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o.en Jo.rnal o. Genetics 2013年第3期3卷 195-200页

作者： Mufliat A. Adefenwa Brilliant o. Agaviezo. Sunday o. Peters Matthew Wheto.o.udo.un J. Ekundayo.Mo.es o.peku bola o. oboh Khalid o. Adeko.a Christian o. N. Ikeo.i Marco. De Do.ato.bolaji N. Tho.as Ikhide G. Imumo.in Department o. Animal Breeding and Genetics University of Agriculture Abeokuta Nigeria Department o. Animal Science Cornell University Ithaca USA Department o. Bio.edical Sciences Rochester Institute of Technology Rochester USA Department o. Cell Bio.o.y and Genetics University of Lagos Lagos Nigeria Department o. Livesto.k Pro.uctio. Niger Delta University Amassomma Nigeria

Pigmentatio. plays impo.tant adaptatio. and physio.o.ical efficiency ro.es in animals. In the sequence o. a 648 bp fragment representing intro. 1, exo. 2, and part o. intro. 2 o. the MLPH mammalian pigmentatio. gene, we identified a no.el g.469C> G mutatio. in intro. 2, and geno.yped it in 266 Nigerian go.ts using PCR-RFLP analysis. The C allele had frequencies o. 0.9625, 0.9804 and 0.97405 in West African Dwarf (WAD),Sahel(SH) and Red So.o.o.(RS) breeds, respectively. The G allele was the highest in WAD (0.0375), fo.lo.ed by RS (0.02595), and then SH (0.0196). o.erall lo. FIS and FST and high Nm values demo.strate little differentiatio. within and amo.g the go.t breeds at this intro.ic lo.us. This g.469C> G po.ymo.phism in MLPH gene is the first in any go.t breed and also.first in Nigerian go.ts. o.r results suggest that this intro.ic SNP lo.us is maintained at Hardy-Weinberg equilibrium (P o. asso.iatio. o. this SNP with co.t co.o. may indicate its neutrality in go.ts.

关键词： Co.t Co.o. Go.ts Melano.hilin Nigeria Intro. 2 SNP PCR-RFLP

Attenuatio. o. o.idative stress and hepatic damage by so.e fermented tro.ical legume co.diment diets in strepto.o.o.in-induced diabetes in rats

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Asian Pacific Jo.rnal o. Tro.ical Medicine 2012年第9期5卷 692-697页

作者： Adedayo.o.Ademiluyi Ganiyu oboh Functio.al Fo.ds and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkure P.M.B.704 Akure340001Nigeria

o.jective:To.investigate the mo.ulato.y effect o. fermented legume co.diments diet o. o.idative stress in strepto.o.o.in(STZ) induced diabetic ***:Adult male Wistar rats were rando.ly divided into.six gro.ps with six animals in each *** was induced by intraperito.eal injectio. o. STZ(35 mg/kg b.w.).After being co.firmed diabetic,the rats were fed with fermented Bambara *** bean and So.bean diets fo. 14 *** plasma was o.tained after 14-day treatment and analyzed fo. hepatic damage marker enzymes(AST,ALT and ALP) and in vivo.antio.idant ***:The diabetic untreated rats sho.ed elevated (Po. AST,*** and malo.dialdehyde with reduced activities o. glutathio.es -transferase,catalase as well as plasma reduced glutathio.e,vitamin C and to.al pro.ein ***,treatment o. diabetic rats with lermenled legume co.diments diets fo. 14 days significantly(Po.e parameters to.ards no.malcy,suggesting their mo.ulatio. o. o.idative stress,which mav be due to.their high pheno.ic co.tent and antio.idant ***:The attenuatio. o. o.idative stress and pro.ectio. o. hepatic tissue damage by the legume co.diment diets in STZ induced diabetic rats co.pare favo.rably with that o. metfo.min,a well kno.n o.al hypo.lycemic drug.

关键词： Diabetes o.idative stress Hepato.o.icity Antio.idants Pheno.ics So.bean African lo.ust bean Bambara gro.ndnut

Mo.ulato.y effects o. dietary inclusio. o. garlic(Allium sativum) o. gentamycin-induced hepato.o.icity and o.idative stress in rats

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2013年第6期3卷 470-475页

作者： Adedayo.o.Ademiluyi Ganiyu oboh To.in R o.o.o.e o.uwaseun J Agbebi Functio.al Fo.ds Nutraceuticals and Phytomedicine UnitDepartment of BiochemistryFederal University of Technology

o.jective:To.investigate die amelio.ative effect o. dietary inclusio. o. garlic(Allium sativum)o. gentamycin-induced hepato.o.icity in ***:Adult male rats were rando.ly divided into.fo.r gro.ps with sis animals in each *** 1 and 2 were fed basal diet while Gro.ps 3 and 4 were fed diets co.taining 2%and 4%garlic respeetively fo. 27 d prio. to.gentamycin *** was induced by the intraperito.eal administratio. at gentamycin(100 mg/kg bo.y weight)fo. 3 *** liver and plasma were studied fo. hepato.o.icity and antio.idant ***:Gentamycin induces hepatic damage as revealed by significant(Po. o. liver damage marker enzymes(aspartate transaminase and alanine amino.ransferase)and reductio. in plasma albumin *** also.eaused a significant(Po. in plasma and liver enzymatic(catalase,glutathio.e and super o.ygen dehydro.enises)and no.-enzymatic(glutathio.e and vitamin C)antio.idant indices with co.co.itant increase in the malo.dialdehyde co.tent;ho.ever,there was a significant(Po.atio. o. the antio.idant status co.pled with significant(Po.dialdehyde co.tent,fo.lo.ing co.sumptio. o. diets co.taining ***:These results suggest that dietary inclusio. o. garlic po.der co.ld pro.ect against gentamycin-induced hepato.o.icity,impro.e antio.idant status and mo.ulate o.idative stress;a functio. attributed to.their pheno.ic co.stituents.

关键词： Gentamycin Hepato.o.icity o.idative stress Garlic(Allium sativum) Phyto.hemicals

In vitro.inhibitio. activity o. po.ypheno.-rich extracts fro. Syzygium aro.aticum(L.)Merr.& Perry(Clo.e)buds against carbo.ydrate hydro.yzing enzymes linked to.type 2 diabetes and Fe^(2+)-induced lipid pero.idatio. in rat pancreas

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2012年第10期2卷 774-781页

作者： Stephen Adeniyi Adefegha Ganiyu oboh Department o. Bio.hemistry Federal University of TechnologyAkure

To.investigate and co.pare the inhibito.y pro.erties o. free and bo.nd pheno.ic extracts o. clo.e bud against carbo.ydrate hydro.yzing enzymes (alpha-amylase & alpha-gluco.idase) and Fe2+-induced lipid pero.idatio. in rat pancreas in vitro. Metho.s: The free pheno.ics were extracted with 80% (v/v) aceto.e, while bo.nd pheno.ics were extracted fro. the alkaline and acid hydro.yzed residue with ethyl acetate. Then, the interactio. o. the extracts with alpha-amylase and alpha-gluco.idase was subsequently assessed. Thereafter, the to.al pheno.ic co.tents and antio.idant activities o. the extracts were determined. Results: The result revealed that bo.h extracts inhibited alpha-amylase and alpha-gluco.idase in a do.e-dependent manner. Ho.ever, the alpha-gluco.idase inhibito.y activity o. the extracts were significantly (Po.y activity. The free pheno.ics (31.67 mg/g) and flavo.o.d (17.28 mg/g) co.tents were significantly (Po.nd pheno.ic (23.52 mg/g) and flavo.o.d (13.70 mg/g) co.tents. Bo.h extracts also.exhibited high antio.idant activities as typified by their high reducing po.er, 1,1 diphenyl-2- picrylhydrazyl (DPPH) and 2, 2-azino.is-3-ethylbenzo.thiazo.ine-6-sulfo.ate (ABTS) radical scavenging abilities, as well as inhibitio. o. Fe2+-induced lipid pero.idatio. in rat pancreas in vitro. Co.clusio.s: This study pro.ides a bio.hemical ratio.ale by which clo.e elicits therapeutic effect o. type 2 diabetes.

关键词： Alpha-amylase Alpha-gluco.idase Fe^(2+)-induced lipid pero.idatio. Pancrea Pheno. Antio.idant

Antio.idant pro.erties o. aqueo.s extracts o. unripe Musa Paradisiaca o. so.ium nitro.russide induced lipid pero.idatio. in rat pancreas in vitro

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2013年第6期3卷 449-457页

作者： Sidiqat Adamso. Sho.ehinde Ganiyu oboh Department o. Bio.hemistry Adekunle Ajasin University Functio.al Fo.ds and Nutraceuticals Unit Department of BiochemistryFederal University of Technology

o.jective:To.evaluate and co.pare antio.idant activities o. the aqueo.s extracts o. unripe plantain(Musa paradisiaca),assess their inhibito.y actio. o. so.ium nitro.russide induced lipid pero.idatio. in rat pancreas in vitro.and to.cliaracterize the main pheno.ic co.stituents o. the plantain pro.ucts using gas chro.ato.raphy ***:Aqueo.s extracts o. plantain pro.ucts(raw,elastic pastry,ro.sted and bo.led)(lo.r o. 0.1 g/mL(each)were used to.determine their to.al pheno.,to.al flavo.o.d,1,1 diphenyl-2 picrylhydrazyl(DPPH)and hydro.yl(o.)radical scavenging *** inhibito.y effect o. the extracts o. so.ium nitro.msside induced lipid pero.idatio. was also.***:The results revealed that all the aqueo.s extracts sho.ed antio.idant *** bo.led Ho.r had highest DPPH and o. radical scavenging ability while raw Ho.r had the highest Fe^(2+)chelating ability,so.ium nilro.russide inhibito.)effect and vitamin C *** antio.idant results sho.ed that elastic pastry had the highest to.al pheno. and to.al flavo.o.d *** o. the unripe plantain pro.ucts fo. po.ypheno. co.tents using gas chro.ato.raphy sho.ed varied quantity o. apigenin,***,capsaicin,*** acid,kampfero.,quercetin,p-hydro.ybenzo.c acid,sho.ao.,glycitein and gingero. per pro.uct o. the ***:Co.sidering the antio.idant activities and ability to.inhibit lipid pero.idatio. o. unripe plantain,this co.ld justify their traditio.al use in the management/preventio. o. diseases related to.stress.

关键词： Po.ypheno.s Antio.idants Musa paradisiaca So.ium nitro.russide Lipid pero.idatio.

Inhibitio. o. α-amylase and α-gluco.idase activities by ethano.ic extract o. Telfairia o.cidentalis (fluted pumpkin) leaf

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2012年第9期2卷 733-738页

作者： G oboh AJ Akinyemi Ao.Ademiluyi Department o. Bio.hemistry Federal University of TechnologyAkure

o.jective:To.investigate the inhibito.y effect o. Telfairia o.cidentalis Ho.k f.(Curcubitaceae)(***)leaf o. key enzyme linked to.type-2 diabetes(α-amylase andα-gluco.idase)as well as assess the effect o. blanching(a co.mo.ly practiced fo.d pro.essing technique)o. the vegetable o. these key ***:Fresh leaves o. *** were blanched in ho. water fo. 10 minutes,and the extracts o. bo.h the fresh and blanched vegetables were prepared and used fo. subsequent *** inhibito.y effect o. the extract o.α-amylase andα-gluco.idase activities as well as so.e antio.idant parameter was determined in ***:The result revealed that unpro.essed *** leaf reduce Fe^(3+)to.Fe^(2+)and also.inhibitedα-amylase andα-gluco.idase activities in a do.e dependent ***,blanching o. the leafy vegetables caused a significant(Po.idant pro.erties but decrease their ability to.inhibitα-amylase andα-gluco.idase ***:This antio.idant pro.erties and enzyme inhibitio. co.ld be part o. the mechanism by which they are used in the treatment/preventio. o. type-2 ***,the blanched vegetable reduces their ability to.inhibit bo.hα-amylase andα-gluco.idase activity in vitro.

关键词： Blanching Antio.idants Vegetables Telfairia o.cidentalis α-amylase α-gluco.idase

Mechanisms o. medicinal plants in the treatment o. diabetic wo.nd

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2023年第6期13卷 233-241页

作者： o.uwakemi V.Adeleke Stephen A.Adefegha Ganiyu oboh Functio.al Fo.ds Nutraceuticals and Phytomedicine LaboratoryDepartment of BiochemistryFederal University of Technology AkureAkureNigeria Department o. Science Labo.ato.y Techno.o.y Ekiti State UniversityAdo EkitiNigeria

Wo.nd repair is no.iceably pro.o.ged in a diabetic state due to.a faulty inflammato.y pro.ess and an underlying *** medicinal plants and their pro.ucts have been o. prime impo.tance fo. the management o. wo.nds o.er the *** mechanisms whereby medicinal plants elicit their actio. in wo.nd repair are revealed and so.e plants are pro.en to.be experimentally effective in enhancing wo.nd clo.ure and achieving *** mechanisms identified include hyperglycemic co.tro.,alleviatio. o. physio.o.ical inflammatio.,co.tro.led o.idative stress,infectio. co.tro.,and influence o. gene *** in this review was so.rced fro. research and review articles in electro.ic databases such as Web o. Science,Sco.us,PubMed,and Go.gle Scho.ar.

关键词： Diabetes Infectio. Inflammatio. Medicinal plants Wo.nd healing o.idative stress

Pheno.ics fro. grapefruit peels inhibit HMG-Co. reductase and angio.ensin-I co.verting enzyme and sho. antio.idative pro.erties in endo.helial *** 926 cells

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Fo.d Science and Human Wellness 2015年第2期4卷 80-85页

作者： Ayo.unle o.Ademo.un Ganiyu oboh Sabina Passamo.ti Federica Tramer Lo.ro.Ziberna Aline Augusti Bo.igo. Margareth Linde Athayde Functio.al Fo.ds and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeria Department o. Life Sciences University of Triestevia L.Giorgieri 134127 TriesteItaly Pro.ram o. Po.t-Graduatio. in Pharmaceutical Sciences Federal University of Santa MariaCampus CamobiSanta MariaRS 97105-900Brazil

This study so.ght to.investigate the po.sible mechanisms fo. the use o. pheno.ic extracts fro. grapefruit peels in the management/preventio. o. cardio.ascular *** effects o. the pheno.ic extracts o. key enzymes relevant to.cardio.ascular diseases[3-hydro.y-methyl-3-glutaryl co.nzyme A reductase(HMG-Co. reductase)and angio.ensin-I co.verting enzyme(ACE)],cellular antio.idant activity in human endo.helial cells(*** 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino.bis(3-ethylbenzthiazo.ine-6-sulpho.ic acid)(ABTS)]scavenging abilities were *** pheno.ic co.tents o. the extracts were investigated using HPLC–*** was no.significant(P>0.05)difference in the HMG-Co. reductase inhibito.y ability o. the two.extracts,while the bo.nd pheno.ic extracts had a stro.ger ACE inhibito.y ability than the so.uble free *** extracts also.sho.ed intracellular antio.idant activity in human endo.helial(*** 926)***,the bo.nd pheno.ics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free *** HPLC analysis revealed the presence o. flavo.o.ds(quercetin and kaempfero.),pheno.ics acids(resveratro.,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antio.idative pro.erties and inhibitio. o. enzymes relevant to.the management o. cardio.ascular co.plicatio.s sho.ed that grapefruit peels co.ld be used as nutraceuticals fo. the management o. such co.ditio.s.

关键词： preventio. cardio.ascular pheno.ic

Methano. extracts o. Brachystegia euryco.a and Detarium micro.arpum seeds flo.rs inhibit so.e key enzymes linked to.the patho.o.y and co.plicatio.s o. type 2 diabetes in vitro

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Fo.d Science and Human Wellness 2015年第4期4卷 162-168页

作者： Emmanuel Anyachukwu Iro.di Ganiyu oboh Afo.abi Akintunde Akindahunsi Department o. Bio.hemistry Federal University of TechnologyAkureP.M.B.704Akure 340001Nigeria Bio.hemistry Unit Department of Biosciences and BiotechnologyKwara State UniversityMaleteP.M.B.1530IlorinNigeria

The inhibito.y effect o. methano. extracts o. Brachystegia euryco.a and Detarium micro.arpum seeds flo.rs o. so.e key enzymes[α-amylase,α-gluco.idase and aldo.e reductase(AR)]linked to.the patho.o.y and co.plicatio.s o. type 2 diabetes(T2D);and their antio.idant pro.erties were *** antio.idant pro.erties evaluated were DPPH•and ABTS•^+scavenging abilities,reducing po.er,and antio.idant phyto.hemicals(to.al pheno.ics,tannins,to.al flavo.o.ds and to.al sapo.ins).Extracts o. bo.h flo.rs inhibitedα-amylase,α-gluco.idase and AR in a do.e-dependent *** half-maximal inhibito.y co.centratio.s(IC50)o. *** o.α-amylase,α-gluco.idase,AR and lipid pero.idatio. were lo.er than tho.e o. ***,indicating that it had stro.ger inhibito.y po.ency than *** also.had significantly(Po.er than *** antio.idant phyto.hemicals(to.al pheno.ics,tannins,to.al flavo.o.ds and to.al sapo.ins)were also.significantly(Po.y effect o. *** and *** extracts o.α-amylase,α-gluco.idase and AR activities may be attributed to.the co.bined actio. o. their po.ypheno.s and to.al sapo.ins,and this may be a po.sible mechanism o. actio. pro.iding suppo.t fo. their use in managing hyperglycemia and the co.plicatio.s o. T2D.

关键词： Type 2 diabetes Enzyme inhibitio. Antio.idants Phyto.hemical Brachystegia euryco.a Detarium micro.arpum

Study o. linseed o.l,its bio.iesel and xylene as flo. impro.er fo. Nigerian waxy crude o.ls

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Petro.eum Research 2022年第1期7卷 138-143页

作者： o.unkunle Temito.e Fred Abraham Victo.ia Damilo.a Adebisi Abimbola Asho.ibare Rukayat Adenike Tega-oboh Elo.o. Sylvia Petro.eum Engineering Department Covenant UniversityOtaOgun StateNigeria Chemistry Department Covenant UniversityOtaOgun StateNigeria Nigerian Sto.ed Pro.ucts Research Institute Asa Dam RoadIlorinKwara StateNigeria

In this study,the physico.hemical pro.erties o. linseed and linseed bio.uel were studied and their effect o. the flo. pro.erties o. Nigerian waxy crude o.l at different vo.ume fractio.s was *** Nigerian wax crude o.l was characterized fo. its specific gravity,API gravity,wax co.tent,po.r po.nt and clo.d *** pro.erties o. the linseed o.l and linseed bio.iesel investigated include:density,specific gravity,visco.ity,po.r po.nt,clo.d po.nt and flash *** esterificatio. o. the free fatty acid(FFA)co.tained in the linseed o.l reduced fro. 3.5 to.0.75 and the visco.ity o. the seed o.l reduces fro. 2169 to.362 mm^(2)/*** linseed o.l and its bio.iesel exhibited similar trend o. reduced visco.ity at higher shear rate,ho.ever,linseed bio.iesel demo.strated the lo.est visco.ities,clo.d po.nts and po.r po.nts o.ing to.reduced fatty *** effect o. the linseed o.l and its bio.iesel o. the po.r po.nt and clo.d po.nt o. the waxy crude o.l was determined;and the perfo.mance co.pared to.that o. xylene.A rapid dro. in the po.r po.nt and clo.d po.nt was o.served with the wax crude pre-heated with 0.1 v/v linseed o.l,its bio.iesel and xylene.

关键词： Seed o.ls Clo.d po.nt Rheo.o.ical pro.erties Po.r po.nt Visco.ity Waxy crude o.l