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Extremely rare case of successful treatment of metastatic ovarian undifferentiated carcinoma with high-dose combination cytotoxic chemotherapy: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4488-4493页

作者： Hong Beum kim Hee Jeong Lee Ran Hong Sang-gon Park Department of Premedical Course Chosun University School of MedicineGwngju 505717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 505717South Korea Department of Pathology Chosun University HospitalGwangju 505717South Korea

BACKGROUND Ovarian undifferentiated carcinomas are significantly rare and have an aggressive clinical *** resection is the only curative treatment in early-stage ovarian undifferentiated carcinomas that has a favorable *** case of recurrent and metastatic disease,palliative chemotherapy is the only available ***,the effectiveness of standard chemotherapy regimen is not well-known,specifically in the case of extra-ovarian *** report an ovarian undifferentiated carcinoma of recurrent and inoperable advanced stage that was successfully treated with high-dose combination *** SUMMARY A 52-year-old woman presented with a 1-mo history of right lower quadrant and epigastric pain.A computed tomography(CT)scan of the abdomen revealed a multicystic mass with extensive internal necrosis of the right ovary without evidence of metastatic disease.A total hysterectomy with bilateral salpingooophorectomy and omentectomy was performed,but the surgery had a positive resection ***,it was diagnosed as ovarian undifferentiated carcinoma with sarcomatoid *** adjuvant chemotherapy was planned,it was delayed for 6 wk because of postoperative recovery,and the patient complained of abdominal pain.A CT scan and positron emission tomography-CT revealed a huge mass with multiple nodules in the pelvic cavity and para-aortic lymph node *** of standard therapy such as paclitaxel and platinum,combined chemotherapy with etoposide,ifosfamide,and cisplatin was *** patient experienced no recurrence for 5 *** This is a case of metastatic ovarian undifferentiated carcinoma with sarcomatoid change that was successfully treated with high-dose combination cytotoxic chemotherapy.

关键词： Ovarian undifferentiated carcinoma Sarcomatoid change Chemotherapy Etoposide,ifosfamide,cisplatin Case report

Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3039-3046页

作者： Hong-Beum kim Yong Sub Na Hee-Jeong Lee Sang-gon Park Department of Premedical Course Chosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea

BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.

关键词： Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report

Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

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World Journal of Gastroenterology 2010年第26期16卷 3249-3257页

作者： Mi-Young Song Ui-Jin Bae Bong-Hee Lee Kang-Beom Kwon Eun-A Seo Sung-Joo Park Min-Sun kim Ho-Joon Song Keun-Sang Kwon Jin-Woo Park Do-gon Ryu byung-Hyun Park Department of Biochemistry Medical School and Diabetes Research Center Chonbuk National University Jeonju Jeonbuk 561-756 South Korea Department of Physiology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Food and Nutrition School of Human Environmental Science Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Herbology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Preventive Medicine Medical School Chonbuk National University Jeonju Jeonbuk 561-756 South Korea

AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were completely abolished when mice were pretreated with NJE. Inhibition of streptozotocin-induced hyperglycemia by NJE was mediated by suppression of nuclear factor (NF)-κB activation. In addition, NJE protected against cytokine-mediated cytotoxicity. Incubation of RINm5F cells and islets with NJE resulted in a signif icant reduction in cytokine-induced NF-κB activation and downstream events, inducible nitric oxide synthase expression and nitric oxide production. The protective effect of NJE was further demonstrated by the normal insulin secretion of cytokine-treated islets in response to glucose. CONCLUSION: NJE provided resistance to pancreatic β-cell damage from cytokine or streptozotocin treatment. The β-cell protective effect of NJE is mediated by suppressing NF-κB activation.

关键词： Nardostachys jatamansi Cytokines Streptozotocin Pancreatic β cells Nuclear factor κB Nitric oxide Diabetes mellitus

Recent updates and current issues of sentinel node navigation surgery for early gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 142-149页

作者： Sung gon kim Bang Wool Eom Hong Man Yoon Chan Gyoo kim Myeong-Cherl Kook Young-Woo kim Keun Won Ryu Center for Gastric Cancer Research Institute&HospitalNational Cancer CenterGoyang-si 410-769Republic of Korea

With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard *** node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with *** many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is *** issues regarding technical standardization and oncological safety need to be *** several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future.

关键词： Sentinel node navigation surgery function-preserving surgery early gastric cancer SENORITA

Design of 32 kbit one-time programmable memory for microcontroller units

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Journal of Central South University 2012年第12期19卷 3475-3483页

作者： JEON Hwang-gon CHOI In-hwa HA Pan-bong kim Young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 32 kbit OTP(one-time programmable)memory for MCUs(micro-controller units)used in remote controllers was *** OTP memory is used for program and data *** is required to apply 5.5V to BL(bit-line)and 11V to WL(word-line)for a OTP cell of 0.35μm ETOX(EEPROM tunnel oxide)type by *** use 5V transistors on column data paths to reduce the area of column data paths since they require small *** addition,we secure device reliability by using HV(high-voltage)transistors in the WL ***,we change from a static logic to a dynamic logic used for the WL driver in the core ***,we optimize the WD(write data)switch ***,we can implement them with a small-area *** addition,we implement the address predecoder with a small-area logic *** area of the designed 32 kbit OTP with 5V and HV devices is 674.725μm×258.75μm(=0.1745mm2)and is 56.3% smaller than that using 3.3V devices.

关键词：可编程存储器微控制器单元格一次性设计 OTP存储器 EEPROM 高压设备

Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

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Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min gon kim Changhan Yoon Hyung Ham kim KKirk Shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report

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World Journal of Clinical Cases 2020年第13期8卷 2833-2840页

作者： Hong-Beum kim Sang-gon Park Ran Hong Seong-Ho Kang Yong Sub Na Department of Premedical Course Chosun University School of MedicineGwangju 61452South Korea Department of Hemato-oncology Chosun University HospitalGwangju 61453South Korea Department of Pathology Chosun University HospitalGwangju 61453South Korea Department of Laboratory Medicine Chosun University HospitalGwangju 61453South Korea Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND Pembrolizumab is a highly selective IgG4 kappa isotype monoclonal antibody against the programmed cell death-1(PD-1)*** the treatment of nonsmall cell lung cancer(NSCLC),pembrolizumab has demonstrated significant efficacy,significant survival outcomes,long-lasting responses,and a good safety profile compared with cytotoxic *** SUMMARY A 79-year-old Korean male presented with a left side palpable neck *** ultrasound-guided core-needle biopsy of the largest neck mass was performed,and squamous cell carcinoma was confirmed based on the histological and immunohistochemical *** was diagnosed with squamous cell carcinoma of the lung with multiple lymph nodes and rib metastases(T1N3M1b,Stage IVA)using enhanced chest computed tomography and 18F-fluorodeoxyglucose positron emission/computed *** 4 cycles of gemcitabine and carboplatin,we clinically judged the disease as *** to the high PD-1 expression demonstrated by the patient,pembrolizumab was initiated(200 mg every 3 wk).After 3 cycles of pembrolizumab,a complete response was *** the 4th cycle of pembrolizumab,the white blood cell count was markedly *** blood smear analysis and bone marrow biopsy were *** patient was diagnosed with acute myelomonocytic *** We present the first report of acute myelomonocytic leukemia during pembrolizumab treatment in an NSCLC patient;the mechanism remains unknown.

关键词： Acute myeloid leukemia Immunotherapy Non-small cell lung cancer Adverse events Case report

Magnesium citrate with a single dose of sodium phosphate for colonoscopy bowel preparation

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World Journal of Gastroenterology 2011年第2期17卷 242-248页

作者： Yong Sung Choi Jung Pil Suh Jong Kyu kim In Taek Lee Eui gon Youk Doo Seok Lee Do Sun kim Doo Han Lee Department of Gastroenterology Daehang Hospital Department of Surgery Daehang Hospital

AIM:To evaluate the efficacy and acceptability of magnesium citrate and a single dose of oral sodium phosphate(45 mL) solution for morning colonoscopy bowel preparation. METHODS:A total of 159 patients were randomly assigned to receive two split doses of 90 mg of sodium phosphate(GroupⅠ,n=79) or magnesium citrate(250 mL,the day before the procedure) followed by 45 mL of sodium phosphate(the day of procedure,GroupⅡ,n= 80) .The quality of bowel cleansing and the acceptability of each regimen were compared,including the satisfaction,taste,willing to repeat and adverse effects of each regimen. RESULTS:The quality of bowel cleansing of GroupⅡ was as good as that of GroupⅠ(An Aronchick scale score of good or excellent:70.9%vs 81.0%,respectively,P=0.34;the Ottawa system score:4.4±2.6 vs 3.8 ±3.0,respectively,P=0.76) .There was no statisticallysignificant difference between both groups with regard to acceptability,including the satisfaction,taste and willingness to repeat the regimen.A significantly greater number of older patients(over 65 years old) in Group Ⅱgraded the overall satisfaction as satisfactory(48.1% vs 78.1%,respectively;GroupⅠvs GroupⅡ,P=0.01) . There were no significant adverse reactions. CONCLUSION:Magnesium citrate and a single dose of sodium phosphate was as effective and tolerable as the conventional sodium phosphate regimen and is a satisfactory option.

关键词：柠檬酸钠磷酸钠结肠镜剂量肠道检查镁满意度

Fabrication of Variable Optical Attenuator With Low Insertion Loss

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光学学报 2003年第S1期23卷 305-306页

作者： Yone-gon Seo Yong-Tak kim Jemin kim Hyung-Do Yoon Young-Min Im Korea Electronics Technology Institute 455-6 MaSan-Ri JinWi-Myon PyungTaek-Si KyungGi-Do Korea Department of Advanced Materials Engineering Sungkyunkwan University Jangan-gu Suwon 440-746 Korea

A voltage-controlled variable optical attenuator (VOA) based on silica-based planar lightwave circuits (PLC) was fabricated by flame hydrolysis deposition (FHD). The variable attenuator with Cr heater achieves 20dB attenuation with 318mW electrical power at 1550 nm. The insertion loss and the polarization dependent loss (PDL) at 0 attenuation are 1dB and 0.23dB, respectively.

关键词： electrical power insertion loss