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Montanide ISA-720 and Naloxone in HBsAg Vaccine Formulation:Cytokine Profiling and Monitoring of Long-Lasting Humoral Immune Responses

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Biomedical and Environmental Sciences 2022年第9期35卷 792-803页

作者： Mina Mirzaee Setareh Haghighat bahareh Golkaran Fatemeh Asgarhalvaei Rayhaneh Mirzaee Morteza Taghizadeh Mohammad Ali Savoji Behzad Esfandiari Mehdi Mahdavi Department of Microbiology Faculty of Advanced Sciences&TechnologyTehran Medical SciencesIslamic Azad University(IAUPS)TehranIran Department of Biotechnology Faculty of Advanced Sciences&TechnologyPharmaceutical Sciences BranchIslamic Azad UniversityTehran-Iran(IAUPS) Department of Medical vaccine Razi Vaccine and Serum Research InstituteAgricultural ResearchEducation and Extension Organization(AREEO)KarajIran Department of Epidemiology and Biostatistics Pasteur Institute of IranTehranIran Department of Laboratory Animal Science Pasteur Institute of IranKarajIran Advanced Therapy Medicinal Product(ATMP)Department Breast Cancer Research CenterMotamed Cancer InstituteAcademic Center for EducationCulture and Research(ACECR)TehranIran Recombinant Vaccine Research Center Tehran University of Medical SciencesTehranIran Department of Immunology Pasteur Institute of IranTehranIran Immunotherapy Group The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehranIran

Objective This study aimed to investigate the effects of Montanide ISA-720 and Naloxone(NLX)in Hepatitis B surface antigen(HBsAg)vaccine formulation on cytokine and long-lasting antibody *** First,the HBsAg was formulated in Montanide ISA-720 adjuvant and Naloxone at 5 and 10mg/*** experimental mice were immunized three times at a 2-week interval,and then IL-4,IL-2,TNF-α,and IFN-γcytokines;long-lasting IgG antibody responses 220 days after the last shot;and IgG1/IgG2a isotypes were assessed by *** The HBsAg-Alum group exhibited the highest IL-4 cytokine response among the experimental groups,whereas NLX in HBsAg-MON720 vaccine formulation did not affect cytokine *** addition,NLX in Alum-based vaccine suppressed IL-4 cytokine response and increased the IL-2/IL-4 cytokine ***,HBsAg-MON720 was more potent than HBsAg-Alum in the induction of antibody responses,and NLX in Alum-and MON720-based vaccines induced long-lasting antibody *** NLX in Alum-based vaccine decreased IL-4 cytokine response,increased IL-2/IL-4 cytokine ratio,and improved long-lasting humoral immune responses in both vaccine ***,the adjuvant activity of NLX in the vaccine formulation depends on the type of adjuvant and the nature of the antigen in the vaccine formulation.

关键词： HBsAg Vaccine Naloxone Montanide ISA-720 Long-lasting humoral response

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Microbial Community from MTBE-Contaminated Soil for Aerobic Biodegradation of MTBE

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Journal of Geoscience and Environment Protection 2016年第1期4卷 93-99页

作者： bahareh Montazeri Mohammad Hossein Sarrafzadeh School of Chemical Engineering College of Engineering University of Tehran Tehran Iran

This Methyl tert-butyl ether (MTBE) is one of the main additives in gasoline to increase octane rating and consequently reduce air pollution. The physico-chemical properties of this substance (high water solubility, low sorption in soil) result in high mobility and considerable concentrations in aquifers. In this survey, Isfehan Refinery that was encountered with MTBE contamination problem was selected as a case study and the MTBE degradation ability of this contaminated area by its indigenous microorganisms was investigated. In the first step of this survey, the influence of various factors on the aerobic degradation of MTBE such as mixed culture type, incubation time, microbial culture and optimal concentration of MTBE were investigated in shaking flasks and the most important factors were specified by means of fractional factorial design 1/2. In the second stage by using optimal values which obtained from the first stage, the effects of co-substare parameter and inoculum parameter were assayed by means of response surface method. The results of the experiments showed that the mixed culture type and initial concentration of MTBE were the most significant factors. The results of the experiments showed that the mixed indigenous culture acted better than activated sludge. The initial concentration of MTBE was also one of the most significant factors. At the best condition about 31 percent of MTBE was treated by co-substrating with n-hexane in a ratio of 0.2.

关键词： Bioremediation MTBE Contamination Groundwater Cometabolism Indigenous Microorganisms

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A Facile and Efficient One-Pot Regioselective Synthesis of 2-Hydroxyalkyl Dithiocarbamates under Catalyst-Free Conditions

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International Journal of Organic Chemistry 2012年第3期2卷 248-253页

作者： Barahman Movassagh bahareh Shokri Department of Chemistry K. N. Toosi University of Technology Tehran Iran

A simple catalyst-free, and highly regioselective approach to 2-hydroxyalkyl dithiocarbamates is described which involves a one-pot reaction of various amines and carbon disulfide,CS2, with epoxides in ethanol at room... 详细信息

关键词： 2-Hydroxyalkyl Dithiocarbamates Epoxides Regioselective Amines Carbon Disulfide

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Green CoNi_(2)S_(4)/porphyrin decorated carbon-based nanocomposites for genetic materials detection

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Journal of Bioresources and Bioproducts 2021年第3期6卷 215-222页

作者： Mohammad Reza Saeb Navid Rabiee Farzad Seidi bahareh Farasati Far Mojtaba Bagherzadeh Eder C.Lima Mohammad Rabiee Universitéde Lorraine CentraleSupélecLMOPSF57000 MetzFrance Department of Chemistry Sharif University of TechnologyTehranIran Provincial Key Lab of Pulp&Paper Sci and Tech and Joint International Research Lab of Lignocellulosic Functional MaterialsNanjing Forestry UniversityNanjing 210037China Department of Chemistry Iran University of Science and TechnologyTehranIran Institute of Chemistry Federal University of Rio Grande do Sul(UFRGS)Av.Bento Goncalves 9500Postal Box15003ZIP91501-970 Brazil Biomaterial Group Department of Biomedical EngineeringAmirkabir University of TechnologyTehranIran

A one-pot synthesis method was conceptualized and implemented to develop green carbon-based nanocomposites working as *** was synthesized to adorn the surface of nanocomposites making them highly sensitive for giving rise to π-π interactions between the genetic materials,proteins and porphyrin *** hydrogen bond formed between the proteins(analytes)and the nitrogen in the porphyrin structure as well as the surface hydroxyl groups was equally *** this context,different forms of porphyrins were incorporated to explore the interrelationship between the surface morphology and the ability of detection of genetic material and/or proteins by the aid of the synthesized *** phenomenon was conceptualized to optimize the interactions between the biomolecules and the substrate by reaching significant biosensor application in the presence of Anti-cas9 protein and sgRNA(concentration changed between 10 and 500 n mol/L).Almost full quenching of fluorescence emission was observed after addition of 300 n mol/L of Anti-cas9 protein and 250 n mol/L of ***,CoNi_(2)S_(4)provided 12%-29%cytotoxicity in both HEK-293 and PC12 cell lines.

关键词： Biosensor Biomedicine Anti-cas9 Green nanocomposite sgRNA

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Synergistic Effect of Silver Nanoparticles with Neomycin or Gentamicin Antibiotics on Mastitis-Causing Staphylococcus aureus

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Open Journal of Ecology 2016年第7期6卷 452-459页

作者： Shahab Jamaran bahareh Rahimian Zarif Department of Biology Sanandaj Branch Islamic Azad University Sanandaj Iran

Objective: Mastitis is one of the most costly diseases in dairy cows, which greatly decreases milk production. Use of antibiotics in cattle leads to antibiotic-resistance of mastitis-causing bacteria. The present study aimed to investigate synergistic effect of silver nanoparticles (AgNPs) with neomycin or gentamicin antibiotic on mastitis-causing Staphylococcus aureus. Materials and Methods: In this study, 46 samples of milk were taken from the cows with clinical and subclinical mastitis during the august-October 2015 sampling period. In addition to biochemical tests, nuc gene amplification by PCR was used to identify strains of Staphylococcus aureus. Disk diffusion test and microdilution were performed to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Fractional Inhibitory Concentration (FIC) index was calculated to determine the interaction between a combination of AgNPs and each one of the antibiotics. Results: Twenty strains of Staphylococcus aureus were isolated from 46 milk samples and were confirmed by PCR. Based on disk diffusion test, 35%, 10% and 55% of the strains were respectively susceptible, moderately susceptible and resistant to gentamicin. In addition, 35%, 15% and 50% of the strains were respectively susceptible, moderately susceptible and resistant to neomycin. According to FIC index, gentamicin antibiotic and AgNPs had synergistic effects in 50% of the strains. Furthermore, neomycin antibiotic and AgNPs had synergistic effects in 45% of the strains. Conclusion: It could be concluded that a combination of AgNPs with either gentamicin or neomycin showed synergistic antibacterial properties in Staphylococcus aureus isolates from mastitis. In addition, some hypotheses were proposed to explain antimicrobial mechanism of the combination.

关键词： Staphylococcus aureus Mastitis Silver Nanoparticles Gentamicin Neomycin Synergistic

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Microorganism-derived biological macromolecules for tissue engineering

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Frontiers of Medicine 2022年第3期16卷 358-377页

作者： Naser Amini Peiman Brouki Milan Vahid Hosseinpour Sarmadi bahareh Derakhshanmehr Ahmad Hivechi Fateme Khodaei Masoud Hamidi Sara Ashraf Ghazaleh Larijani Alireza Rezapour Cellular and Molecular Research Center Iran University of Medical SciencesTehran ***Iran Institutes of Regenerative Medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Tissue Engineering and Regenerative Medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Pharmaceutics University of MinnesotaMN 55455USA Burn Research Center Department of Plastic and Reconstructive SurgeryIran University of Medical SciencesTehran ***Iran Department of Medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRasht ***Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran ***Iran Cellular and Molecular Research Centre Qom University of Medical SciencesQom ***Iran Department of Tissue Engineering and Regenerative Medicine School of MedicineQom University of Medical SciencesQom ***Iran

According to literature,certain microorganism productions mediate biological ***,their beneficial characteristics remain ***,scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative *** present review aims to introduce microorganism-derived biological macromolecules,such as pullulan,alginate,dextran,curdlan,and hyaluronic acid,and their available sources for tissue *** evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological *** natural-based materials are attractive in pharmaceutical,regenerative medicine,and biomedical *** study provides a detailed overview of natural-based biomaterials,their chemical and physical properties,and new directions for future research and therapeutic applications.

关键词： biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate

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General Considerations for the Practice of Pediatric Dentistry in the Period of COVID-19 Pandemic: A Review

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Journal of Biosciences and Medicines 2021年第8期9卷 29-42页

作者： Shayan Darvish bahareh Nazemi Salman Pardis Health Centre Shahid Beheshti University of Medical Sciences Tehran Iran Department of Pediatric Dentistry School of Dentistry Zanjan University of Medical Sciences Zanjan Iran

Context: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been identified in December 2019. Since then, it has been spreading around the world and has caused a pandemic. Strict safety protocols should be followed to resume dental treatments. Evidence Acquisition: A comprehensive search was conducted on PubMed, Scopus, Medline and google scholar databases using the MeSH words of COVID-19, SARS-COV-2, Dentistry, and Child from December 2019 until July 2020. Results: Among COVID-19 patients, asymptomatic patients still are considered to be serious carriers of the COVID-19 which can play a key role in transmission of the virus. Children are reported to be less than 2 percent of the infected population and are considered as serious potential carriers. Telemedicine can take a key part in educating parents regarding this matter. Chronic and rare diseases such as Kawasaki Disease (KD) might show acute and more frequent symptoms amongst COVID-19 patients. Salivary testing can be a convenient chairside way for COVID-19 and it has been shown to be effective in identifying critically ill patients. Dry mouth and amblygeustia have been reported to be the oral symptoms of the COVID-19. Conclusions: Dentists must make tough decisions in prioritizing patient’s needs in the period of pandemic. They should frequently get updated as the situation is fluid and the protocols might change.

关键词： COVID-19 Child Dentistry Dentistry SARS-COV-2 Novel Coronavirus Coronavirus

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Design and Implementation Challenges of Microelectrode Arrays: A Review

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Materials Sciences and Applications 2013年第8期4卷 483-495页

作者： bahareh Ghane-Motlagh Mohamad Sawan Polystim Neurotechnologies Laboratory Department of Electrical Engineering Polytechnique Montreal Montreal Canada

The emerging field of neuroprosthetics is focused on design and implementation of neural prostheses to restore some of the lost neural functions. Remarkable progress has been reported at most bioelectronic levels—particularly the various brain-machine interfaces (BMIs)—but the electrode-tissue contacts (ETCs) remain one of the major obstacles. The success of these BMIs relies on electrodes which are in contact with the neural tissue. Biological response to chronic implantation of Microelectrode arrays (MEAs) is an essential factor in determining a successful electrode design. By altering the material compositions and geometries of the arrays, fabrication techniques of MEAs insuring these ETCs try to obtain consistent recording signals from small groups of neurons without losing microstimulation capabilities, while maintaining low-impedance pathways for charge injection, high-charge transfer, and high-spatial resolution in recent years. So far, none of these attempts have led to a major breakthrough. Clearly, much work still needs to be done to accept a standard model of MEAs for clinical purposes. In this paper, we review different microfabrication techniques of MEAs with their advantages and drawbacks, and comment on various coating materials to enhance electrode performance. Then, we propose high-density, three-dimensional (3D), silicon-based MEAs using micromachining methods. The geometries that will be used include arrays of penetrating variable-height probes.

关键词： Microelectrode Arrays Electrodes-Tissues Contacts Microelectrode Impedance Neural Prosthesis

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Modeling of a SiGeSn quantum well laser

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Photonics Research 2021年第7期9卷 1234-1254页

作者： bahareh MARZBAN DANIELA STANGE DENIS RAINKO ZORAN IKONIC DAN BUCA JEREMY WITZENS Institute of Integrated Photonics RWTH Aachen University52074 AachenGermany Jülich-Aachen Research Alliance(JARA) Fundamentals of Future Information TechnologiesGermany Peter Grünberg Institute 52428 JulichGermany University of Leeds School of Electronic and Electrical EngineeringWoodhouseLeeds LS29JTUK

We present comprehensive modeling of a Si GeSn multi-quantum well laser that has been previously experimentally shown to feature an order of magnitude reduction in the optical pump threshold compared to bulk *** combine experimental material data obtained over the last few years with k·p theory to adapt transport,optical gain,and optical loss models to this material system (drift-diffusion,thermionic emission,gain calculations,free carrier absorption,and intervalence band absorption). Good consistency is obtained with experimental data,and the main mechanisms limiting the laser performance are discussed. In particular,modeling results indicate a low non-radiative lifetime,in the 100 ps range for the investigated material stack,and lower than expectedΓ-L energy separation and/or carrier confinement to play a dominant role in the device properties. Moreover,they further indicate that this laser emits in transverse magnetic polarization at higher temperatures due to lower intervalence band absorption losses. To the best of our knowledge,this is the first comprehensive modeling of experimentally realized Si GeSn lasers,taking the wealth of experimental material data accumulated over the past years into account. The methods described in this paper pave the way to predictive modeling of new (Si)GeSn laser device concepts.

关键词： laser polarization pump

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Mid-Infrared Reflectance and Ultraviolet-Visible Spectroscopy of Demantoid from Kerman Province, Iran

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宝石和宝石学杂志 2018年第S1期20卷 143-144页

作者： bahareh Shirdam Soheila Aslani Gemmological Research Laboratory School of Mining EngineeringCollege of EngineeringUniversity of Tehran

Mid-infrared(mid-IR)spectroscopy of 15 demantoid samples from Bagh-eBorj,Esfandagheh district,Kerman Province,Iran,has been studied and their mid-IR and Ultraviolet-Visible(UV-Vis)were *** samples has been collected from serpentinites of Esfandahge's Chromium Bearing Ophiolititic complex in Sanandaj-Sirjan Structural Zone,southern ***-Vis spectroscopy is a suitable method for detection of transition ions responsible for mineral's colour such as *** UV-Vis spectra of demantoid samples with a colour range of yellowish green to green were slightly different,representing peaks at 392,437,573 and 865 nm related to and 437 and 481 nm bands attributed *** the 855 nm band's absorbance changed moderately by the tolerance of Cr content which correlated the green ***-IR spectroscopy identifies the hydroxyl ***-IR spectra of all samples presented close results in the 3 800-3 400 cm^(-1) region but differences could be observed in the 1 500-800 cm^(-1) *** two absorption peaks at 3 550 cm^(-1) and 3 596 cm^(-1) are related to hydroxide,which can be present in andradite as a minor component,in the form of structurally bonded OH-.It is needed to be mentioned that from 15 studied sample,6 samples contained"horsetail"inclusions,which confirms their serpentinite geologic origin.

关键词： demantoid IR UV-Vis origin

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