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Immun. res.on.e to in.ctivated bacterial vector carryin. the recombin.n. K39 an.igen.of Leis.man.a in.an.um in.mice

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As.an.Pacific Journ.l of Tropical Biomedicin. 2024年第5期14卷 199-206页

作者： Lucelin. s.Araújo Brun. B.s.lva Eduarda n.F.n.s.n.os.Arn.ldo s.Bezerra s.muel s.Frota As.is.R.Mon.en.gro Eridan.O.P.T.Florean.Maurício Fvan.Tilburg Maria Izabel F.Guedes Laboratory of Biotechn.logy an. Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterin.ry Medicin. State University of CearáFortalezaBrazil

Objective:To evaluate the immun.logical res.on.e elicited by an.in.ctivated bacterial vector carryin. the K39 an.igen.of Leis.man.a in.an.um,an. a purified ***:Mice were s.bjected to the followin. treatmen.s.(1)Purified recombin.n. K39(rK39)protein.at a 20μg dos. with complete Freun.’s.adjuvan.;(2)In.ctivated Es.herichia coli(BL21 DE3)carryin. the K39 protein.at an.equivalen. total protein.con.en. of 200μg;(3)In.ctivated bacteria lackin. the K39 protein.(4)n.n.immun.zed con.rol *** mon.torin. was.*** groups.were challen.ed by in.raperiton.al in.ection.of 10^(7) Leis.man.a in.an.um *** euthan.s.a,the liver an. s.leen.were collected to an.lyze the levels.of Tn.,IFn.γ,IL-12,IL-4,an. ***:Mice immun.zed with purified rK39 or the in.ctivated bacterial vector carryin. the K39 an.igen.of Leis.man.a in.an.um s.owed a lon.-las.in. immun. res.on.e with high levels.of polyclon.l an.ibodies.s.ecifically recogn.zin. the recombin.n. *** IgG1 s.bclas. was.the predomin.n. immun.globulin.however,the in.uction.of IgG2a an. the profile of cytokin.s.produced were in.icative of the in.uction.of a mixed-type ***:The in.ctivated bacterial vector carryin. the K39 an.igen.as.well as.the purified an.igen.can.in.uce a lon.-las.in. immun. res.on.e in.immun.zed mice,predomin.n.ly favourin. a Th2 profile res.on.e.

关键词： Vis.eral leis.man.as.s K39 In.ctivated bacterial vector Vaccin. Immun. res.on.e Th1 Th2 Leis.man.a in.an.um

Polio eradication.s.rveillan.e in.s.i Lan.a,2019-2023

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As.an.Pacific Journ.l of Tropical Medicin. 2024年第6期17卷 268-272页

作者： M.A.Y.Fern.n.o n.s.Madaras.n.he C.Ran.an. n.Weeras.n.he D.C.U.D.Weligamage J.I.Abeyn.yake Departmen. of Medical Microbiology an. Immun.logy Faculty of MedicineUniversity of ColomboSri Lanka Departmen. of Virology Medical Research InstituteColombo 08Sri Lanka Medical Res.arch In.titute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory s.rveillan.e carried out from Jan.ary,2019 to May,2023 by the Polio Region.l Referen.e Laboratory,s.i ***:This.retros.ective s.udy an.lyzed all s.ool s.mples.received un.er the acute flaccid paralys.s.AFP)an. immun.deficien. vaccin.-derived poliovirus.VDPV)s.rveillan.e at Polio Region.l Referen.e Laboratory,s.i Lan.a from Jan.ary,2019 to May,*** res.lts.of the tes.in. methodologies.were extracted from the laboratory data s.s.em,i.e.,poliovirus.virus.is.lation.in.ra-typic differen.iation.VDPV real time revers. tran.criptas. polymeras. chain.reaction.ITD/VDPV rRTPCR)an. s.quen.in.,alon. with the data on.timin. of reportin. res.lts.s.ool adequacy an. *** was.an.lyzed us.n. des.riptive ***:A total of 2141 s.ool s.mples.from 1644 cas.s.were received for AFP s.rveillan.e from s.i Lan.a(93.61%),Maldives.1.52%),an. immun.deficien. VDPV(4.86%)*** poliovirus.s.19/1644,1.15%)an. n.n.polio en.erovirus.s.73/1644,4.44%)were is.lated,while s.bin.like 3 virus.was.detected in.majority(12/19,63.15%)amon. the poliovirus.*** poliovirus.s.or circulatin. VDPVs.were n.t detected amon. the *** all years.of the s.udy,the n.n.polio AFP detection.rate was.1/100000 in.children.aged les. than.15 years.whereas.s.ool adequacy rate was.80%.All res.lts.were reported within.14 days.of receipt,en.urin. timely reportin. as.per global ***:The Polio Region.l Referen.e Laboratory,s.i Lan.a plays.a vital role in.main.ain.n. the polio-free s.atus.in.the coun.ry through its.robus. laboratory s.rveillan.e,while adherin. to the s.rveillan.e ***-detection.of wild poliovirus.s.an. circulatin. VDPV durin. the s.udy period rein.orces.the polio-free s.atus.in.the coun.ry.

关键词： Poliovirus Polio laboratory s.rveillan.e Region.l referen.e laboratory Polio eradication

Weather in.luen.ed n.s.lin. growth of an.in.ectivorous.but n.t a gran.vorous.gras.lan. pas.erin. in.Argen.in.

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Avian.Res.arch 2024年第2期15卷 156-162页

作者： Martín.Alejan.ro Colombo Adrian.Jauregui Lucian. n.s.gura Laboratorio de Ecología de Aves.In.titute“Dr.Raúl A.Rin.uelet”(ILPLA)-Un.P/COn.CET Boulevard 1201437La PlataB1900Buenos AiresArgentina

n.s.lin. growth of birds.can.be affected by weather *** gen.ral,it is.expected that higher temper-atures.favor growth by improvin. food availability an. n.s.lin. metabolis.,while rain.hin.ers.it by reducin. foragin. ***,mos. of thes. pattern. have been.des.ribed in.in.ectivorous.cavity-n.s.in. birds.in.temperate *** tes.ed thes. prediction. in.two n.otropical gras.lan. groun.-n.s.in. birds.with con.ras.in. n.s.lin. diets.an. therefore poten.ially differen. res.on.es.to *** meas.red n.s.lin.s.of the Hellmayr’s.Pipit(An.hus.hellmayri,an.in.ectivorous.pas.erin.)an. the Gras.lan. Yellow-Fin.h(s.calis.luteola,which feeds.its.n.s.lin.s.exclus.vely with s.eds.durin. three breedin. s.as.n.(2017-2020)in.cen.ral-eas.ern.*** took meas.remen.s.of tars.s.an. body mas.,modeled growth curves.us.n. n.n.in.ar mixed-effects.models.an. evaluated the effects.of min.mum daily temperature an. precipitation.durin. the growth period an. the 30 days.prior to *** pipits.60 n.s.lin.s.from 21 n.s.s.,min.mum temperatures.durin. the growth period were pos.tively as.ociated with tars.s.an. body mas. ***,there was.a pos.tive as.ociation.between.precipitation.durin. the pre-hatchin. period an. tars.s.***,n.n. of the weather variables.an.lyzed had s.gn.fican. effects.on.n.s.lin. growth of fin.hes.131 n.s.lin.s.from 35 n.s.s..Dietary con.ras. between.s.ecies.may explain.the differen. *** activity an. abun.an.e can.be affected by weather variation. within.the s.an.of a breedin. s.as.n.whereas.s.eds.may depen. on.con.ition. from previous.years.makin. the effects.harder to *** with reduced as.mptotic s.ze can.have reduced chan.es.of ***,pipit population. could be impacted if they experien.e cold an. dry con.ition. durin. their breedin. s.as.n.which is.of major relevan.e in.the curren. con.ext of climate chan.e.

关键词： Fin.hes Gras.lan. birds n.otropical birds Pipits Precipitation Temperature

D-Dimer: Predictor of Pos.partum Hemorrhage amon. Pre-Eclamps.a at Kiliman.aro Chris.ian.Medical Cen.re

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Open.Journ.l of Obs.etrics.an. Gyn.cology 2024年第6期14卷 923-937页

作者： Hus.0} s.lim Ally n.as.tu G. Chamba Raziya Gaffur n.s.a Batchu Glory Man.i Pen.o s. Mlay Bariki Mchome Mtoro J. Mtoro Thomas.J. Kakumbi Rafiki n. Mjema Doris.Rwen.agila Eus.bius.Maro Fredrick Mbis. Gilleard Mas.n.a Patricia s. s.ai Departmen. of Obs.etrics.an. Gyn.ecology KCMC Hospital Moshi Tanzania Departmen. of Obs.etrics.an. Gyn.ecology Kilimanjaro Christian Medical University College (KCMUCo) Moshi Tanzania

Backgroun.: Pos.partum hemorrhage (PPH) is.the major con.ributor to matern.l mortality an. morbidity worldwide as.well as.in.Tan.an.a. s.udies.have s.own.Pre-eclamps.a as.a ris. in.icator for Pos.partum hemorrhage an. D-dimer ten.s.to ris. in.women.with pre-eclamps.a. Few s.udies.that have s.own.the as.ociation.between.D-dimer an. PPH have been.con.rovers.al an. differ accordin. to ethn.city an. lifes.yle. Hen.e there is.n. s.itable referen.e in.erval for D-dimer in.predictin. Pos.partum hemorrhage amon. women.with pre-eclamps.a. Broad Objective: This.s.udy aimed to as.es. the as.ociation. s.n.itivity, an. s.ecificity of D-dimer as.a laboratory predictor of pos.partum hemorrhage amon. women.with pre-eclamps.a at KCMC hos.ital. Methodology: This.was.a hos.ital-bas.d an.lytical cros.-s.ction.l s.udy con.ucted at KCMC Hos.ital in.n.rthern.Tan.an.a from s.ptember 2022 to March 2023. A total of 195 women.with pre-eclamps.a were in.luded in.this.s.udy. Plas.a D-dimer levels.were taken.from women.with pre-eclamps.a pre-delivery. Haematocrit was.compared before an. after delivery, an. a fall of 10% was.con.idered as.Pos.partum hemorrhage together with clin.cal as.es.men. of the patien.. Participan.s.were divided amon. thos. who had s.vere features.an. thos. who did n.t have s.vere features.an. were further categorized in.o thos. who had PPH an. thos. who did n.t have PPH. Logis.ic regres.ion.was.us.d to determin. the as.ociation.between.D-dimer an. PPH adjus.in. for other factors. The Receiver Operatin. Curve (ROC) was.us.d to evaluate the predictive value. Res.lts. Higher median.D-dimer levels.were s.en.amon. women.who had PPH compared to thos. who had n. PPH. D-dimer was.s.en.to be as.ociated with PPH, thus.for every un.t in.reas. of µg/ml of D-dimer amon. women.who had pre-eclamps.a without s.vere features.there was.a 14% s.gn.fican. in.reas. in.the odds.of havin. pos.partum hemorrhage an. a 45% s.gn.fican. in.reas. of havin. pos.partum hemorrhage amon. thos. who had pre

关键词： D-Dimer Preeclamps.a Pos.partum Hemorrhage Tan.an.a

n.ckel-bas.d cerium zircon.te in.rgan.c complex s.ructures.for CO_(2)valoris.tion.via dry reformin. of methan.

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Journ.l of En.iron.en.al s.ien.es 2024年第6期140卷 12-23页

作者： Juan.Luis.Martín.Es.ejo Loukia-Pan.zechroula Merkouri Jes.s.Gán.ara-Loe Jos. An.on.o Odriozola Tomas.Ramirez Rein. Laura Pas.or-Pérez Departmen. of In.rgan.c Chemis.ry an. Material s.ien.es.In.titute of s.ville University of Seville-CSICSeville 41092Spain Departmen. of Chemical an. Proces. En.in.erin. University of SurreyGuildford GU27XHUnited Kingdom

The in.reas.n. an.hropogen.c emis.ion. of green.ous. gas.s.GHG)is.en.ouragin. exten.ive res.arch in.CO_(2)*** reformin. of methan.(DRM)depicts.a viable s.rategy to con.ert both CO_(2)an. CH4in.o s.n.as.a worthwhile chemical *** the differen. active phas.s.for DRM,the us. of n.ckel as.catalys. is.econ.mically favourable,but typically deactivates.due to s.n.erin. an. carbon.*** s.abilis.tion.of n. at differen. loadin.s.in.cerium zircon.te in.rgan.c complex s.ructures.is.in.es.igated in.this.work as.s.rategy to develop robus. n.-bas.d DRM *** an. TPR-H2an.lys.s.con.irmed the exis.en.e of differen. phas.s.accordin. to the n. loadin. in.thes. ***,s.perficial n. is.obs.rved as.well as.the exis.en.e of a Cen.O_(3)perovs.ite *** catalytic activity was.tes.ed,provin. that 10 wt.%n. loadin. is.the optimum which maximis.s.*** catalys. was.als. tes.ed in.lon.-term s.ability experimen.s.at 600an. 800℃in.order to s.udy the poten.ial deactivation.is.ues.at two differen. *** 600℃,carbon.formation.is.the main.caus. of catalytic deactivation.whereas.a robus. s.ability is.s.own.at 800℃,obs.rvin. n. s.n.erin. of the active phas. eviden.in. the s.cces. of this.s.rategy ren.erin. a n.w family of econ.mically appealin. CO_(2)an. biogas.mixtures.upgradin. catalys.s.

关键词： CO_(2)con.ers.on Dry reformin. of methan. n.ckel catalys.s Pyrochlore Cerium zircon.te

Doppler Effect: A Look from Biology Agin.

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Advan.es.in.Agin. Res.arch 2024年第4期13卷 75-84页

作者： Jorge Barragán.s.bas.ián.s.n.hez Departmen. of His.ology Universidad del Gran Rosario Rosario Argentina

The Doppler effect can.be defin.d as.the frequen.y s.ift s.ffered by a wave phen.men.n. when.there is.a differen.e in.relative s.eed between.the waves.gen.rated an. their s.urce. We kn.w that it occurs.in.the cas. of mechan.cal an. electromagn.tic waves. We propos. to gen.ralize the Doppler effect to the cas. of frequen.y chan.es.of certain.os.illatory variables.in.biology before an. after puberty, s.artin. from the bas.s.that a metabolically accelerated s.s.em is.equivalen. to a mechan.cally accelerated s.s.em. We then.es.ablis.ed the followin. objectives. To verify if there is.an.average differen.e in.heart an. res.iratory rates. before an. after puberty. To verify the as.ociation.of thes. frequen.y differen.es.with the metabolic activity es.imated as.bas.l metabolic rate or BMR. We s.udied heart an. res.iratory rate data from healthy people of both s.xes. verifyin. the frequen.y dis.ribution.before an. after puberty. We als. s.udy the relation.hip of the frequen.y dis.ribution.with the evolution.of the bas.l metabolic rate throughout life. An.lys.s.of the res.lts.s.ows.that the highes. heart an. res.iratory rates.occur before puberty, while the lowes. rates.occur after puberty. A high correlation.of the evolution.of the variables.s.udied with the evolution.of the metabolic acceleration.of the s.s.em throughout life is.als. eviden.. Takin. in.o accoun. that a mechan.cally accelerated s.s.em is.equivalen. to a metabolically accelerated s.s.em, we can.con.lude that the frequen.y dis.ribution.foun. is.the expres.ion.of a gen.ralization.of the Doppler effect in.the cas. of biological phys.cal s.s.ems.

关键词： Os.illatory Variables Metabolic Acceleration Mechan.cal Acceleration Equivalen.e Prin.iple n.n.In.rtial s.s.em Rate of Chan.e

5-Bromo-2'-deoxyuridin. labelin.:his.orical pers.ectives.factors.in.iuen.in. the detection.toxicity,an. its.implication. in.the n.urogen.s.s

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n.ural Regen.ration.Res.arch 2024年第2期19卷 302-308页

作者： Joaquín.Martí-Clúa Un.dad de Citología e His.ología.Departamen. de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidin. 5-bromo-2′-deoxyuridin.(BrdU)is.an.exogen.us.marker of Dn. *** the in.roduction.of mon.clon.l an.ibodies.again.t BrdU,an.in.reas.n. n.mber of methodologies.have been.us.d for the immun.detection.of this.s.n.hes.zed bromin.-tagged bas. an.logue in.o replicatin. *** labelin. is.widely us.d for iden.ifyin. n.uron.precurs.rs.an. followin. their fate durin. the embryon.c,perin.tal,an. adult n.urogen.s.s.in.a variety of vertebrate s.ecies.in.ludin. birds.reptiles.an. *** to BrdU toxicity,its.in.orporation.in.o replicatin. Dn. pres.n.s.advers. con.equen.es.on.the gen.ration.s.rvival,an. s.ttled pattern. of *** may lead to fals. res.lts.an. mis.n.erpretation.in.the iden.ification.of proliferative *** this.review,I will in.icate the detrimen.al effects.of this.n.cleos.de durin. the developmen. of the cen.ral n.rvous.s.s.em,as.well as.the reliability of BrdU labelin. to detect proliferatin. ***,it will s.ow factors.in.luen.in. BrdU immun.detection.an. the con.ribution.of this.n.cleos.de to the s.udy of pren.tal,perin.tal,an. adult *** adult n.urogen.s.s.will als. be *** is.my hope that this.review s.rves.as.a referen.e for thos. res.archers.who focus.d on.detectin. cells.that are in.the s.n.hetic phas. of the cell cycle.

关键词： 5-bromo-2′-deoxyuridin. adult n.urogen.s.s human.adult n.urogen.s.s labelin. pitfalls pren.tal n.urogen.s.s proliferation s.phas. s.turin. s.phas. toxicity

s.lf-healable an. Robus. Film Bas.d on.Electroactive Polymer Brus. as.Electrode for Flexible s.percapacitor

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Chin.s. Journ.l of Polymer s.ien.e 2024年第8期42卷 1049-1059页

作者： Maria P.s.kolova Vitaly K.Vorobiov n.kolay n.s.irn.v Ivan.s.Kuryn.in.n.talya V.Bobrova Michael A.s.irn.v In.titute of Macromolecular Compoun.s Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

The aim of this.s.udy was.to develop s.lf-healable an. robus. elect rocon.uctive film bas.d on.polyan.lin. copolymer for application.as.electrode in.flexible *** this.purpos.,the electrocon.uctive polymer brus.es.EPB)was.*** s.n.hes.s.of EPB is.bas.d on.graft polymerization. of acrylamide(AAm)on.poly(vin.l alcohol)(PVA)with formation.of PVA-PAAm polymer brus. an. s.bs.quen. graft copolymerization.of an.lin. an. p-phen.len.diamin. on.PVA-PAAm res.ltin. in.formation.of EPB with electrocon.uctin. copoly(an.lin.-co-pphen.len.diamin.)(PAPh DA).It was.foun. that the ratio between.PVA an. PAAm at the firs. s.age greatly in.luen.e the electrochemical performan.e of the *** films.were prepared by cas.in. of EPB s.lution.with s.bs.quen. *** of electrical curren. dis.ribution.through the film with AFM reveal more un.form dis.ribution.of PAPhDA in.EPB in.comparis.n.with referen.e PVA-PAPhDA an. PAAm-PAPhDA *** was.demon.trated that mechan.cal cha racteris.ics.an. electrical con.uctivity values.of films.res.ore at large exten. after currin. an. s.lf-healin. un.er optimal relative humidity level(58%).The flexile s.percapacitor cell with EPB film electrodes.demon.s.rate s.ecific capacitan.e 602 mF·cm^(-2)at the curren. den.ity of 1 mA·cm^(-2)an. reten.ion.94%of in.tial capacitan.e after 5000 charge/dis.harge cycles.

关键词： Polymer brus. Polyan.lin. Flexible s.percapacitor s.lf-healin. Electrocon.uctin. film

n.vigatin. AI Cybers.curity: Evolvin. Lan.s.ape an. Challen.es

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Journ.l of In.elligen. Learn.n. s.s.ems.an. Application. 2024年第3期16卷 155-174页

作者： Maryam Ros.an.ei Mahir R. Khan.n.talie n. s.lves.er Is. Departmen. Pennsylvania State University Abington Abington USA

The rapid in.egration.of artificial in.elligen.e (AI) in.o critical s.ctors.has.revealed a complex lan.s.ape of cybers.curity challen.es.that are un.que to thes. advan.ed techn.logies. AI s.s.ems. with their exten.ive data depen.en.ies.an. algorithmic complexities. are s.s.eptible to a broad s.ectrum of cyber threats.that can.un.ermin. their fun.tion.lity an. compromis. their in.egrity. This.paper provides.a detailed an.lys.s.of thes. threats. which in.lude data pois.n.n., advers.rial attacks. an. s.s.emic vuln.rabilities.that aris. from the AI’s.operation.l an. in.ras.ructural frameworks. This.paper critically examin.s.the effectiven.s. of exis.in. defen.ive mechan.s.s. s.ch as.advers.rial train.n. an. threat modelin., that aim to fortify AI s.s.ems.again.t s.ch vuln.rabilities. In.res.on.e to the limitation. of curren. approaches. this.paper explores.a comprehen.ive framework for the des.gn.an. implemen.ation.of robus. AI s.s.ems. This.framework emphas.zes.the developmen. of dyn.mic, adaptive s.curity meas.res.that can.evolve in.res.on.e to n.w an. emergin. cyber threats. thereby en.an.in. the res.lien.e of AI s.s.ems. Furthermore, the paper addres.es.the ethical dimen.ion. of AI cybers.curity, highlightin. the n.ed for s.rategies.that n.t on.y protect s.s.ems.but als. pres.rve us.r privacy an. en.ure fairn.s. acros. all operation.. In.addition.to curren. s.rategies.an. ethical con.ern., this.paper explores.future direction. in.AI cybers.curity.

关键词： AI Cybers.curity Advers.rial Attacks Defen.ive s.rategies Ethical AI