Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

作     者：Hyun-Jung Park Ji Hyun Kim Insop Shim 

作者机构：Department of PhysiologyCollege of MedicineKyung Hee UniversitySeoul(130-701)Republic of Korea Department of Food Science&BiotechnologyCollege of Science and EngineeringSuwon-si(16227)Republic of Korea 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2019年第25卷第12期

页      面：895-901页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 

基　　金：Supported by the a grant from Integrative Medicine Research Project through Wonkwang University Jangheung Integrative Medical Hospital,funded by the Ministry of Health&Welfare,Republic of Korea(No.1465027127) Kyung Hee University in 2019(KHU-20191211) 

主　　题：Panax ginseng ginsenosides hypothalamus obesity 

摘      要：Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P0.05 or P0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.