检索结果-南通市图书馆

Development of NK cell-based cancer immunotherapies through receptor engineering

cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey page Nicolas chuvin Jenny Valladeau-Guilemond Stéphane Depil centre de Recherche en cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance centre Léon Bérard LyonFrance Universitéclaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells cell therapy Receptor engineering cAR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Silicon-photonics-enabled chip-based 3D printer

引用

Light(Science & Applications) 2024年第7期13卷 1320-1330页

作者： Sabrina corsetti Milica Notaros Tal Sneh Alex Stafford Zachariah A.page Jelena Notaros Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of chemistry The University of Texas at AustinAustinTX 78712USA

Imagine if it were possible to create 3D objects in the palm of your hand within seconds using only a single photonic *** 3D printing has revolutionized the way we create in nearly every aspect of modern society,current 3D printers rely on large and complex mechanical systems to enable layer-by-layer addition of *** limits print speed,resolution,portability,form factor,and material *** there have been recent efforts in developing novel photocuring-based 3D printers that utilize light to transform matter from liquid resins to solid objects using advanced methods,they remain reliant on bulky and complex mechanical *** address these limitations,we combine the fields of silicon photonics and photochemistry to propose the first chip-based 3D *** proposed system consists of only a single millimeter-scale photonic chip without any moving parts that emits reconfigurable visible-light holograms up into a simple stationary resin well to enable non-mechanical 3D ***,we experimentally demonstrate a stereolithography-inspired proof-of-concept version of the chip-based 3D printer using a visible-light beam-steering integrated optical phased array and visible-light-curable resin,showing 3D printing using a chip-based system for the first *** work demonstrates the first steps towards a highlycompact,portable,and low-cost solution for the next generation of 3D printers.

关键词： printer printing visible

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Promising Molecular Markers of Prostate cancer Progression:ErbB3, Akt and NF-κB

Promising Molecular Markers of Prostate Cancer Progression:E...

引用

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Isma■l Hervé Koumakpayi cécile le page Laurent lessard Jean-Simon Diallo Philippe O. Gannon Benjamin Péant Nathalie Delvoye Anne-Marie Mes-Masson Fred Saad cHUM-Höpital Notre-Dame Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada

＜正＞Background and Aims: The treatment of prostate cancer （Pca） depends on stage. To improve treatment strategies, it would be helpful to have reliable molecular markers able to predict Pca progression. However, to date, such markers have not yet been included in therapeutic decisions. Recently, several studies from our laboratory described the prognostic potential of molecular markers that include ErbB3, Akt and Nuclear Factor kappaB （NF- κB） . ErbB3 is a member of the growth factor receptor family ErbB. Akt is a signaling component of the ErbB receptor family. Phos-phoinositol 3 - kinase （PI3K） through Akt regulates downstream signaling proteins such as NF - κB. Most of these molecules are often overexpressed and/or activated in cancer cells. Furthermore, they can be detected in the cytoplasm and/or nucleus of Pca cells. They are known to be involved in cell survival, cell growth, cell cycle progression and apoptotic response. The aim of our study was to determine whether these molecules could be used as markers to predict Pca progression.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

非凡与平凡现代科技可救人一命,也可料理餐食

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第7期 14-16,40-42页

作者： page DESIGN BY VIcKY TSUNG 不详

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可... 详细信息

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可以开创心脏外科手术的新领域,使年轻患者在日后的人生当中免于接受多次高风险的手术。

关键词：心脏移植手术心脏外科手术捐赠者年轻患者新生儿外科医生现代科技

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乐高如何培养客户忠诚度

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 32-33,48页

作者： Jason Aten VIcKY TSUNG(page DESIGN) 不详

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱... 详细信息

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱用乐高积木建造作品。在你可能接触到的所有品牌当中,乐高也许拥有最忠诚的粉丝。

关键词：客户忠诚度粉丝玩具制造商成年人

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

从空中发现疾病

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 14-15,41,42页

作者： Grace Toohey OLIVE cHU(page DESIGN) 不详

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好... 详细信息

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好消息一此产业每年因为这种摧毁作物的疾病而损失数十亿美元一一同时,它也有助于全球农业的整体发展。

关键词：植物病毒葡萄种植疾病检测美国宇航局葡萄产业影像技术潜在效益葡萄酒

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

你就是专家

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 36-37,50页

作者： Emma Fox OLIVE cHU(page DESIGN) 不详

许多类型的专业人士选择在社交媒体上聚焦他们的职业,有的是为了引起人们对其职业的兴趣、更正错误观念、吸引客户、赚取额外收入,有的只是为了好玩。观众也乐于关注他们。你是否想要迈出那一步来成为线上专家?你想不想和自己领域里的... 详细信息

许多类型的专业人士选择在社交媒体上聚焦他们的职业,有的是为了引起人们对其职业的兴趣、更正错误观念、吸引客户、赚取额外收入,有的只是为了好玩。观众也乐于关注他们。你是否想要迈出那一步来成为线上专家?你想不想和自己领域里的其他专业人士产生联结,并和群众分享资源?下面是一些决窍,告诉你如何利用自己在工作上已经建立的专长来打造个人品牌。

关键词：社交媒体个人品牌专业人士额外收入兴趣更正错误专家职业

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于众测操作记录的Web测试用例自动生成方法

引用

计算机技术与发展 2024年第1期34卷 83-90页

作者：张清睿黄松孙乐乐陆军工程大学指挥控制工程学院江苏南京210007

众包测试是软件测试领域的一种新兴趋势,具有更加可靠、成本更低和效率更快的优点。但是由于众测工人专业水平不同,提交的测试用例报告缺乏规范性,为报告的审核、缺陷的复现都增加了困难。该文提出了一种通过众测工人的操作记录自动生... 详细信息

众包测试是软件测试领域的一种新兴趋势,具有更加可靠、成本更低和效率更快的优点。但是由于众测工人专业水平不同,提交的测试用例报告缺乏规范性,为报告的审核、缺陷的复现都增加了困难。该文提出了一种通过众测工人的操作记录自动生成文本测试用例的新方法,并实现了该测试工具。首先,对测试工人的操作进行录制从而获取录制信息,录制信息可以划分为三大模块,包含静态页面信息、动态页面信息和交互信息;其次,通过深度优先遍历算法获取组件名称、组件类型、交互动作和交互数据,并按照众测工人的实际操作步骤生成测试序列;对于测试序列中存在组件名称匹配错误的问题,通过YOLOv5目标检测和OcR文字识别技术设计了n元组生成算法,用于生成组件名称与其选项的对应关系,并对匹配错误的组件名称进行自动修改;最后,通过自定义规则集将测试序列转换为文本测试用例。该方法自动生成统一规范的测试用例,降低了众测的门槛,提高了测试效率,并且有利于众测服务平台的质量评估工作。为了验证该方法的有效性,针对不同开发技术的Web系统进行了测试,并与目前最新版本的UFT,Selenium IDE和Katalon Recorder三款工具进行了对比。实验结果表明,该方法生成的测试用例在测试步骤完整性、测试用例信息完整性和时间性能方面具有较好的表现。

关键词：众包测试 Web测试测试记录文本测试用例测试用例生成

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of phosphonated graphene oxide by electrochemical exfoliation to enhance the performance and durability of high-temperature proton exchange membrane fuel cells

引用

Journal of Energy chemistry 2023年第1期76卷 448-458,I0011页

作者： Jianuo chen Zunmin Guo Maria Perez-page Yifeng Jia Ziyu Zhao Stuart M.Holmes Department of chemical Engineering and Analytical Science University of ManchesterOxford RoadManchester M139PLUnited Kingdom chemistry Research Laboratory Department of ChemistryUniversity of Oxford12 Mansfield RoadOxford OX13TAUnited Kingdom

The doping of functionalized graphene oxide(GO)in the membranes becomes a promising method for improving the performance of high-temperature proton exchange membrane fuel cells(HT-PEMFc).Phosphonated graphene oxide(PGO)with a P/O ratio of 8.5%was quickly synthesised by one-step electrochemical exfoliation based on a three-dimensiaonal(3D)printed reactor and natural graphite *** with the GO prepared by the two-step electrochemical exfoliation method,the PGO synthesized by the one-step electrochemical exfoliation can better improve the performance of the membrane-electrode-assembly(MEA)based on the polybenzimidazole(PBI)membrane in the *** doping of 1.5 wt%GO synthesised by electrochemical exfoliation with the 2-step method or reactor method in PBI increased the peak power density by 17.4%or 35.4%compared to MEA based on pure PBI membrane at 150℃,*** addition,the doping of PGO in PBI improves its durability under accelerated stress test(AST).

关键词： Electrochemical exfoliation Phosphonated graphene oxide High-temperature fuel cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

引用

Frontiers of Environmental Science & Engineering 2017年第4期11卷 63-72页

作者： John c. Radcliffe Declan page Bruce Naumann Peter Dillon cSIRO Land and Water Private Bag 2 Glen Osmond South Australia 5064 Australia city of Salisbury 12 James St Salisbury South Australia 5108 Australia

Australia has developed extensive policies and guidelines for the management of its water. The city of Salisbury, located within metropolitan Adelaide, South Australia, developed rapidly through urbanisation from the 1970s. Water sensitive urban design principles were adopted to maximise the use of the increased rim-off generated by urbanisation and ameliorate flood risk. Managed aquifer recharge was introduced for storing remediated low-salinity stormwater by aquifer storage and recovery （ASR） in a brackish aquiter for subsequent lrngatlon. Ibis paper outlines now a municipal government has progressively adopted principles of Water Sensitive Urban Design during its development within a framework of evolving national water policies. Salisbury＇s success with stormwater harvesting led to the formation of a pioneering w aterbusiness that includes linking projects from nine sites to provide a non-potable supply of 5 ×10^6 m^3 year. These installations hosted a number of applied research projects addressing well configuration, water quality, reliability and economics and facilitated the evaluation of its system as a potential potable water source. The evaluation showed that while untreated stonnwater contained contaminants, subsurface storage and end-use controls were sufficient to make recovered water sale for public open space irrigation, and with chlorination acceptable lbr third pipe supplies. Drinking water quality could be achieved by adding microfiltration, disinfection with UV and chlorination. The costs that would need to be expended to achieve drinking water safety standards were found to be considerably less than the cost of establishing dual pipe distribution systems. The full cost of supply was determined to be AUD$1.57 m ＂ for non-potable water for pubhc open space lrngatlon much cheaper than mares water, AUD $3.45 m at that time. Producing and storing potable water was found to cost AUDS1.96 to $2.24 m .

关键词： Managed Aquifer Recharge (MAR) Stormwater harvesting Water recycling drinking water Low impact development Water sensitive urban design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：