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signaling pathways of chronic kidney diseases,implications for therapeutics

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signal Transduction and Targeted Therapy 2022年第7期7卷 2245-2271页

作者： Qian Yuan ben Tang Chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Chronic kidney disease(CKD)is a chronic renal dysfunction syndrome that is characterized by nephron loss,inflammation,myofibroblasts activation,and extracellular matrix(ECM)*** and oxidative stress are the driving force for the loss of nephron including tubules,glomerulus,and ***3 inflammasome signaling,MAPK signaling,PI3K/Akt signaling,and RAAs signaling involves in *** upregulated Nox expression and the decreased Nrf2 expression result in oxidative stress *** injured renal resident cells release proinflammatory cytokines and chemokines to recruit immune cells such as macrophages from bone ***-κB signaling,NLRP3 inflammasome signaling,JAK-sTAT signaling,Toll-like receptor signaling,and cGAs-sTING signaling are major signaling pathways that mediate inflammation in inflammatory cells including immune cells and injured renal resident *** inflammatory cells produce and secret a great number of profibrotic cytokines such as TGF-β1,Wnt ligands,and angiotensin ***-βsignaling,Wnt signaling,RAAs signaling,and Notch signaling evoke the activation of myofibroblasts and promote the generation of *** potential therapies targeted to these signaling pathways are also introduced *** this review,we update the key signaling pathways of lipotoxicity,oxidative stress,inflammation,and myofibroblasts activation in kidneys with chronic injury,and the targeted drugs based on the latest *** these pathways and the targeted therapies will be instrumental to advance further basic and clinical investigation in CKD.

关键词： NLRP3 inflammation kidney

Three-space Problems for the Bounded Compact Approximation Property

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Acta Mathematica sinica,English series 2013年第4期29卷 625-632页

作者： Dong Yang CHEN ben Tuo ZHENG school of Mathematical sciences Xiamen University Department of Mathematical sciences The University of Memphis

In this paper, the notion of the bounded compact approximation property （BCAP） of a pair [Banach space and its subspace] is used to prove that if X is a closed subspace of Eoo with the BCAP, then L∞/X has the BCAP. We also show that X＊ has the A-BCAP with conjugate operators if and only if the pair （X, Y） has the A-BCAP for each finite codimensional subspace Y C X. Let M be a closed subspace of X such that M~ is complemented in X＊. If X has the （bounded） approximation property of order p, then M has the （bounded） approximation property of order p.

关键词： The bounded compact approximation property a pair the (bounded) approximationproperty of order p

On Douglas General(α,β)-metrics

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Acta Mathematica sinica,English series 2017年第7期33卷 951-968页

作者： Xiao Ming WANG ben Ling LI Department of Mathematics Ningbo UniversityNingbo 315211P.R.China

Douglas metrics are metrics with vanishing Douglas curvature which is an important projective invariant in Finsler geometry. To find more Douglas metrics, in this paper we consider a class of Finsler metrics called general （α, β）-metrics, which are defined by a Riemannian metric and a . We obtain the differential equations that characterizes these metrics with vanishing Douglas curvature. By solving the equivalent PDEs, the metrics in this class are totally determined. Then many new Douglas metrics are constructed.

关键词： Finsler metric general (α β)-metrics Douglas metric Douglas curvature

Neuronal-like cell differentiation of non-adherent bone marrow cell-derived mesenchymal stem cells

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Neural Regeneration Research 2013年第22期8卷 2078-2085页

作者： Yuxin Wu Jinghan Zhang Xiaoming ben Department of Neurosurgery Nanjing Children's Hospital of Nanjing Medical University Department of Newborn Medicine Nanjing Children's Hospital of Nanjing Medical University Department of Newborn Medicine Shanghai First Maternity and Infant HospitalTongji University School of Medicine

Non-adherent bone marrow cell-derived mesenchymal stem cells from C57BL/6J mice were sepa- rated and cultured using the ＂pour-off＂ method. Non-adherent bone marrow cell-derived mesen- chymal stem ceils developed colony-forming unit-fibroblasts, and could be expanded by supple- mentation with epidermal growth factor. Immunocytochemistry showed that the non-adherent bone marrow cell-derived mesenchymal stem cells exposed to basic fibroblast growth factor/epidermal growth factor/nerve growth factor expressed the neuron specific markers, neurofilament-200 and NeuN, in vitro. Non-adherent bone marrow cell-derived mesenchymal stem cells from 13-galactosidase transgenic mice were also transplanted into focal ischemic brain （right corpus striatum） of C57BL/6J mice. At 8 weeks, cells positive for LacZ and 13-galactosidase staining were observed in the ischemic tissues, and cells co-labeled with both 13-galactosidase and NeuN were seen by double immunohistochemical staining. These findings suggest that the non-adherent bone marrow cell-derived mesenchymal stem cells could differentiate into neuronal-like cells in vitro and in vivo.

关键词： neural regeneration stem cells non-adherent bone marrow cell-derived mesenchymal stem cells neuronal-like cells colony-forming unit-fibroblasts proliferation differentiation beta-galactosidasetransgenic mouse cell transplantation cerebral ischemia bone marrow cells-derived mesenchymalstem cells grants-supported paper neuroregeneration

synthesis and Properties of Perfluorinated Alkyl silicone Oil Modified Epoxy Resin

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Journal of Wuhan University of Technology(Materials science) 2014年第2期29卷 361-366页

作者：孙明慧 MA ben 翁睿 school of Materials science and Engineering Wuhan University of Technology

Perfluorinated alkyl silicone oil （PFAsO） was successfully synthesized from N-ethyl-N- hydroxylethyl perfluorinated octane sulfonamide, succinie anhydride and amino silicone oil by esterification and amide reaction at moderate temperature in the presence of different catalysts. The chemical structure of the synthesized samples was characterized by Fourier transform infrared spectroscopy （FT-IR）, the relative molecular mass（MM） and molecular mass distribution（MMD） of PFAsO were tested by gel filtration chromatography（GFC）. A commercial epoxy resin （DGEBA） was modified with PFAsO, with the content of PFAsO 1-5 phr. Thermo-gravimetric analysis （TGA）, impact tests, scanning electron microscope （sEM） and water contact angle test were applied to provide accurate results on the thermal stability, toughness and hydrophobicity of PFAsO/epoxy complex. The experimental results reveal that epoxy resins can be successfully modified by adding a small amount of as-synthesized modifiers via simple direct mixing, and verify that the as-synthesized modifier can improve the toughness and hydrophobicity of epoxy resin without sacrificing its thermal properties.

关键词： perfluorinated alkyl silicone oil epoxy resin modification

Introduction of H2sO4 and H3PO4 into Crystalline Porous Organic salts(CPOs-1)for Outstanding Proton Conductivity

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Chemical Research in Chinese Universities 2020年第5期36卷 976-980页

作者： WANG Yuxia YAN Tingting ben Teng Department of Chemistry Jilin UniversityChangchun 130012P.R.China shandong Key Laboratory of Biophysics Institute of BiophysicsDezhou UniversityDezhou 253023P.R.China

To improve the proton conduction of crystalline porous organic salts(CPOs-l),H2sO4 and H3PO4 were introduced into the channel to obtain H2sO4@CPOs-1 and H3PO4@*** to CPOs-1,the proton conductivities of H2sO4@CPOs-1 and H3PO4@CPOs-1 increased two orders of magnitude and one order of magnitude at 303 K and 100%RH,*** can be attributed to the increasing concentration of the protons,which disso ciates trom the acids.

关键词： Proton conductivity Crystalline porous organic salt H2sO4 H3PO4

Cryogel scaffolds: soft and easy to use tools for neural tissue culture

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Neural Regeneration Research 2022年第9期17卷 1981-1983页

作者： ben Newland Katherine R.Long school of Pharmacy and Pharmaceutical sciences Cardiff UniversityCardiffUK Centre for Developmental Neurobiology Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMRC Centre for Neurodevelopmental DisordersKing’s College LondonLondonUK

The mammalian central nervous system(CNs)is highly complex,with a vast array of processes and interactions occurring in a dynamic and often transient *** these processes are combined to regulate our behavior remains poorly *** has in turn led to a lack of understanding of how these processes have gone awry in the many disorders of the nervous *** order to address this,researchers need a controlled way to manipulate the nervous system in in vitro and ex vivo cultures,in both a specific area and for a specific period of time to start to pick apart these *** date,this has been technically challenging,especially when modeling focal injury to the CNs or when working with human brain tissue.

关键词： culture neural transient

Numerical Analysis of the Behavior of A New Aeronautical Alloy (Ti555-03) Under the Effect of A High-speed Water Jet

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China Ocean Engineering 2019年第1期33卷 114-126页

作者： I.ben Belgacem L.Cheikh E.M.Barhoumi W.Khan W.ben salem Laboratoire de Génie Mécanique Ecole Nationale d’Ingénieurs de MonastirUniversité de Monastir Institut Préparatoire aux Etudes d’Ingénieur de Monastir Université de Monastir Department of Electrical and Computer Engineering College of EngineeringDhofar University University of Waterloo Institut supérieur des Arts et Métiers de Mahdia Université de Monastir

In this paper, we present a numerical simulation of a water jet impacting a new aeronautical material Ti555-03 *** Computational Fluid Dynamics(CFD) behavior of the jet is investigated using a FV(Finite Volume) *** Fluid–structure Interaction(FsI) is studied using a coupled sPH(smoothed Particle Hydrodynamics)-FE(Finite Element) method. The jets hit the metal sheet with an initial velocity 500 m/s. Two configurations which differ from each other by the position(angle of inclination) of the plate relatively to the axis of revolution of the jet inlet are investigated in this study. The objective of this study is to predict the impact of the fluid produced at high pressure and high speed especially at the first moment of impact. Numerical simulations are carried out under ABAQUs. We have shown in this study that the inclination of the titanium alloy plate by 45° stimulates the phenomenon of recirculation of water. This affects the velocity profile, turbulence and boundary layers in the impact zone. The stagnation zone and the phenomenon of water recirculation are strongly influenced by the slope of the plate which gives a pressure gradient and displacement very important between the two configurations. Fluctuations of physical variables(displacement and pressure) prove the need for a noise and vibratory study. These predictions will subsequently be used for the modeling of the problem of an orthogonal cut in a high-speed machining process assisted by high-pressure water jet.

关键词： Titanium alloy(Ti555-03) CFD turbulence ABAQUs smoothed Particle Hydrodynamics(sPH) Fluid structure Interaction(FsI)

Autonomous reconfigurable hybrid tail-sitter UAV U-Lion

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science China(Information sciences) 2017年第3期60卷 202-217页

作者： Kangli WANG Yijie KE ben M.CHEN Unmanned systems Research Group 4 Engineering Drive 3 National University of Singapore

We present in this work the development of a novel hybrid unmanned aircraft platform, U-Lion,which has both vertical take-off and landing(VTOL) and cruising flight capabilities. Our design is in tail-sitter structure with reconfigurable wings, which combines the advantages of a fixed-wing plane and a rotor helicopter effectively. This allows it to transit from vertical take-off to hovering, before flying in cruise mode for efficient long duration flight. The propulsion comes from two coaxial contra-rotating motors fixed on a gimbal mechanism,which can change the direction of the motors for the required thrust. This thrust-vectored propulsion system primarily provides control in the VTOL mode but also enhances flight capabilities in the cruise mode. The hybrid aircraft is equipped with GPs and airspeed sensors, and has an onboard avionic system with advanced flight control algorithms to perform fully autonomous VTOL and cruising flights, in addition to transiting effectively between VTOL and cruising flight modes. The overall design has been successfully verified by actual flight experiments.

关键词： unmanned aerial vehicle vertical take-off and landing hybrid platform aircraft platform design flight control system