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Medicinal Plant 2024年第2期15卷 1-5,14页

作者： Yan LIN bo tu Shanggao LIAO Minghui HE Guizhou Provincial Higher Education Institutions Genuine Medicinal Materials Chronic Disease Prevention and Control Engineering Research Center College of PharmacyGuizhou Medical UniversityGuiyang 550025China

[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine *** using the nitric oxide(NO)anti-inflammatory activity model.[Results]Five components,8(xanthohumol),13(kurarinol),27(4-methoxysalicylic acid),28(b-resorcic acid)and 30(b-resorcic acid),exhibited significant anti-inflammatory activity,with IC 50 values of 5.99,4.76,6.96,3.41 and 5.22μM,***,8(xanthohumol)and 13(kurarinol)were typical lavandulyl flavonoids in ***,which were worth further ***,UPLC-Q-Exactive and GNPS molecular networking technique were used for rapid analysis of lavandulyl flavonoids from ***.A total of 15 components were identified.[Conclusions]This work lays a theoretical foundation for further separation and analysis of lavandulyl flavonoids with anti-inflammatory activity from ***.

关键词： Sophora flavescens Molecular network Anti-inflammatory activity Lavandulyl flavonoids

A New Flavonoid Glycoside from Polygonum capitatum

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Medicinal Plant 2024年第1期15卷 28-31页

作者： Lei HE Yan LIN Minghui HE bo tu School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Engineering Research Center of Chronic Disease Prevention and Treatment of Authentic Medicinal Materials for Institutions of Higher Education in Guizhou Province Guiyang 550025China

[Objectives]To discover novel compounds with significant anti-inflammatory activity in the alcohol extract of Polygonum capitatum.[Methods]Firstly,a new flavonoid glycoside,capitaone B(1),was isolated from the ethyl acetate extract from ***,and then 27 compounds were screened using NO anti-inflammatory activity model.[Results]Four compounds,such as kaempferol(12),1,2,6-trigalloyl-β-d-glucose(15),catechin(16)andβ-sitosterol(26),could significantly inhibit LPS-induced NO production in macrophages,with IC 50 values of 15.31,8.43,6.92 and 5.72μM,respectively.[Conclusions]The chemical composition and anti-inflammatory activity of *** were preliminarily studied,and the results provide a theoretical basis for further research on the action mechanism of subsequent anti-inflammatory active compounds of ***.

关键词： Polygonum capitatum Chemical composition Anti-inflammatory activity

Using Network Pharmacology to Explore Therapeutic Effect of Polygonum capitatum on Renal Calculus in Rats

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Medicinal Plant 2024年第3期15卷 45-49页

作者： bo tu Xu ZHANG Yan LIN Huang YANG Minghui HE Engineering Research Center of Chronic Disease Prevention and Treatment of Authentic Medicinal Materials in Guizhou Higher Education Institutions School of Pharmaceutical SciencesGuizhou Medical UniversityGuiyang 550025China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550004China

[Objectives]To explore the therapeutic effect of Polygonum capitatum on renal calculus in rats based on network pharmacology.[Methods]Through the preliminary construction of ***-urolithiasis disease target network,explore the active components,action pathway and action target of ***-urolithiasis treatment,and use 1%ethylene glycol+2%ammonium chloride to induce SD rat kidney calcium oxalate stone model to verify the efficacy of ***-urolithiasis treatment.[Results]Through the network pharmacological prediction,it is found that the important active components in *** were quercetin,gallic acid,rutin,silybin,catechin,kaempferol and so on;potential active targets include INS,CAT,IL-6,MOCOS,*** results also suggest that forkhead transcription factor signaling pathway(FoxO signaling pathway),tumor necrosis factor signaling pathway(TNF signaling pathway)and hypoxia-inducible factor signaling pathway(HIF-1 signaling pathway)are the core *** results of biochemical indicators in animal experiment showed that the contents of serum urea nitrogen(BUN),creatinine(Cr)and malondialdehyde(MDA)in renal tissue in the treatment group(200,500 mg/kg)were significantly lower than those in the model group,while the content of superoxide dismutase(SOD)was significantly higher than that in the model *** addition,the kidney tissue H&E staining sections showed that *** alcohol extract administration group rats kidney calcium oxalate crystals were significantly reduced compared with the model group,the degree of renal tubular lumen expansion was lighter than the model group,suggesting that *** alcohol extract has the effect of improving renal calculus in rats.[Conclusions]This study provides a theoretical reference for the deep development of *** in the treatment of renal calculus.

关键词： Polygonum capitatum Urolithiasis Network pharmacology

Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

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Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU bo tu Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

基于0.18μm CMOS工艺的低温漂低功耗延时电路

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半导体技术 2024年第3期49卷 257-262页

作者：陆兆俊涂波徐玉婷杨煜无锡中微亿芯有限公司江苏无锡214072

基于0.18μm CMOS工艺设计了一款低温漂延时电路,适用于不能使用锁相环电路又对信号传输精度有要求的低功耗传感检测应用。采用正温度系数的偏置电压,通过电流镜为延时电路提供一个正温度系数的偏置电流,利用偏置电流约束电路的延时温漂... 详细信息

基于0.18μm CMOS工艺设计了一款低温漂延时电路,适用于不能使用锁相环电路又对信号传输精度有要求的低功耗传感检测应用。采用正温度系数的偏置电压,通过电流镜为延时电路提供一个正温度系数的偏置电流,利用偏置电流约束电路的延时温漂,实现温漂粗调。采用数字时间转换器,通过外部输入配置,对粗调后的延时进行动态细调,使得延时电路具有更高的动态稳定性和更低的温漂特性。电路测试结果表明,在3.3 V的电源电压下,-55~125℃内延时电路的温度系数为125×10^(-6)/℃,静态功耗仅为0.72 mW。

关键词：低温漂延时电路数字时间转换器低功耗模拟集成电路

Facile Fabrication of Hierarchically Porous Carbonaceous Monoliths with Ordered Mesostructure via an Organic Organic Self-Assembly

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Nano Research 2009年第3期2卷 242-253页

作者： Chunfeng Xue bo tu Dongyuan Zhao Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsKey Laboratory of Molecular Engineering of PolymersLaboratory of Advanced MaterialsFudan UniversityShanghai 200433China

A simple strategy for the synthesis of macro-mesoporous carbonaceous monolith materials has been demonstrated through an organic organic self-assembly at the interface of an organic scaffold such as polyurethane(PU)*** porous carbonaceous monoliths with cubic(Im m)or hexagonal(p6mm)mesostructure were prepared through evaporation induced self-assembly of the mesostructure on the three-dimensional(3-D)interconnecting struts of the PU foam *** preparation was carried out by using phenol/formaldehyde resol as a carbon precursor,triblock copolymer F127 as a template for the mesostructure and PU foam as a sacrificial monolithic *** hierarchical pore system was macroscopically fabricated with cable-like mesostructured carbonaceous *** carbonaceous monoliths exhibit macropores of diameter 100450μm,adjustable uniform mesopores(3.87.5 nm),high surface areas(200870 m2/g),and large pore volumes(0.170.58)cm3/*** with the corresponding evaporation induced self-assembly(EISA)process on a planar substrate,this facile process is a time-saving,labor-saving,space-saving,and highly effi cient pathway for mass production of ordered mesoporous materials.

关键词： Self-assembly synthesis mesoporous materials carbonaceous monolith templating macroporous materials

大学生创新创业教育体系建设探索——以贵州医科大学学生创新创业工作开展为例

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教育教学论坛 2024年第27期 169-172页

作者：朱真怡涂波王国泽贵州医科大学科技创新与产业发展处贵州贵阳561113 贵州医科大学公共卫生与健康学院贵州贵阳561113

随着我国人口结构与经济结构深度调整,社会产业转型升级、技术进步对创新创业人才需求的不断提高,大学生创新创业教育得到高度重视,其教育改革已成为高校当下关注的重点。通过对贵州医科大学开展创新创业教育工作建设的探索和凝练,结合... 详细信息

随着我国人口结构与经济结构深度调整,社会产业转型升级、技术进步对创新创业人才需求的不断提高,大学生创新创业教育得到高度重视,其教育改革已成为高校当下关注的重点。通过对贵州医科大学开展创新创业教育工作建设的探索和凝练,结合当下高校创新创业教育存在的以理论教育覆盖为主、实践教育所占比例不够高、成果转移转化路径不够通畅等系列问题做出剖析,通过实际案例说明,以期总结出适合于医科类院校的创新创业育人模式。

关键词：新医科创新创业教育育人模式

One-pot synthesis of thermally stable gold@mesoporous silica core-shell nanospheres with catalytic activity

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Nano Research 2013年第12期6卷 871-879页

作者： Junchen Chen Renyuan Zhang Lu Han bo tu Dongyuan Zhao Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Laboratory of AdvancedMaterials Fudan University Shanghai 200433 China

A facile one-pot method has been developed to synthesize uniform gold@mesoporous silica nanospheres （Au@MSNs）, which have a well-defined core-shell structure with ordered mesoporous silica as a shell. The resulting Au@MSNs have a high surface area （-521 rna/g） and uniform pore size （-2.5 nm） for the mesoporous silica shell. The diameter of the gold core can be regulated by adjusting the amount of HAuC14. The catalytic performance of the Au@MSNs was investigated using the reduction of 4-nitrophenol as a model reaction. The mesopores of the silica shells provide direct access for the reactant molecules to diffuse and subsequently interact with the gold cores. In addition, the Au@MSNs display the great advantage of sintering-resistance to 950 ℃ because the mesoporous silica shells inhibit aggregation or deformation of the gold cores. The high thermal stability enables the Au@MSNs to be employed in high-temperature catalytic reactions.

关键词： core-shell nanostructures gold mesoporous silica synthesis catalysis

Multicomponent Domino [4＋1＋1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones

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Chinese Journal of Chemistry 2013年第6期31卷 737-744页

作者： Ying Li Haiwei Xu Liping Fu Qingqing Shi bo Jiang Shujiang tu School of Chemistry and Chemical Engineering Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou Jiangsu 221116 China

Concise and efficient three-component domino [4＋ 1 ＋ 1] carbocyclization to highly substituted fluoren-9-one derivatives promoted by K2CO3 has been developed under microwave irradiation conditions. The direct bis-cyanation and aryl amination residing in fluoren-9-one framework were achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good to excellent chemical yields.

关键词： fluoren-9-one synthesis multicomponent reactions carbocyclization regioselectivity microwaveheating

鲍氏不动杆菌血流感染的临床分离株耐药性及毒力相关基因分布

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中华医院感染学杂志 2024年第8期34卷 1121-1125页

作者：王婧婧毛旭建赵莹杜强屠博文王凤鸣黎俊宏南京医科大学公共卫生学院江苏南京211166 常州市疾病预防控制中心江苏常州213022

目的探讨鲍氏不动杆菌血流感染的分离株耐药性及毒力相关基因分布差异。方法分析2018年1月-2021年12月从常州市疾病预防控制中心等数家合作医疗机构中检出的鲍氏不动杆菌的标本来源、感染科室分布及耐药状况;全自动微生物药敏分析仪做... 详细信息

目的探讨鲍氏不动杆菌血流感染的分离株耐药性及毒力相关基因分布差异。方法分析2018年1月-2021年12月从常州市疾病预防控制中心等数家合作医疗机构中检出的鲍氏不动杆菌的标本来源、感染科室分布及耐药状况;全自动微生物药敏分析仪做菌株鉴定、药敏试验,多位点序列分型探讨菌株克隆型,黏液拉丝试验鉴定菌株的毒力表型,聚合酶链式反应检测菌株毒力基因、荚膜血清型。结果鲍氏不动杆菌菌株主要来源于痰、伤口分泌物、血液标本;鲍氏不动杆菌菌株分布主要科室是重症监护病房(ICU)、创伤显微外科、神经外科;鲍氏不动杆菌菌株对亚胺培南、美罗培南、头孢哌酮/舒巴坦的耐药率比较高,具有多药耐药和广泛耐药性;鲍式不动杆菌菌株种包含15种ST型(牛津分型),主要为ST195,共检测出黏液丝试验阳性菌株22株(占比15.28%),共检出40株荚膜血清型(占比27.78%),菌株毒力基因主要为abaI、ompA、HemO、bap、CsuE、bfmS基因。结论鲍氏不动杆菌菌株主要来源于痰等标本,主要分布在ICU,其多药耐药及广泛耐药率均较高。鲍氏不动杆菌菌株以ST195型为主要流行菌株。鲍氏不动杆菌携带多种毒力基因,临床应严格防控重症监护病房中耐药高毒力鲍氏不动杆菌菌株的传播。

关键词：血流感染鲍氏不动杆菌毒力基因耐药机制耐药性菌株分布