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丹参提取物对皮肤表皮分化和水合促进作用的研究

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丹参提取物对皮肤表皮分化和水合促进作用的研究

Midazolam dose is associated with recurrence of paradoxical reactions during endoscopy

第九届中国化妆品学术研讨会

作者： LEE jin Young KIM Han Byul LEE Sung Hoon LEE Ok Chan bae ji hyun LEE Hae Kwang Amorepacific Corporation R&D Center

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得... 详细信息

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得到评估。在本研究中,我们发现丹参提取物(ESM)可以刺激正常人角质细胞和Amo Re Skin(本实验室建立的重建人类皮肤模型)中丝聚蛋白的表达。实时定量PCR试验证实了这一结论,丹参提取物(ESM)干预能够上调角质细胞中丝聚蛋白m RNA的表达。免疫染色试验证实丹参提取物(ESM)干预后Amo Re Skin中丝聚蛋白的表达增加。此外,实时定量PCR试验也证实角质细胞中表皮分化的标志物角蛋白1 m RNA的量增多。这些结果表明,丹参提取物(ESM)可以增强表皮分化和水合的活性,可能会增强表皮对抗皮肤老化的功能。

关键词：丹参丝聚合蛋白表皮分化

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World Journal of Clinical Cases 2021年第29期9卷 8763-8772页

作者： Eun Hyo jin ji hyun Song Jooyoung Lee Jung Ho bae Su jin Chung Department of Internal Medicine Healthcare Research InstituteHealthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea

BACKGROUND Midazolam is commonly used for sedation during gastrointestinal ***,some patients experience paradoxical reactions characterized by excessive movement or *** To investigate the rate of recurrence of paradoxical reactions to midazolam during an upper *** We retrospectively reviewed 122152 sedative endoscopies among a total of 58553 patients at the Seoul National University Hospital,Healthcare System Gangnam Center,from July 2013 to December *** them,361 patients with a history of paradoxical reaction during sedative upper endoscopy were *** characteristics of patients in the recurrent and non-recurrent groups were compared via multivariable analysis using logistic *** Paradoxical reactions occurred in 0.86%(1054/122152)of endoscopies,and in 1.51%(888/58553)of *** the 361 subjects with previous paradoxical reactions in sedative endoscopies,111(30.7%)experienced further paradoxical *** analysis revealed that the total midazolam dose used was higher in the recurrent group(6.74±2.58 mg)than in the non-recurrent group(5.49±2.04 mg;P<0.0001).Patients were administered a lower dose of midazolam than previous doses:1 mg less in the recurrent group and 2 mg less in the non-recurrent *** analysis showed that the midazolam dose difference was an independent risk factor for recurrent paradoxical reaction(odds ratio:1.213,95%CI:1.099-1.338,P=0.0001).CONCLUSION The rate of recurrence of paradoxical reactions is significantly associated with midazolam *** dose of midazolam administered to patients with previous paradoxical reactions should be less than that previously used.

关键词： Gastroscopy Endoscopy Conscious sedation Midazolam Flumazenil

Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

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Chinese Journal of Integrative Medicine 2019年第12期25卷 895-901页

作者： hyun-Jung Park ji hyun Kim Insop Shim Department of Physiology College of MedicineKyung Hee UniversitySeoul(130-701)Republic of Korea Department of Food Science&Biotechnology College of Science and EngineeringSuwon-si(16227)Republic of Korea

Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P<0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.

关键词： Panax ginseng ginsenosides hypothalamus obesity

Effect of Length Scale Tuning of Background Error in WRF-3DVAR System on Assimilation of High-Resolution Surface Data for Heavy Rainfall Simulation

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Advances in Atmospheric Sciences 2012年第6期29卷 1142-1158页

作者： ji-hyun HA Dong-Kyou LEE Atmospheric Sciences Program School of Earth and Environmental SciencesSeoul National UniversitySeoul 151-747Korea

We investigated the impact of tuning the length scale of the background error covariance in the Weather Research and Forecasting （WRF） three-dimensional variational assimilation （3DVAR） system. In particular, we studied the effect of this parameter on the assimilation of high-resolution surface data for heavy rainfall forecasts associated with mesoscale convective systems over the Korean Peninsula. In the assimilation of high-resolution surface data, the National Meteorological Center method tended to exaggerate the length scale that determined the shape and extent to which observed information spreads out. In this study, we used the difference between observation and background data to tune the length scale in the assimilation of high-resolution surface data. The resulting assimilation clearly showed that the analysis with the tuned length scale was able to reproduce the small-scale features of the ideal field effectively. We also investigated the effect of a double-iteration method with two different length scales, representing large and small-length scales in the WRF-3DVAR. This method reflected the large and small-scale features of observed information in the model fields. The quantitative accuracy of the precipitation forecast using this double iteration with two different length scales for heavy rainfall was high; results were in good agreement with observations in terms of the maximum rainfall amount and equitable threat scores. The improved forecast in the experiment resulted from the development of well-identified mesoscale convective systems by intensified low-level winds and their consequent convergence near the rainfall area.

关键词： WRF 3DVAR tuning surface data heavy rainfall

Epirubicin,Cisplatin,5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第1期20卷 235-241页

作者： ji Eun Lee Si hyun bae Jong Young Choi Seung Kew Yoon Young Kyoung You Myung Ah Lee Division of Medical Oncology Hepato-Biliary-Pancreatic Cancer CenterCancer Research Institute Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Internal Medicine Hepato-Biliary-Pancreatic Cancer CenterCancer Research InstituteSeoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Division of Hepatology Hepato-Biliary-Pancreatic Cancer CenterCancer Research Institute Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Surgery Hepato-Biliary-Pancreatic Cancer CenterCancer Research InstituteSeoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM: To evaluate the clinical efficacy and safety of epirubicin, cisplatin, and 5-FU combination chemotherapy for the sorafenib-refractory metastatic hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Sorafenib Epirubicin Cisplatin 5-FU

Improved continuous precipitation kinetics and tensile properties of extruded AZ80 alloy through {10-12} twin formation

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Journal of Magnesium and Alloys 2023年第9期11卷 3323-3337页

作者： hyun ji Kim Sumi Jo Sung Hyuk Park Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566the Republic of Korea

This study investigates the effect of{10-12}deformation twins on the continuous precipitation behavior of an extruded Mg-8.0Al-0.5Zn-0.2Mn(AZ80)alloy during *** extruded AZ80 alloy is compressed along the transverse direction to introduce{10-12}twins,followed by an aging treatment at 300℃.The extruded material exhibits a twin-free microstructure with low internal strain energy,whereas the pre-twinned material possesses abundant{10-12}twins and has high internal strain *** aging results reveal that the peak-aging time of the pre-twinned material(1 h)is one-eighth of that of the extruded material(8 h).Although Mg_(17)Al_(12)continuous precipitates(CPs)are observed in both the peak-aged materials,these CPs are much smaller and more densely distributed in the pre-twinned material despite the significantly shorter aging *** CPs size in the peak-aged materials increases in the following order:twinned region in the pre-twinned material(0.47μm)

关键词： AZ80 alloy {10-12}twin Aging Continuous precipitation Tensile properties

Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SEN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jong Un Lee hyun ji Kim Sang-Cheol jin Ye jin Kim Young Min Kim Bong Sun You Jun Ho bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research Institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SEN alloys)recently developed at the Korea Institute of Materials *** alloys are produced by adding small amounts of Ca and Y(each<1 wt%)into commercial Mg–Al based alloys,resulting in exceptional ignition and corrosion resistances and impressive mechanical *** main advantages of SEN alloys are as follows.(1)A dense multi-oxide layer of SEN alloys comprising MgO,CaO,and Y_(2)O_(3) impedes the outward dispersion of Mg vapor and the inward penetration of O_(2) during oxidation,thereby enhancing the oxidation and ignition resistances.(2)The presence of Ca-and Y-based second-phase particles in SEN alloys can enhance their corrosion resistance because Ca-containing particles prevent the spread of corrosion,and the replacement of Al-containing particles with less noble ones containing Y(e.g.,Al–Mn–Y or Al–Y particles)retards corrosion.(3)The addition of minor amounts of Ca and Y renders excellent mechanical properties due to improved strengthening *** enhanced properties are attributed to more pronounced dynamic recrystallization and grain refining behaviors caused by the second-phase particles during extrusion.(4)Despite the presence of various types of second-phase particles,the fatigue properties of SEN9 alloys are similar to those of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elongation of aged SEN alloys.(6)Adding mischmetal into the SEN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SEN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SEN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties Extrudability.

Acceleration of aging behavior and improvement of mechanical properties of extruded AZ80 alloy through(10–12) twinning

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Journal of Magnesium and Alloys 2023年第2期11卷 671-683页

作者： hyun ji Kim Ye jin Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The effects of pre-existing {10–12} extension twins on the precipitation behavior of an extruded AZ80 material during aging and on its mechanical properties after peak aging are investigated. The material containing {10–12} twins-which are formed by compression before aging(twinned material)-has a finer grain size and higher dislocation density than the extruded material. Although the peak hardnesses of the twinned and extruded materials are almost the same, the time to reach the peak hardness is considerably shorter in the former material than in the latter(4 h and 24 h, respectively). In the twinned material, the high dislocation density of the {10–12} twins promotes continuous precipitation, which results in the formation of numerous fine Mg17Al12precipitates within the twins in the early stage of *** formation of these continuous precipitates reduces the driving force for discontinuous precipitation, which consequently suppresses the formation and growth of coarse Mg17Al12precipitates at the grain boundaries. Despite its shorter peak-aging time, the 4 h-peak-aged twinned material shows higher tensile strength and elongation than the 24 h-peak-aged extruded material. These higher mechanical properties of the former material are attributed primarily to the presence of more abundant fine continuous precipitates, which are effective in strengthening the material, and less abundant coarse discontinuous precipitates, which can act as crack initiation sites. These results demonstrate that the introduction of {10–12} twins into wrought Mg–Al-based alloys can accelerate the Mg17Al12precipitation kinetics considerably and improve the strength and ductility of the peak-aged alloys simultaneously.

关键词： AZ80 alloy Twin Aging Precipitation Tensile properties

Adhesive ginsenoside compound K patches for cartilage tissue regeneration

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Regenerative Biomaterials 2023年第1期10卷 1442-1450页

作者： Jun-Ho Yang hyun Ho Shin Donghyeon Kim ji hyun Ryu Eun-Jung jin Department of Biological Sciences College of Health SciencesWonkwang UniversityIksanJeonbuk 54538South Korea Department of Chemical Engineering Wonkwang UniversityIksanJeonbuk 54538South Korea Department of Carbon Convergence Engineering Wonkwang UniversityIksanJeonbuk 54538South Korea Integrated Omics Institute Wonkwang UniversityIksanJeonbuk 54538South Korea

Biomaterial-based drug delivery systems have been developed to expedite cartilage regeneration;however,challenges related to drug recovery,validation,and efficient drug delivery *** instance,compound K(CK)is a major metabolite of ginsenosides that is known to protect against joint degeneration by inhibiting the production of inflammatory cytokines and the activation of immune ***,its effects on cartilage degradation and tissue regeneration remain ***,tissue-adhesive drug delivery depots that stably adhere to cartilage defects are required for CK *** this study,CK-loaded adhesive patches were reported to seal cartilage defects and deliver CK to defect sites,preventing cartilage degradation and accelerating cartilage tissue *** patches are stable and suitable for application in surgical procedures under physiological conditions and show excellent adhesiveness to cartilage *** addition,there were no significant differences in the adhesive polymeric networks before and after CK ***-loaded hydrocaffeic acid-conjugated chitosan patches significantly inhibited the stimulation of cartilage-degrading enzymes and apoptosis in osteoarthritic cartilage by releasing CK in cartilage ***,the NFkB signaling pathway of released CK from the adhesive patches in the treatment of osteoarthritis is ***,the CK-loaded adhesive patches are expected to significantly contribute to cartilage regeneration.

关键词： ginsenoside compound K adhesive patch drug delivery hydrocaffeic acid-conjugated chitosan osteoarthritis