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低速高电荷态离子Xe^(q+)在金属Al(111)面掠角散射的中性化过程研究

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核技术 2006年第7期29卷 499-502页

作者：胡碧涛王丽丽宋玉收顾建刚陈春花兰州大学物理学院原子核研究所兰州730000

本文在经典过垒模型(COBM)下,通过计算机模拟研究了低速高电荷态离子Xeq+在金属Al(111)表面掠角散射过程中,高电荷态Xeq+离子的中性化过程、其电荷态与该高电荷态离子到Al(111)表面的距离R的关系。此外,还计算了不同电荷态的Xeq+离子在... 详细信息

本文在经典过垒模型(COBM)下,通过计算机模拟研究了低速高电荷态离子Xeq+在金属Al(111)表面掠角散射过程中,高电荷态Xeq+离子的中性化过程、其电荷态与该高电荷态离子到Al(111)表面的距离R的关系。此外,还计算了不同电荷态的Xeq+离子在掠射过程中所获得的镜像能,并把该结果与实验值进行了比较。我们模拟的镜像能与实验值符合得非常好。

关键词：低速高电荷态离子中空原子经典过垒模型镜像能

DAMPE-PSD探测单元模块大动态范围读出方案的实验验证

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原子核物理评论 2016年第4期33卷 461-465页

作者：周勇余玉洪孙志宇张永杰方芳陈俊岭胡碧涛中国科学院近代物理研究所兰州730000 兰州大学核科学与技术学院兰州730000 中国科学院大学北京100049

暗物质粒子探测卫星(Dark Matter Particle Explorer,DAMPE)的塑闪阵列探测器(Plastic Scintillator Detector,PSD)需要实现高能e/γ粒子的鉴别功能以及对Z=1～20的宇宙线重离子的电荷测量功能。它使用光电倍增管作为读出器件,并从打拿... 详细信息

暗物质粒子探测卫星(Dark Matter Particle Explorer,DAMPE)的塑闪阵列探测器(Plastic Scintillator Detector,PSD)需要实现高能e/γ粒子的鉴别功能以及对Z=1～20的宇宙线重离子的电荷测量功能。它使用光电倍增管作为读出器件,并从打拿极5和打拿极8同时引出信号来增大读出动态范围。基于该设计方案的探测单元模块在兰州重离子加速器冷却储存环(HIRFL-CSR)上的外靶终端(ETF)进行了束流测试实验。实验得到了PSD单元条在中能轻核区(Z 8)的能量响应,并证明了单元条的衰减长度与入射粒子种类无关。通过将实验结果外推至高能重核区,同时结合衰减长度、入射角度和能量涨落等因素,可以估算出PSD探测单元模块输出信号幅度的动态范围。结果显示,该范围在PSD前端电子学模块的线性工作区间内,从而验证了PSD大动态范围读出方案设计的合理性。

关键词：塑料闪烁体大动态范围猝灭效应

基于XUV激光脉冲和反应显微成像技术的原子分子光物理实验平台

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原子核物理评论 2020年第2期37卷 225-232页

作者：雷建廷海帮张敏董达谱赵冬梅胡碧涛马新文刘作业张少锋兰州大学核科学与技术学院兰州730000 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049

基于高次谐波技术的超快激光系统可以通过控制脉冲时序实现对目标量子态的精准操控,反应显微成像谱仪实现了4π立体角内对量子少体碰撞过程的准确测量,两项先进系统的结合将极大拓展量子少体动力学研究的领域。目前,高次谐波的单频选择... 详细信息

基于高次谐波技术的超快激光系统可以通过控制脉冲时序实现对目标量子态的精准操控,反应显微成像谱仪实现了4π立体角内对量子少体碰撞过程的准确测量,两项先进系统的结合将极大拓展量子少体动力学研究的领域。目前,高次谐波的单频选择至关重要,同时反应显微成像谱仪的分辨率受真空度及冷靶分散度的影响较大。中国科学院近代物理研究所通过采用多级差分、钛真空靶室的设计,使得谱仪的真空度达到10^–11 mbar量级,有效降低了本底噪声的影响;升级改造传统超音速冷靶系统的靶束产生装置,实现了靶厚度的自由调控,大大提高了探测器记录事件的准确性;本实验平台结合高次谐波产生多阶XUV脉冲单能化技术,实现了单能XUV超快激光系统和反应显微成像谱仪成功结合,该系统可以产生能量范围在20~100 eV之间的XUV脉冲,能够研究电离能或解离能在100 eV以下的原子分子动力学过程。

关键词： XUV脉冲反应显微成像谱仪原子分子光物理实验平台单电离

中国科技前沿元素在大学普通物理教学中的渗透

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物理与工程 2021年第3期31卷 73-77,84页

作者：刘作业丁晶洁王集锦张鸿飞杨毅胡碧涛兰州大学核科学与技术学院甘肃兰州730000

如何在理工科专业课的活动教学中有效地润物细无声地开展思政教育成为了新时代大学教育教学工作值得深思的一个问题。我们在大学普通物理的课堂教学中进行了新的尝试:在进行基础物理理论讲授的同时,引入了最新的中国科技前沿成果,渗透... 详细信息

如何在理工科专业课的活动教学中有效地润物细无声地开展思政教育成为了新时代大学教育教学工作值得深思的一个问题。我们在大学普通物理的课堂教学中进行了新的尝试:在进行基础物理理论讲授的同时,引入了最新的中国科技前沿成果,渗透进了中国科学家的故事。有机融合课程思政教育和创新能力培养,在激发了他们的科研兴趣、培养创新能力的同时,使学生对中国科技发展现状有了全新的认识,在“不经意间”激励学生的家国情怀、提升民族认同感,树立正确的人生观。

关键词：普通物理课程思政教育中国科技前沿创新能力培养民族认同感

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

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Research 2024年第1期2023卷 281-299页

作者： bitao Lu Enling hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital ***,multiple hemostatic strategies are critical for treating large bleeding *** this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug *** aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug *** ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally *** novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

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Bioactive Materials 2021年第9期6卷 2956-2968页

作者： Luoxiao Ran bitao Lu Haoyu Qiu Guofang Zhou Jing Jiang Enling hu Fangyin Dai Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China Chongqing General Hospital University of Chinese Academy of Sciences No.118Xingguang AvenueLiangjiang New AreaChongqingChina

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of *** infections are detrimental to our life and *** reduce the abuse of antibiotics and treat biofilm-related bacterial infections,a biomimetic nano-antibacterial system,RBCM-NW-G namely,that controls the release of antibiotics through near infrared was *** hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading,and then,biomimetics are applied with red blood cell membranes(RBCM).RBCM-NW-G,which retains the performance of RBCM,shows enhanced permeability and retention *** imaging in mice showed the effective accumulation of RBCM-NW-G at the site of *** addition,the biomimetic nanoparticles showed a longer blood circulation time and good ***-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect,silver iron,and ***,by constructing a mouse infection model,the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

关键词： Red blood cell membrane Nanoworms Antibiotics release Bacterial infection

Gemini Dressing with Both Super‑hydrophilicity and ‑hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

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Advanced Fiber Materials 2023年第4期5卷 1447-1466页

作者： Qing Li Enling hu Kun Yu Ruiqi Xie Fei Lu bitao Lu Rong Bao Fangyin Dai Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of Sericulture Textile and Biomass ScienceSouthwest UniversityChongqing 400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China The Ninth People’s Hospital of Chongqing No.69 Jialing VillageBeiBei DistrictChongqing 400715China

Achieving efficient hemostasis and wound management is vital to preserve life and restore health in case of extensive hemor-rhagic skin ***,we develop a filter pump-like hierarchical porous-structure(HPS)dressing based on a non-woven substrate,konjac glucomannan(KGM)aerogel,and bi-functional microporous starch(BMS).The KGM aerogel intercalates into the non-woven network structure,forming a hydrophilic frame to stimulate the plasma permeation toward the interior in synergy with the hydrophilic pores of the *** BMS surface forms a hydrophobic matrix that fills the spaces of the KGM hydrophilic frame,contributing to the isolation and aggregation of blood cells on the surface of the HPS dressing to establish rapid *** model experiments suggest reliable HPS dressing hemostatic capacity,as it is able to stop ear artery and liver bleeding within 97.6±15.2 s and 67.8±5.4 s,***,the dressings exhibit antibacterial properties and enabled wound healing within 2 *** vitro hemolysis and cytotoxicity tests also confirm the biocompatibility of HPS *** novel“two-in-one”hemostatic dressing facilitates tissue repair of bleeding wounds over the entire recovery period,thereby providing a convenient strategy for wound management.

关键词： Hierarchical porous-structure Blood cell isolation Hemostasis Antibacterial activity Wound healing

Microcluster colloidosomes for hemostat delivery into complex wounds:A platform inspired by the attack action of torpedoes

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Bioactive Materials 2022年第10期7卷 372-387页

作者： bitao Lu Enling hu Ruiqi Xie Kun Yu Fei Lu Rong Bao Chenhui Wang Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing Village BeiBei DistrictChongqing400715China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing University55 South Daxuecheng RoadChongqing401331China

Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature,thereby causing massive blood loss and significantly increased *** by the attack action of torpedoes,we synthesized microcluster(MC)colloidosomes equipped with magnetic-mediated navigation and“blast”systems to deliver hemostats into the cavity of vase-type ***_(3)/Fe_(2)O_(3)(CF)microparticles functionalized with Arg-Gly-Asp(RGD)modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots(CDs)to form MC colloidosomes,which were loaded with thrombin and protonated tranexamic acid(TXA-NH_(3)^(+)).The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH_(3)^(+).The CO_(2) bubbles generated during disassembly produced a“blast”that propelled thrombin into the wound *** bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within~60 ***,in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC *** study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis,creating a new paradigm for combating trauma treatment.

关键词： Torpedoes-inspired Microcluster colloidosomes Magnetic guidance Disintegration Hemostasis

Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds

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Bioactive Materials 2021年第12期6卷 4625-4639页

作者： Qing Li Enling hu Kun Yu Mengxing Lu Ruiqi Xie Fei Lu bitao Lu Rong Bao Guangqian Lan State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400715China Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile Chongqing400715China The Ninth People’s Hospital of Chongqing No.69 Jialing VillageBeiBei DistrictChongqing400715China

Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex ***,we present a novel hemostatic strategy based on magnetic field-mediated *** biphasic Janus magnetic particle(MSS@Fe2O3-T)comprised aggregates ofα-Fe2O3 nanoparticles(Fe_(2)O_(3) NPs)as the motion actuator,negatively modified microporous starch(MSS)as the base hemostatic substrate,and thrombin as the loaded hemostatic *** application,the particles were first wrapped using NaHCO_(3) and then doped with protonated tranexamic acid(TXA-NH_(3)^(+)),which ensured their high self-dispersibility in *** application,the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic *** vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds(“V”-shaped femoral artery and“J”-shaped liver bleeding models).The present strategy,for the first time,extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds.

关键词： Janus particle Sustained driving Magnetic guidance Hemostasis Complex wound