Fucoxanthin improves serum lipids,liver metabolism and gut microbiota in hyperlipidemia mice

作     者：Yonghui Zhou Jingyi Zhang Kun Xu Weihao Zhang Feng Chen Bin Liu Bingbing Guo 

作者机构：Faculty of Environment and LifeBeijing University&TechnologyBeijing 100124China Shenzhen Key Laboratory of Marine Microbiome EngineeringInstitute for Carbon NeutralityInstitute for Advanced StudyShenzhen UniversityShenzhen 518060China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康(英文))

年 卷 期：2025年第14卷第1期

页      面：236-249页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(31901624) the Key-Area Research and Development Program of Guangdong Province(2018B020206001) Guangdong Province Zhujiang Talent Program(2019ZT08H476) Shenzhen Science and Technology Program(KQTD20180412181334790) the Innovation Team Project of Universities in Guangdong Province(2020KCXTD023) 

主　　题：Fucoxanthin Lipids Hyperlipidemia Liver metabolism Gut microbiota 

摘      要：Fucoxanthin,a kind of exclusively algae-derived carotenoids,could reduce lipid content and regulate gut microbiota composition in obese mice,showing potential in preventing *** study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice,as well as investigate the underlying association with gut microbiota *** showed that fucoxanthin significantly reduced body weight gain and body white fat of the *** the serum,total triglycerides(TG),total cholesterol(TC)contents were significantly decreased and high-densitylipoprotein cholesterol levels was significantly ***,fucoxanthin remarkedly prevented lipid accumulation in the ***,metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control,indicating the advance of hepatic lipid *** acids profile in the liver was also greatly changed by ***,fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio,Blautia and Clostridia ***,correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum ***,this study showed great potential of fucoxanthin in improving serum lipids profile,hepatic lipids and bile acids metabolism of hyperlipidemia mice,which was associated with gut microbiota alteration.