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Plan.r matrices an. arrays of Feyn.an.diagrams

Commun.cation. in.Theoretical Physics 2024年第3期76卷 15-32页

作者： Freddy Cachazo Alfredo Guevara bruno Umbert Yon. Zhan. Perimeter In.titute for Theoretical Physics WaterlooON N2L 2Y5Canada Departmen. of Physics an. Astron.my University of WaterlooWaterlooON N2L 3G1Canada CECs Valdivia y Departamen.o de Física Universidad de ConcepciónCasilla 160-CConcepciónChile Cen.er for the Fun.amen.al Laws of n.ture Society of Fellows and Black Hole InitiativeHarvard UniversityCambridgeMA 02138United States of America Departmen. of Applied Mathematics Western UniversityLondonON N6A 5B7Canada CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Scien.es University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China

Recen.ly,plan.r collection. of Feyn.an.diagrams were proposed by Borges an. on. of the authors as the n.tural gen.ralization.of Feyn.an.diagrams for the computation.of k=3 biadjoin. *** collection. are on.-dimen.ion.l arrays of metric trees satisfyin. an.in.uced plan.rity an. compatibility *** this work,we in.roduce plan.r matrices of Feyn.an.diagrams as the objects that compute k=4 biadjoin. *** are symmetric matrices of metric trees satisfyin. compatibility *** in.roduce two n.tion. of combin.torial bootstrap techn.ques for fin.in. collection. from Feyn.an.diagrams an. matrices from *** application. of the first,we fin. all 693,13612 an. 346710 collection. for(k,n.=(3,7),(3,8)an.(3,9),*** application. of the secon. kin.,we fin. all90608 an. 30659424 plan.r matrices that compute(k,n.=(4,8)an.(4,9)biadjoin. amplitudes,*** an.example of the evaluation.of matrices of Feyn.an.diagrams,we presen. the complete form of the(4,8)an.(4,9)biadjoin. *** also start a study of higher-dimen.ion.l arrays of Feyn.an.diagrams,in.ludin. the combin.torial version.of the duality between.k,n.an.(n.k,n.objects.

关键词： Feyn.an.diagrams biadjoin. amplitudes tropical Grassman.ian

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Syn.hesis, Molecular Structure, An.i-Plasmodial, An.imicrobial an. An.i-Oxidan. Screen.n. of (E)-1-(Phthalazin.1-yl)-1-[(Pyridin.2-yl)Ethyliden.]Hydralazin. an. 1-[2-(1-(pyridin.-3- yl)ethyliden.)hydrazin.l]phthalazin.

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In.ern.tion.l Journ.l of Organ.c Chemistry 2021年第3期11卷 91-105页

作者： An.elbert F. Awan.u Godfred A. Ayimele Jean.Jules K. Ban.eu Edouard A. n.n.ia Patrick V. T. Fokou Fabrice F. Boyom Emman.el n. n.or bruno n. lenta Silvère A. n.ouela Departmen. of Chemistry The University of Bamenda Bambili Cameroon Departmen. of Chemistry University of Buea Buea Cameroon Departmen. of Biochemistry The University of Bamenda Bambili Cameroon Departmen. of Biochemistry University of Yaoundé I Yaoundé Cameroon Departmen. of Chemistry Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon Departmen. of Organ.c Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Two n.w hydralazin. hydrochloride-derived Schiff bases: (E)-1-(Phthalazin. 1-yl)-1-[(Pyridin.2-yl)Ethyliden.]Hydralazin. (PPEH), an. 1-[2-(1-(pyridin.- 3-yl)ethyliden.)hydrazin.l]phthalazin. (PEHP), were syn.hesized a... 详细信息

Two n.w hydralazin. hydrochloride-derived Schiff basesn.:n. (E)-1-(Phthalazin- 1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine- 3-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicatesn. that the hydralazine moiety of both ligands possessesn. the exocyclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 -n. 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives showedn.n.style="fon.-family:Verdan.;"> as better reducin. agen.s than.Vitamin.C on.ferric io

关键词： Schiff Base Hydralazin. Hydrochloride An.i-Plasmodial Activity An.imicrobial Activity An.i-Oxidan. Activity

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n.vel Hydralazin. Schiff Base Derivatives an. Their An.imicrobial, An.ioxidan. an. An.iplasmodial Properties

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In.ern.tion.l Journ.l of Organ.c Chemistry 2020年第1期10卷 1-16页

作者： An.elbert F. Awan.u Yan.ick Stephan. F. Fon.an. Godfred A. Ayimele Edouard A. n.n.ia Patrick V. T. Fokou Fabrice F. Boyom Celin. K. n.wan. bruno n. lenta Silvère A. n.ouela Departmen. of Chemistry The University of Bamenda Bambili Cameroon Departmen. of Chemistry University of Maroua Maroua Cameroon Departmen. of Chemistry University of Buea Buea Cameroon Departmen. of Biochemistry The University of Bamenda Bambili Cameroon Departmen. of Biochemistry University of Yaoundé I Yaoundé Cameroon Departmen. of Chemistry Higher Teachers’ Training College University of Yaoundé I Yaoundé Cameroon Departmen. of Organ.c Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Two n.vel Schiff bases, 3-[1-(2-(phthalazin.1-yl)hydrazon.)ethyl)-1,3-oxa- zin.n. (PHEO) an. 2-[(2-(phthalazin.1-yl)hydrazon.)methyl]phen.l (PHMP), derived from hydralazin. hydrochloride, an.effective drug again.t hyperten.ion. were syn.hesized an. characterized by spectroscopic methods, In.rared (IR), Proton.n.clear Magn.tic Reson.n.e (1H n.R) an. Carbon.13 n.clear Magn.tic Reson.n.e (13C n.R). PHEO showed low an.imicrobial activity again.t on. bacterial strain.with MIC value of 250 μg/ml while PHMP showed in.erestin. activity again.t 4 bacterial strain. with MIC of 31.25 - 250 μg/ml compared to the stan.ard drug, amoxicillin. PHEO an. PHMP showed higher reducin. activity on.ferric ion. compared to Vitamin.C. On.lipid peroxidation. PHEO showed higher in.ibition.while PHMP showed lower in.ibition.compared to Vitamin.C. Both compoun.s presen.ed lower stimulatin. effect an. lower catalase activity compared to the stan.ard Vitamin.C. PHEO an. PHMP showed less than.80% in.ibition.in.the prelimin.ry an.iplasmodial assay an. so were n.t con.idered for the dose-respon.e studies.

关键词： Hydralazin. Hydrochloride Schiff Bases An.imicrobial An.i-Oxidan. An.i-Plasmodial Activities

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Immun. respon.e to in.ctivated bacterial vector carryin. the recombin.n. K39 an.igen.of Leishman.a in.an.um in.mice

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Asian.Pacific Journ.l of Tropical Biomedicin. 2024年第5期14卷 199-206页

作者： Lucelin. S.Araújo bruno B.Silva Eduarda n.F.n.San.os Arn.ldo S.Bezerra Samuel S.Frota Assis R.Mon.en.gro Eridan.O.P.T.Florean.Maurício Fvan.Tilburg Maria Izabel F.Guedes Laboratory of Biotechn.logy an. Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterin.ry Medicin. State University of CearáFortalezaBrazil

Objective:To evaluate the immun.logical respon.e elicited by an.in.ctivated bacterial vector carryin. the K39 an.igen.of Leishman.a in.an.um,an. a purified ***:Mice were subjected to the followin. treatmen.s:(1)Purified recombin.n. K39(rK39)protein.at a 20μg dose with complete Freun.’s adjuvan.;(2)In.ctivated Escherichia coli(BL21 DE3)carryin. the K39 protein.at an.equivalen. total protein.con.en. of 200μg;(3)In.ctivated bacteria lackin. the K39 protein.(4)n.n.immun.zed con.rol *** mon.torin. was *** groups were challen.ed by in.raperiton.al in.ection.of 10^(7) Leishman.a in.an.um *** euthan.sia,the liver an. spleen.were collected to an.lyze the levels of Tn.,IFn.γ,IL-12,IL-4,an. ***:Mice immun.zed with purified rK39 or the in.ctivated bacterial vector carryin. the K39 an.igen.of Leishman.a in.an.um showed a lon.-lastin. immun. respon.e with high levels of polyclon.l an.ibodies specifically recogn.zin. the recombin.n. *** IgG1 subclass was the predomin.n. immun.globulin.however,the in.uction.of IgG2a an. the profile of cytokin.s produced were in.icative of the in.uction.of a mixed-type ***:The in.ctivated bacterial vector carryin. the K39 an.igen.as well as the purified an.igen.can.in.uce a lon.-lastin. immun. respon.e in.immun.zed mice,predomin.n.ly favourin. a Th2 profile respon.e.

关键词： Visceral leishman.asis K39 In.ctivated bacterial vector Vaccin. Immun. respon.e Th1 Th2 Leishman.a in.an.um

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Physical activity volume,frequen.y,an. in.en.ity:Association. with hyperten.ion.an. obesity over 21 years in.Australian.women

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Journ.l of Sport an. Health Scien.e 2024年第5期13卷 631-641页

作者： Gregore I.Mielke Din. Din. Shelley E.Keatin. bruno P.n.n.s Ruth Brady Wen.y J.Brown School of Public Health The University of QueenslandBrisbaneQLD 4006Australia Sydn.y School of Public Health Faculty of Medicine and HealthThe University of SydneySydneyNSW 2006Australia The Charles Perkin. Cen.re The University of SydneySydneyNSW 2006Australia School of Human.Movemen. an. n.trition.Scien.es The University of QueenslandBrisbaneQLD 4072Australia School of n.rsin. Federal University of PelotasPelotasRio Grande do Sul 96010-610Brazil Faculty of Health Scien.es an. Medicin. Bond UniversityGold CoastQLD 4226Australia

Backgroun.:Optimal pattern. of accrual of recommen.ed levels of physical activity(PA)for preven.ion.of hyperten.ion.an. obesity are n.t *** overall aim of this study was to in.estigate whether differen. pattern. of accumulation.of PA are differen.ially associated with hyperten.ion.an. obesity in.Australian.women.over 21 ***,we in.estigated whether,for the same weekly volume of PA,the n.mber of session.(frequen.y)an. vigorousn.ss of PA(in.en.ity)were associated with a reduction.in.the occurren.e of hyperten.ion.an. obesity in.***:Data from the 1973-1978 an. 1946-1951 cohorts of the Australian.Lon.itudin.l Study on.Women.s Health were an.lyzed(n.20,588;12%-16%with a Bachelor's or higher degree).Self-reported PA,hyperten.ion.height,an. weight were collected usin. mail surveys every 3 years from 1998/2000 to 2019/*** Estimatin. Equation.models with a 3-year lag model were used to in.estigate the association.of PA volume(metabolic equivalen. min.week)(n.n.;33-499;500-999;≥1000,weekly frequen.y(n.n.;1-2 times;3-4times;5-7 times;≥8 times),an. the proportion.of vigorous PA to total volume of PA(n.n.;0%;1%-33%;34%-66%;67%-100%)with odds of hyperten.ion.an. obesity from 2000 to ***:The cumulative in.iden.e of hyperten.ion.was 6%in.the 1973-1978 an. 23%in.the 1946-1951 cohort;27%of women.in.the 1973-1978;an. 15%in.the 1946-1951 cohort developed obesity over the ***,a higher volume of PA was associated with reduced odds of hyperten.ion.an. *** the volume of PA was con.idered,the odds of hyperten.ion.did n.t vary accordin. to the frequen.y or in.en.ity of ***,in.reased proportion.of vigorous PA to the total volume of PA was associated with a small addition.l reduction.in.the risk of obe ***:PA volume appears to be more importan. than.the pattern.of accumulation.for the preven.ion.of hyperten.ion.an. *** more session.,particularly of vigorous-in.en.ity PA,may provide extr

关键词： Physical activity Frequen.y In.en.ity In.iden.es Epidemiology Women

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En.O impacts on.litter stocks an. water holdin. capacity in.secon.ary forests in.eastern.Amazon.a

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Journ.l of Forestry Research 2024年第1期35卷 83-89页

作者： Julia Isabella de Matos Rodrigues Walmer bruno Rocha Martin. Victor Pereira de Oliveira Myriam Suelen.da Silva Wan.erley Hélio Brito dos San.os Jún.or Fran.isco de Assis Oliveira Graduate Program in.Forestry Scien.es Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural Un.versity of Amazon.a Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural Un.versity of Amazon.a Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil n.tion.l In.titute of Amazon.a Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Amon. the impacts of climate chan.e,there is the in.en.ification.of phen.men. such as the El n.ño South-ern.Oscillation.En.O)respon.ible for El n.ño an. La n.ñ***,un.erstan.in. their effects on.the fun.tion.l pro-cesses of forests is ***,this study evaluated the effects of En.O on.litter stock an. water holdin. capac-ity(WHC)in.a succession.l forest in.eastern.*** occurred in.periods with the most rain.all in.El n.ño(2019)an. least in.La n.ña(2021)*** perman.n. plots were used to sample *** effects were eviden. for WHC,higher durin. El n.ñ***,this in.luen.e was n.t clear for litter,as on.y in.the rain. season.effects were *** was a positive correlation.of WHC with precipitation.an. humidity,while litter stocks were n.gatively correlated with temperature an. win. *** the subject of this study requires lon.-term assessmen.s,prelimin.ry results suggests that,depen.in. on.the in.en.ity of En.O,forest fun.tion.l processes can.be stron.ly impacted an. *** con.lusion.rein.orces warn.n.s by the scien.ific commun.ty about the impacts of climate chan.e on.the main.en.n.e of litter stocks,decomposition.an.,con.equen.ly,the biogeochemical cycle an. essen.ial ecosystem services for the main.en.n.e of Amazon.a *** n.ed to develop lon.-term research to un.erstan. the effects of climatic chan.e on.litter stocks an. water holdin. capacity is highlighted,especially in.Amazon.a.

关键词： Season.lity Climate chan.e Succession.ecosystem Biogeochemical cycle Amazon.a biodiversity

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Con.ribution.of Satellite Observation. in.the Optical an. Microphysical Characterization.of Aerosols in.Burkin. Faso, West Africa

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Atmospheric an. Climate Scien.es 2024年第1期14卷 154-171页

作者： n.bon.Bado Serge Dimitri Bazyomo Germain.Wen.e Pouiré Ouedraogo bruno Korgo Mamadou Simin. Dramé Floren. P. Kien. Sié Kam Laboratoire d’En.rgies Thermiques Ren.uvelables (L.E.T.RE) Université Joseph KI ZERBO Ouaga Burkina Faso Laboratoire de Physique de l’Atmosphère et de l’Océan.Siméon.Fon.an. Université Cheikh Anta DIOP Dakar-Fann Sénégal In.titute of Mathematics an. Physical Scien.es University of Abomey-Calavi Porto-Novo Benin

In.this work, we proceed to an.optical an. microphysical an.lysis of the observation. reversed by the MODIS, SeaWiFS, MISR an. OMI sen.ors with the aim of proposin. the best-adapted airborn. sen.or for better mon.torin. of aerosols in.Burkin. Faso. To this en., a comparison.of AOD between.satellite observation. an. in.situ measuremen.s at the Ouagadougou site reveals an.un.erestimation.of AEROn.T AOD except for OMI which overestimates them. Also, an.in.er-comparison.don. based on.the lin.ar regression.lin. represen.ation.shows the correlation.between.the aerosol models in.orporated in.the airborn. sen.or in.ersion.algorithms an. the aerosol population.probed. This can.be seen.through the correlation.coefficien.s R which are 0.84, 0.64, 0.55 an. 0.054 for MODIS, SeaWiFS, MISR an. OMI respectively. Furthermore, an.optical an.lysis of aerosols in.Burkin. Faso by the MODIS sen.or from 2001 to 2016 in.icates a large spatial an. temporal variability of particles stron.ly domin.ted by desert dust. This is corroborated by the an.ual an. season.l cycles of the AOD at 550 n. an. the An.ström coefficien. measured in.the spectral ran.e between.412 n. an. 470 n.. A zoom on.a few sites chosen.accordin. to the three climatic zon.s con.irms the majority presen.e of min.ral aerosols in.Burkin. Faso, whose maxima are observed in.sprin. an. summer.

关键词： AEROn.T Airborn. Sen.ors Aerosol Optical an. Microphysical Properties

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Drivin. factors behin. multiple population.

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Scien.e Chin.(Physics,Mechan.cs & Astron.my) 2024年第5期67卷 172-181页

作者： Ruoyun.Huan. Baitian.Tan. Chen.yuan.Li Doug Geisler Mario Mateo Yin.-Yi Son. Holger Baumgardt Julio A.Carballo-Bello Yue Wan. Jun.an.n.e bruno Dias JoséG.Fern.n.ez-Trin.ado School of Physics an. Astron.my Sun Yat-sen UniversityZhuhai 519082China CSST Scien.e Cen.er for the Guan.don.-Hon. Kon.-Macao Greater Bay Area Zhuhai 519082China Departamen.o de Astron.mía Universidad de ConcepcionConcepcionChile In.tituto de In.estigación.Multidisciplin.rio en.Cien.ia y Tecn.logía Universidad de La SerenaLa SerenaChile Departamen.o de Astron.mía Facultad de CienciasUniversidad de La SerenaChile Departmen. of Astron.my University of MichiganAnn Arbor 48109USA David A.Dun.ap Departmen. of Astron.my&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dun.ap In.titute for Astron.my&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics an. Physics The University of QueenslandSt.Lucia QLD 4072Australia In.tituto de Alta In.estigación Universidad de TarapacáAricaChile CAS Key Laboratory of Optical Astron.my National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China In.tituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile In.tituto de Astron.mía Universidad Católica del NorteAntofagastaChile

Star clusters were historically con.idered simple stellar population.,with all stars sharin. the same age an. in.tial chemical ***,the presen.e of chemical an.malies in.globular clusters(GCs),called multiple stellar population.(MPs),has challen.ed star formation.theories in.den.e *** studies show that mass,metallicity,an. age are likely con.rollin. parameters for the man.festation.of *** the limit between.clusters with/without MPs in.physical parameter space is crucial to reveal the drivin. mechan.sm behin. their *** this study,we look for MP sign.ls in.Whitin. 1,which is tradition.lly con.idered a youn. *** the Magellan.telescope,we obtain.d low-resolution.spectra within.λ=3850-5500?for eight gian.s of Whitin. *** measured the C an. n.abun.an.es from the Cn.an. CH spectral in.ices.C an. n.abun.an.es have variation. comparable with their measuremen. errors(~0.1 dex),suggestin. that MPs are absen. from Whitin. *** these fin.in.s with literature studies,we propose a limit in.the metallicity *** compactn.ss in.ex parameter space,which relatively clearly separates star clusters with/without MPs(GCs/open.clusters).This limit is physically *** a larger scale,the galactic en.iron.en. determin.s cluster compactn.ss an. metallicity,leadin. to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our un.erstan.in. of the formation.of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar population. because the en.iched galactic en.iron.en. is n. lon.er suitable for MP formation.

关键词： stellar galactic galaxy

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Association. between.physical activity levels an. ATPase in.ibitory factor 1 con.en.ration. in.older adults

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Journ.l of Sport an. Health Scien.e 2024年第3期13卷 409-418页

作者： Jérémy Raffin.Yves Rollan. An.elise Gen.ux Guillaume Combes Mikael Croyal Bertran. Perret Sophie Guyon.et bruno Vellas Lauren. O.Martin.z Philipe de Souto Barreto For the MAPT/DSA Group In.titut du Vieillissemen. Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Cen.re d'Epidémiologie et de Recherche en.San.édes Population. UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAgin. Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'In.titut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Backgroun.:Aden.sin. triphosphatase in.ibitory factor 1(IF1)is a key protein.in.olved in.en.rgy ***1 has been.lin.ed to various agerelated diseases,although its relation.hip with physical activity(PA)remain. ***,the apolipoprotein.A-I(apoA-I),a PA-modulated lipoprotein.could play a role in.this relation.hip because it shares a bin.in. site with IF1 on.the cell-surface ATP *** examin.d here the association. between.chron.c PA an. plasma IF1 con.en.ration. amon. older adults,an. we in.estigated whether apoA-I mediated these ***:In.the presen. work,1096 healthy adults(63.8%females)aged 70 years an. over who were in.olved in.the Multidomain.Alzheimer Preven.ion.Trial study were ***1 plasma con.en.ration.(square root of n./mL)were measured at the 1-year visit of the Multidomain.Alzheimer Preven.ion.Trial,while PA levels(square root of metabolic equivalen. task min.week)were assessed usin. question.aires admin.stered each year from baselin. to the 3-year *** lin.ar regression. were performed to in.estigate the association. between.the first-year mean.PA levels an. IF1 *** an.lyses were con.ucted to examin. whether apoA-I mediated these *** lin.ar regression. were carried out to in.estigate whether the 1-year visit IF1 con.en.ration. predicted subsequen. chan.es in.***:Multiple lin.ar regression. in.icated that first-year mean.PA levels were positively associated with IF1 con.en.ration.(B=0.021;SE=0.010;p=0.043).Mediation.an.lyses revealed that about 37.7%of this relation.hip was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Lon.itudin.l in.estigation. demon.trated that higher con.en.ration. of IF1 at the 1-year visit predicted a faster declin. in.PA levels over the subsequen. 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Con.lusion.This study demon.trates that regular PA is associated with plasma IF1 con.en.ration.,an. it suggests that apoA-I partly med

关键词： Agin. Apolipoprotein Bioen.rgetics Exerkin. Mitochon.ria

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Rifaximin.on.epigen.tics an. autophagy in.an.mal model of hepatocellular carcin.ma secon.ary to metabolic-dysfun.tion.associated steatotic liver disease

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World Journ.l of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Lon.o Melin. Belén.Kein.eski bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolin. Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division.of Gastroen.erology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in.Gastroen.erology an. Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimen.al Laboratory of Hepatology an. Gastroen.erology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of In.lammatory an. n.oplastic Cells Universidade Federal do ParanáParaná81530900Brazil Departmen. of Gastroen.erology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Cien.ias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Un.t of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Cen.er of Biotechn.logy Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Departmen. of Morphological Scien.es Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Con.elho n.cion.l de Desen.olvimen.o Cien.ífico e Tecn.lógico(Cn.q) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUn. Prevalen.e of hepatocellular carcin.ma(HCC)is in.reasin.,especially in.patien.s with metabolic dysfun.tion.ssociated steatotic liver disease(MASLD).AIM To in.estigate rifaximin.RIF)effects on.epigen.tic/autophagy markers in.*** Adult Sprague-Dawley rats were ran.omly assign.d(n.8,each)an. treated from 5-16 wk:Con.rol[stan.ard diet,water plus gavage with vehicle(Veh)],HCC[high-fat cholin. deficien. diet(HFCD),diethyln.trosamin.(DEn.in.drin.in. water an. Veh gavage],an. RIF[HFCD,DEn.an. RIF(50 mg/kg/d)gavage].Gen. expression.of epigen.tic/autophagy markers an. circulatin. miRn.s were *** All HCC an. RIF an.mals developed metabolic-dysfun.tion.associated steatohepatitis fibrosis,an. cirrhosis,but three RIF-group did n.t develop *** an.mals who developed HCC with those who did n.t,miR-122,miR-34a,tubulin.alpha-1c(Tuba-1c),metalloprotein.ses-2(Mmp2),an. metalloprotein.ses-9(Mmp9)were sign.fican.ly higher in.the *** opposite occurred with Becn.,coactivator associated argin.n. methyltran.ferase-1(Carm1),en.an.er of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),an. p62/sequestosome-1(p62/SQSTM1)-*** with con.rols,Map1 Lc3b,Becn. an. Ezh2 were lower in.HCC an. RIF-groups(Pn.HCC compared to RIF(Pn.of Mmp9 was higher in.HCC in.relation.to the con.rol;the opposite was observed for p62/Sqstm1(Pn.of p62/SQSTM1 protein.was lower in.the RIF-group compared to the con.rol(P=0.024).There was n. differen.e amon. groups for Tuba-1c,Aldolase-B,alpha-fetoprotein.an. Mmp2(P>0.05).miR-122 was higher in.HCC,an. miR-34a in.RIF compared to con.rols(Pn.HCC compared to RIF,an. the in.erse was observed for miR-224(Pn. differen.e amon. groups regardin. miR-33a,miR-143,miR-155,miR-375 an. miR-21(P>0.05).COn.LUSIOn.RIF might have a possible ben.ficial effect on.preven.in./delayin. liver carcin.gen.sis throu

关键词： An.mal model Autophagy Epigen.tic Hepatocellular carcin.ma Metabolic dysfun.tion.associated steatotic liver disease Rifaximin

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