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Spatial assessment of the areas sensitive to degradation in the rural area of the municipality (c)ukarica

International Soil and Water conservation Research 2019年第1期7卷 71-80页

作者： Natalija Momirovi(c) Ratko Kadovi(c) Veljko Perovi(c) Milo(s)Marjanovi(c) Aleksandar Baumgertel Institute of Forestry Kneza Vi(s)eslava 311030 BelgradeSerbia Faculty of Forestry University of BelgradeKneza Vi(s)eslava 111030 BelgradeSerbia Institute for Biological Research'Sini(s)a Stankovi(c)' University of BelgradeBulevar despota Stefana 14211060 BelgradeSerbia Faculty of Mining and Geology University of BelgradeDu(s)ina 711000 BelgradeSerbia

In this paper,the assessment of the sensitivity of the soil in the rural area of (c)ukarica municipality to the processes of degradation is *** areas,especially in the vicinity of large cities,are exposed to numerous processes of degradation:soil erosion,urban and industrial zone expansion at the expense of fertile agricultural soils,activation of landslides and a number of other significant ecological *** on the characteristics of the research area,the MEDALUS (Mediterranean Desertification and Land Use) model was applied,and for the assessment of sensitivity to the processes of degradation the main quality indicators were considered:soil,climate,vegetation and *** each of the analyzed quality indicators,parameter groups were *** parameter is quantified according to the defined method by giving them a sensitivity coefficient between 1.0 and *** 10.0 has been applied to analyze and prepare layers of quality ***,the geometric mean for all four quality indicators was used to generate the map of environmental sensitivity to *** results obtained show that 41.54% of the study area is classified as critical;22.34% of the surface as fragile;8.47% of the areas are potentially endangered and 9.58% not threatened to degradation *** results have also shown that MEDALUS model is a functional tool for simulations which support sustainable land management in the areas prone to degradation.

关键词： MEDALUS Land degradation Landslides Human pressures GIS mapping

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Important step towards an understanding of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanced Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of particle physics,which contains the field theories for the electro-weak interaction(QED)and the strong interaction(QcD),is an extremely successful theory describing a huge variety of phenomena at... 详细信息

关键词： interaction atomic describing

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Hepatitis c Virus, Insulin Resistance, and Steatosis

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Journal of clinical and Translational Hepatology 2016年第1期4卷 66-75页

作者： Dominik Kralj Lucija Virovi(c) Juki(c) Sanja Stojsavljevi(c) Marko Duvnjak Martina Smoli(c) Ines Bili(c) (c)ur(c)i(c) Department of Gastroenterology and Hepatology Sisters of Charity University Hospital Center Zagreb Croatia Department of Pharmacology Faculty of Medicine University of Osijek Osijek Croatia Department of Pharmacology Faculty of MedicineUniversity of Osijek Department of Endocrinology and metabolism disorders University Hospital Center Osijek Osijek Croatia

Hepatitis c virus (HcV) is one of the main causes of liver disease *** steatosis is a common finding in many hepatic and extrahepatic disorders,the most common being metabolic syndrome (MS).Overtime,it has been shown that the frequent coexistence of these two conditions is not coincidental,since many epidemiological,clinical,and experimental studies have indicated HcV to be strongly associated with liver steatosis and numerous metabolic ***,we present an overview of publications that provide clinical evidence of the metabolic effects of HcV and summarize the available data on the pathogenetic mechanisms of this *** has been shown that HcV infection can induce insulin resistance (IR) in the liver and peripheral tissues through multiple *** research has suggested that HcV interferes with insulin signaling both directly and indirectly,inducing the production of several proinflammatory *** replication,assembly,and release from hepatocytes require close interactions with lipid droplets and host *** modulation of lipid metabolism in host cells can induce hepatic steatosis,which is more pronounced in patients with HcV genotype *** risk of steatosis depends on several viral factors (including genotype,viral load,and gene mutations) and host features (visceral obesity,type 2 diabetes mellitus,genetic predisposition,medication use,and alcohol consumption).HcV-related IR and steatosis have been shown to have a remarkable clinical impact on the prognosis of HcV infection and quality of life,due to their association with resistance to antiviral therapy,progression of hepatic fibrosis,and development of hepatocellular ***,HcV-induced IR,oxidative stress,and changes in lipid and iron metabolism lead to glucose intolerance,arterial hypertension,hyperuricemia,and atherosclerosis,resulting in increased cardiovascular mortality.

关键词： Hepatitis c virus Metabolic syndrome Insulin resistance Steatosis

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Influence of B4c and ZrB2 reinforcements on microstructural,mechanical and wear behaviour of AA 2014 aluminium matrix hybrid composites

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Defence Technology（防务技术） 2024年第10期40卷 242-254页

作者： Ramesh Babu R Rajendran c Saiyathibrahim A Rajkumar Velu Department of Mechanical Engineering Karpagam Institute of TechnologyCoimbatore 641105India Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore 641008India Department of Mechanical Engineering Indian Institute of Technology JammuJammu and Kashmir 181221India

considering their affordability and high strength-to-weight ratio,lightweight aluminium alloys are the subject of intensive research aimed at improving their properties for use in the aerospace *** research effort aims to develop novel hybrid composites based on AA 2014 alloy through the use of liquid metallurgy stir casting to reinforce dual ceramic particles of Zirconium Diboride(ZrB_(2))and Boron carbide(B4c).The weight percentage(wt%)of ZrB_(2) was varied(0,5,10,and 15),while a constant 5 wt%of B4c was maintained during this *** as-cast samples have been assessed using an Optical Microscope(OM)and a Scanning Electron Microscope(SEM)with Energy Dispersive Spectroscopy(EDS).The properties such as hardness,tensile strength,and wear characteristics of stir cast specimens were assessed to examine the impact of varying weight percentages of reinforcements in AA 2014 *** particular,dry sliding wear behaviour was evaluated considering varied loads using a pin-on-disc *** the weight%of ZrB_(2) grew and B4c was incorporated,hybrid composites showed higher hardness,tensile strength,and wear ***,the incorporation of a cumulative reinforcement consisting of 15 wt%ZrB_(2) and 5 wt%B4c resulted in a significant 31.86%increase in hardness and a 44.1%increase in tensile strength compared to AA 2014 *** addition,it has been detected that wear resistance of hybrid composite pin(containing 20 wt%cumulative reinforcement)is higher than that of other stir cast wear test pins during the whole range of applied *** surfaces of tensile specimens showed ductile fracture in the AA 2014 matrix and mixed mode for hybrid *** surfaces obtained employing higher applied load indicated abrasive wear with little plastic deformation for hybrid composites and dominant adhesive wear for matrix ***,the superior mechanical and tribological performance of hybrid composites can be attributed to dual reinforcement pa

关键词： AA 2014 alloy Stir casting Hybrid composite Hardness Tensile strength Specific wear rate

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Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis c

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World Journal of Gastroenterology 2009年第40期15卷 5010-5013页

作者： Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli c Burcin Taner Rolland c Dickson Division of Transplant Surgery and Transplant Hepatology Division of Interventional Radiology

Hepatitis c is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis c recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis c. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

关键词： Hypersplenism Leukopenia Recurrenthepatitis c Thrombocytopenia Liver transplant

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Genetic diversity of the hepatitis c virus: Impact and issues inthe antiviral therapy

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World Journal of Gastroenterology 2007年第17期13卷 2416-2426页

作者： H Le Guillou-Guillemette S Vallet c Gaudy-Graffin c Payan A Pivert A Goudeau F Lunel-Fabiani Laboratory of Virology University Hospital of Angers France and Laboratory HIFI UPRES EA 3859 University of Angers France Department of Microbiology EA 3882 CHU Morvan University Hospital of Brest France Université Francois Rabelais INSERM ERI 19 et CHRU de Tours Tours France

The hepatitis c Virus (HcV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HcV geno- type. Both structural and non structural genomic regions of HcV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HcV diversity. Then, the HcV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review.

关键词： Hepatitis c virus Genetic diversity Therapyresistance E2 NS3 NSSA NSSB

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c_c(X)Spaces with X Locally compact

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1593-1600页

作者： J.c.FERRANDO S.MOLL centro de Investigación Operativa Universidad Miquel Hernández Departamento de Matemática Aplicada Universidad Politécnica

In this paper, we show, among other results, that if X is a [separable] locally compact space X [satisfying the first countability axiom] then the space cc （X） has countable tightness [if and only if it has bounding tightness] if and only if it is Frechet-Urysohn, if and only if cc （X） contains a dense （LM） subspace and if and only if X is a-compact.

关键词： Frechet-Urysohn space countable [bounding] tightness (LM)-space

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Fabrication and Properties of SiB6-B4c with Phenolic Resin as a carbon Source

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Journal of Materials Science & Technology 2008年第1期24卷 102-104页

作者： G. c.Hwang J.Matsushita United Graduate School of Science and Engineering Tokai University 1117 Kitakaname Hiratsuka 259-12921 Japan

Si-B-c ceramic composites were synthesized using SiB-6,B-4c,and phenolic resin as a carbon source by pressureless sintering in an Ar ***,the Si-B-c ceramic composites were fabricated to determine their potential for applications as high hardness and high temperature *** X-ray diffraction patterns of sintered bodies of SiB-6-B-4c with carbonized phenolic resin can be seen that SiB-6 and c changed to B-4c and *** this study,it is obtained that carbonized phenolic resin is good addition material as a reaction material comparing to carbon powder at 1683 K for 1 h by pressureless sintering in an Ar atmosphere.

关键词： Silicon boride Boron carbide Phenolic resin

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Different effects of a cD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis c infection

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World Journal of Gastroenterology 2005年第38期11卷 6031-6037页

作者： c Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich c Hellerbrand Department of Internal Medicine I Department of Psychiatry Department of Pathology Institute for clinical chemistry and Laboratory Medicine

AIM： clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a c-T （-159） polymorphism in the promoter region of the cD14 gene was detected and found to confer increased cD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease （ALD） and chronic hepatitis c virus （HcV） infection. METHODS： cD14 genotyping was performed by PcR-RFLP analysis in （a） 121 HcV patients, （b） 62 patients with alcohol-associated cirrhosis （AIc-ci）, （c） 118 individuals with heavy alcohol abuse without evidence of advanced liver damage （Alc-w/o ci）, and （d） 247 healthy controls. Furthermore, serum levels of soluble cD14 （scD14） and transaminases were determined. RESULTS： The TT genotype was significantly more frequent in Alc-ci compared to Alc-w/o ci or controls （40.3% vs 23.7% or 24.0%, respectively）. In Alc-w/o ci, serum levels of transaminases did not differ significantly between patients with different cD14 genotypes. In HcV patients, TT-homozygotes had significantly higher scD14 levels and scD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However, no association was found between cD14 genotypes and histological staging or grading. cONcLUSION： considering serum transaminases as surrogate markers for alcoholic liver damage, the cD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HcV patients and alcoholics and the known functional impact of this polymorphism on cD14 expression levels further indicate differences in the pathophysiological role of cD14 and cD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease.

关键词： cD14 gene Alcoholic liver disease chronic hepatitis c infection

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Why is dimerization essential for class-c GPcR function？ New insights from mGluR1 crystal structure analysis

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Protein & cell 2014年第7期5卷 492-495页

作者： Xuejun c. Zhang Jianfeng Liu Daohua Jiang National Laboratory of Macromolecules National Center of Protein Science--Beijing Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China School of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

G-protein coupled receptors （GPcRs） play an essential role in eukaryotic cells signaling. According to phylogenetic analysis, most GPcRs belong to one of four classes, i.e. A, B, c, and Frizzled （Lagerstrom and Schioth, 2008）. The class-c GPcR family contains metabotropic glutamate receptors （mGluR）, y-aminobutyric acid B receptors （GABAB receptor or GBR）, several taste-sensing receptors （e.g.

关键词： receptors feature Kniazeff

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