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Neuroscience Bulletin 2021年第5期37卷 729-734页

作者： Lin Cui bingbing guo Dan Zhao Jiaxin Li Yu Luo Ming Meng Key Laboratory of Brain Cognition and Education SciencesMinistry of EducationChina/School of PsychologyCenter for Studies of Psychological Applicationand Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou 510631China School of Teacher Education Nanjing Xiaozhuang UniversityNanjing 211171China

Dear Editor,Naturally, both consensual and idiosyncratic experiences are formed when we watch a movie. What are the neural mechanisms underlying the formation of these experiences? Abundant fMRI studies on watching mo... 详细信息

关键词： watch movie Movie

Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study

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Global Health Journal 2020年第2期4卷 57-63页

作者： Peicheng Wang Junfang Xu bingbing guo Jason K Wang Liangmin Gao Qianyun Wang Jun Jing Feng Cheng Research Center for Public Health School of MedicineTsinghua University30 Shuangqing RoadBeijing 100084China Research Institute of Health Policy School of Public HealthZhejiang University866 Yuhangtang RoadHangzhou 310058China College of Life Science and Bioengineering Beijing University of Technology100 Ping Le YuanBeijing 100124China Schwarzman College Tsinghua University30 Shuangqing RoadBeijing 100084China Department of Sociology Tsinghua University30 Shuangqing RoadBeijing 100084China

Background:This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus(HIV)patients in whom antiretroviral therapy(ART)was ***:In this retrospective study,a total of 9,418 HIV patients who failed in ART during 2004–2016 were included and divided into two treatment groups—Group 1(treatment time≤3 years,n1=5,218)and Group 2(treatment time>3 years,n2=4,200).Patient follow-up data,including age,cluster of differentiation 4(CD4)count,and viral load,glucose,creatinine,and triglyceride levels,were extracted from electronic health record *** analysis for repeated measures was used to analyze the biochemical indicators,and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment ***:The median initial CD4 count was 175.0 cells/μl(interquartile range,77.0–282.0),while the initial CD4 counts for Group 1 were lower than those for Group 2(P<0.05).A significant interaction between group and time effects was observed(P<0.05)in total cholesterol(TC).Changes in hemoglobin level among HIV patients were also significantly associated with treatment time(P=0.001).The initial CD4 count(odds ratio[OR]=0.756),female sex(OR=0.713),Zerit(d4T)(OR=1.443),TC(OR=1.285),and aspartate aminotransferase level(OR=1.002)were significantly associated with the survival time of dead patients with HIV(P<0.05).Additionally,the initial CD4 count(OR=1.456),age(OR=1.022),time interval(OR=0.903),patient’s living status(OR=0.597),d4T(OR=2.256),and triglyceride(OR=0.930)and hemoglobin levels(OR=0.997)were significantly associated with the treatment time of HIV patients with drug withdrawal(P<0.05).Conclusion:The initial biochemical parameters can affect the survival and treatment time of HIV *** a comprehensive understanding of the physiological and biochemical indicators

关键词： Treatment time Biochemical indicators HIV/AIDS Failure of antiretroviral therapy

Fucoxanthin improves serum lipids， liver metabolism and gut microbiota in hyperlipidemia mice

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Food Science and Human Wellness 2024年

作者： Yonghui Zhou Jingyi Zhang Kun Xu Weihao Zhang Feng Chen Bin Liu bingbing guo Faculty of Environment and Life， Beijing University & Technology Shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Carbon Neutrality， Institute for Advanced Study， Shenzhen University

Fucoxanthin， a kind of exclusively algae-derived carotenoids， could reduce lipid content and regulate gut microbiota composition in obese mice， showing potential in preventing hyperlipidemia. This study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice， as well as investigate the underlying association with gut microbiota changes. Results showed that fucoxanthin significantly reduced body weight gain and body white fat of the mice. In the serum， total triglycerides (TG)， total cholesterol (TC) contents were significantly decreased and high-density-lipoprotein cholesterol levels was significantly upregulated. Moreover， fucoxanthin remarkedly prevented lipid accumulation in the liver. Especially， metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control， indicating the advance of hepatic lipid metabolism. Bile acids profile in the liver was also greatly changed by fucoxanthin. Meanwhile， fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio， Blautia and Clostridia genera. Finally， correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum lipids. Altogether， this study showed great potential of fucoxanthin in improving serum lipids profile， hepatic lipids and bile acids metabolism of hyperlipidemia mice， which was associated with gut microbiota alteration.

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Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

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Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu Jiawei Yang Chaofan Zhou Zhaoning Hu Saiyu Bu bingbing guo Yixuan Zhao Junhao Liao Mingpeng Shang Ge Chen Kaicheng Jia Jianbo Yin Qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China Second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

Flexible Zr-MOF Design for Efficient Removal of PPCPs

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Flexible Zr-MOF Design for Efficient Removal of PPCPs

Synthesis,Structure and Magnetic Properties of a Cage-like Cu6Gd6 Compound

中国化学会第十届全国无机化学学术会议

作者： bingbing guo Liangliang Zhang Daofeng Sun School of Materials Science and Engineering College of Science China University of Petroleum (East China) Institute of Flexible Electronics(IFE) Northwestern Polytechnical University(NPU)

Metal-organic frameworks（MOFs） as a crystalline porous material, due to its large specific surface area and porosity, has shown potential application in many fields such as gas adsorption and separation, catalysis, removal of harmful macromolecules, etc[1]. However, their structural prediction design and stability improvement are still a problem that restricts their applications [2]. We successfully synthesized a series of Zr-MOF named PCN-206, 207, 208. First, the modulating linkers will affect the coordination of linkers and/or clusters, which will affect the final structure and the phase purity, we obtained the（4,10）-connected PCN-207 with flu topology and PCN-206 in scu topological configuration by adjusting the mount of benzoic acid. In addition, the introduction of ancillary ligands will also affect the configuration and functionality of the crystal. Based on the length of the ligand and the distance between the nodes in the obtained crystal structure, together with the flexibility of the ligand, we successfully inserted the BDC and NDC into the PCN-207 and inserted the FA into the PCN-206 to obtain（4,10）-connected PCN-206-FA, PCN-207-BDC, PCN-207-NDC. By changing the amount of the ancillary ligand NDC, it is also possible to form a（4,12）-connected PCN-208-NDC, which is sufficient to see the criticality of the ancillary ligand variable. Subsequently, we performed PPCPs（pharmaceuticals and personal care products） removal experiments on the PCN-206, 207, 208 series. PCN-206 series has very good removal ability, which is closely related to the smooth channel structure in its scu topological configuration.

关键词： Metal-organic frameworks Structural design auxiliary ligands removal of pharmaceutical waste

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Synthesis,Structure and Magnetic Properties of a Cage-like C...

圆形巷道围岩加速蠕变影响下冲击地压的启动条件

中国化学会第八届全国配位化学会议

作者： bingbing guo Hua Yang Dacheng Li Jianmin Dou Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engineering Liaocheng University Institute of BioPharmaceutical Research Liaocheng University

The lanthanide-based SMMs are attracting the growing attentions due to the intrinsic strong spin-orbital coupling and magnetic anisotropy of lanthanide(Ⅲ) ions[1].Their promising high anisotropic energy barrier(U) for the magnetization reversal and the blocking temperature(T)play a key role in their potential application in the high-density information storage[2].Based on these considerations,we designed the reaction of 2-hydroxy-3-carboxy-5-chlorobenzaldehyde oxime(H hccbdo) with gadolinium nitrate and copper acetate and obtained a novel dodecanuclear 3 d-4 f complex[Cu Gd(Hhccbdo)(hccbdo)(DMF)(H O)].The coplanar four Gd ions are ligated with carboxyl groups of ligands and form a 16-MC-4 cyclic structure with[Gd-O-C-O]repeating *** 16-MC-4 rings assembled into a rare cage-like *** copper ions are located the outside of the cage(Fig.1).Magnetic susceptibility reveals the ferromagnetic coupling between the metal ions of complex(Fig.2 a),and further AC magnetic data indicates the slow magnetic relaxation,a typical of single-molecule magnets behavior(Fig.2 b).

关键词： 2-Hydroxy-3-Carboxy-5-Chloro-Benzaldehyde Oxime 3d-4f Complex Slow Magnetic Relaxation

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煤炭学报 2020年第10期45卷 3401-3407页

作者：陈国祥郭兵兵镐振河南工程学院安全工程学院河南郑州451191

针对高静载巷道蠕变型冲击地压现象,研究弹性区煤岩加速蠕变对巷道冲击的影响。基于等时应力应变曲线与全应力应变曲线的关系,得到了煤岩加速蠕变破坏的时效力学参数。通过分析巷道弹性区煤岩加速蠕变过程及其条件,并考虑围岩塑性区强... 详细信息

针对高静载巷道蠕变型冲击地压现象,研究弹性区煤岩加速蠕变对巷道冲击的影响。基于等时应力应变曲线与全应力应变曲线的关系,得到了煤岩加速蠕变破坏的时效力学参数。通过分析巷道弹性区煤岩加速蠕变过程及其条件,并考虑围岩塑性区强度的应变软化,推导出圆形巷道围岩蠕变塑性区应力场。在此基础上,借鉴冲击地压扰动响应判别准则理论的思想,探讨了巷道围岩加速蠕变影响下的冲击启动机制,给出了冲击启动临界条件的解析解,分析了支护力和等时应力-应变曲线的割线模量比Mt对冲击临界条件的影响。结果表明:高地应力、初次支护的低支护力和煤的低单轴长期强度为巷道弹性区煤岩产生加速蠕变提供了有利条件,加速蠕变导致冲击启动通过弹性区煤岩强度的时效劣化实现;巷道所处地应力越高,弹性区煤岩只需历经较小的强度劣化,就可冲击启动;加速蠕变影响下,增大支护力对抑制冲击发生有促进作用,表现在支护力越高,弹性区煤岩需历经较大的强度劣化才可冲击启动,且启动时围岩内峰值应力较低、塑性区阻抗较大;煤岩单轴压缩峰后与峰前模量比(λ/E0)是巷道弹性区煤岩产生加速蠕变的非影响因素,但其是巷道冲击启动的重要影响因素,即巷道弹性区煤岩产生加速蠕变的临界地应力判据与模量比无关,模量比越小弹性区煤岩需历经更大程度的强度劣化才可冲击启动;抑制巷道蠕变冲击的核心在于控制弹性区煤岩不满足产生加速蠕变的条件。

关键词：蠕变冲击加速蠕变时效强度塑性区启动条件

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回收碳纤维混凝土导电性

复合材料学报 2022年第6期39卷 2855-2863页

作者：王艳张彤昕郭冰冰牛荻涛西安建筑科技大学材料科学与工程学院西安710055 西安建筑科技大学土木工程学院西安710055 西安建筑科技大学省部共建西部绿色建筑国家重点实验室西安710055

碳纤维增强树脂复合材料从生产、服役到退役的整个生命周期都会产生巨量废弃物,带来了严重的环境污染与资源浪费问题。本文将生产过程中产生的废弃碳纤维掺加到混凝土中,研究其对混凝土强度及导电性的影响规律与机制。结果表明,回收碳... 详细信息

碳纤维增强树脂复合材料从生产、服役到退役的整个生命周期都会产生巨量废弃物,带来了严重的环境污染与资源浪费问题。本文将生产过程中产生的废弃碳纤维掺加到混凝土中,研究其对混凝土强度及导电性的影响规律与机制。结果表明,回收碳纤维对混凝土强度改善效果不明显,这是由于工业碳纤维表面的涂层使其在混凝土拌合过程中更易聚集成束,不易分散。回收碳纤维的掺入可明显提升混凝土导电性,掺量为0wt%~0.3wt%时,干燥/吸水过程改变混凝土孔结构且C−S−H凝胶重新排列、局部收缩与部分不可逆特性使混凝土产生新的导电路径,电阻率随含水率降低呈现先升后降的趋势;掺量为0.4wt%~1.5wt%时,混凝土内部形成了稳定的物理接触导电网络,龄期及含水率对导电率无明显影响。

关键词：回收碳纤维纤维增强混凝土导电性纤维掺量含水率

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整流罩用隔热材料的研制

宇航材料工艺 2006年第Z1期36卷 28-30页

作者：郭扬郭冰冰张巍北京航空材料研究院北京100095 中国中元兴华工程公司北京100089

以改性有机硅树脂基体和无纺纤维毡为原料,经喷涂定型工艺制备了低密度阻燃隔热材料。材料密度和热导率分别为0.27~0.36 g/cm3和0.032~0.036 W/(m.K)。测试分析了基体拉伸强度以及材料密度和厚度对隔热效果的影响。结果表明,隔热性能可... 详细信息

以改性有机硅树脂基体和无纺纤维毡为原料,经喷涂定型工艺制备了低密度阻燃隔热材料。材料密度和热导率分别为0.27~0.36 g/cm3和0.032~0.036 W/(m.K)。测试分析了基体拉伸强度以及材料密度和厚度对隔热效果的影响。结果表明,隔热性能可满足直升机发动机整流罩的热防护要求。

关键词：有机硅热防护发动机整流罩

无锡市部分城区学龄前儿童乳牙龋齿与肥胖相关性调查研究

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实用口腔医学杂志 2017年第4期33卷 561-563页

作者：刘静郭冰冰无锡市妇幼保健院儿童口腔保健科 214000

根据国外文献数据估样,随机选取无锡市部分城区1 263例3~6岁在校学龄前儿童进行龋齿与肥胖之间关系的调查研究。超重儿童191人,肥胖儿童104人,体重正常968人,分别检查患龋情况。经SPSS分析,儿童年龄越大患龋程度越高(F=31.77,P=0.000 1)... 详细信息

根据国外文献数据估样,随机选取无锡市部分城区1 263例3~6岁在校学龄前儿童进行龋齿与肥胖之间关系的调查研究。超重儿童191人,肥胖儿童104人,体重正常968人,分别检查患龋情况。经SPSS分析,儿童年龄越大患龋程度越高(F=31.77,P=0.000 1);儿童体重状态与年龄无相关性(χ~2=36.00,P=0.33);学龄前儿童乳牙患龋与体重状态无相关性(F=0.21,P=0.808)。认为,肥胖并非是学龄前儿童乳牙龋齿的易感因素。

关键词：学龄前儿童乳牙龋齿肥胖