Analysis of Lavandulyl Flavonoids from Sophora flavescens with Antiinflammatory Activity Based on Molecular Network Technology
作者机构：Guizhou Provincial Higher Education Institutions Genuine Medicinal Materials Chronic Disease Prevention and Control Engineering Research CenterCollege of PharmacyGuizhou Medical UniversityGuiyang 550025China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2024年第15卷第2期
页 面：1-5,14页
基 金：Supported by Guizhou Provincial Science and Technology(ZK(2022)-362,ZK(2024)-047,ZK01) The Innovation and Entrepreneurship Training Program for Undergraduates from China Science Foundation of Guizhou Education Technology(2022-064) University Engineering Research Center for the Prevention and Treatment of Chronic Diseases by Authentic Medicinal Materials in Guizhou Province(035) Science and Technology Research Project of Guizhou Administration of Traditional Chinese Medicine(QZYY-2024-134)
主 题：Sophora flavescens Molecular network Anti-inflammatory activity Lavandulyl flavonoids
摘 要：[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine *** using the nitric oxide(NO)anti-inflammatory activity model.[Results]Five components,8(xanthohumol),13(kurarinol),27(4-methoxysalicylic acid),28(b-resorcic acid)and 30(b-resorcic acid),exhibited significant anti-inflammatory activity,with IC 50 values of 5.99,4.76,6.96,3.41 and 5.22μM,***,8(xanthohumol)and 13(kurarinol)were typical lavandulyl flavonoids in ***,which were worth further ***,UPLC-Q-Exactive and GNPS molecular networking technique were used for rapid analysis of lavandulyl flavonoids from ***.A total of 15 components were identified.[Conclusions]This work lays a theoretical foundation for further separation and analysis of lavandulyl flavonoids with anti-inflammatory activity from ***.
维普期刊数据库