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Complement factor H in molecular regulation of angiogenesis

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Medical Review 2024年第5期4卷 452-466页

作者： Jiang Li Kaili Wang Maria N.Starodubtseva Eldar Nadyrov Carolyn M.Kapron Josephine hoh Ju Liu Laboratory of Translational Medicine in Microvascular Regulation Institute of Microvascular MedicineMedical Research CenterThe First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanShandong Province250014China Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging JinanShandong ProvinceChina Medical Research Center Shandong Provincial Qianfoshan HospitalShandong UniversityJinanShandong Province 250014China Gomel State Medical University GomelBelarus Institute of Radiobiology of NAS of Belarus GomelBelarus Department of Biology Trent UniversityPeterboroughONCanada Department of Ophthalmology Yale School of MedicineNew HavenCTUSA

Angiogenesis,the process of formation of new capillaries from existing blood vessels,is required for multiple physiological and pathological *** factorH(CFH)is a plasma protein that inhibits the alternative pathway of the complement *** of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity,including complement 3a,complement 5a,and membrane attack *** protein contains binding sites for C-reactive protein,malondialdehyde,and endothelial heparan *** of CFH prevents its interaction with these molecules and initiates pro-angiogenic *** in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal *** Cfh-deficient mice show an increase in angiogenesis,which is decreased by administration of recombinant CFH pro*** this review,we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH *** therapeutic potential of recombinant CFH protein in angiogenesisrelated diseases has also been discussed.

关键词： complement factor H angiogenesis mechanical properties therapeutic target

Continuous Casting of Demanding HSLA Steel Grades for Heavy Plate Application

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Journal of Iron and Steel Research International 2011年第S1期18卷 535-540页

作者： Bernhard hoh Process Technology Steel Eichenweg 2546569 HuenxeGermany

Continuous casting has evolved as the most important production process in the steel *** it counts for about 95% of the world’s steel *** to its rising significance,the process technologies have been enhanced in yield,productivity and-in particular quality of semi-finished products has been improved close to the realm of *** optimizing the product quality beyond the present status has to put the whole manufacturing route from hot metal and/or steel melting through refining to continuous casting under integrated *** for the production of HSLA steel grades of the highest standard are clean steel,internal soundness and defect-free slab *** this context a brief look is cast on the recent trend of process technology in casting "thick slabs" for extra-heavy plate production.

关键词： HSLA steel integrated process control clean steel heavy slab surface cracking segregation heavy plate

Topic Modeling Based Warning Prioritization from Change Sets of Software Repository

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Journal of Computer Science & Technology 2020年第6期35卷 1461-1479页

作者： Jung-Been Lee Taek Lee hoh Peter In College of Informatics Korea UniversitySeoul 02841Korea College of Knowledge-Based Services Engineering Sungshin UniversitySeoul 02844Korea

Many existing warning prioritization techniques seek to reorder the static analysis warnings such that true positives are provided first. However, excessive amount of time is required therein to investigate and fix prioritized warnings because some are not actually true positives or are irrelevant to the code context and topic. In this paper, we propose a warning prioritization technique that reflects various latent topics from bug-related code blocks. Our main aim is to build a prioritization model that comprises separate warning priorities depending on the topic of the change sets to identify the number of true positive warnings. For the performance evaluation of the proposed model, we employ a performance metric called warning detection rate, widely used in many warning prioritization studies, and compare the proposed model with other competitive techniques. Additionally, the effectiveness of our model is verified via the application of our technique to eight industrial projects of a real global company.

关键词： automated static analysis topic modeling warning prioritization

The indigenous populations as the model by nature to understand human genomic-phenomics interactions

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Quantitative Biology 2022年第1期10卷 35-43页

作者： Boon-Peng hoh Thuhairah Abdul Rahman Faculty of Medicine and Health Sciences UCSI UniversityKuala LUmpur 56000Malaysia Clinical Pathology Diagnostic Centre Research Laboratory Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai Buloh 47000Malaysia

Background:The advancement of genomics has progressed in lightning speed over the past two *** large-scale genome sequencing initiatives were announced,along with the rise of the holistic precision medicine ***,the field of genomic medicine has now come to a bottleneck since genomic-phenomic interactions are not fully comprehended due to the complexity of the human systems biology and environmental influence,hence the emergence of human ***:This review attempts to provide an overview of the potential advantages of investigating the human phenomics of indigenous populations and the challenges ***:We believe that the indigenous populations serve as an ideal model to excavate our understanding of genomic-environmental-phenomics interactions.

关键词： indigenous populations Orang Asli genomics phenomics

Do astrocytes respond to light,sound,or electrical stimulation?

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Neural Regeneration Research 2023年第11期18卷 2343-2347页

作者： Audrey Le Naour Emilien Beziat Jaimie hoh Kam Pierre Magistretti Alim-Louis Benabid John Mitrofanis UniversitéGrenoble Alpes Fonds de dotationClinatecGrenobleFrance King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Astrocytes are not only the most populous cell type in the human brain,but they also have the most extensive and dive rse sets of connections,across synapses,axons,blood vessels,as well as having their own internal ***,they are associated with many brain functions;from the synaptic transmission to energy metabolism and fluid homeostasis,and from cerebral blood flow and blood-brain barrier maintenance to neuroprotection,memory,immune defenses and detoxification,slee p,and early *** yet,notwithstanding these key roles,so many current therapeutic approaches to a range of brain disorders have largely neglected their potential *** this review,we consider the role of astrocytes in three brain therapies;two are emerging treatments(photobiomodulation and ultrasound),while the other is well-established(deep brain stimulation).In essence,we explore the issue of whether external sources,such as light,sound,or electricity,can influence the function of astrocytes,as they do *** find that,when taken all together,each of these external sources can influence many,if not,all of the functions associated with *** include influencing neuronal activity,prompting neuroprotection,reducing inflammation(astrogliosis) and potentially increasing cerebral blood flow and stimulating the glymphatic *** suggest that astrocytes,just like neurons,can respond positively to each of these external applications and that their activation co uld each impart many beneficial outcomes on brain function;they are likely to be key playe rs underpinning the mechanisms behind many therapeutic strategies.

关键词： deep brain stimulation high frequency infrared mitochondria red ultrasound

Respiratory plasticity following spinal cord injury:perspectives from mouse to man

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Neural Regeneration Research 2022年第10期17卷 2141-2148页

作者： Katherine C.Locke Margo L.Randelman Daniel J.hoh Lyandysha V.Zholudeva Michael A.Lane Department of Neurobiology&Anatomy Drexel UniversityPhiladelphiaPAUSA Marion Murray Spinal Cord Research Center PhiladelphiaPAUSA Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFLUSA Cardiovascular Disease Gladstone InstitutesSan FranciscoCAUSA

The study of respiratory plasticity in animal models spans *** the bench,researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord *** field of research is highly clinically *** living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3-C5 typically have significant impairments in breathing which may require assisted *** who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life ***-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical *** how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical *** three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury,discuss plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical *** investigating current targets of respiratory plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.

关键词： breathing phrenic plasticity rehabilitation respiration spinal cord injury translation

The Middle East in the Eyes of the Far East:A Book Review

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Asian Journal of Middle Eastern and Islamic Studies 2007年第1期1卷 78-79,I0007页

作者： Anchi hoh Library of Congress USA

Weilie Zhu,Zhan Zai Yuandong Kan Zhongdong(Arabic title:al-Sharq al-Awsat min Manzur Ustadh Sini,English translation:Observing the Middle East from the Standpoint of the Far East),Shanghai:Shanghai Foreign Language Education Press,*** one ever has questions about the Middle East and Islamic studies in China,how its education curricula are formed,or what role they have played in the history of China-Middle East relationship.

关键词： relationship. Middle has

Dark Matter Creation and Anti-Gravity Acceleration of the Expanding Universe

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Journal of Modern Physics 2021年第3期12卷 139-160页

作者： F. C. hoh Retired Dragarbrunnsg Uppsala Sweden

Dark matter is identified as negative relative energy between quarks in proton and is generated in cold hydrogen gas with pressure gradient in gravitational field. Positive relative energy PRE can be generated between quarks in protons in cold hydrogen gas in outskirts of the universe. The mechanisms for such creation of dark matter and PRE are reviewed and updated in greater detail and clearer manner. The so-generated dark matter in a galaxy can account for the galaxy’s rotation curve. Star formation in this galaxy uses up the hydrogen atoms and thereby reduces its dark matter content. Dark matter created in intergalactic hydrogen gas can form filaments. In a hypothetical model of the universe, a hydrogen atom with a small amount of negative relative energy or dark matter at the outskirts of this universe can via collisions with other atoms turn into one with a small positive relative energy PRE. Once such a sign change takes place, gravitational attraction switches to anti-gravity repulsion unopposed by any pressure gradient. This leads to a “run away” hydrogen atom moving away from the mass center of the universe and provides a basic mechanism for the accelerating expansion of the universe. This theoretical expansion and the measured redshift data are both compatible with the conception of an acceleratingly expanding universe and complement each other. But they cannot verify each other directly because the present model has been constructed for purposes different from those of the measurements. But it can be shown that both approaches do support each other qualitatively under certain circumstances for small velocities. Dark matter and PRE in the present model are not foreign objects like WIMPs and dark energy-cosmological constant but can only be created in cold hydrogen gas in gravitational field. To achieve this, infrequent collisions among the hydrogen atoms must take place. Dark matter was created first and can eventually later evolve into PRE in the outskirt

关键词： Relative Energy between Quarks Scalar Strong Interaction Hadron Theory SSI Negative Relative Energy Dark Matter Positive Relative Energy PRE Anti-Gravity Repulsion Universe Expansion Proton Orbit Hubble’s Law

Higgs-Like Boson and Bound State of Gauge Bosons W⁺W^-

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Journal of Modern Physics 2016年第1期7卷 36-42页

作者： F. C. hoh Retired Dragarbrunnsg. 55C Uppsala Sweden

The Higgs-like boson H(126) discovered in 2012 is tentatively assigned to a newly found bound state of two charged gauge bosons W+W-. Starting from the scalar strong interaction hadron theory, a first principles’ theory, a nonlinear, soliton-like differential equation dependent upon the distance between the two W bosons is derived. This equation is solved on a computer. A new, nonlinear confinement mechanism, not yet understood, binds the both bosons and gives a bound state mass EB = 155.8 GeV. This EB, derived at the quantum mechanical level, is estimated to reduce to EB = 110 GeV when quantized field effects are included via coarse approximations and replacement of the bare constants by renormalized ones. These developments lead to a revised status of the standard model.

关键词： Bound State of W+W- Scalar Strong Interaction Soliton-Like Equation