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Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

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World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R c Janssen Inger N Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R c Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BAcKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%cI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%cI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%cI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

Surface-modified Ag@Ru-P25 for photocatalytic cO_(2) conversion with high selectivity over cH_(4) formation at the solid–gas interface

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carbon Energy 2024年第1期6卷 182-196页

作者： chaitanya B.Hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee Gong Hwapyong Kim Hong Soo Kim Jin-Woo Jung chang-Hee cho bryan M.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of cO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with H_(2)O_(2) treatment was designed in this study to convert cO_(2) and H_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas H_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–OH)groups and promotes cO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,cO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of H_(2)O_(2) treatment in increasing cO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent cO_(2) reduction activity into cO,cH4,and c2H6 with a~95%selectivity of cH4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of H_(2)O_(2) treatment on the photocatalyst that dramatically increases cO_(2) reduction activity.

关键词： gas-phase cO_(2) reduction H_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

Nitric oxide and geriatrics:Implications in diagnostics and treatment of the elderly

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Journal of Geriatric cardiology 2011年第4期8卷 230-242页

作者： Ashley c Torregrossa Mayank Aranke Nathan S bryan Texas Therapeutics Institute Brown Foundation Institute of Molecular MedicineUniversity of Texas Health Science Center at Houston1825 Pressler St.530CHoustonTX 77030USA The University of Texas at Austin University StationAustinTX 78712USA The University of Texas Graduate School of Biomedical Sciences 6767 Bertner Av.HoustonTX 77030USA

The nation’s aging population is growing *** 2030,the number of adults age 65 and older will nearly double to 70 *** are living longer and older adults can now live for many years with multiple chronic illnesses but with a substantial cost to health *** percent of the Medicare population has at least five chronic conditions i.e.,hypertension,diabetes,arthritis,*** in experimental models and even humans reveal that constitutive production of nitric oxide(NO)is reduced with aging and this circumstance may be relevant to a number of diseases that plague the aging *** is a multifunctional signaling molecule,intricately involved with maintaining a host of physiological processes including,but not limited to,host defense,neuronal communication and the regulation of vascular *** is one of the most important signaling molecules in our body,and loss of NO function is one of the earliest indicators or markers of *** studies provide evidence that insufficient NO production is associated with all major cardiovascular risk factors,such as hyperlipidemia,diabetes,hypertension,smoking and severity of atherosclerosis,and also has a profound predictive value for disease progression including cardiovascular and Alzheimers *** plus years after its discovery and over 13 years since a Nobel Prize was awarded for its discovery,there have been no hallmark therapeutic breakthroughs or even NO based *** will review the current state of the science surrounding NO in the etiology of a number of different diseases in the geriatric *** these observations,it can be concluded that enzymatic production of NO declines steadily with increasing age in healthy human *** strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient.

关键词： nitrite nitrate cardiovascular disease Alzheimer’s disease bloodflow circulation

The effect of milling additives on powder properties and sintered body microstructure of NiO

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Journal of Advanced ceramics 2015年第2期4卷 142-151页

作者： L.Jay DEINER Michael A.ROTTMAYER bryan c.EIGENBRODT Department of chemistry New York City College of TechnologyCity University of New York300 Jay St.BrooklynNY 11201USA The Air Force Research Labs Wright-Patterson Air Force BaseOH 45433USA Department of chemistry Villanova University800 E.Lancaster Ave.VillanovaPA 19085USA

The evolution of powder particle size,crystal structure,and surface chemistry was evaluated for micron scale NiO powders subjected to impact milling with commonly employed milling additives:methanol,Vertrel XF,and amorphous *** effect of the different comminution protocols on sintered body microstructure was evaluated for high temperature sintering in inert atmosphere(N_(2)).X-ray photoelectron spectroscopy showed that NiO powder surface chemistry is surprisingly sensitive to milling additive *** particular,the proportion of powder surface defect sites varied with additive,and methanol left an alcohol or alkoxy residue even after *** sintering to intermediate temperatures(1100℃),scanning electron microscopy(SEM)showed that slurry milled NiO powders exhibit hindered sintering *** effect was amplified for NiO milled with methanol,in which sub-500 nm grain sizes dominated even after sintering to 1100℃.Upon heating to high temperatures(1500℃),simultaneous differential scanning calorimetry/thermogravimetric analysis(DSc/TGA)showed that the powders containing carbon residues undergo carbothermal reduction,resulting in a melting transition between 1425 and 1454℃.Taken together,the results demonstrated that when processing metal oxide powders for advanced ceramics,the choice of milling additive is crucial as it exerts significant control over sintered body microstructure.

关键词： nickel oxide impact milling sintering densification grain growth

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox christopher chin Deena Najjar Irina Matei Irenaeus chan carlos cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian c.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane c.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA children's cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer cancer center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PcR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(cHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of cHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

A feeder-free,human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro

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cell Regeneration 2012年第1期1卷 38-46页

作者： Fiona c Lewis Nicholas bryan John A Hunt clinical Engineering UKCTEInstitute of Ageing and Chronic DiseaseUniversity of LiverpoolLiverpool L693GAUK

Background:Human embryonic stem cells(hEScs)represent a tremendous resource for cell therapies and the study of human development;however to maintain their undifferentiated state in vitro they routinely require the use of mouse embryonic fibroblast(MEF)feeder-layers and exogenous protein media ***:These well established requirements can be overcome and in this study,it will be demonstrated that phenotypic stability of hEScs can be maintained using a novel,human plasma protein-based hydrogel as an extracellular culture matrix without the use of feeder cell *** were resuspended in human platelet poor plasma(PPP),which was gelled by the addition of calcium containing DMEM-based hESc culture *** and genomic expression of the pluripotency markers OcT4,NANOG and SOX2 were measured using immunohistochemistry and qRT-PcR *** hESc morphology was demonstrated throughout in vitro culture and both viability and phenotypic stability were maintained throughout extended culture,up to 25 ***:PPP-derived hydrogel has demonstrated to be an efficacious alternative to MEF co-culture with its hydrophilicity allowing for this substrate to be delivered via minimally invasive procedures in a liquid phase with polymerization ensuing in *** this provides a novel technique for the study of this unique group of stem cells in either 2D or 3D both in vitro and in vivo.

关键词： Embryonic stem cells Hydrogel Pluripotent stem cells cell culture

A MAGNETIc SURVEY OF EXPLORER SEAMOUNT——REcENT SPREADING AT THE EXPLORER TRENcH

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Journal of Oceanology and Limnology 1986年第2期4卷 183-195页

作者：吴铭先,Patrick J.c.Ryall,Joanne bryan Shandong college of Oceanology Department of Geology Dalhousie University Department of Geology Dalhousie University

In 1981 a magnetic and bathymetric survey was carried out over Explorer Seamount located approximately between 48°50′ and 49°30′N and 130°40′ and 131°30′W. During the cruise four pillow fragments were dredged from peaks in this area. Based on the observed ***, it was identified that the main peak of Explorer Seamount should be of the Bruhnes age while the magnetic high in the N W of study area would be Gauss. This would yield a spreading rate of about 2 cm per year for the Matuyama epoch. The results of intensities of remanence measured from the pillow fragments indicate that the ages are less than 106 years. Similarly the curie temperature is consistent with ages of around 106 years. An attempt was made to model the observed magnetic field using a series of uniformly magnetized NE-SW trending blocks of alternating polarity. Agreement between the model and observed results is satisfied. Oxidation ratios calculated from measured samples suggest that the main peak of Explorer Seamount is

关键词： Explorer A MAGNETIc SURVEY OF EXPLORER SEAMOUNT REcENT SPREADING AT THE EXPLORER TRENcH Figure AT

Hydrothermal carbonization of livestock mortality for the reduction of pathogens and microbially-derived DNA

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 107-114页

作者： Thomas F. Ducey Jessica c. collins Kyoung S. Ro bryan L. Woodbury D. Dee Griffin coastal Plains Soil Water and Plant Research Center Agricultural Research Service United States Department of Agriculture Florence SC 29501 USA South carolina Governor's School for Science and Mathematics Hartsville SC 29550 USA U.S. Meat Animal Research center Agricultural Research Service United States Department of Agriculture Clay Center NE 68933 USA University of Nebraska-Lincoln Great Plains Veterinary Education Center Lincoln NE 68588 USA

Hydrothermal carbonization （HTc）, utilizing high temperature and pressure, has the potential to treat agricultural waste via inactivating pathogens, antibiotic resistance genes （ARG）, and contaminants of emerging concern （cEc） in a environmental and economical manner. Livestock mortality is one facet of agricultural waste that can pose a threat to the surrounding environment. While several methods are utilized to treat livestock mortality, there remains a paucity of data on the elimination of microbially- derived DNA in these treatment practices. This DNA, most notably ARGs, if it survives treatment can be reintroduced in agricultural environments where it could potentially be passed to pathogens, posing a risk to animal and human populations. HTc treatments have been successfully utilized for the treatment of cEcs, however very little is understood on how ARGs survive HTc treatment. This study aims to fill this knowledge gap by examining the survivability ofmicrobially-derived DNA in the HTc treatment of livestock mortality. We examined three treatment temperatures （100℃, 150℃, and 200℃） at autogenic pressures at three treatment times （30, 60, and 240 min）. We examined the amplification of a plasmid-bome reporter gene carried by Escherichia coli DH 10B introduced to both beef bone and tissue. Results indicate that while all three temperatures, at all treatment times, were suitable for complete pathogen kill, only temperatures of 150℃ and 200℃ were sufficient for eliminating microbial DNA. These results serve as the basis for future potential HTc treatment recommendations for livestock mortality when considering the elimination of pathogens and ARGs.

关键词： High-temperature carbonization Microbial DNA Livestock mortality

Electrochemical reduction of cr(Ⅵ)in the presence of sodium alginate and its application in water purification

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Journal of Environmental Sciences 2021年第3期33卷 304-312页

作者： bryan Butter Paola Santander Guadalupe del cPizarro Diego POyarzún Federico Tasca Julio Sánchez Facultad de Química y Biología Universidad de Santiago de ChileUSACHCasilla 40Correo 33SantiagoChile Departamento de Química Universidad Tecnológica MetropolitanaJ.P.Alessandri 1242SantiagoChile Laboratorio de Nanotecnología Recursos Naturales y Sistemas ComplejosFacultad de Ciencias NaturalesUniversidad de AtacamaCopayapu 485CopiapóChile

chromium(cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem *** concentrations of cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this *** work examined the conversion of cr(Ⅵ)to cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF *** electroanalysis of cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the cr(Ⅵ)concentration,pH,presence of cr(Ⅲ),SA concentration and scan *** addition,the quantitative reduction of cr(Ⅵ)to cr(Ⅲ)was studied through the bulk electrolysis *** results showed efficient reduction with well-defined peaks at approximately 0.3 V ***/Agcl,using a gold working *** the pH increased,the reduction signal strongly decreased until its *** optimum SA concentration was 10 mmol/L,and it was observed that the presence of cr(Ⅲ)did not interfere in the cr(Ⅵ)*** the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all cr(Ⅵ)to cr(Ⅲ)followed by its removal via PEUF.

关键词： Alginate solution chromium Electroanalytical chemistry Ultrafiltration Water purification