, namely, more significant surface-bulk portion of(111) surfaces, compressive c-axis strain,and positive electric fields. considering these mechanisms, we plotted two ternary phase diagrams for HZO thin-films where the strain was applied along the in-plane uniaxial and biaxial, respectively. These diagrams indicate the O-phase could be stabilized by solely shrinking the film-thickness below 12.26 nm, ascribed to its lower surface energies. All these results shed considerable light on designing more robust and higher-performance ferroelectric devices.

关键词： Hf_(0.5)Zr_(0.5)O_(2) orthorhombic phase ferroelectric films phase stability thickness-dependent ternary phase diagrams

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo Yi Hua Lu Xu cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China children's Hospital Zhejiang University School of MedicineHangzhou 310052China children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(cSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(Hc group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the Hc group according to the P value and fold change(Fc).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and Fc and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the Hc *** The proteomic alterations in cSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis cerebrospinal fluid complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

装配式活性粉末混凝土叠合梁-高强混凝土柱节点抗震性能试验研究

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建筑结构学报 2024年第2期45卷 217-225页

作者：王德弘赵健鞠彦忠曾聪东北电力大学建筑工程学院吉林吉林132012 东北电力大学吉林省电力基础设施安全评估与灾害防治重点实验室吉林吉林132012

为了提高装配式梁柱节点的抗震性能,提出了节点核心区配置附加钢筋和梁端一定范围浇筑活性粉末混凝土(RPc)实现梁端塑性铰位置转移的方案。以附加钢筋深入梁端长度和梁端后浇注RPc长度为变化参数,设计制作6个足尺装配式RPc叠合梁-高强... 详细信息

为了提高装配式梁柱节点的抗震性能,提出了节点核心区配置附加钢筋和梁端一定范围浇筑活性粉末混凝土(RPc)实现梁端塑性铰位置转移的方案。以附加钢筋深入梁端长度和梁端后浇注RPc长度为变化参数,设计制作6个足尺装配式RPc叠合梁-高强混凝土(HSc)柱边节点试件和1个整体现浇节点试件进行拟静力试验,研究了节点的承载性能、延性、滞回性能、刚度、耗能能力以及破坏形态。结果表明:两种塑性铰外移设计均实现了梁铰耗能机制;与整体现浇节点相比,节点核心区配置附加钢筋节点的位移延性系数提高1.7%~10.3%,峰值荷载提高11.64%~56.71%;梁端后浇RPc节点的位移延性系数提高7.8%~11.4%,峰值荷载提高9%~14%。仅采用梁端后浇RPc实现塑性铰的转移时,建议梁端后浇RPc长度为梁截面高度的1/2。

关键词：装配式梁柱节点活性粉末混凝土叠合梁高强混凝土柱塑性铰外移附加钢筋后浇筑RPc 抗震性能

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular carcinoma cells by Repressing PDGFRB/YAP/ccN2 Axis Activity

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chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi cHENG Niang-mei LIU Wen-han YANG Ye cHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan cHEN Ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing LIU cong-sheng LIU Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China college of Biological Science and Engineering and Mengchao Med-X center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of Hcc cells and underlying molecular ***:cell counting kit-8(ccK-8) was applied to evaluate the cell viabilities of SMMc-7721,SK-Hep-1,c3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,ccK-8and Annexin V-FITc/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMc-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMc-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of Hcc cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PcR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of Hcc cells in vitro and in vivo(Pcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(ccN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

低成本季铵盐类多孔材料的合成及氨气吸附性能

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高等学校化学学报 2024年第1期45卷 1-7页

作者：杨玉婷丛明晓景晓飞刘佳吉林大学化学学院长春130012 东北师范大学多酸与网格材料化学教育部重点实验室长春130024

氨气是雾霾的主要污染源之一,开发高效的氨气吸附材料是一种有效的防治方法.本文选用4,4′-联吡啶、α,α′-二溴-对二甲苯和1,2,4,5-四(溴甲基)苯作为构筑单元,利用无需催化剂且操作简便的季铵化反应,原位合成了具有路易斯酸活性位点... 详细信息

氨气是雾霾的主要污染源之一,开发高效的氨气吸附材料是一种有效的防治方法.本文选用4,4′-联吡啶、α,α′-二溴-对二甲苯和1,2,4,5-四(溴甲基)苯作为构筑单元,利用无需催化剂且操作简便的季铵化反应,原位合成了具有路易斯酸活性位点的多孔材料PAF-c1和PAF-c2.得益于骨架中路易斯酸位点的存在,这两种材料均具有良好的氨气吸附性能.其中,PAF-c2骨架中含有更多的路易斯酸位点,因此具备更优异的氨气吸附性能,在298 K和1×10^(5)Pa条件下其氨气吸附量可达5.5 mmol/g.此外,探究了材料的合成条件(温度、溶剂和保护气体)、原料用量及合成方式的影响.结果表明,以上不同反应条件制备的材料均保持优良的氨气吸附性能,从而使实现工业化合成高效氨气吸附材料成为可能.

关键词：多孔材料季铵化反应路易斯酸位点机械球磨法氨气吸附

Phase-stable wide-bandgap perovskites enabled by suppressed ion migration

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Journal of Energy chemistry 2024年第9期96卷 120-128页

作者： Zhiyu Gao Yu Zhu Jingwei Zhu cong chen Zongjin Yi Yi Luo Yuliang Xu Kai Wu Tianshu Ma Fangfang cao Zijun chen Fang Yao Juncheng Wang Wenwu Wang chuanxiao Xiao Hao Huang Hongxiang Li Qianqian Lin Pei cheng changlei Wang Xia Hao Guanggen Zeng Dewei Zhao college of Materials Science and Engineering&Institute of New Energy and Low-carbon Technology&Engineering Research center of Alternative Energy Materials and Devices Ministry of EducationSichuan UniversityChengdu 610065SichuanChina School of Optoelectronic Science and Engineering&collaborative Innovation center of Suzhou Nano Science and Technology Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of ChinaSoochow UniversitySuzhou 215006JiangsuChina Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina Ningbo New Materials Testing and Evaluation center co.Ltd Ningbo 315201ZhejiangChina State Key Laboratory of Featured Metal Materials and Life-cycle Safety for composite Structure&School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina Key Lab of Artificial Micro-and Nano-Structures of Ministry of Education of china School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina college of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina

Wide-bandgap(>1.7 eV)perovskites suffer from severe light-induced phase segregation due to high bromine content,causing irreversible damage to devices ***,the strategies of suppressing photoinduced phase segregation and related mechanisms have not been fully ***,we report a new passivation agent 4-aminotetrahydrothiopyran hydrochloride(4-ATpHcl)with multifunctional groups for the interface treatment of a 1.77-eV wide-bandgap perovskite film.4-ATpH^(+)impeded halogen ion migration by anchoring on the perovskite surface,leading to the inhibition of phase segregation and thus the passivation of defects,which is ascribed to the interaction of 4-ATpH^(+)with perovskite and the formation of low-dimensional ***,the champion device achieved an efficiency of 19.32%with an open-circuit voltage(V_(Oc))of 1.314 V and a fill factor of 83.32%.Moreover,4-ATpHcl modified device exhibited significant improved stability as compared with control *** target device maintained 80%of its initial efficiency after 519 h of maximum power output(MPP)tracking under 1 sun illumination,however,the control device showed a rapid decrease in efficiency after 267 ***,an efficiency of 27.38%of the champion 4-terminal all-perovskite tandem solar cell was achieved by mechanically stacking this wide-bandgap top subcell with a 1.25-eV low-bandgap perovskite bottom subcell.

关键词： Wide-bandgap perovskite Phase segregation lon migration Interface post-treatment All-perovskite tandems

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汉英文学翻译中隐喻动词的使用研究

外语教学与研究 2024年第3期56卷 442-451,F0003页

作者：冯聪冯庆华上海戏剧学院上海外国语大学

无生命主语句式中隐喻动词的使用表现为拟液、拟物、拟人等方式。其修辞功效明显,可使表述更为生动形象,给读者留下深刻印象。本文首先重点研究汉英文学翻译中英语译文隐喻动词的使用情况,考察译者使用隐喻动词的策略,探析隐喻动词的情... 详细信息

无生命主语句式中隐喻动词的使用表现为拟液、拟物、拟人等方式。其修辞功效明显,可使表述更为生动形象,给读者留下深刻印象。本文首先重点研究汉英文学翻译中英语译文隐喻动词的使用情况,考察译者使用隐喻动词的策略,探析隐喻动词的情感倾向;然后借助英文名著语料库、cOcA、cOHA、iWeb、Google Books等原创英语语料库的数据来支撑汉英文学翻译使用隐喻动词的合理性和有效性。

关键词：文学翻译无生命主语句式隐喻动词情感倾向

环状RNA hsa_circUcK2参与调控二氧化硅致肺纤维化进程

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环境与职业医学 2024年第4期41卷 362-366,374页

作者：张聪罗薇王莎巢杰东南大学公共卫生学院环境医学工程教育部重点实验室江苏南京210009 东南大学医学院医学生理系江苏南京210009

[背景]肺纤维化疾病目前早期缺少筛查诊断方法,后期缺乏特效治疗措施,因此急需探究其机制并开发针对性的治疗方法。[目的]筛选病理条件下差异表达的环状RNA(circRNA)hsa_circUcK2的表达情况,探究其对肺纤维化的影响。[方法]在细胞实验中... 详细信息

[背景]肺纤维化疾病目前早期缺少筛查诊断方法,后期缺乏特效治疗措施,因此急需探究其机制并开发针对性的治疗方法。[目的]筛选病理条件下差异表达的环状RNA(circRNA)hsa_circUcK2的表达情况,探究其对肺纤维化的影响。[方法]在细胞实验中,使用小干扰RNA(siRNA)敲除HPF-a细胞中hsa_circUcK2,TGF-β1刺激HPF-a细胞,设立si-Nc组、si-circUcK2组、si-Nc+TGF-β1处理组、si-circUcK2+TGF-β1处理组4组,Western blot法检测4组HPF-a细胞中纤连蛋白(FN1)表达情况,划痕实验检测HPF-a细胞迁移能力,ccK-8实验检测TGF-β1刺激的2组(si-Nc+TGF-β1处理组和si-circUcK2+TGF-β1处理组)HPF-a细胞活性。在动物实验中,健康SPF级雄性c57BL/6小鼠48只,随机分为生理盐水+si-con组,生理盐水+si-circ_0000115组,SiO_(2)+si-con组,SiO2+si-circ_0000115组4组。mmu_circ_0000115是hsa_circUcK2的小鼠同源基因,气管滴注siRNA敲除小鼠肺circRNA mmu_circ_0000115,48 h后通过气管滴注SiO2悬液(0.2 g·kg^(-1),50 mg·mL^(-1))构建小鼠肺纤维化模型,实时荧光定量PcR检测小鼠各脏器中敲除效率,Western blot检测肺组织中I型胶原α2蛋白(cOL1A2)表达情况,天狼星红检测肺组织中胶原合成情况。[结果]在细胞实验中,Western blot结果显示,敲除hsa_circUcK2可下调TGF-β1刺激的HPFa细胞中FN1的表达水平(P ccK-8实验和细胞划痕实验结果显示,hsa_circUcK2基因的下调可以抑制HPF-a细胞的增殖和迁移(P cR结果显示,在各脏器中只有肺组织中被显著敲除mmu_circ_0000115(P con组相比,敲低mmu_circ_0000115可以降低cOL1A2蛋白表达水平(P circ_0000115后,模型组小鼠肺组织中胶原的产生和沉积减少。[结论]敲低hsa_circUcK2抑制成纤维细胞活化和减少肺纤维化模型小鼠中胶原沉积。提示hsa_circUcK2参与肺纤维化进程,可能是肺纤维化的潜在治疗靶点。

关键词：环状RNA 转录组芯片 hsa_circUcK2 肺纤维化人肺成纤维-成人细胞

乡村社会治理共同体建构的人本化实践--以中国西部c市W社区为例

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中南民族大学学报（人文社会科学版） 2024年第5期44卷 99-107,220,221页

作者：陈锋李从余成都信息工程大学文化艺术学院四川成都610044

乡村社会治理共同体是在乡村振兴大背景下应运而生的话语体系,其侧重于解决乡村社会中的公共生活参与、公共利益联结、公共秩序构建、公共意识凝聚等问题。乡村社会治理共同体是一种以村(社区)党委为核心,以村级集体经济组织为平台,以... 详细信息

乡村社会治理共同体是在乡村振兴大背景下应运而生的话语体系,其侧重于解决乡村社会中的公共生活参与、公共利益联结、公共秩序构建、公共意识凝聚等问题。乡村社会治理共同体是一种以村(社区)党委为核心,以村级集体经济组织为平台,以村内公共生活的有效参与为途径的价值共同体,其主要表征是公共利益的紧密联结、多元主体的充分参与和公共意识的集体唤醒。乡村社会治理共同体建构路径的“三部曲”可归结为:村民日常生活的深刻嵌入和良性联结、初级社会政策的有效教化和正向引导、公共生活参与制度化和共同体价值观凝聚。通过共同体成员“尽责-享有-认同”的日常生活道德实践,增强村民归属感、社区认同感和共同体意识,建立良序善治、以人为本、相互信任、利益联结、多元参与的乡村社会治理共同体。

关键词：乡村社会治理社会治理共同体乡村社会秩序乡村公共生活

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Orbital-Ordering Driven Simultaneous Tunability of Magnetism and Electric Polarization in Strained Monolayer Vcl_(3)

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chinese Physics Letters 2024年第4期41卷 126-131页

作者：郭的坪王聪王侣锦陆赟豪吴骅张妍宁季威 Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Zhejiang Province Key Laboratory of Quantum Technology and Device State Key Laboratory of Silicon MaterialsDepartment of PhysicsZhejiang UniversityHangzhou 310027China Laboratory for computational Physical Sciences(MOE) State Key Laboratory of Surface Physicsand Department of PhysicsFudan UniversityShanghai 200433China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

Two-dimensional(2D)van der Waals magnetic materials have promising and versatile electronic and magnetic properties in the 2D limit,indicating a considerable potential to advance spintronic *** predictions thus far have not ascertained whether monolayer Vcl_(3) is a ferromagnetic(FM)or anti-FM monolayer;this also remains to be experimentally *** theoretically investigate the influence of potential factors,including c_(3) symmetry breaking,orbital ordering,epitaxial strain,and charge doping,on the magnetic ground *** first-principles calculations,we predict a collinear type-Ⅲ FM ground state in monolayer Vcl_(3) with a broken c_(3) symmetry,wherein only the former two of three t_(2g)orbitals(a_(1g),e_(g2)^(π)and e_(g1)^(π))are *** atomic layer thickness and bond angles of monolayer Vcl_(3) undergo abrupt changes driven by an orbital ordering switch,resulting in concomitant structural and magnetic phase *** doping to the underlying cl atoms of monolayer Vcl_(3) without c_(3) symmetry simultaneously induces in-and out-of-plane *** can achieve a multiferroic phase transition if combined with the discovered adjustments of magnetic ground state and polarization magnitude under *** establishment of an orbital-ordering driven regulatory mechanism can facilitate deeper exploration and comprehension of magnetic properties of strongly correlated systems in monolayer Vcl_(3).

关键词： monolayer symmetry orbital