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Induction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis c

World Journal of Gastroenterology 2008年第44期14卷 6844-6852页

作者： Yalena Amador-caizares Liz Alvarez-Lajonchere Ivis Guerra Ingrid Rodríguez-Alonso Gillian Martínez-Donato Julián Triana Eddy E González-Horta Angel Pérez Santiago Dueas-carrera centro de Ingeniería Genética y Biotecnología Ave 31e/ 158 and 190PlayaP.O. Box 6162HavanaCuba

AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMc） proliferative responses against hepatitis c virus （HcV） antigens were evaluated in HcV chronically infected patients. METHODS： Paired serum and PBMc samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of cD4＋ or cD8＋ T cells, being the capsid poorly recognized. cONcLUSION： These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HcV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.

关键词： Hepatitis c Antibody response Lymphoproliferation core Envelope

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c_c(X)Spaces with X Locally compact

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1593-1600页

作者： J.c.FERRANDO S.MOLL centro de Investigación Operativa Universidad Miquel Hernández Departamento de Matemática Aplicada Universidad Politécnica

In this paper, we show, among other results, that if X is a [separable] locally compact space X [satisfying the first countability axiom] then the space cc （X） has countable tightness [if and only if it has bounding tightness] if and only if it is Frechet-Urysohn, if and only if cc （X） contains a dense （LM） subspace and if and only if X is a-compact.

关键词： Frechet-Urysohn space countable [bounding] tightness (LM)-space

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Fabrication and Properties of SiB6-B4c with Phenolic Resin as a carbon Source

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Journal of Materials Science & Technology 2008年第1期24卷 102-104页

作者： G. c.Hwang J.Matsushita United Graduate School of Science and Engineering Tokai University 1117 Kitakaname Hiratsuka 259-12921 Japan

Si-B-c ceramic composites were synthesized using SiB-6,B-4c,and phenolic resin as a carbon source by pressureless sintering in an Ar ***,the Si-B-c ceramic composites were fabricated to determine their potential for applications as high hardness and high temperature *** X-ray diffraction patterns of sintered bodies of SiB-6-B-4c with carbonized phenolic resin can be seen that SiB-6 and c changed to B-4c and *** this study,it is obtained that carbonized phenolic resin is good addition material as a reaction material comparing to carbon powder at 1683 K for 1 h by pressureless sintering in an Ar atmosphere.

关键词： Silicon boride Boron carbide Phenolic resin

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Laparoscopic and robot-assisted laparoscopic digestivesurgery:Present and future directions

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World Journal of Gastroenterology 2016年第6期22卷 1975-2004页

作者： Juan c Rodríguez-Sanjuán Marcos Gómez-Ruiz Soledad Trugeda-carrera carlos Manuel-Palazuelos Antonio López-Useros Manuel Gómez-Fleitas Department of General Surgery University Hospital Marqués de Valdecilla39008 SantanderSpain Department of Medical and Surgical Sciences University of Cantabria39010 SantanderSpain

Laparoscopic surgery is applied today worldwide to most digestive procedures. In some of them, such as cholecystectomy, Nissen's fundoplication or obesity surgery, laparoscopy has become the standard in practice. In others, such as colon or gastric resection, the laparoscopic approach is frequently used and its usefulness is unquestionable. More complex procedures, such as esophageal, liver or pancreatic resections are, however, more infrequently performed, due to the high grade of skill necessary. As a result, there is less clinical evidence to support its implementation. In the recent years, robot-assisted laparoscopic surgery has been increasingly applied, again with little evidence for comparison with the conventional laparoscopic approach. This review will focus on the complex digestive procedures as well as those whose use in standard practice could be more controversial. Also novel robot-assisted procedures will be updated.

关键词： Laparoscopy Robotic surgery colectomy Esophagectomy Gastrectomy Obesity surgery Liverresection Pancreatectomy Laparoscopic training

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End-of-life care in a cardiology department： have we improved？

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Journal of Geriatric cardiology 2016年第7期13卷 587-592页

作者： Juan Rulz-Garcia Pablo Dlez-Villanueva Ana Ayesta Vanessa Brufia Lourdes M figueiras-Graillet Laura Gallego-Parra Francisco Fernandez-Aviles Manuel Martinez-Selles Department of cardiology Hospital General Universitario Gregorio Maranon Calle Doctor Esquerdo Madrid Spain Department of cardiology Hospital Universitario de Torrejon Calle Mateo Inurria Torrejon de Ardoz Madrid Spain Universidad Francisco de Vitoria Carretera Pozuelo a Majadahonda Pozuelo de Alareon Madrid Spain Department of cardiology Hospital Universitario de la Princesa Calle de Diego de Leon Madrid Spain Departmet of cardiology Hospital Universitario del Sureste Ronda del Sur Arganda del Rey Madrid Spain Universidad complutense de Madrid Av. Seneca Madrid Spain Universidad Europea de Madrid Urbanizacion E1Bosque Calle Tajo Villaviciosa de Odon Madrid Spain

Background End-of-life care is not usually a priority in cardiology departments. We sought to evaluate the changes in end-of-life care after the introduction of a do-not-resuscitate （DNR） order protocol. Methods ＆ Results Retrospective analysis of all deaths in a cardiology department in two periods, before and after the introduction of the protocol. comparison of demographic characteristics, use of DNR orders, and end-of-life care issues between both periods, according to the presence in the second period of the new DNR sheet （Group A）, a conven- tional DNR order （Group B） or the absence of any DNR order （Group c）. The number of deaths was similar in both periods （n = 198 vs. n = 197）. The rate of patients dying with a DNR order increased significantly （57.1% vs. 68.5%; P = 0.02）. Only 4% of patients in both periods were aware of the decision taken about cardiopulmonary resuscitation. Patients in Group A received the DNR order one day earlier, and 24.5% received it within the first 24 h of admission （vs. 2.6% in the first period; P 〈 0.001）. All patients in Group A with an implantable cardioverter defibrillator （IcD） had shock therapies deactivated （vs. 25.0% in the first period; P = 0.02）. conclusions The introduction of a DNR order protocol may improve end-of-life care in cardiac patients by increasing the use and shortening the time of registration of DNR orders. It may also contribute to increase IcD deactivation in patients with these orders in place. However, the introduction of the sheet in late stages of the disease failed to improve patient participation.

关键词： cardiology cardiopulmonary resuscitation End-of-life Palliative care

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Finite element analysis of the effect of interlayer on interfacial stress transfer in layered graphene nanocomposites

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Journal of Materials Science & Technology 2019年第6期35卷 1147-1152页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of Kentucky

Understanding the roles of interlayers in reinforcement efficiencies by layered graphene is very important in order to produce strong and light graphene based nanocomposites. The present paper uses the finite element method to evaluate the interfacial strain transfers and reinforcement efficiencies in layered graphene-polymer composites. Results indicate that the presence of compliant interlayers in layered graphene plays significant roles in the transfers of strain/stress from matrix to graphene and subsequently the reinforcement effectiveness of layered graphene. In general, the magnitude of shear strain transferred onto the rigid graphene decreases as the thickness of the interlayer increases. This trend becomes insignificant as the graphene becomes sufficiently large(s>25,000). The shear strain at the interface of graphene-matrix is also greatly influenced by the interlayer modulus. A stiffer interlayer would result in a higher shear strain transferred on the graphene. The performance of the interlayers is further affected by the property of the composite and the architecture of the layered graphene stack. If a composite contains more graphene phase, the efficiency of reinforcement by a layered graphene becomes improved. If a graphene stack contains more interlayers, the effectiveness of reinforcement at the edges of the graphene becomes negatively affected.

关键词： Interlayer Layered graphene Nanocomposites Interfacial stress transfer Finite element method

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Analytical modeling of effect of interlayer on effective moduli of layered graphene-polymer nanocomposites

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Journal of Materials Science & Technology 2017年第8期33卷 827-833页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of KentuckyLexingtonKY 40506-0503USA

Nanocomposites enhanced with two-dimensional, layered graphene fillers are a new class of engineering materials that exhibit superior properties and characteristics to composites with conventional ***, the roles of ＂interlayers＂ in layered graphene fillers have yet to be fully explored. This paper examines the effect of interlayers on mechanical properties of layered graphene polymer *** an effective filler, the fundamental properties（in-plane Young＇s modulus E（L1）, out-of-plane Young＇s modulus E（L2）; shear modulus G（L12）, major Poisson＇s ratio V（L12）） of the layered graphene were computed by using the Arridge＇s lamellar model. The effects of interlayers on effective moduli of layered graphene epoxy composites were examined through the Tandon-Weng model. The properties of the interlayer show noticeable impact on elastic properties of the composites, particular the out-of-plane properties（Young＇s modulus E2 and shear modulus G（12））. The interlayer spacing is seen to have much great influence on properties of the composites. As the interlayer spacing increases from 0.34 nm to 2 nm, all elastic properties of the composites have been greatly decreased.

关键词： Interlayer Layered graphene Nanocomposite Effective moduli

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Why is dimerization essential for class-c GPcR function？ New insights from mGluR1 crystal structure analysis

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Protein & cell 2014年第7期5卷 492-495页

作者： Xuejun c. Zhang Jianfeng Liu Daohua Jiang National Laboratory of Macromolecules National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China School of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

G-protein coupled receptors （GPcRs） play an essential role in eukaryotic cells signaling. According to phylogenetic analysis, most GPcRs belong to one of four classes, i.e. A, B, c, and Frizzled （Lagerstrom and Schioth, 2008）. The class-c GPcR family contains metabotropic glutamate receptors （mGluR）, y-aminobutyric acid B receptors （GABAB receptor or GBR）, several taste-sensing receptors （e.g.

关键词： receptors feature Kniazeff

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HYERS—ULAM—RASSIAS STABILITY OF QUADRATIc FUNcTIONAL EQUATIONS IN BANAcH MODULES OVER A c^＊—ALGEBRA

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chinese Annals of Mathematics,Series B 2003年第2期24卷 261-266页

作者： c. PARK J. PARK J. SHIN Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.Department of Mathematics Chungnam National University DaeJeon 305-764 South Korea.

The authors prove the Hyers-Ulam-Rassias stability of the quadratic mapping in Banachmodules over a unital c*-algebra, and prove the Hyers-Ulam-Rassias stability of the quadraticmapping in Banach modules over a unital... 详细信息

关键词： Stability B-quadratic Functional equation Banach module over Banach algebra

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Effect of B_(4)c on strength coefficient,cold deformation and work hardening exponent characteristics of Mg composites

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Journal of Magnesium and Alloys 2022年第5期10卷 1381-1400页

作者： S.Suresh M.Navaneetha Krishnan S.c.Vettivel Department of Mechanical Engineering University College of EngineeringNagercoilTamilnaduIndiaPin:629004 Department of Mechanical Engineering Universal College of Engineering and TechnologyVallioorTamilnaduIndiaPin:627117 Department of Mechanical Engineering Chandigarh College of Engineering and TechnologyChandiagarh 160019India

The emphasis of this exploration was to examine the workability and work hardening performance of Mg(Magnesium)specimen and Mg-B_(4)c composites created via the powder metallurgy *** pure Mg and Mg-B_(4)c composites are made with distinct weight percentages(Mg-5%B_(4)c,Mg-10%B_(4)c,and Mg-15%B_(4)c)at the unit aspect *** powders and composites characterization are executed by SEM(Scanning Electron Microscope),EDS(Energy Dispersive Spectrum)with an elemental map,and XRD(X-ray Diffraction)*** displays that,the B_(4)c particles were dispersed consistently with the Mg *** workability and work hardening examination was conducted in triaxial stress conditions using the cold deformation *** consequence of workability stress exponent factor(β_(σ)),distinct stress proportion factors(σ_(m)/σ_(eff)and σ_(θ)/σ_(eff)),instantaneous work hardening exponent(n_(1)),work hardening exponent(n),coefficient of strength(k)and instantaneous coefficient of strength(k_(1))are *** outcome displays that Mg-15%B_(4)c specimen has greater workability and work hardening parameter,initial relative density,and triaxial stresses compared with the Mg specimen and Mg-(5–10%)B_(4)c composites.

关键词： Powder metallurgy cold deformation Workability Instantaneous work hardening exponent Workability stress exponent Triaxial stress

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