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现代制造 2006年第28期 58-60页

作者： bernd-arno behrens manfred hoffmann ANDERE

在钢板成形领域里，工业方面对刀具耐用度、结构部分的坚固度及质量要求不断提高。从而要求开发和使用新的、有创造性的刀具设计和刀具材料，因为传统的刀具往往不能满足或不能完全满足这些要求。

关键词：高效率刀具耐用度钢板成形质量要求刀具材料刀具设计

Omicron spike protein:a clue for viral entry and immune evasion

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3639-3640页

作者： G.M.N.behrens A.Cossmann M.hoffmann Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany German Centre for Infection Research partner site Hannover-BraunschweigHannoverGermany CiiM Centre for Individualized Infection MedicineHannoverGermany Infection Biology Unit German Primate CenterGöttingen 37077Germany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany

In a recent study in Science,Bowen et al.1 report that mutations in Omicron sublineage’s spike protein enhance ACE2 binding,impair fusogenicity,and dampen the neutralizing activity of antibodies after vaccination or *** data describe how Omicron and especially the BA.5 variant evade neutralizing antibody responses and argue for using mRNA booster vaccination to increase immunity.

关键词： ACE2 Bowen al.

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滑动拉伸弯曲成形

现代制造 2005年第8期 56-56,58-59页

作者： bernd-arno behrens Stefan Muetze

用滑拉弯曲的灵活方法,开发轻型结构的全新用途,可以采用成本低廉的方法制造样机或进行小批量生产,这些产品可以作为组件直接使用,并可用于后续成形加工。

关键词：模具成形加工轻型结构滑动拉仲弯曲成形加工方案

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

磁控溅射Al-Zr薄膜在微拉深成形中的拉深性能(英文)

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中国有色金属学会会刊：英文版 2012年第S2期22卷 268-274页

作者： Gerrit behrens Julien KOVAC bernd KHLER Frank VOLLERTSEN Heinz-Rolf STOCK BIAS-Bremer Institut für Angewandte Strahltechnik GmbH Klagenfurter Str. 2 D-28359 Bremen Germany IWT-Stiftung Institut für Werkstofftechnik Badgasteiner Str. 3 D-28359 Bremen Germany

拉深成形可以用来制备形状复杂的零部件,甚至可达微加工水平。采用磁控溅射方法,在基底温度分别为310K和433K下,制备了厚度约为15μm的两种不同的AlZr薄膜。将这两种薄膜做为坯料,采用冲头直径为0.75mm的微拉深设备研究其拉深性能。虽... 详细信息

拉深成形可以用来制备形状复杂的零部件,甚至可达微加工水平。采用磁控溅射方法,在基底温度分别为310K和433K下,制备了厚度约为15μm的两种不同的AlZr薄膜。将这两种薄膜做为坯料,采用冲头直径为0.75mm的微拉深设备研究其拉深性能。虽然这两种材料在拉伸试验中显示出较小的最大应变,但还是成功地实现了微拉深成形。在基底温度为310K和433K制备的两种材料的极限拉深比分别为1.8和1.7。这些结果比先前采用AlSc合金的结果要好,与采用传统轧制方法所得纯铝薄膜的拉深结果相似。结果表明,采用磁控溅射方法制备的薄膜可以用来进行微拉深成形。

关键词： Al-Zr薄膜微拉深成形成形极限磁控溅射

Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination

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Cellular & Molecular Immunology 2021年第10期18卷 2455-2456页

作者： Swantje I.Hammerschmidt Berislav Bosnjak Günter Bernhardt Michaela Friedrichsen Inga Ravens Alexandra Dopfer-Jablonka Markus hoffmann Stefan Pöhlmann Georg M.N.behrens Reinhold Förster Institute of Immunology Hannover Medical SchoolHannoverGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany Infection Biology Unit German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany German Center for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany German Center for Lung Research(DZL) HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany

Since the beginning of the COVID-19 pandemic,divergent variants of concern(VoCs)of SARS-CoV-2 have evolved and become the most prevalent SARS-CoV-2 variants in distinct locations at different ***,the Delta variant(B.1.617.2)dominates infection events in large parts of the *** campaigns,however,still use SARS-CoV-2 vaccines based on the spike(S)protein of the original Wuhan virus.

关键词： Delta homologous campaign

Experiments on the Saturation of Fluorite in Magmatic Systems: Implications for Maximum F Concentration and Fluorine-Cation Bonding in Silicate Melt

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Journal of Earth Science 2020年第3期31卷 456-467页

作者： Xiaoyan Li Chao Zhang Lianxun Wang Harald behrens Francois Holtz State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China Institute of Mineralogy Leibniz University HannoverHannover 30167Germany State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of Geosciences Wuhan 430074China

The effects of melt composition,temperature and pressure on the solubility of fluorite(CaF2),i.e.,fluorine concentration in silicate melts in equilibrium with fluorite,are summarized in this *** authors present a statistic study based on experimental data in literature and propose a predictive model to estimate F concentration in melt at the saturation of fluorite(CFin melt^Fl-sat).The modeling indicates that the compositional effect of melt cations on the variation in can be expressed quantitatively as one parameter FSI(fluorite saturation index):FSI=(3Al^NM+Fe^2++6Mg+Ca+1.5Na-K)/(Si+Ti+Al^NF+Fe^3+),in which all cations are in mole,and Al^NF and Al^NM are A1 as network-forming and network-modifying cations,*** dependence of CFin melt^Fl-sat on FSI is regressed as:CFin melt^Fl-sat=1.130-2.014·exp(1000/T)+2.747·exp(P/T)+0.111·CmeltH2O+17.641·FSI,in which T is temperature in Kelvin,P is pressure in MPa,CmeltH2O is melt H2O content in wt.%,and CFin melt^Fl-sat is in wt.%(normalized to anhydrous basis).The reference dataset used to establish the expression for conditions within 540-1010℃,50-500 MPa,0-7 wt.%melt H2O content,0.4 to 1.7 for A/CNK,0.3 wt.%-7.0 wt.%for CFin melt^*** discrepancy of CFin melt^Fl-sat between calculated and measured values is less than±0.62 wt.%with a confidence interval of 95%.The expression of FSI and its effect on CFin melt^Fl-sat indicate that fluorine incorporation in silicate melts is largely controlled by bonding with network-modifying cations,favorably with Mg,Al^NM,Na,Ca and Fe^2+in a decreasing *** proposed model for predicting CFin melt^Fl-sat is also supported by our new experiments saturated with magmatic fluorite performed at 100-200 MPa and 800-900℃.The modeling of magma fractional crystallization emphasizes that the saturation of fluorite is dependent on both the compositions of primary magmas and their initial F contents.

关键词： fluorine fluorite solubility silicate melt experimental petrology

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基于作用介质的铝合金体积成形

锻造与冲压 2006年第4期 52-52,54,56页

作者： arno behrens

随着地球能源的日益短缺，以及环保、技术与协作标准的要求越来越高，在机械制造众多领域中，轻质材料的应用越来越多。因此，铝合金以其较高的强重比，越来越多地应用在重负荷部件中，如发动机底盘。

关键词：铝合金体积成形介质机械制造轻质材料重负荷发动机应用

Assessing the USLE Crop and Management Factor C for Soil Erosion Modeling in a Large Mountainous Watershed in Central China

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Journal of Earth Science 2010年第6期21卷 835-845页

作者： Sarah Schnbrodt Patrick Saumer Thorsten behrens Christoph Seeber Thomas Scholten Institute of Geography Department of Physical Geography and Soil Science University of Tübingen Science Strategy Coordination and Planning Office European Space Agency-ESRIN Center for International Development and Environmental Research Giessen University

Due to the impoundment of the Yangtze River, the Three Gorges Dam in China fosters high land-use dynamics. Soil erosion is expected to increase dramatically. One of the key factors in soil erosion control is the vegetation cover and crop type. However, determining these factors adequately for the use in soil erosion modeling is very time-consuming especially for large mountainous areas, such as the Xiangxi （香溪） catchment in the Three Gorges area. In our study, the crop and management factor C was calculated using the fractional vegetation cover （CFvc） based on Landsat-TM images from 2005, 2006, and 2007 and on literature studies （CLIT）. In 2007, the values of CFvc range between 0.001 and 0.98 in the Xiangxi catchment. The mean CFVC value is 0.05. CLIT values are distinctly higher, ranging from 0.08 to 0.46 with a mean value of 0.32 in the Xiangxi catchment. The mean potential soil loss amounts to 120.62 t/ha/a in the Xiangxi catchment when using CLIT for modeling. Based on CFVC, the predicted mean soil loss in the Xiangxi catchment is 11.50 t/ha/a. Therefore, CLIT appears to bemore reliable than the C factor based on the fractional vegetation cover.

关键词： C factor soil erosion modeling Universal Soil Loss Equation fractional vegetation cover Three Gorges Dam Yangtze River.

Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2

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Cellular & Molecular Immunology 2022年第9期19卷 1067-1069页

作者： Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka Martin S.Winkler Hans-Martin Jäck Georg M.N.behrens Stefan Pöhlmann Markus hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany German Centre for Infection Research(DZIF) Partner Site Hannover-BraunschweigHannoverGermany Centre for Individualised Infection Medicine(CiiM) HannoverGermany Department of Anesthesiology University of Göttingen Medical CenterGöttingenGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany

The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing *** the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive *** most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].

关键词： ACE2 harbor neutral