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薄煤层n.0工法巷道顶板控制机理及分区补偿支护技术

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Journ.l of Cen.ral South Un.versity 2024年第2期31卷 602-620页

作者：杨军刘奔王亚军张俊侯世林王育坤吴星李宏财 State Key Laboratory for Geomechan.cs&Deep Un.ergroun. En.in.erin. China University of Mining&TechnologyBeijing 100083China School of Civil an. Resources En.in.erin. University of Science and Technology BeijingBeijing 100083China Shen.u n.n.tiaota Coal Min.n. Compan. Ltd. Shaanxi Coal Mining GroupYulin 719300China

薄煤层n.0工法的提出,革新了传统的煤矿开采模式、关键技术与装备系统,并取得了成功应用。而新开采模式下的巷道围岩控制技术尚不完善,为实现薄煤层n.0工法巷道顶板结构的安全稳定,考虑其工艺流程和顶板变形特点,将巷道划分为超前硐室... 详细信息

薄煤层n.0工法的提出,革新了传统的煤矿开采模式、关键技术与装备系统,并取得了成功应用。而新开采模式下的巷道围岩控制技术尚不完善,为实现薄煤层n.0工法巷道顶板结构的安全稳定,考虑其工艺流程和顶板变形特点,将巷道划分为超前硐室、垮落成巷两个阶段。并基于Hoek-Brown.线性岩体强度破坏准则,确定了巷道顶板不同阶段的锚杆/索预紧力的计算公式,提出了巷道顶板锚杆/索预紧力及长度设计方法。此外,结合数值模拟研究了不同阶段巷道顶板锚杆/索支护作用机理及不同锚杆/索支护组合对围岩应力分布的影响,揭示了锚杆/索支护关键参数对顶板稳定性的影响机制。最后,综合理论与数值模拟分析结果,提出了分区补偿支护技术,确定了锚杆/索预紧力、长度及选材的设计原则,该技术在现场取得了良好的应用效果。

关键词： n.0工法沿空留巷上限法支护设计数值模拟

Preparation.an. Quality Evaluation.of Exten.ed Beef Roun.s Con.ain.n. Gum Arabic from Acacia sen.gal var. keren.is

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Food an. n.trition.Scien.es 2016年第11期7卷 977-988页

作者： John.on.K. Mwove Lilian.A. Gogo ben n. Chikamai Mary n. Omwamba Symon.M. Mahun.u Dairy an. Food Scien.e an. Techn.logy Departmen. Egerton University Egerton Kenya Ken.a Forest Research In.titute Nairobi Kenya

It was of in.erest to determin. the water holdin. effect of the gum from the Acacia sen.gal var. keren.is in.exten.ed beef roun.s. Beef roun.s in.ected at two in.ection.levels (30% an. 35% over green.weight) with curin. brin.s con.ain.n. gum arabic at 1%, 1.5%, 2.0%, 2.5% an. 3.0% of the fin.l product were in.estigated. A n.n.in.ected sample an. a product in.ected with soy protein.con.en.rate (SPC) at 3.5% of the fin.l product weight were prepared for comparison. Mean.results in.icated that the level of gum arabic from Acacia sen.gal var. keren.is used in.curin. brin.s sign.fican.ly in.reased the cook yield an. reduced the extractable moisture in.cooked exten.ed beef roun.s. The in.ection.of beef with curin. brin. also sign.fican.ly in.reased the cook yield an. the extractable moisture of the exten.ed beef roun.s as compared to the n.n.in.ected beef samples. Both in.ection.an. gum levels had a sign.fican. effect on.the proximate composition.an. sen.ory properties of the resultin. beef roun.s. Sen.ory an.lysis revealed that samples con.ain.n. gum arabic at 2.5% were juicier an. comparable to those con.ain.n. SPC at 3.5% in.ection.level. Furthermore, these samples had the highest overall preferen.e comparable to samples in.ected with curin. brin.s con.ain.n. SPC. This is the first report on.the physicochemical properties of exten.ed beef roun.s con.ain.n. gum arabic from Acacia sen.gal var. keren.is.

关键词： Gum Arabic Expressible Moisture Exten.ed Beef Roun.s Curin. Brin. In.ection

探讨补阳还五汤通过AMPK/ULK1线粒体自噬通路抑制细胞焦亡治疗糖尿病周围神经病变

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中国实验方剂学杂志 2024年第15期30卷 1-10页

作者：安静文宋林春陈蝶张旺田佳鑫张天雅贲莹河北中医药大学中西医结合学院河北省中西医结合肝肾病证重点实验室石家庄050091

目的:观察补阳还五汤通过腺苷酸活化蛋白激酶(AMPK)/Un.-51样激酶1(ULK1)线粒体自噬通路抑制细胞焦亡治疗糖尿病周围神经病变(DPn.的作用机制。方法:动物实验采用雄性SPF级SD雄性大鼠(6~7周)60只,按体质量进行编号,计算机产生随机数字... 详细信息

目的:观察补阳还五汤通过腺苷酸活化蛋白激酶(AMPK)/Un.-51样激酶1(ULK1)线粒体自噬通路抑制细胞焦亡治疗糖尿病周围神经病变(DPn.的作用机制。方法:动物实验采用雄性SPF级SD雄性大鼠(6~7周)60只,按体质量进行编号,计算机产生随机数字法随机分为4组,分别为正常组、模型组、α-硫辛酸组(60 mg·kg^(-1))、补阳还五汤组(15 g·kg^(-1)),每组15只。通过注射链脲佐菌素(STZ)制备糖尿病模型。造模成功后α-硫辛酸组和补阳还五汤组分别给与相应药物,正常组和模型组给予生理盐水。给药12周结束后检测感觉神经传导速度(Sn.V)和机械性痛阈(PWT)。免疫组化和蛋白免疫印迹法(Western.blot)检测背根神经节(DRG)中磷酸化腺苷酸活化蛋白激酶(p-AMPK)、磷酸化Un.-51样激酶1(p-ULK1)、微管相关蛋白1轻链3(LC3)、选择性自噬受体(p62/SQSTM1)、Beclin.、n.D样受体热蛋白结构域相关蛋白3(n.RP3)、胱天蛋白酶-1(Caspase-1)、白细胞介素-1β(IL-1β)的表达。免疫荧光检测gasdermin.D的n.(n.GSDMD)表达。结果:与正常组比较,模型组大鼠空腹血糖显著升高(Pn.V、PWT显著降低(Pn.、p-AMPK/AMPK、p-ULK1/ULK1显著降低(Pn.RP3、n.GSDMD/GSDMD、IL-1β、剪切的(cleaved)Caspase-1/Caspase-1显著升高(Pn.V、PWT显著升高(Pn.、p-AMPK/AMPK、p-ULK1/ULK1明显升高(Pn.GSDMD/GSDMD、cleaved Caspase-1/Caspase-1、n.RP3、IL-1β明显降低(Pn.V、PWT明显升高(Pn.RP3、n.GSDMD/GSDMD明显降低(Pn.其治疗效果较α-硫辛酸可能更好。

关键词：糖尿病周围神经病变线粒体自噬焦亡补阳还五汤

Multifocal structured illumin.tion.optoacoustic microscopy

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Light(Scien.e & Application.) 2020年第1期9卷 568-576页

作者： Zhen.ue Chen.Ali Ozbek Johan.es Reblin. Quan.u Zhou Xose Luis Dean.ben Dan.el Razan.ky In.titute for Biomedical En.in.erin. an. In.titute of Pharmacology an. Toxicology University of Zurich and ETH ZurichZurichSwitzerland

Optoacoustic(OA)imagin. has the capacity to effectively bridge the gap between.macroscopic an. microscopic realms in.biological ***-resolution.OA microscopy has so far been.performed via poin.-by-poin. scan.in. with a focused laser beam,thus greatly restrictin. the achievable imagin. speed an./or field of *** we in.roduce multifocal structured illumin.tion.OA microscopy(MSIOAM)that attain. real-time 3D imagin. *** this purpose,the excitation.laser beam is shaped to a grid of focused spots at the tissue surface by mean. of a beamsplittin. diffraction.gratin. an. a con.en.er an. is then.scan.ed with an.acousto-optic deflector operatin. at kHz *** both phan.om an. in.vivo mouse experimen.s,a 10mm wide volumetric field of view was imaged with 15 Hz frame rate at 28μm spatial *** proposed method is expected to greatly aid in.biological in.estigation. of dyn.mic fun.tion.l,kin.tic,an. metabolic processes across multiple scales.

关键词： illumin.tion beam excitation

Mid/far-in.rared photo-detectors based on.graphen. asymmetric quan.um wells

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Chin.se Physics B 2016年第9期25卷 573-580页

作者： E ben Salem R Chaaban. S Jaziri In.titut Preparatoire aux Etudes d'In.en.eurs de Tun.s 2 Rue Jawaher Lel Nahrou Monfleury 1089 Tunisie Laboratoire de Physique de la Matiere Con.en.ee Departement de Physique Faculte des Sciences de Tunis Campus Universitaire 2092 Tunisie Departemen. de Physique Faculte des Sciences de Bizerte Jarzouna 7021 Bizerte

We con.ucted a theoretical study on.the electron.c properties of a sin.le-layer graphen. asymmetric quan.um *** of en.rgy levels is limited by electron.hole con.ersion.at the barrier in.erfaces an. free-electron.***–hole con.ersion.at the barrier in.erfaces can.be con.rolled by in.roducin. an.asymmetry between.barriers an. takin. in.o accoun. the effect of the in.eraction. of the graphen. sheet with the *** in.eraction.with the substrate in.uces an.effective mass to carriers,allowin. observation.of Fabry–P′erot reson.n.es un.er n.rmal in.iden.e an. extin.tion.of Klein.*** asymmetry,between.barriers creates a tran.mission.gap between.con.in.d states an. free-electron.con.in.um,allowin. the large graphen. asymmetric quan.um well to be exploited as a photo-detector operatin. at mid-an. far-in.rared frequen.y regimes.

关键词： graphen. quan.um wells reflection.coefficien. photo-detector

Syn.hesis an. Properties of Perfluorin.ted Alkyl Silicon. Oil Modified Epoxy Resin

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Journ.l of Wuhan.Un.versity of Techn.logy(Materials Scien.e) 2014年第2期29卷 361-366页

作者：孙明慧 MA ben 翁睿 School of Materials Scien.e an. En.in.erin. Wuhan University of Technology

Perfluorin.ted alkyl silicon. oil （PFASO） was successfully syn.hesized from n.ethyl-n. hydroxylethyl perfluorin.ted octan. sulfon.mide, succin.e an.ydride an. amin. silicon. oil by esterification.an. amide reaction.at moderate temperature in.the presen.e of differen. catalysts. The chemical structure of the syn.hesized samples was characterized by Fourier tran.form in.rared spectroscopy （FT-IR）, the relative molecular mass（MM） an. molecular mass distribution.MMD） of PFASO were tested by gel filtration.chromatography（GFC）. A commercial epoxy resin.（DGEBA） was modified with PFASO, with the con.en. of PFASO 1-5 phr. Thermo-gravimetric an.lysis （TGA）, impact tests, scan.in. electron.microscope （SEM） an. water con.act an.le test were applied to provide accurate results on.the thermal stability, toughn.ss an. hydrophobicity of PFASO/epoxy complex. The experimen.al results reveal that epoxy resin. can.be successfully modified by addin. a small amoun. of as-syn.hesized modifiers via simple direct mixin., an. verify that the as-syn.hesized modifier can.improve the toughn.ss an. hydrophobicity of epoxy resin.without sacrificin. its thermal properties.

关键词： perfluorin.ted alkyl silicon. oil epoxy resin modification

Light-Triggered Catalytic Performan.e En.an.emen. Usin. Magn.tic n.n.motor En.embles

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Research 2020年第1期2020卷 986-996页

作者： Fen.ton. Ji ben Wan. Li Zhan. Departmen. of Mechan.cal an. Automation.En.in.erin. The Chinese University of Hong KongShatin N.T.Hong KongChina Chow Yuk Ho Techn.logy Cen.re for In.ovative Medicin. The Chinese University of Hong KongShatin N.T.Hong KongChina

Micro/n.n.machin.s have attracted exten.ive atten.ion.in.the biomedical an. en.iron.en.al fields for realizin. fun.tion.lities at small ***,they have been.rarely in.estigated as active *** n.n.catalysts have exception.l reusability an. recyclability,an. in.egration.with magn.tic materials en.bles their recovery with min.mum ***,we propose a model active n.n.catalyst usin. magn.tic n.n.motor en.embles(Mn.s)that can.degrade con.amin.n.s in.an.aqueous solution.with high catalytic *** composed of a magn.tite core coated with gold n.n.particles as the n.n.catalyst can.rotate un.er the action.of a programmable extern.l field an. carry out rapid reduction.of 4-n.trophen.l(4-n.).The hydrogen.bubbles gen.rated in.the catalytic reaction.provide ran.om perturbation. for the Mn.s to travel in.the reaction.solution.resultin. in.un.form *** reduction.can.be further boosted by irradiation.with n.ar-in.rared(n.R)*** field in.uces the rotation.of the Mn.s an. provides microstirrin. in.the *** en.an.es the catalytic activity via the photothermal *** Mn.s are also capable of movin. to the targeted region.through the application.of a programmable magn.tic field an. then.process the con.amin.n. in.the targeted *** expect that such magn.tic Mn.s may help better in.applyin. active heterogen.ous n.n.catalysts with magn.tic field an. light-en.an.ed performan.e in.in.ustrial application. due to their advan.ages of low material cost an. short reaction.time.

关键词： effect catalyst stirrin.

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纳米晶仿生钙磷颗粒的理化性质及细胞相容性

中国组织工程研究 2024年第22期28卷 3502-3508页

作者：陈明学牛建华林海燕吴刚万奔首都医科大学附属北京积水潭医院北京市100035 上海市黄浦区牙病防治所上海市200020 杭州医学院浙江省杭州市310059 杭州彗搏科技有限公司浙江省杭州市311217

背景:临床上人工合成的羟基磷灰石陶瓷颗粒被广泛用于修复大体积骨缺损,但制备过程中的高温烧结会降低羟基磷灰石陶瓷颗粒的可降解性和生物活性,限制其骨修复效果。目的:采用新型低温沉积技术制备纳米晶仿生钙磷颗粒,表征其理化性能与... 详细信息

背景:临床上人工合成的羟基磷灰石陶瓷颗粒被广泛用于修复大体积骨缺损,但制备过程中的高温烧结会降低羟基磷灰石陶瓷颗粒的可降解性和生物活性,限制其骨修复效果。目的:采用新型低温沉积技术制备纳米晶仿生钙磷颗粒,表征其理化性能与细胞相容性。方法:采用改良后的过饱和钙磷矿化液和重复静置重悬洗涤方式制备纳米晶仿生钙磷颗粒,以羟基磷灰石生物陶瓷颗粒为对照,通过扫描电镜、X射线衍射仪、傅里叶变换红外光谱仪表征两种颗粒的形貌和物相组成,通过BET-n.法、硬度和接触角测试表征两种颗粒的比表面积、孔隙度分布、硬度和亲水性行为,利用BCA法检测两种颗粒对牛血清白蛋白和胎牛血清蛋白的吸附性能。将两种颗粒或颗粒浸提液分别与人脐带间充质干细胞共培养,采用MTT法检测细胞增殖。结果与结论:①扫描电镜显示两种颗粒表面略微粗糙并伴有微小颗粒存在,羟基磷灰石生物陶瓷颗粒表面致密光滑,纳米晶仿生钙磷颗粒主要由不均匀纳米尺寸的针/板状晶体组成,并在晶体之间形成纳米孔结构。X射线衍射、傅里叶变换红外光谱显示,相较于羟基磷灰石生物陶瓷颗粒,纳米晶仿生钙磷颗粒的结晶粒小、结晶度低,含有更多的结合水和碳酸根基团。与羟基磷灰石生物陶瓷颗粒相比,纳米晶仿生钙磷颗粒具有更高的比表面积、更好的亲水性、更低的硬度与更高的蛋白吸附能力。②MTT检测结果显示,两种颗粒浸提液基本无细胞毒性,人脐带间充质干细胞在两种颗粒表面存活良好,并且纳米晶仿生钙磷颗粒表面的细胞增殖活性更强。③结果表明与羟基磷灰石生物陶瓷颗粒相比,纳米晶仿生钙磷颗粒具有更好的理化性能与细胞相容性。

关键词：纳米晶仿生钙磷颗粒羟基磷灰石骨再生修复生物相容性,蛋白吸附人脐带间充质干细胞

Cryogel scaffolds: soft an. easy to use tools for n.ural tissue culture

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n.ural Regen.ration.Research 2022年第9期17卷 1981-1983页

作者： ben n.wlan. Katherin. R.Lon. School of Pharmacy an. Pharmaceutical Scien.es Cardiff UniversityCardiffUK Cen.re for Developmen.al n.urobiology Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMRC Centre for Neurodevelopmental DisordersKing’s College LondonLondonUK

The mammalian.cen.ral n.rvous system(Cn.)is highly complex,with a vast array of processes an. in.eraction. occurrin. in.a dyn.mic an. often.tran.ien. *** these processes are combin.d to regulate our behavior remain. poorly *** has in.turn.led to a lack of un.erstan.in. of how these processes have gon. awry in.the man. disorders of the n.rvous *** order to address this,researchers n.ed a con.rolled way to man.pulate the n.rvous system in.in.vitro an. ex vivo cultures,in.both a specific area an. for a specific period of time to start to pick apart these *** date,this has been.techn.cally challen.in.,especially when.modelin. focal in.ury to the Cn. or when.workin. with human.brain.tissue.

关键词： culture n.ural tran.ien.