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Chinese Chemical Letters 2003年第6期14卷 603-604页

作者： Li Jun HE, wen Zhu ZHANG, bo wen, xia LIU, Sheng xiang JIANG* Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000 Lanzhou Inst. of Chemical Physics Chinese Academy of Science Lanzhou 730000 China

A simple, effective HPLC method for separation of ephedrines was achieved by using 1-butyl-3-methylimidazolium-tetrafluoroborate ionic liquid solution (0.1% v/v) as eluent at pH 3.0. The involved mechanism may be due to that the imidazolium cations can effectively shield the silanol groups of alkylsilica surface, thereby decreasing band tailing and increasing the separation efficiency.

关键词： Ionic liquid ephedrine HPLC.

Isobaric tags for relative and absolute quantitation-based quantitative proteomic analysis of X-linked inhibitor of apoptosis and H2AX in etoposide-induced renal cell carcinoma apoptosis

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Chinese Medical Journal 2019年第24期132卷 2941-2949页

作者： Tian-Shu Liu Chao Chen Biao Zhou bo-wen xia Zong-Ping Chen Yong Yan Department of Urology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Vascular Surgery People's Hospital of Peking UniversityBeijing 100044China Department of Urology The Affiliated Hospital of Zunyi Medical CollegeZunyiGuizhou 563000China

Background:X-linked inhibitor of apoptosis(xiaP)is a vital factor in the anti-apoptosis mechanism of tumors and is highly expressed in renal cell carcinoma(RCC).However,the mechanism through which xiaP regulates DNA damage repair is *** study investigated the regulatory mechanism of xiaP in etoposide-induced apoptosis in two Caki-1 cell lines with high or low xiaP ***:The two cell lines were established using RNA interference *** differentially expressed proteins in the two cell lines were globally analyzed through an isobaric tags for relative and absolute quantitation-based quantitative proteomics *** analysis revealed 255,375,362,and 5 differentially expressed proteins after 0,0.5,3,and 12 h of drug stimulation,respectively,between the two cell *** identified differentially expressed proteins were involved in numerous biological *** addition,the expression of histone proteins(H1.4,H2AX,H3.1,H3.2,and H3.3)was drastically altered,and the effects of xiaP silencing were accompanied by the marked downregulation of ***-protein interactions were assessed and confirmed through immunofluorescence and Western blot ***:The results suggested that xiaP may act as a vital cell signal regulator that regulates the expression of DNA repair-related proteins,such as H2AX,and influences the DNA repair ***:Given these functions,xiaP may be the decisive factor in determining the sensitivity of RCC cell apoptosis induction in response to chemotherapeutic agents.

关键词： Apoptosis H2AX iTRAQ Renal cell carcinoma X-linked inhibitor of apoptosis

Robot assisted transperitoneal laparoscopic pyeloplasty

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Chinese Medical Journal 2008年第4期121卷 380-382页

作者： JIN Xun-bo LI Peng JIANG Shao-bo WANG Mu-wen xia Qing-hua ZHAO Yong XIONG Hui SUN Peng CHEN Xiu-de Minimally Invasive Urology Center Shandong Provincial Hospital Shandong University Jinan Shandong 250021 China

Nowadays, with laparoscope techniques increasingly developed its indications are covering more complicated medical fields. Moreover, as a camera holder, the robotic system of an automated endoscopic system for optimal positioning （AESOP） can be controlled directly by the surgeon＇s voice. It can be more effectively manipulated and more accurately control the video endoscope, which enables the unification of the operator＇s thoughts and visual field and decreases the inadvertent movements from a human assistant. It also improves the learning curve for complicated minimally invasive *** April 2003 anti December 2005, 25 patients with ureteropelvic junction （UPJ） stricture underwent robot assisted transperitoneal laparoscopic pyeloplasty.

关键词： robotics ureteropelvic junction stricture laparoscopic surgery

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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中华绒螯蟹肌肉组织特性及其肉质嫩度的比较

水产学报 2009年第1期33卷 151-156页

作者：郑海波夏文水江南大学食品学院

采用肌原纤维小片化指数(MFI)、胶原蛋白(总胶原蛋白、热溶性胶原蛋白、热残留胶原蛋白)和肌纤维直径3种评定方法,分别测定了4个地区中华绒螯蟹肌肉的组织特性,并初步探讨了采用综合指数法比较肉质的嫩度。结果表明,中华绒螯蟹肌肉的肌... 详细信息

采用肌原纤维小片化指数(MFI)、胶原蛋白(总胶原蛋白、热溶性胶原蛋白、热残留胶原蛋白)和肌纤维直径3种评定方法,分别测定了4个地区中华绒螯蟹肌肉的组织特性,并初步探讨了采用综合指数法比较肉质的嫩度。结果表明,中华绒螯蟹肌肉的肌纤维小片化指数为50~90;肌纤维直径为350~560μm;总胶原蛋白含量为0.1~0.18 g/100 g;热溶性胶原蛋白含量为0.03~0.12 g/100 g;热残留胶原蛋白含量为0.04~0.1 g/100 g。与牛肉相比,中华绒螯蟹肌肉的肌纤维较粗,胶原蛋白含量较低。3种评定方法均可以划分出不同地区河蟹间肌肉嫩度等级,但各指标间的嫩度排序有差异。肌纤维直径的分辨率最高,而胶原蛋白的分辨率最低。采用综合指数法评定肉质嫩度从大到小的顺序为:B>C>A>D(雄);A>C>B>D(雌)。

关键词：中华绒螯蟹肌肉嫩度胶原蛋白肌纤维

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石油勘探开发领域空间信息检索方法

兰州大学学报（自然科学版） 2017年第5期53卷 576-581页

作者：王志宝王成波文必龙夏昊乔彦友东北石油大学计算机与信息技术学院黑龙江大庆163318 中国科学院遥感与数字地球研究所北京100101

提出了面向石油勘探开发的空间信息检索技术方法,给出了文档空间主题计算模型,设计了支持文本与三维空间查询的高性能索引结构,在原有研究的基础上实现了原型系统PetroScope.经过真实数据的性能测试和比较分析,原型系统的准确度得到了... 详细信息

提出了面向石油勘探开发的空间信息检索技术方法,给出了文档空间主题计算模型,设计了支持文本与三维空间查询的高性能索引结构,在原有研究的基础上实现了原型系统PetroScope.经过真实数据的性能测试和比较分析,原型系统的准确度得到了一定程度的提高,性能能够满足该领域空间信息检索的需求。

关键词：空间信息检索石油勘探开发空间信息提取实体消歧混合索引结构

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen bo Zeng xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： Yun-Peng Guo Ling-Xue Bao Yu-Yang Wang Quan wen Gai Hang bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis