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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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推广数字货币应解决信任问题

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商学院 2024年第4期 15-15页

作者： Rebecca beyer 耶鲁大学管理学院

全球范围内,许多国家的中央银行正在考虑采用数字货币来提高金融包容性和支付效率。萨尔瓦多则采取了与众不同的做法,2021年其成为首个将比特币作为法定货币的国家,同时,该国推出了Chivo Wallet应用,提供了类似中央银行数字货币(CBDC)... 详细信息

全球范围内,许多国家的中央银行正在考虑采用数字货币来提高金融包容性和支付效率。萨尔瓦多则采取了与众不同的做法,2021年其成为首个将比特币作为法定货币的国家,同时,该国推出了Chivo Wallet应用,提供了类似中央银行数字货币(CBDC)的便利,包括可访问性、比特币存取功能等。耶鲁大学管理学院的大卫·阿金特(David Argente)和戴安娜·范·帕顿(DianaVan Patten)共同撰写的一项关于萨尔瓦多用比特币作为法定货币的新研究发现,缺乏信任导致加密货币的使用量迅速下降。

关键词：中央银行数字货币戴安娜法定货币可访问性耶鲁大学比特币全球范围

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城市气候适应力差距源于什么?

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商学院 2024年第2期 17-17页

作者： Rebecca beyer 耶鲁大学管理学院

一项由耶鲁大学管理学院Anya Nakhmurina和哈佛商学院Shirley Lu合作完成的研究揭示了美国城市在适应气候变化过程中存在的关键差距。该研究基于400多个美国城市的财务披露数据,对洪水风险进行了重点关注,为人们提供了深入了解美国城市... 详细信息

一项由耶鲁大学管理学院Anya Nakhmurina和哈佛商学院Shirley Lu合作完成的研究揭示了美国城市在适应气候变化过程中存在的关键差距。该研究基于400多个美国城市的财务披露数据,对洪水风险进行了重点关注,为人们提供了深入了解美国城市气候准备水平的机会。一般而言,高风险城市的适应能力会比低风险城市更高,但研究发现,超过一半的高风险城市适应水平低于平均水平。同时值得注意的是,与低适应水平相关的因素里包括预算限制和较短期的规划,而与政治倾向无关。

关键词：城市气候哈佛商学院耶鲁大学政治倾向适应力适应气候变化洪水风险低风险

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Near infrared light-induced dynamic modulation of enzymatic activity through polyphenol-functionalized liquid metal nanodroplets

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中国化学快报：英文版 2023年第2期34卷 475-480页

作者： Chaojun Zhang Yang Tang Qin Wang Yunxiang He Xiaoling Wang Sebastian beyer Junling Guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China School of Pharmacy Southwest Minzu UniversityChengdu 610225China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu 610065China Department of Biomedical Engineering Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China Bioproducts Institute Department of Chemical and Biological EngineeringUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

Dynamic manipulation of enzymatic activity is a challenging task for applications in chemical and pharmaceutical industries due to the difficult modification and variable conformation of various ***, we report a new strategy for reversible dynamic modulation of enzymatic activity by near-infrared light-induced photothermal conversion based on polyphenol-functionalized liquid metal nanodroplets(LM). The metal-phenolic nanocoating not only provides colloidal stability of LM nanodroplets but also generates nanointerfaces for the assembly of various enzymes on the LM nanodroplets. Upon near infrared(NIR) irradiation, the localized microenvironmental heating through photothermal effect of the LM nanodroplets allows tailoring the enzymatic activity without affecting the bulk temperature. A library of functional enzymes, including proteinase K, glucoamylase, glucose oxidase, and Bst DNA polymerase, is integrated to perform a reversible control and enhanced activities even after five times of cycles, demonstrating great potential in bacterial fermentation, bacteriostasis, and target gene amplification.

关键词： Enzymatic activity Photo-modulation Near infrared light Liquid metal nanodroplets Metal-phenolic nanocoating

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3D extrusion of multi-biomaterial lattices using an environmentally informed workflow

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Frontiers of Architectural Research 2022年第4期11卷 691-708页

作者： Vasiliki Panagiotidou Andreas Koerner Marcos Cruz Brenda Parker Bastian beyer Sofoklis Giannakopoulos Bio-Integrated Design Lab The Bartlett School of ArchitectureUniversity College LondonLondonWC1E 6BTUnited Kingdom

The conventional building material palette has been proven limited in terms of adaptability to our current environmental challenges. Innovations in computational design and digital manufacturing have supported the broadening of biomaterial applications as an alternative. While biomaterials are characteristically responsive to stimuli such as temperature and humidity, their unpredictable behaviour is a hurdle to standardization and architectural utilisation. To examine the nexus between material formulation, computation and manufacturing, multi-biomaterial lattice structures were produced through an environmentally informed workflow. Customized biomaterial development resulted in three candidate biopolymer blends with varying levels of hydro-responsiveness and transparency. The computational strategy included a machine learning clustering algorithm to customise results and dictate material distribution outputs. To test the workflow, environmental data of solar radiation exposure and solar heat gain from a specific location was used to inform the material deposition via pneumatic extrusion for the design and digital fabrication of a deformation-controlled prototype of 350 mm × 350 mm. This led to a series of multi-biomaterial wall panel components that can be applied at architectural scale. In future, these techniques can support the incorporation of living elements to be embedded within the built environment for truly animate architecture.

关键词： Hydrogels Multi-biomaterials Hygroscopic properties Pneumatic extrusion Environmentally informed deposition Integrated workflows

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Rapid,simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection

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Journal of Pharmaceutical Analysis 2013年第6期3卷 408-414页

作者： Markus Küsters Soren beyer Stephan Kutscher Harald Schlesinger Michael Gerhartz Central Hospital of the German Federal Armed Forces Koblenz Pharmacy Section Central Institute of the German Federal Armed Forces Koblenz Laboratory Department of Food and Environmental Chemistry

A rapid and simple method for the determination of potyhexamethylene biguanide （polyhexanide, PHMB） in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection （HPLC DAD） was devel- oped. Best separation was achieved using a cyanopropyl bonded phase （Agilent Zorbax Eclipse XDB-CN column 4.6mm x 75 mm with particle size of 3.5 μm） as well as gradient elution consisting of acetonitrile/deionized water at a flow rate of 1.0 mL/min. The optimized and applied chromatographic conditions permitted separation of polyhexanide from interacting raatrix with subsequent detection at a wavelength of 235 nm with good sensitivity. The method validation was carried out with regard to the guidelines for analytical procedures demanded by the International Conference on Harmonisation （ICH）. Mean recoveries of 102% and 101% for gel-like as well as liquid preparations were obtained. Suitable repeatability as well as intermediate precision could bc achieved with limits of detection ≤0.004 mg/mL for both formulations, equivalent to ≤0.004% PHMB concerning sample preparation. Determination of PHMB was accomplished without tedious sample preparation. Interacting matrix could be eliminated by the chromatographicprocedure with excellent performance of system suitability. All analytical requirements were fulfilled permitting a reliable and precise determination of PHMB in pharmaceuticals. Further- more, the developed method was applied to stability testing of pharmaceutical preparations containing PHMB.

关键词： Polyhexamethylene biguanide Polyhexanide Pharmaceuticals High performance liquid chromatography

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The Middle Eastern Eagle： How the MENA Region Can Rise

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International Relations and Diplomacy 2014年第2期2卷 144-149页

作者： Anna Cornelia beyer University of Hull Quebec UK

The Middle Eastern and North African （MENA） region has the potential to rise if it puts the recent changes to good use. Political changes in some countries might have opened the way for liberalization, which in turn again might facilitate democratization. Both will benefit the economic development of the region. So far, economic growth is hindered by excessive and ineffective public sectors, which do not provide sufficient opportunities for the growing young population. Privatization of some services and a general liberalization of the markets might help bring the young workforce into employment and in the long run will fuel an economic upswing.

关键词： Middle Eastern and North African (MENA) economic democracy

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Golden rice on a mission

Golden rice on a mission

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第十四届全国植物基因组学大会

作者： Peter beyer Faculty of Biology University of Freiburg

Golden Rice(GR) denotes a genetically modified rice(Oryza sativa) that produces B-carotene(provitamin A) in the grain’s *** ofβ-carotene confers a yellow color to the grain,which becomes visible after *** towards th... 详细信息

关键词： rice provitamin A beta carotene biofortification genetic modification

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Heterogeneous populations of neural stem cells contribute to myelin repair

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Neural Regeneration Research 2017年第4期12卷 509-517页

作者： Rainer Akkermann Felix beyer Patrick Küry Neuroregeneration Laboratory Department of NeurologyMedical FacultyHeinrich-Heine-University

As ingenious as nature＇s invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis （MS）, leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demon-strated the increasing inability of oligodendrocyte precursor cells （OPCs） to replace lost oligodendrocytes （OLs） in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair.

关键词： heterogeneity oligodendrocyte neuroregeneration multiple sclerosis inhibitors intracellular proteinlocalization adult neural stem cell niche remyelination

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Pierre-Auguste Renoir, 1841-1919

Pierre-Auguste Renoir, 1841-1919

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作者： Peter H. Feist translation Hugh beyer.

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