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PEX16 contributions to peroxisome import and metabolism revealed by viable Arabidopsis pex16 mutants

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Journal of Integrative Plant Biology 2019年第7期61卷 853-870页

作者： Sarah E.Burkhart Roxanna J.Llinas bonnie bartel Department of BioSciences Rice University

Peroxisomes rely on peroxins(PEX proteins) for biogenesis, importing membrane and matrix proteins, and fission. PEX16, which is implicated in peroxisomal membrane protein targeting and forming nascent peroxisomes from the endoplasmic reticulum(ER), is unusual among peroxins because it is inserted co-translationally into the ER and localizes to both ER and peroxisomal membranes. PEX16 mutations in humans, yeast, and plants confer some common peroxisomal defects; however, apparent functional differences have impeded the development of a unified model for PEX16 action. The only reported pex16 mutant in plants, the Arabidopsis shrunken seed1 mutant, is inviable,complicating analysis of PEX16 function after embryogenesis. Here, we characterized two viable Arabidopsis pex16 alleles that accumulate negligible PEX16 protein levels. Both mutants displayed impaired peroxisome function-slowed consumption of stored oil bodies, decreased import of matrix proteins, and increased peroxisome size. Moreover,one pex16 allele exhibited reduced growth that could be alleviated by an external fixed carbon source, decreased responsiveness to peroxisomally processed hormone precursors, and worsened or improved peroxisome function in combination with other pex mutants. Because the mutations impact different regions of the PEX16 gene, these viable pex16 alleles allow assessment of the importance of Arabidopsis PEX16 and its functional domains.

关键词： pex16 mutants peroxisome metabolism

Disruption of Arabidopsis CHY1 Reveals an Important Role of Metabolic Status in Plant Cold Stress Signaling

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Molecular Plant 2009年第1期2卷 59-72页

作者： Chun-Hai Dong Bethany K. Zolman bonnie bartel Byeong-ha Lee Becky Stevenson Manu Agarwal Jian-Kang Zhu Department of Botany and Plant Science 2150 Batchelor Hall University of California at Riverside Riverside CA 92521 USA Department of Biology University of Missouri-St Louis St Louis MO 63121 USA Department of Biochemistry and Cell Biology Rice University Houston TX 77005 USA Present address: Department of Cell Biology and Molecular Genetics University of Maryland College Park MD 20742 USA Present address: Department of Life Science Sogang University Seoul 121-742 South Korea

To study cold signaling, we screened for Arabidopsis mutants with altered cold-induced transcription of a firefly luciferase reporter gene driven by the CBF3 promoter （CBF3-LUC）. One mutant, chy1-10, displayed reduced cold-induction of CBF3-LUC luminescence. RNA gel blot analysis revealed that expression of endogenous CBFs also was reduced in the chyl mutant, chy1-10 mutant plants are more sensitive to freezing treatment than wild-type after cold acclimation. Both the wild-type and chyl mutant plants are sensitive to darkness-induced starvation at warm temperatures, although chyl plants are slightly more sensitive. This dark-sensitivity is suppressed by cold temperature in the wildtype but not in chyl. Constitutive CBF3 expression partially rescues the sensitivity of chyl-10 plants to dark treatment in the cold. The chyl mutant accumulates higher levels of reactive oxygen species, and application of hydrogen peroxide can reduce cold-induction of CBF3-LUC in wild-type. Map-based cloning of the gene defective in the mutant revealed a nonsense mutation in CHY1, which encodes a peroxisomal β-hydroxyisobutyryl （HIBYL）-CoA hydrolase needed for valine catabolism and fatty acid β-oxidation. Our results suggest a role for peroxisomal metabolism in cold stress signaling, and plant tolerance to cold stress and darkness-induced starvation.

关键词： Cold stress signal transduction gene regulation CHY1 β-hydroxyisobutyryI-CoA hydrolase.

Comparison of surgical outcome of trabeculectomy and phacotrabeculectomy in Chinese glaucoma patients

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1928-1930页

作者： bonnie Nga Kwan Choy Department of Ophthalmology LKS Faculty of Medicinethe University of Hong KongHong KongChina

Our study retrospectively reviewed the surgical outcomes up to 3 mo of 38 consecutive Chinese glaucoma patients who underwent trabeculectomy（n=18） or phacotrabeculectomy（n=20）.Baseline age,visual acuity,and intraocular pressure were *** pressure from post-operative 1 d to 3 mo were similar between 2 *** success was achieved in 65% of phacotrabeculectomy,and 66.7% of trabeculectomy cases;while failure occurred in 16.7% of phacotrabeculectomy,and 10% of trabeculectomy cases at 3 *** group consistently showed better improvement in visual *** blebs occurred in 65% of phacotrabeculectomy and 83% of trabeculectomy eyes;and flat blebs in 35% of phacotrabeculectomy,but none after *** was more hypotony（5% vs 0） after *** conclude,phacotrabeculectomy and trabeculectomy demonstrated comparable intraocular pressure control up to 3 mo ***,phacotrabeculectomy patients had better visual acuity ***,more diffuse bleb and less hypotony were present following trabeculectomy.

关键词： trabeculectomy phacotrabeculectomy glaucoma surgery surgical outcome

On the exoneration of Dr. William H. Stewart: debunking an urban legend

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Infectious Diseases of Poverty 2013年第1期2卷 17-21页

作者： Brad Spellberg bonnie Taylor-Blake Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles(UCLA)Medical Center TorranceCAUSA The David Geffen School of Medicine at UCLA Los AngelesCAUSA University of North Carolina School of Medicine Chapel Hill WilmingtonNCUSA

Background:It is one of the most infamous quotes in the history of biomedicine:“It is time to close the book on infectious diseases,and declare the war against pestilence won.”Long attributed to the United States Surgeon General,*** ***(1965-1969),the statement is frequently used as a foil by scientific and lay authors to underscore the ever-increasing problems of antibiotic-resistant and emerging ***,the primary source for the quote has never been ***:We undertook a comprehensive search of multiple databases encompassing medical literature,news articles,and congressional records to attempt to identify sources for the ***:No source of the quote was ***,a trail of source documents was identified that clearly serves as the basis for subsequent,incorrect attribution of the quote to *** multiple source documents,*** made statements to the opposite effect,clearly recognizing that infectious diseases had not been *** urban legend was created by a combination of lack of primary witnesses to the originating speech,misunderstanding of points made by *** in the speech,and increasing societal concern about emerging and re-emerging infectious ***:Attribution to *** of a belief that it was time to close the book on infectious diseases is an urban legend;he never made any such *** other verifiable sources,however,confirm that other people in academia adopted this *** should no longer be cited in this regard,and should be replaced with verifiable sources.

关键词： William H.Stewart Urban legend History of antibiotics Antibiotic development Antibiotic crisis Public policy

Analogous Systems Principles and Concepts of Traditional Chinese Medicine and Congruence Couple Therapy

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Chinese Medicine and Culture 2020年第1期3卷 22-28页

作者： bonnie K.Lee Faculty of Health Sciences University of LethbridgeLethbridgeAlbertaCanada

This article explicates the analogous principles and concepts between traditional Chinese medicine(TCM)and congruence couple therapy(CCT).Although originating out of vastly different times and places,TCM and CCT share a view of health based on systems understanding to facilitate the interconnections of the parts of an organism rather than focusing on eliminating *** approaches aim to release Qi(气)and vitality by removing blockages through adjusting the interactions,adaptation,and balance of multiple elements and Yin‑Yang *** goal is to liberate the Qi or life force through improved holistic balance and *** TCM focuses on interventions at the level of the body,CCT focuses on the attention,awareness,acknowledgement,and alignment of the four human dimensions consisting of the intrapsychic,interpersonal,intergenerational,and universal‑*** light of the current trend toward increasing mental,substance use,and neurological disorders,in particular among countries of middle and low income,dialogue to explore these compatibilities between TCM and CCT is conducive to the continuous evolution of TCM and Western therapies to address not only physical health but also the exigencies of contemporary addiction and mental health care within a mind–body relationship matrix.

关键词： Addictive disorder congruence couple therapy family therapy mental disorder substance use systemic therapy traditional Chinese medicine Yin‑Yang(阴阳)

Literary Translation:The Pleasure Principle

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中国翻译 2007年第5期28卷 22-26页

作者： bonnie S. McDougall The Chinese University of Hong Kong

Chinese to English literary translation (CELT) has brought enormous reading pleasure to large numbers of people. These readers are not necessarily committed to China or Chinese literature as a cause or profession: they are disinterested readers. Publishers today, such as the Foreign Languages Press, can significantly increase their publication figures and strengthen their impact by going beyond captive readers to reach this wider audience. Guidelines that may lead to such a result can be summed up in the phrase: trust the reader. Readers of literary translations already belong to a limited class: they are risk-takers; they are curious and knowledgeable about other cultures; and they are skilled literary readers in their own language.

关键词：文学翻译快乐原则汉译英读物

Prostate cancer:a presentation of climcopathologic prognosticators among Filipino and American men at radical prostatectomy

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Asian Journal of Andrology 2021年第5期23卷 516-519页

作者： Mayen T Grageda bonnie Choy Gladell P Paner Jeffrey S So Institute of Pathology St.Luke's Medical Center-Global CityTaguigMetro Manila 1634Philippines Department of Pathology The University of ChicagoChicagoIL 60637USA lnstitute of Pathology St.Luke's Medical Center-Quezon CityMetro Manila 1112Philippines

Lower incidence and mortality rates from prostate cancer(PCa)have been shown in Asian men in general compared to *** is the first study detailing the clinicopathologic features of resected prostate cancer in Filipino men living in the Philippines(PH)_This study investigated the supposed“lower risk”Filipino and“higher risk”American PCa patients from the PH and the United States of America(USA),*** examined 348(176 from PH,172 from USA)radical prostatectomy *** clinicopathologic features of both groups(age at time of diagnosis,preoperative prostate-specific antigen[pre-op PSA]level,Gleason score[GS],Grade groups[GG],margin involvement,extra prostatic extension[EPE],seminal vesicle invasion[SVI],and regional lymph node[RLN]metastasis)were *** of seven prognosticators examined were more strongly associated with Filipinos than with *** were older at diagnosis(PH:64.32±6.56 years vs USA:58.98±8.08 years)and had higher pre-op PSA levels(PH:21.39±46.40 ng ml^(-1) vs USA:7.63±9.19 ng ml^(-1)).Filipino men had more advanced grade,GG 2 with minor pattern 5(PH:6.2%vs USA:2.9%)and GG 5(PH:14.8%vs USA:3.5%).Likewise,other adverse pathological features in margin positivity(PH:52.3%vs USA:23.8%),focal EPE(PH:14.2% vs USA:2.3%),and SVI(PH:17.1%vs USA:5.8%)were more commonly observed in *** study reveals the prognostic disadvantage of Filipinos versus Americans and highlights an important difference of Filipinos from other studied Asian ethnicities that have repeatedly been shown to have lower-risk *** study,the first on Filipino PCa patients with RP,suggests the need to modify Western-based risk stratification when employed in other countries like the PH.

关键词： clinicopathologic features Filipino prostate cancer radical prostatectomy

Development of Ultra-High Density Silicon Nanowire Arrays for Electronics Applications

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Nano Research 2008年第1期1卷 9-21页

作者： Dunwei Wang bonnie A.Sheriff Michael McAlpine James R.Heath Department of Chemistry Boston College140 Commonwealth AveChestnut HillMA 02467USA Division of Chemistry and Chemical Engineering and the Kavli Nanoscience Center Caltech127-72PasadenaCA 91125USA

This article reviews our recent progress on ultra-high density nanowires(NWs)array-based *** superlattice nanowire pattern transfer(SNAP)method is utilized to produce aligned,ultra-high density Si NW *** fi rst cover processing and materials issues related to achieving bulk-like conductivity characteristics from 1020 nm wide Si *** then discuss Si NW-based fi eld-effect transistors(FETs).These NWs&NW FETs provide terrifi c building blocks for various electronic circuits with applications to memory,energy conversion,fundamental physics,logic,and *** focus our discussion on complementary symmetry NW logic circuitry,since that provides the most demanding metrics for guiding *** such as controlling the density and spatial distribution of both p-and n-type dopants within NW arrays are discussed,as are general methods for achieving Ohmic contacts to both p-and n-type *** various materials and nanofabrication advances are brought together to demonstrate energy effi cient,complementary symmetry NW logic circuits.

关键词： Ultra-high density nanowire superlattice nanowire pattern transfer logic circuit

Medical terminology : a living language / 4th ed./Fremgen, bonnie F

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Medical terminology : a living language / 4th ed./Fremgen, B...