Nitric oxide and geriatrics:Implications in diagnostics and treatment of the elderly

作     者：Ashley C Torregrossa Mayank Aranke Nathan S Bryan 

作者机构：Texas Therapeutics InstituteBrown Foundation Institute of Molecular MedicineUniversity of Texas Health Science Center at Houston1825 Pressler St.530CHoustonTX 77030USA The University of Texas at AustinUniversity StationAustinTX 78712USA The University of Texas Graduate School of Biomedical Sciences6767 Bertner Av.HoustonTX 77030USA 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2011年第8卷第4期

页      面：230-242页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 1002[医学-临床医学] 020205[经济学-产业经济学] 

主　　题：nitrite nitrate cardiovascular disease Alzheimer’s disease bloodflow circulation 

摘      要：The nation’s aging population is growing *** 2030,the number of adults age 65 and older will nearly double to 70 *** are living longer and older adults can now live for many years with multiple chronic illnesses but with a substantial cost to health *** percent of the Medicare population has at least five chronic conditions i.e.,hypertension,diabetes,arthritis,*** in experimental models and even humans reveal that constitutive production of nitric oxide(NO)is reduced with aging and this circumstance may be relevant to a number of diseases that plague the aging *** is a multifunctional signaling molecule,intricately involved with maintaining a host of physiological processes including,but not limited to,host defense,neuronal communication and the regulation of vascular *** is one of the most important signaling molecules in our body,and loss of NO function is one of the earliest indicators or markers of *** studies provide evidence that insufficient NO production is associated with all major cardiovascular risk factors,such as hyperlipidemia,diabetes,hypertension,smoking and severity of atherosclerosis,and also has a profound predictive value for disease progression including cardiovascular and Alzheimers *** plus years after its discovery and over 13 years since a Nobel Prize was awarded for its discovery,there have been no hallmark therapeutic breakthroughs or even NO based *** will review the current state of the science surrounding NO in the etiology of a number of different diseases in the geriatric *** these observations,it can be concluded that enzymatic production of NO declines steadily with increasing age in healthy human *** strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient.