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Excited State Properties of fucoxanthin Aggregates

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Chemical Research in Chinese Universities 2019年第4期35卷 627-635页

作者： ZUO Jialing TAN Liming XU Yi MA Yingchao DONG Jia WANG Peng ZHANG Jianping Department of Chemistry Renmin University of China Beijing 100872 P. R. China

The structure and excited state properties of the H- and J-aggregates of the marine carbonyl carotenoid, fucoxanthin(Fx), were studied by various spectroscopic methods, and compared with those of Fx monomers in polar organic solvents. The fluorescent analysis indicated tliat the higher vibronic states of S2 contribute more to populating the S1 state, from which fluorescent emission mainly originates. Resonance Raman and density functional theory calculations confirmed the ‘card-packed' and chead-to-taiF structures of the H- and J-aggregates of Fx, respectively. An fs time-resolved absorption study proved the coexistence of Si and intramolecular charge transfer relaxation pathways upon excitation to the S2 state for both tlie monomers and aggregates.

关键词： fucoxanthin aggregate Resonance Raman fs Time-resolved absorption Excited state property Singlet fission

fucoxanthin Isolated from Undaria pinnatifida Can Interact with Escherichia coli and lactobacilli in the Intestine and Inhibit the Growth of Pathogenic Bacteria

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Journal of Ocean University of China 2019年第4期18卷 926-932页

作者： LIU Zonglin SUN Xiaowen SUN Xun WANG Shuhui XU Ying College of Food Science and Engineering Ocean University of China Qingdao 266003 China Qingdao Municipal Center for Disease Control & Prevention Qingdao 266033 China

fucoxanthin is a xanthophyll-type carotenoid that provides many benefits to human health. However, the mechanism by which fucoxanthin interacts with microbes and inhibits pathogenic bacteria is unknown. In this study, we investigated the effects of fucoxanthin isolated from the edible seaweed Undaria pinnatifida on pathogenic bacteria Escherichia coli and lactobacilli both in vitro and in vivo. fucoxanthin strongly inhibited the growth of Gram-positive pathogenic bacteria but was less effective against Gram-negative bacteria. fucoxanthin extracted from the crude mixture had a recovery rate of 93.38% and a purity of 82.70%, which were higher than those of fucoxanthin extracted using a previous method. fucoxanthin also promoted the growth of intestinal mi- crobes in mice. fucoxanthinol, a metabolite of fucoxanthin, was generated in the culture media. fucoxanthin can be deacetylated into fucoxanthinol not only by conventional digestive enzymes in the digestive tract, but also by E. coli and lactobacilli in the intestine. These results indicate that fucoxanthin interacts with and influences E. coli and lactobacilli in the intestine. Therefore, fucoxanthin isolated from Undaria pinnatifida possibly can be applied in human health maintenance.

关键词： fucoxanthin Undaria pinnatifida pathogenic bacteria antibacterial

fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling

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Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 207-215页

作者： Peramaiyan Rajendran Abdullah M AlZahrani Department of Biological Sciences College of ScienceKing Faisal UniversityAl Ahsa 31982Saudi Arabia

Objective:To explore the impact of fucoxanthin on oxidized low-density lipoprotein(OxLDL)-induced stress and inflammation in human endothelial cells and its underlying ***:HUVECs were treated with OxLDL and/or fucoxanthin for a range of time points and *** evaluated the effects of fucoxanthin on OxLDL-induced HUVECs using the MTT assay,reactive oxygen species accumulation assay,ELISA,RT-PCR,immunofluorescence,and Western ***:fucoxanthin enhanced the cell viability in a dose dependent manner after OxLDL ***,fucoxanthin pretreatment significantly decreased OxLDL-induced reactive oxygen species production and prevented the activation of the nuclear factor kappa-B pathway,which led to substantial suppression of pro-inflammatory gene ***-induced upregulation of interleukin-6,intercellular adhesion molecule-1,vascular cell adhesion molecule-1,interleukin-1β,monocyte chemotactic protein-1,cyclooxygenase-1,and tumor necrosis factor-αwas significantly reduced by ***:fucoxanthin can inhibit OxLDL-induced vascular inflammation and oxidative stress in HUVECs by targeting Nrf2 signaling pathways.

关键词： Oxidized low-density lipoprotein fucoxanthin Atherosclerosis Inflammation Oxidative stress Cell viability HUVEC Nrf2 signaling pathway NF-κB

Inhibitory activities of microalgal fucoxanthin againstα-amylase,α-glucosidase, and glucose oxidase in 3T3-L1cells linked to type 2 diabetes

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Journal of Oceanology and Limnology 2019年第3期37卷 928-937页

作者： KAWEE-AI Arthitaya KIM Aaron Taehwan KIM Sang Moo Department of Marine Food Science and Technology Gangneung-Wonju National UniversityGangneung 25457Republic of Korea Department of Biotechnology Chiang Mai UniversityChiang Mai 50200Thailand Department of Food Science and Biotechnology Kyung Hee UniversityYongin 17104Republic of Korea

Postprandial hyperglycemia is an early indication of type 2 diabetes and the target of many anti-diabetic and anti-obesity studies.α-Glucosidase and α-amylase are the crucial factors in regulating starch digestion and glucose absorption,making them key targets for many studies to treat postprandial *** studied the inhibitory activities of microalgal fucoxanthin against rat-intestinalα-glucosidase and pancreaticα-amylase along with the antidiabetic eff ect to induce diff erentiation in 3T3-L1 pre-adipocytes using Oil Red-O *** displayed strong hindrance activities towardα-amylase in a concentration-dependent manner,with an IC50 value of 0.68mmol/L,whereas weak inhibitory activity against α-glucosidase,with an IC 50 value of 4.75 mmol/*** also considerably elevated glucose oxidase activity in 3T3-L1 cells by 31.3%at 5μmol/*** adipocyte differentiation,fucoxanthin showed lipid accumulation in 3T3-L1 cells with no cytotoxicity up to 20μmol/***,fucoxanthin had no inhibitory activity on glucose-6-phosphate *** results suggest that fucoxanthin might be useful for the prevention of obesity or diabetes by inhibiting carbohydrate-hydrolyzing enzymes and lipid accumulation and be utilized as an ingredient for a functional food or dietary supplement.

关键词： α-glucosidase amylase diabetes fucoxanthin glucose oxidase microalgae

Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core

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Frontiers of Materials Science 2017年第1期11卷 66-74页

作者： Xuanxuan WANG Hongyan LI Fangqin WANG Guixue XIA Hongjun LIU Xiaojie CHENG Ming KONG Ya LIU Chao FENG Xiguang CHEN Ying WANG College of Marine Life Science Ocean University of China 5# Yushan Road Qingdao 266003 China Aquatic Product Processing & Quality Control Research Centre Marine Biology Institute of Shandong Province 7# Youyun Road Qingdao 266002 China Laboratory for Marine Drug and Bioproduct Qingdao National Laboratory for Marine Science and Technology 1# Wenhai Road Qingdao 266200 China

The objective of this study was to isolate fucoxanthin from Sargassum thunbergii and develop microcapsules with palm stearin as the solid lipid core for stability and efficient oral delivery of fucoxanthin. The microcapsules had smooth surfaces with the volume weighted mean diameter （d4.3） of 19.19 μm. Encapsulation efficiency and loading capacity of microcapsules with fucoxanthin were 98.3% and 0.04%, respectively. Moreover, the fucoxanthin in microcapsules presented higher stability than free fucoxanthin against light, humidity and temperature. Especially, the retention rates of fucoxanthin encapsulated in microcapsules reached 97.20% at 4℃, 92.60% at 25℃, 92.32% with the relative humidity of 33% and 92.60% in the dark. The cumulative amount of fucoxanthin released from microcapsules was 22.92% in simulated gastric fluid （SGF） and 56.55% in simulated intestinal fluid （SIF）.

关键词： fucoxanthin Sargassum thunbergii microcapsules palm stearin solidlipid core

Multi-omics Analyses Provide Insight into the Biosynthesis Pathways of fucoxanthin in Isochrysis galbana

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1138-1153页

作者： Duo Chen Xue Yuan Xuehai Zheng Jingping Fang Gang Lin Rongmao Li Jiannan Chen Wenjin He Zhen Huang Wenfang Fan Limin Liang Chentao Lin Jinmao Zhu Youqiang Chen Ting Xue The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Products of the State Oceanic Administration Center of Engineering Technology Research for Microalga Germplasm Improvement of FujianFujian Key Laboratory of Special Marine Bioresource Sustainable UtilizationFujian Key Laboratory of Developmental and Neural BiologySouthern Institute of OceanographyCollege of Life SciencesFujian Normal UniversityFuzhou 350117China Fujian Fishery Resources Monitoring Center Fuzhou 350003China

Isochrysis galbana is considered an ideal bait for functional foods and nutraceuticals of humans because of its high fucoxanthin(Fx)***,multi-omics analysis of the regulatory networks for Fx biosynthesis in *** has not been *** this study,we report a high-quality genome assembly of *** LG007,which has a genome size of 92.73 Mb,with a contig N50 of 6.99 Mb and 14,900 protein-coding *** analysis confirmed the monophyly of Haptophyta,with *** sister to Emiliania huxleyi and Chrysochromulina *** analysis revealed an estimated divergence time between *** and *** of~133 million years *** family analysis indicated that lipid metabolism-related genes exhibited significant expansion,including IgPLMT,IgOAR1,and *** analysis showed that the content of carotenoids in *** cultured under green light for 7 days was higher than that under white light,andβ-carotene was the main carotenoid,accounting for 79.09%of the total *** multi-omics analysis revealed that the content ofβ-carotene,antheraxanthin,zeaxanthin,and Fx was increased by green light induction,which was significantly correlated with the expression of IgMYB98,IgZDS,IgPDS,IgLHCX2,IgZEP,IgLCYb,and *** findings contribute to the understanding of Fx biosynthesis and its regulation,providing a valuable reference for food and pharmaceutical applications.

关键词： Isochrysis galbana fucoxanthin Whole-genome duplication Metabolome Transcriptome

A comparative analysis of fatty acid composition and fucoxanthin content in six Phaeodactylum tricornutum strains from diff erent origins

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Chinese Journal of Oceanology and Limnology 2016年第2期34卷 391-398页

作者：吴华莲李涛王广华戴世鲲何慧向文洲 Key Laboratory of Tropical Marine Bio - Resources and Ecology Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences

Phaeodactylum tricornutum is a potential livestock for the combined production of eicosapentaenoic acid(EPA) and fucoxanthin. In this study, six marine diatom strains identified as P. tricornutum were cultured and their total lipid, fatty acid composition and major photosynthetic pigments determined. It was found that the cell dry weight concentration and mean growth rate ranged between 0.24–0.36 g/L and 0.31–0.33/d, respectively. Among the strains, SCSIO771 presented the highest total lipid content, followed by SCSIO828, and the prominent fatty acids in all strains were C16:0, C16:1, C18:1, and C20:5(EPA). Polyunsaturated fatty acids, including C16:2, C18:2, and EPA, comprised a significant proportion of the total fatty acids. EPA was markedly high in all strains, with the highest in SCSIO828 at 25.65% of total fatty acids. fucoxanthin was the most abundant pigment in all strains, with the highest in SCSIO828 as well, at 5.50 mg/g. The collective results suggested that strain SCSIO828 could be considered a good candidate for the concurrent production of EPA and fucoxanthin.

关键词： Phaeodactylum tricornutum fatty acid composition polyunsaturated fatty acids eicosapentaenoic acid fucoxanthin

Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model

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Food Science and Human Wellness 2023年第5期12卷 1693-1700页

作者： Vijayan Raji Chitra Loganathan Thiyagarajan Ramesh Palvannan Thayumanavan Department of Biochemistry Periyar UniversitySalemTamil Nadu 636011India Department of Basic Medical Sciences College of MedicinePrince Sattam Bin Abdulaziz UniversityAl-Kharj 11942Kingdom of Saudi Arabia

In a previous study from our laboratory, fucoxanthin purified from brown algae, Sargassum wightii Greville has found to exhibit antioxidant activity and inhibition of angiotensin-I-converting enzyme(ACE)in vitro. The present study aims in understanding the protective effect of fucoxanthin purified from S. wightii against diabetes with hypertension in in vivo. Diabetes and hypertension were induced in rat by streptozotocin and sodium chloride treatment, respectively. In diabetes with hypertension rat, the blood pressure was increased along with hyperglycemia. Administration of fucoxanthin significantly reduced the blood pressure and ACE activity in diabetes with hypertension rat. Furthermore, administration of fucoxanthin significantly reduced the hyperglycemic state. The activity of various enzymes in the liver(hexokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1,6-phosphatase)and serum(creatine kinase)were normalized to that of control level. The level of glycogen, glycoprotein component and lipid profile were equivalent to control level by fucoxanthin administration in diabetes with hypertension rats. fucoxanthin ameliorated the oxidative stress by preserving the endogenous antioxidant levels in diabetes with hypertension rats. Also, the pancreatic histological integrity was similar to that of control level in diabetes with hypertension rats by fucoxanthin treatment. Altogether, fucoxanthin showed dual antidiabetic and antihypertensive activity in vivo.

关键词： fucoxanthin Diabetes Hypertension Oxidative stress Angiotensin-I-converting enzyme

Cultivation of Anabena variabilis,Synechococcus elongatus,Spirulina platensis for the production of C-Phycocyanin,C-Phycoerythrin and Thalassiosira,Skeletonema,Chaetoceros for fucoxanthin

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Systems Microbiology and Biomanufacturing 2021年第3期1卷 356-361页

作者： Bharti Mishra Archana Tiwari Diatom Research Laboratory Amity Institute of BiotechnologyAmity UniversityNoidaUttar Pradesh201313India

The pigments are vital parts of photosynthetic machinery in algae and exhibit a myriad of applications as nutraceuticals,cosmetics,colorants,which find huge applications in many industires,including the paint industry and paper *** antimicrobial,antioxidative,anti-inflammatory,and anti-cancer potential of microalgal pigments contribute towards their varied industrial *** this study,pigments(fucoxanthin,C-phycocyanin,and C-phycoerythrin),extracted from microalgae were investigated to check the antimicrobial efficacy using agar well diffusion and disc diffusion methods against pathogenic bacteria:Staphylococcus aureus and Escherichia *** fucoxanthin pigment isolated from diatom Thalassiosira *** the highest antibacterial activity against Staphylococcus aureus(17±1.53 mm)and in contrast fucoxanthin pigment isolated from Chaetoceroes *** the highest bactericidal activity against Escherichia coli(18±1).The pigment extract of Spirulina plantesis showed the highest antibacterial activity against ***(41±0.3)and *** also exhibited high antibacterial activity against ***(32±0.5)while Anabaena variabilis showed the highest antibacterial activity against Staphylococcus aureus(34±0.5).The potential of microalgal pigments is highly valuable and further extensive studies can elaborate the underlying mechanisms.

关键词： Antimicrobial efficacy fucoxanthin Microalgae Phycocyanin Phycoerythrin