咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Heterogeneous populations of n... 收藏

Heterogeneous populations of neural stem cells contribute to myelin repair

Heterogeneous populations of neural stem cells contribute to myelin repair

作     者:Rainer Akkermann Felix Beyer Patrick Küry 

作者机构:Neuroregeneration LaboratoryDepartment of NeurologyMedical FacultyHeinrich-Heine-University 

出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))

年 卷 期:2017年第12卷第4期

页      面:509-517页

核心收录:

学科分类:1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基  金:The German Academic Exchange Service (DAAD) supported RA supported by grants to PK by the German Research Council (DFG SPP1757/KU1934/2_1, KU1934/5-1) the Christiane and Claudia Hempel Foundation for clinical stem cell research and Young Glia supported in part by the Walter and Ilse Rose Foundation the James and Elisabeth Cloppenburg, Peek & Cloppenburg Düsseldorf Foundation 

主  题:heterogeneity oligodendrocyte neuroregeneration multiple sclerosis inhibitors intracellular proteinlocalization adult neural stem cell niche remyelination 

摘      要:As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis (MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demon-strated the increasing inability of oligodendrocyte precursor cells (OPCs) to replace lost oligodendrocytes (OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分