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Hypokalemic myopathy in a patient with gluten-sensitive enteropathy and dermatitis herpetiformis Duhring: A case report

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World Journal of Gastroenterology 2005年第13期11卷 2039-2040页

作者： Zsolt barta Zsofia Miltenyi Laszlo Toth Arpad Illes 3rd Department of Medicine Department of Pathology

The case of a 22-year-old patient with symptomatic hypokalemia caused by rhabdomyolysis is presented as a rarely reported complication of gluten-sensitive enteropathy (GSE) and dermatitis herpetiformis Duhring. The patient's myopathy ceased on potassium supplementation and her other complaints resolved while on gluten-free *** was otherwise uneventful with a rapid decline in serum CPK level. At the time of her last follow-up a few months later, she was free of symptoms and CPK remained stable. Patients with GSE may present with hypokalemia in association with diarrhea and emesis, and if potassium loss is rapid, rhabdomyolysis may occur.

关键词： Gluten-sensitive enteropathy Hypokalemia RhabdomyolysisAbstract

High yield production of 1,4-cyclohexanediol from lignin derived2,6-dimethoxybenzoquinone via Raney Ni Mn catalyst in hydrogen free conditions

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Journal of Energy Chemistry 2023年第8期83卷 275-286,I0009页

作者： Zhe-Hui Zhang Xianyuan Wu Xiaohong Ren Zeming Rong Zhuohua Sun Katalin barta Tong-Qi Yuan Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing 100083China Stratingh Institute for Chemistry University of GroningenGroningenThe Netherlands State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116012LiaoningChina Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/Ⅱ8010 GrazAustria

Transformation of lignin to valuable chemicals via sustainable pathways is recognized as one of the most efficient ways to explore its value and replace the nonrenewable petroleum resource. In this work, an environmental-friendly transfer hydrogenation process has been developed to convert lignin derived2,6-dimethoxybenzoquinone to 1,4-cyclohexanediol. Compared with previous work under hydrogen pressure(30 bar), this process uses isopropanol as both solvent and hydrogen donor, which significantly simply the operation process. The core of this study is the design and preparation of Mn modified Raney Ni catalysts by ball milling process. A series of Raney Ni Mn catalysts with different ball milling time and Mn content were prepared and investigated. Characterizations by X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), scanning electron microscope(SEM) and transmission electron microscope(TEM) etc. showed that Ni Mn Al alloy was formed during the ball milling process and then transformed to Ni Mn alloy after treatment by aqueous Na OH. After optimization, a yield as high as 86.1% could be achieved for 1,4-cyclohexanediol at 200℃ in only 1 h.

关键词： Lignin Raney Ni 1,4-Cyclohexanediol Transfer hydrogenation

Life on the Mississippi

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Life on the Mississippi

LSFEM Implementation of MHD Numerical Solver

作者： Mark Twain with an introduction and notes by Petr barta.

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Applied Mathematics 2012年第11期3卷 1842-1850页

作者： Jan Skala Miroslav barta University J.E.Purkinje Ustínad LabemCzech Republic Max Planck Institute for Solar System Research Katlenburg-LindauGermany Astronomical Institute of Czech Academy of Sciences OndrejovCzech Republic

Many problems in physics are inherently of multi-scale nature. The issues of MHD turbulence or magnetic reconnection, namely in the hot and sparse, almost collision-less astrophysical plasmas, can stand as clear examples. The Finite Element Method (FEM) with adaptive gridding appears to be the appropriate numerical implementation for handling the broad range of scales contained in such high Lundquist-number MHD problems. In spite the FEM is now routinely used in engineering practice in solid-state and fluid dynamics, its usage for MHD simulations has recently only begun and only few implementations exist so far. In this paper we present our MHD solver based on the Least-Square FEM (LSFEM) formulation. We describe the transformation of the MHD equations into form required for finding the LSFEM functional and some practical issues in implementation of the method. The algorithm was tested on selected problems of ideal (non-resistive) and resistive MHD. The tests show the usability of LSFEM for solving MHD equations.

关键词： Magnetohydrodynamics (MHD) Least-Squares Finite Element Method Adaptive Mesh Refinement Magnetic Reconnection Solar Eruptions MHD Turbulence

Psychometric validation of satisfaction with simulated clinical learning experience evaluation e corrections(SSCLEE-C)

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International Journal of Nursing Sciences 2016年第1期3卷 58-62页

作者： Desiree A.Dı´az Reagan Louise Deborah Shelton William D.barta University of Central Florida USA University of Connecticut School of Nursing USA School of Nursing Center for Correctional Health Networks-CCHNetUSA Center for Correctional Health Networks-CCHNet USA

Purpose:This study sought to modify a 19-item instrument designed to measure nursing students'satisfaction with a simulated learning experience for use in a correctional system to measure nurse satisfaction with simulated learning experiences;and to establish validity for the modified *** measures were available for use in a correctional setting,and few instruments were available to measure nurse satisfaction with simulation ***/methodology:One hundred and ninety-eight correctional nurses responded to the original 19-item five-point Likert scale *** data were used for an exploratory and confirmatory factor ***:A 3-factor solution accounting for 62%of the *** 3 factors:Fidelity,Objectives,and Problem solving were supported by *** 9-itemCFA exhibited desirable psychometric properties:Rootmeansquare error of approximation(RMSEA)=.046;Akaike Information Criterion(AIC)=76.95;Comparative Fit Index(CFI)=*** model χ^(2)=30.95(ns).Alpha reliability estimates of the three factors were 0.70,0.70 and ***/value:The Satisfaction with Simulated Clinical Learning Experience Evaluation-Corrections(SSCLEE-C)is the only instrument available for ongoing assessment of correctional nurse satisfaction with simulated clinical learning experiences.

关键词： Simulation Satisfaction Correctional nurses Instrument development

Pulse cyclophosphamide therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2006年第8期12卷 1278-1280页

作者： Zsolt barta László Tóth Margit Zeher 3~(rd) Department of Medicine Faculty of MedicineMedical and Health Science CentreUniversity of DebrecenDebrecenHungary Department of Pathology Faculty of MedicineMedical and Health Science CentreUniversity of DebrecenDebrecenHungary

AIM:To assess the efficacy of intravenous cyclophos-phamide pulse therapy for refractory inflammatory boweldisease(IBD).METHODS:We included in our cohort eight patientswith(moderate/severe)steroid refractory IBD(4 withulcerative colitis and 4 with Crohn's disease).They allreceived 6 cycles of intravenous cyclophosphamide(800mg)per ***:Patients entered into remission after the sec-ond/third cyclophosphamide *** activity *** were no side effects and *** thepatients went into long lasting *** Crohn's diseasepatients and 3 of 4 ulcerative colitis patients achievedcomplete *** patient with ulcerative colitisshowed an impressive clinical response but did not enterinto *** the maintenance,patients with Crohn'sdisease were treated with methotrexate(15 mg/wk)andpatients with ulcerative colitis were treated with azathio-prine(2.5 mg/kg body weight/d).CONCLUSION:Remission was maintained in all pa-tients for 6 mo on the *** drug was well *** findings suggest that aggressive immuno-suppressive therapy may be useful in some refractorypatients and further controlled study should be consid-ered in order to fully evaluate this type of treatment as apotential therapy for IBD.

关键词： Crohn's disease Ulcerative colitis Cyclophos-phamide

Celiac disease and microscopic colitis:A report of 4 cases

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World Journal of Gastroenterology 2011年第16期17卷 2150-2154页

作者： Zsolt barta Eva Zold Arpad Nagy Margit Zeher Istvan Csipo 3rd Department of Medicine Institute for Internal MedicineMedical and Health Science CenterUniversity of Debrecen

Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ***,it can be associated also to other immunopathological disorders,and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic *** guidelines for endoscopic investigation of the jejunum are well defined,no indication is defined for colonic *** describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this *** symptoms of these patients were improved initially by a gluten-free diet before the onset of MC *** of the patients were siblings and had an atypical form of *** other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody *** co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known,and no systematic approach has been used to identify the lifelong patterns of these immune-based *** can develop,or present with CD at any stage in life,which can co-exist with other gastrointestinal diseases of (auto-) immune *** addition,the fa-milial co-existence and prevalence of MC in patients with a prior diagnosis of CD are *** managing celiac disease should be aware of these associations and understand when to consider colon investigation.

关键词： Collagen colitis Lymphocytic colitis Celiac disease Fibrosing alveolitis Anti-saccharomyces cerevisiae antibody

Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone

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World Journal of Gastroenterology 2009年第18期15卷 2293-2295页

作者： Eva Zold Arpad Nagy Katalin Devenyi Margit Zeher Zsolt barta Division of Clinical Immunology 3rd Department of MedicineMedical and Health Science CenterUniversity of DebrecenDebrecen 4004Hungary Euromedic Diagnostics Szeged Kft Debrecen 4004Hungary

Crohn＇s disease （CD） is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications. The purpose of treatment is long-term remission, reduction of complications, and improvement of patients＇ quality of life. In many cases, this can be quite challenging and it is necessary to have a well thought out management strategy. We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia. In addition, there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities, indicative of pyoderma gangrenosum. The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab. A positive response to adalimumab therapy was observed： after 2 mo of therapy, the ulcerative skin lesion healed completely and the enterogastric fistula was closed affcer 5 mo adalimumab treatment. Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD.

关键词： Adalimumab Crohn's disease Pyoderma gangrenosum

Gut region-specific TNFR expression:TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats

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World Journal of Diabetes 2023年第1期14卷 48-61页

作者： Bence Pál barta Benita Onhausz Afnan AL Doghmi Zita Szalai János Balázs Mária Bagyánszki Nikolett Bódi Department of Physiology Anatomy and NeuroscienceUniversity of SzegedSzeged 6726Hungary

BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 *** necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a dual role in cell degeneration or survival depending on different *** general,TNFR1 is believed to trigger apoptosis,while TNFR2 promotes cell *** importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy,however,the expression and alterations of different TNFRs in the gastrointestinal tract has not been *** To investigate the TNFR1 and TNFR2 expression in myenteric ganglia and their environment in different intestinal segments of diabetic *** Ten weeks after the onset of hyperglycemia,gut segments were taken from the duodenum,ileum and colon of streptozotocin-induced(60 mg/body weight kg i.p.)diabetic(n=17),insulin-treated diabetic(n=15)and sex-and age-matched control(n=15)*** plexus whole-mount preparations were prepared from different gut regions for TNFR1/HuCD or TNFR2/HuCD double-labeling fluorescent ***1 and TNFR2 expression was evaluated by post-embedding immunogold electron microscopy on ultrathin sections of myenteric *** levels were measured by enzyme-linked immunosorbent assay in muscle/myenteric plexus-containing(MUSCLE-MP)tissue homogenates from different gut segments and experimental *** A distinct region-dependent TNFRs expression was detected in *** density of TNFR1-labeling gold particles was lowest,while TNFR2 density was highest in duodenal ganglia and a decreased TNFRs expression from proximal to distal segments was observed in MUSCLE-MP *** diabetics,the TNFR2 density was only significantly altered in the duodenum with decrease in the ganglia(0.32±0.02 vs 0.45±0.04,P<0.05),while no significant changes in TNFR1 density was *** diabetic MUSCLE-MP h

关键词： Tumor necrosis factor alpha receptors Myenteric ganglia Enteric neurons Neuronal environment Diabetes Insulin