检索结果-南通市图书馆

The circFASN/miR-33a pathway participates in tacrolimusinduced dysregulation of hepatic triglyceride homeostasis

Signal Transduction and Targeted Therapy 2020年第1期5卷 2132-2141页

作者： Chenzhi Zhang Kangchen Chen Rongli Wei Guanghan Fan Xuechun Cai Li Xu beini cen Jianguo Wang Haiyang Xie Shusen Zheng Xiao Xu Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhou 310000China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China

Dyslipidemia exhibits a high incidence after liver transplantation,in which tacrolimus,a widely used immunosuppressant,plays a fundamental *** and related circRNAs represent a class of noncoding RNAs that have been recognized as important regulators of genes associated with lipid ***,their transcriptional activities and functional mechanisms in tacrolimus-related dyslipidemia remain *** this study,we observed that tacrolimus could induce triglyceride accumulation in hepatocytes by stimulating sterol response element-binding proteins(SREBPs)and *** in silico and experimental analyses identified miR-33a as a direct target of *** could downregulate circFASN and result in elevated miR-33a in vivo and in *** of circFASN or silencing of miR-33a decreased the promoting effects of tacrolimus on triglyceride ***,the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a(46.3%vs.18.8%p=0.012,n=73).Our results showed that the circFASN/miR-33a regulatory system plays a distinct role in tacrolimus-induced disruption of lipid ***-33a is likely a risk factor for tacrolimus-related dyslipidemia,providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation.

关键词： tacrolimus homeostasis elevated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular phenotypes reveal heterogeneous engraftments of patient-derived hepatocellular carcinoma xenografts

引用

Chinese Journal of Cancer Research 2021年第4期33卷 470-479页

作者： Jianyong Zhuo Di Lu Jianguo Wang Zhengxing Lian Jiali Zhang Huihui Li beini cen Xuyong Wei Qiang Wei Haiyang Xie Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China National Health Commission Key Laboratory of Combined Multi-organ Transplantation Institute of Organ TransplantationZhejiang UniversityHangzhou 310003China

Objective:Patient-derived xenograft(PDX)models provide a promising preclinical platform for hepatocellular carcinoma(HCC).However,the molecular features associated with successful engraftment of PDX models have not been ***:HCC tumor samples from 76 patients were implanted in immunodeficient *** molecular expression was evaluated by *** and tumor characteristics as well as tumor molecular expressions were compared for PDX engraftment using the Chi-square *** independent prediction parameters were identified by logistic regression ***:The engraftment rate for PDX models from patients with HCC was 39.47%(30/76).Tumors from younger patients and patients with elevated preoperative alpha-fetoprotein level had higher engraftment *** with poor differentiation and vascular invasion were related to engraftment *** positive expression of CK19,CD133,glypican-3(GPC3),and Ki67 in tumor samples was associated with engraftment *** regression analyses indicated that GPC3 and Ki67 were two of the strongest predictors of PDX *** with GPC3/Ki67 phenotypes showed heterogeneous engraftment rates,with 71.9%in GPC3^(+)/Ki67^(+)tumors,30.8%in GPC3^(-)/Ki67^(+)tumors,15.0%in GPC3^(+)/Ki67^(-)tumors,and 0 in GPC3^(-)/Ki67^(-)***:Successful engraftment of HCC PDXs was significantly related to molecular *** with the GPC3+/Ki67+phenotype were the most likely to successfully establish HCC PDXs.

关键词： Hepatocellular carcinoma patient-derived xenografts heterogeneous establishment molecular phenotype

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stratified Analysis of Survival Benefit for ABO-incompatible Deceased-donor Liver Transplantation:Multicenter Propensity Score-matched Study

引用

Journal of Clinical and Translational Hepatology 2023年第4期11卷 827-838页

作者： Mengfan Yang Xuyong Wei Abdul Rehman Khan Qiang Wei Rui Wang Binhua Pan Kun Wang Zhisheng Zhou Di Lu beini cen Shuijun Zhang Wenzhi Guo Shusen Zheng Yang Yang Xiao Xu Department of Organ Transplantation Qilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province HangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiangChina Zhejiang University School of Medicine HangzhouZhejiangChina National center for Healthcare Quality Management in Liver Transplant HangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityHenanChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Hepatobiliary and Pancreatic Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina

Background and Aims:Liver transplantation(LT)using ABO-incompatible(ABOi)grafts can extend the donor pool to a certain extent and hence reduce the waiting time for ***,concerns of the impending prognosis associated with this option,especially for patients with liver failure and higher model for end-stage liver disease(MELD)scores,who tend to be more fragile during the waiting period before ***:Recipients undergoing LT for acute-onchronic liver failure or acute liver failure were retrospectively enrolled at four *** survival was compared and a Cox regression analysis was *** score matching was performed for further *** were stratified by MELD score and cold ischemia time(CIT)to determine the subgroups with survival ***:Two hundred ten recipients who underwent ABOi LT and 1,829 who underwent ABO compatible(ABOc)LT were *** 5-year overall survival rate was significantly inferior in the ABOi group compared with the ABOc group after matching(50.6%vs.75.7%,p0.05).Comparison of the survival rates revealed no statistically significant difference for patients with MELD scores≥40(p>0.05).For patients with MELD scores of 31-39,the overall survival rate was significantly inferior in the ABOi group compared with the ABOc group(p<0.001);however,the rate was increased when the liver graft CIT was<8 ***:For recipients with MELD scores≤30,ABOi LT had a prognosis comparable to that of ABOc LT and can be regarded as a feasible *** recipients with MELD scores≥40,ABOi should be adopted with caution in emergency *** recipients with MELD scores of 31-39,the ABOi LT prognosis was ***,those patients benefited from receiving ABOi grafts with a CIT of<8 h.

关键词： Liver transplantation ABO-incompatible Model for end-stage liver disease score Cold ischemia time Propensity score matching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关节镜辅助微创手术与传统手术治疗胫骨平台骨折的临床有效性对比

引用

世界复合医学（中英文） 2024年第9期10卷 144-147页

作者：张哲龙岑贝妮夏俊杰浙江省中医药大学研究生院浙江杭州310000 中国人民解放军第九〇三医院骨科浙江杭州310000 西湖大学医学院附属杭州市第一人民医院浙江省肿瘤学与智能医学重点实验室浙江杭州310006

目的分析胫骨平台骨折实施不同手术治疗的价值。方法选取2022年3月—2024年3月中国人民解放军第九〇三医院收治的162例胫骨平台骨折患者为研究对象,根据手术方式分为传统组(112例,传统切开复位内固定手术治疗)、微创组(50例,关节镜辅助... 详细信息

目的分析胫骨平台骨折实施不同手术治疗的价值。方法选取2022年3月—2024年3月中国人民解放军第九〇三医院收治的162例胫骨平台骨折患者为研究对象,根据手术方式分为传统组(112例,传统切开复位内固定手术治疗)、微创组(50例,关节镜辅助微创手术治疗)。比较两组围术期指标、转归情况、膝关节功能优良率。结果微创组切口长度、出血量、骨折愈合时间优于传统组,差异有统计学意义(P均<0.05)。微创组关节面塌陷、成角畸形及踝部变宽评分高于传统组,差异有统计学意义(P均<0.05)。微创组膝关节功能优良率为96.00%(48/50),高于传统组的83.93%(94/112),差异有统计学意义(χ^(2)=4.655,P=0.031)。结论关节镜辅助微创手术能提升膝关节功能,改善围术期指标,缩短愈合周期,与传统手术相比优势明显。

关键词：关节镜转归情况胫骨平台骨折围术期指标微创手术

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

白血病抑制因子在肝癌肝移植受者复发预测中的作用

引用

中华肝脏外科手术学电子杂志 2019年第6期8卷 497-501页

作者：金平波鲁迪卓建勇岑贝妮谢海洋郑树森徐骁浙江大学医学院附属第一医院肝胆胰外科肝胰移植科

目的探讨白血病抑制因子(LIF)在肝细胞癌(肝癌)肝移植受者复发预测中的作用。方法回顾性分析2009年8月至2015年12月浙江大学医学院附属第一医院诊治的105例肝癌肝移植受者临床资料。患者及其家属均签署知情同意书,符合医学伦理学规定。... 详细信息

目的探讨白血病抑制因子(LIF)在肝细胞癌(肝癌)肝移植受者复发预测中的作用。方法回顾性分析2009年8月至2015年12月浙江大学医学院附属第一医院诊治的105例肝癌肝移植受者临床资料。患者及其家属均签署知情同意书,符合医学伦理学规定。其中男100例,女5例;平均年龄(50±8)岁;中高-中分化43例,低分化62例;符合米兰标准患者22例。采用免疫组化芯片技术检测LIF表达。LIF在肝癌和癌旁组织中表达比较采用t检验,Cox多因素回归分析建立肝癌肝移植复发预测模型,采用受试者工作特征(ROC)曲线和DeLong检验评估模型预测价值。生存分析采用Kaplan-Meier法和Log-rank检验。结果LIF在肝癌组织中的表达强度为7.3±2.6,明显高于癌旁组织的5.0±2.4(t=6.670,P<0.05)。Cox多因素回归分析显示,肝癌组织LIF表达、lnAFP、血管侵犯是肝癌肝移植受者复发的独立危险因素(HR=1.178,1.177,2.280;P<0.05)。建立复发预测模型:0.164×LIF表达+0.163×lnAFP+0.824×血管侵犯。根据该模型将受者分为低危组及高危组。低危组受者1、3、5年生存率分别为82.7%,77.7%和73.6%,高危组相应为30.2%,17.3%和17.3%,低危组受者预后明显优于高危组(χ2=36.890,P<0.05)。本模型预测肝移植受者肝癌复发的ROC曲线下面积为0.849,预测效能明显强于米兰标准的0.626(Z=3.638,P<0.05)。结论肝癌组织中LIF表达增强,LIF表达是肝癌肝移植术后复发的独立危险因素,由此建立的模型能区分高危和低危复发患者,且较米兰标准更好地预测肝癌肝移植术后复发。

关键词：癌,肝细胞肝移植白血病抑制因子复发预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：