Respiratory plasticity following spinal cord injury:perspectives from mouse to man

作     者：Katherine C.Locke Margo L.Randelman Daniel J.Hoh Lyandysha V.Zholudeva Michael A.Lane Katherine C.Locke;Margo L.Randelman;Daniel J.Hoh;Lyandysha V.Zholudeva;Michael A.Lane

作者机构：Department of Neurobiology&AnatomyDrexel UniversityPhiladelphiaPAUSA Marion Murray Spinal Cord Research CenterPhiladelphiaPAUSA Lillian S.Wells Department of NeurosurgeryUniversity of FloridaGainesvilleFLUSA Cardiovascular DiseaseGladstone InstitutesSan FranciscoCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第10期

页      面：2141-2148页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by funds awarded from the National Institutes of Health R01 NS104291 Wings for Life(to MAL) the Lisa Dean Moseley Foundation(to LVZ). 

主　　题：breathing phrenic plasticity rehabilitation respiration spinal cord injury translation 

摘      要：The study of respiratory plasticity in animal models spans decades.At the bench,researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord injury.This field of research is highly clinically relevant.People living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3-C5 typically have significant impairments in breathing which may require assisted ventilation.Those who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life expectancy.Pre-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical trials.Despite how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical barrier.The three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury,discuss plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical research.By investigating current targets of respiratory plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.