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Science China(l.fe Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-jun Zhang Zi-bing Jin Beijing Institute of Ophthal.ol.gy Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pl.ripotent stem cel.s(iPSCs)has revol.tionized the fiel. of disease research,providing a promising pl.tform for studying various *** the l.st decade,significant progress has been made in combining iPSCs with other cutting-edge technol.gies to investigate disease mechanisms and devel.p potential.treatments.

关键词： conditions patients retinitis

Catal.tical.y generated noncoval.nt ammonium dienol.te:a versatil. pl.tform for the devel.pment of organocatal.tic asymmetric cascade reactions

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Science China Chemistry 2024年第8期67卷 2524-2546页

作者： jun-bing l.n Dong-Sheng Ji Peng-Fei Xu State Key l.boratory of Appl.ed Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China Shaanxi Key l.boratory of Chemical.Reaction Engineering College of Chemistry and Chemical EngineeringYan’an UniversityYan’an 716000China

Organocatal.tic cascade reactions represent a powerful.strategy for the rapid construction of compl.x chiral.mol.cul.s with mul.ipl. stereocenters from simpl. substrates under mil. conditions. The intriguing structural.feature and diverse reactivity of catal.tical.y generated dienol.te species render them competent and versatil. intermediates for the devel.pment of practical.and val.abl. cascade reactions. Over the past years, a pl.thora of innovative and pioneering noncoval.nt ammonium dienol.temediated cascade reactions have been designed and impl.mented under the catal.sis of chiral.organocatal.sts, making dienol.te activation a general. robust, and compl.mentary method for the functional.zation of unsaturated carbonyl.compounds and rel.ted substances. This review il.ustrates the recent advances in organocatal.tic noncoval.nt ammonium dienol.te-mediated cascade reactions(mainl. from 2010 to 2023), incl.ding the cascade transformations of ammonium dienol.tes directl. generated from unsaturated ketone/al.ehyde, ester/l.ctone/azl.ctone, amide/l.ctam/pyrazol.ne/oxindol., and al.yl.dene nitril. compounds. The contents are arranged based on the reaction types of the ammonium dienol.tes, with an emphasis on cascade 2,5-, 3,5-, and 4,5-difunctional.zations of these intermediates. Furthermore, other cascade reactions invol.ing the 1,3-, 2,3-, and even more compl.x 3,4,5-reactivities of ammonium dienol.tes were al.o discussed. The reaction pathway, reaction stereoinduction, and synthetic appl.cations of the ammonium dienol.te-mediated cascade reactions were highl.ghted throughout the articl.. As a stimul.ting and ever-growing research area, the organocatal.tic noncoval.nt ammonium dienol.te-mediated cascade reactions are expected to continue demonstrating their magic power for constructing chiral.targets in the future and further expanding the boundaries of asymmetric catal.sis.

关键词： organocatal.sis asymmetric catal.sis ammonium dienol.te cascade reaction difunctional.zation

Microbiome changes in esophageal.cancer:impl.cations for pathogenesis and prognosis

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Cancer Biol.gy & Medicine 2024年第2期21卷 163-174页

作者： Yi l. bing Wei Xia Xue Hongl. l. jun l. Department of Mol.cul.r Pathol.gy Clinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan Key l.boratory of Mol.cul.r Pathol.gy Zhengzhou 450003China Henan Key l.boratory of Hel.cobacter pyl.ri&Microbiota and Gastrointestinal.Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Esophageal.cancer(EC)is an aggressive mal.gnancy with a poor *** factors,incl.ding dietary habits,and antacid and antibiotic use,have been shown to infl.ence the esophageal.***,enrichment and diversity of the esophageal.microbiome can al.o impact its *** studies have reveal.d preval.nt changes in the esophageal.microbiome among patients with EC,thus suggesting the potential.contribution of the esophageal.microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the rol. of the esophageal.microbiome in modul.ting treatment *** this review,we have examined previous studies on the esophageal.microbiome in heal.hy individual. and patients with EC or other esophageal.diseases,with a focus on identifying microbial.communities associated with EC pathogenesis and *** the rol. of the microbiome in EC may aid in earl. detection and optimized treatment strategies,ul.imatel. l.ading to better outcomes for patients.

关键词： Esophageal.cancer microbiome dysbiosis microenvironment carcinogenesis

Incl.sions modification by rare earth in steel.and the resul.ing properties: A review

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Journal.of Rare Earths 2024年第3期42卷 431-445,I0001页

作者： Xiaoqiang Wang Zhiwei Wu bing l. Wenxiong Chen jun Zhang Jian Mao Col.ege of Material. Science and Engineering Sichuan UniversityChengdu610065China Chengdu Advanced Metal.Material. Industry Technol.gy Research Institute Co. Ltd.Chengdu610303China State Key l.boratory of Metal.Material.for Marine Equipment and Appl.cation Anshan114009China

Rare earth(RE) el.ments are excel.ent modifiers for non-metal.ic incl.sions that inevitabl. appear in steel.and affect steel.properties. This paper reviews the research status of incl.sions modification by RE el.ments and the changes it cause on steel.properties. First, the incl.sion changes caused by RE modification are described. General.y, after adding pure RE, the main evol.tion of incl.sions occurs as M →M + RE-Al.O → RE-Al.O + RE_(2)O_(2)S → RE_(2)O_(2)S + RE—S/RE_(2)O_(2)S + RE-O with an increase in the RE content(M represents the incl.sions before RE addition). The type of final.incl.sion obtained after RE modification is rel.ted to the rel.tive contents of S and O in the steel. Moreover, fine, regul.r, and uniforml. distributed incl.sions can be obtained with appropriate RE addition. However, the effectiveness of incl.sions modification by adding both RE and non-RE el.ments is cl.sel. rel.ted to the order of their addition. Second, the appl.cations and advantages of thermodynamic cal.ul.tions in the study of RE-modified incl.sions are introduced. Third, the changes in the corrosion resistance, impact properties,and other properties of steel.caused by the modification of incl.sions by RE are reviewed. Final.y, the perspectives and trends of incl.sions modified by RE el.ments in the steel.industry are presented.

关键词： Rare earths Incl.sions Modification Thermodynamic cal.ul.tion Properties change

Efficient degradation of aqueous dichl.romethane by an enhanced microbial.el.ctrol.sis cel.:Degradation kinetics,microbial.community and metabol.c mechanisms

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Journal.of Environmental.Sciences 2024年第5期139卷 150-159页

作者： Meng Wu Di Zhao bing Gu ZiruWang jun Hu Zhil.ang Yu Jianming Yu Col.ege of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.l.d. Hangzhou 311121China Zhejiang Tianyi Environmental.Co.l.d. Hangzhou 310000China

Dichl.romethane(DCM)has been l.sted as a toxic and harmful.water pol.utant,and its re moval.needs *** el.ctrol.sis cel.s(MECs)are viewed as a promising al.erna tive for pol.utant removal.which can be strengthened from two aspects:microbial.inocul. tion and *** this study,the MEC for DCM degradation was inocul.ted with the ac tive sl.dge enhanced by Methyl.bacterium rhodesianum H13(strain H13)and then accl.mated in the form of a microbial.fuel.cel.(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantl. promoted DCM *** degradation kinetics were fitted by the Hal.ane model.with V_(max),K_(h),K_(i)and v_(max)val.es of 103.2 mg/l.hr,97.8 mg/l.68.3 mg/l.and 44.7 mg/l.hr/cm^(2),*** cycl.c vol.ammogram impl.es that DCM redox reactions became easier with the setup of MEC,and the el.ctrochemical.impedance spectrogram shows that the accl.mated and enriched microbes reduced the charge transfe resistance from the el.ctrode to the *** the biofil.,the dominant genera shifted from Geobacter to Hyphomicrobium in accl.mation ***,Methyl.bacterium pl.yed an increasingl. important *** metabol.sm mainl. occurred through the hydrol.tic gl.tathione S-transferase pathway,given that the gene dcmA was identified rather than the dhl. and P450/*** exogenous el.ctrons facil.tated the reduction of GSSG,directl. o indirectl. accel.rating the GSH-catal.zed *** study provides support fo the construction of an efficient and stabl. MEC for DCM removal.in water environment.

关键词： Dichl.romethane Microbial.el.ctrol.sis cel.s Metabol.c pathways El.ctron transfer Degradation kinetics

Modul.rl. assembl.d mul.ipl.x prime editors for simul.aneous editing of agronomical.y important genes in rice

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Pl.nt Communications 2024年第2期5卷 67-78页

作者： Ajay Gupta Bo l.u Saad Raza Qi-jun Chen bing Yang Division of Pl.nt Science and Technol.gy Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA State Key l.boratory of Pl.nt Physiol.gy and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional.Genomics and Mol.cul.r Breeding China Agricultural UniversityBeijing 100193China Donal. Danforth Pl.nt Science Center St.LouisMO 63132USA

Prime editing(PE)technol.gy enabl.s precise al.erations in the genetic code of a genome of *** offers great potential.for identifying major agronomical.y important genes in pl.nts and editing them into superior variants,ideal.y targeting mul.ipl. l.ci simul.aneousl. to real.ze the col.ective effects of the ***,we report the devel.pment of a modul.r assembl.-based mul.ipl.x PE system in rice and demon-strate its efficacy in editing up to four genes in a singl. transformation *** dupl.x PE(DPE)system achieved a co-editing efficiency of 46.1%in the T0 generation,converting TFIIAg5 to xa5 and xa23 to *** resul.ing doubl.-mutant l.nes exhibited robust broad-spectrum resistance against mul.ipl. Xanthomonas oryzae pathovar oryzae(Xoo)strains in the T1 *** addition,we success-ful.y edited OsEPSPS1 to an herbicide-tol.rant variant and OsSWEET11a to a Xoo-resistant al.el.,achieving a co-editing rate of 57.14%.Furthermore,with the quadrupl. PE(QPE)system,we edited four genes—two for herbicide tol.rance(OsEPSPS1 and OsAl.1)and two for Xoo resistance(TFIIAg5 and OsSWEET11a)—using one construct,with a co-editing efficiency of 43.5%for al. four genes in the T0 *** performed mul.ipl.x PE usingfive more constructs,incl.ding two for tripl.x PE(TPE)and three for QPE,each targeting a different set of *** editing rates were dependent on the activity of pegRNA and/or *** instance,optimization of ngRNA increased the PE rates for one of the targets(OsSPl.3)from 0%to 30%but did not improve editing at another target(OsGS2).Overal.,our modul.r assembl.-based system yiel.ed high PE rates and streaml.ned the cl.ning of PE reagents,making it feasibl. for more l.bs to util.ze PE for their editing *** have significant impl.cations for advancing gene editing techniques in pl.nts and may pave the way for future agricul.ural.appl.cations.

关键词： prime editing rice bacterial.bl.ght herbicide tol.rance mul.ipl.x genome editing

Diagenetic evol.tion and reservoir qual.ty of the Ol.gocene sandstones in the Baiyun Sag, Pearl.River Mouth Basin, South China Sea

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Acta Oceanol.gica Sinica 2024年第2期43卷 67-82页

作者： bing Tian Shanshan Zuo Youwei Zheng Jie Zhang Jiayu Du jun Tang Institute of Mining and Coal Inner Mongolia University of Science and TechnologyBaotou 014010China Institute of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

The Ol.gocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China *** effective appraisal. expl.ration and expl.itation of such a deep-water hydrocarbon sandstone, sampl.s of five wel.s from depths of 850 m to 3 000 m were studied. A series of comprehensive petrographic and geochemical.anal.ses were performed to unravel.the diagenetic features and their impact on the reservoir ***, the sandstones are dominated by fel.spathic l.tharenites and l.thic arenites with fine to medium grain sizes and moderate to good sorting. The reservoir qual.ty varies greatl. with a range of porosity from 0.2% to 36.1% and permeabil.ty from 0.016 ×10~(–3) μm~2 to 4 301 ×10~(–3) μm~2, which is attributed to compl.x diagenetic evol.tion rel.ted to sedimentary facies;these incl.de compaction, cementation of cal.ite, dol.mite, siderite and framboidal.pyrite in eogenetic stage;further compaction, fel.spar dissol.tion, precipitation of ferrocal.ite and ankerite, quartz cements, formation of kaol.nite and its il.itization, precipitation of al.ite and nodul.r pyrite, as wel. as hydrocarbon charge in mesogenetic stage. The dissol.tion of fel.spar and il.itization of kaol.nite provide internal.sources for the precipitation of quartz cement, whil. carbonate cements are derived from external.sources rel.ted to interbedded mudstones and deep fl.id. Compaction is the predominant factor in reducing the total.porosity, fol.owed by carbonate cementation that l.ads to strong heterogeneity. Fel.spar dissol.tion and concomitant quartz and cl.y cementation barel. changes the porosity but significantl. reduces the *** high-qual.ty reservoirs can be concl.ded as medium-grained sandstones l.ing in the central.parts of thick underwater distributary channel.sandbodies(>2 m) with a high content of detrital.quartz but l.w cement.

关键词： Baiyun Sag Ol.gocene Zhuhai Formation diagenesis reservoir qual.ty

Ferritinophagy: A new idea for l.ver diseases regul.ted by ferroptosis

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Hepatobil.ary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-bing Qian jun-Feng l. Wan-Yuan Xiong Xiao-Rong Mao The First Cl.nical.Medical.Col.ege of l.nzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regul.tory cel. death has l.d to a breakthrough in the therapeutic *** forms of cel. death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,pl.y an important rol. in the devel.pment of l.ver *** general.more than one form of cel. death pathways is responsibl. for the disease ***,it is particul.rl. important to study the regul.tion and interaction of various cel. death forms in l.ver *** sources:We performed a PubMed search up to November 2022 with the fol.owing keywords:ferritinophagy,ferroptosis,and l.ver *** al.o used terms such as signal.path,inducer,and inhibitor to suppl.ment the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regul.tion of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different l.ver ***:Ferritinophagy is a potential.therapeutic target in ferroptosis-rel.ted l.ver diseases.

关键词： Ferritinophagy Ferroptosis l.ver disease

Eval.ating combined bevacizumab and XEl.X in advanced col.rectal.cancer: Serum markers carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199 anal.sis

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Worl. Journal.of Cl.nical.Cases 2024年第1期12卷 15-23页

作者： Dong-bing Zhou jun Cheng Xiong-Hui Zhang Department of Gastroenterol.gy The Second People's Hospital of Jingzhou HubeiJingzhou 434000Hubei ProvinceChina Department of Gastrointestinal.Surgery Qianjiang Central HospitalQianjing 433100Hubei ProvinceChina Department of Gastroenterol.gy Xiantao First People's Hosepital Affiliated to Yangtze UniversityXiantao 433000Hubei ProvinceChina

BACKGROUND Col.rectal.cancer ranks third and second among common and fatal.*** treatment of metastatic col.rectal.cancer(mCRC)is general.y based on XEl.X in cl.nical.practice,which incl.des capecitabine(CAP)and *** tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and CA199 are prognostic factors for various *** To investigate eval.ating combined bevacizumab(BEV)and XEl.X in advanced col.rectal.cancer:Serum markers CEA,CA125,CA199 *** In this retrospective study,a total.of 94 el.erl. patients diagnosed with mCRC were recruited and subsequentl. categorized into two groups based on the distinct treatment modal.ties they *** control.group was treated with XEl.X pl.s CAP(n=47),whil. the observation group was treated with XEl.X pl.s CAP and BEV(n=47).Several.indexes were assessed in both groups,incl.ding disease control.rate(DCR),incidence of adverse effects,serum marker l.vel.(CEA,CA125,and CA19)and progression-free survival.PFS).RESUl.S After 9 wk of treatment,the serum l.vel. of CEA,CA199 and CA125 in the observation group were significantl. l.wer than those in the control.group(Pl. l.nger than that of the control.group(6.49±0.64 mo).Meanwhil.,there was no statistical.y significant difference in the incidence of adverse reactions and DCR between the two groups during maintenance therapy(P>0.05).CONCl.SION On the basis of XEl.X treatment,the combination of BEV and CAP can reduce serum tumor marker l.vel. and prol.ng PFS in patients with mCRC.

关键词： Metastatic col.rectal.cancer Bevacizumab Capecitabine XEl.X Tumor markers

Microstructural.characterization and mechanical.properties of(TiC+TiB)/TA15 composites prepared by an in-situ synthesis method

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China Foundry 2024年第2期21卷 168-174页

作者： Zhi-yong Zhang Jiao-jiao Cheng Jia-qi Xie Shi-bing l.u Kun Shi jun Zhao Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National.Key l.boratory of Advanced Casting Technol.gies Shenyang 110022China

Titanium matrix composites reinforced with ceramic particl.s are considered a promising engineering material.due to their combination of high specific strength,l.w density,and high *** this study,the TA15-based composites reinforced with a vol.me fraction of 10% to 25%(TiB+TiC)were prepared using powder metal.urgy and casting *** characterization and phase constitution were examined using optical.microscopy(OM),scanning el.ctron microscopy(SEM),and X-ray diffraction(XRD).In addition,the microhardness,room temperature(RT)and high temperature(HT)tensil. properties of the composites were *** reveal.d that the reinforcements are distributed uniforml. even in the composites with a high vol.me of TiB and ***,as the vol.me fraction exceeds 15%,TiB and TiC particl.s become coarsening and exhibit rod-l.ke and dendritic-l.ke *** increases gradual.y from 321.2 HV for the base al.oy to a maximum of 473.3 HV as the reinforcement increases to 25vol.%.Tensil. test resul.s indicate that a reinforcement vol.me fraction above 20% is beneficial.for enhancing tensil. strength and yiel. strength at high temperatures,but it has an adverse effect on room temperature ***,if the reinforcement vol.me fraction is bel.w 20%,it can improve high-temperature el.ngation when the temperature exceeds 600℃.

关键词： titanium matrix composites microstucture microhardness tensil. properties in-situ synthesis