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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 44-44页

作者： bar-lev M.R.R. Maayan-Metzger A. Matok i. J. Kuint 王伟华 Department of Neonatology Sheba Medical Center 52621 Ramat Gan Israel Dr.

ObJECTiVE: To assess the incidence of short-term outcomes of low birth weig ht infants (≤1,750 g) exposed prenattally to either dexamethasone or betamethaso ne. METHODS: We retrospectively analyzed a cohort comprising 550 infants who wer e born alive at our center during the period January 1999 through December 2001, who weighed 1,750 g or less at birth, and who were exposed to prenatal steroid treatment. We compared brain ultrasound findings, such as intraventricular hemor rhage and cystic periventricular leukomalacia (PVL), as well as other clinical f indings, including respiratory distress syndrome (RDS), necrotizing enterocoliti s, retinopathy of prematurity, and bronchopulmonary dysplasia, for all premature infants whose mothers received either dexamethasone (from January 1, 1999 to Ju ne 30, 2000, n = 263) or beta-methasone (July 1, 2000 to December 31, 2001, n = 287). RESULTS: Patient characteristics (mothers and infants) were the same in b oth groups, with the exception of the number of steroid courses administered, th e number of women with premature rupture of membranes (defined as >24 hours), an d the number of women who had received tocolysis. No significant difference was found between the 2 groups with respect to intraventricular hemorrhage and cysti c PVL frequencies. No significant differences were found in the incidence of sho rt-term outcomes examined, despite the fact that the dexamethasone group was ex posed to a statistically significantly greater number of courses than the betame thasone group. CONCLUSiON: There seem to be no advantages to maternal antenatal treatment with betamethasone compared with dexamethasone in reducing the risk of PVL in low birth weight (≤1,750 g) infants. both drugs have the same effect on all short-term outcome parameters checked.

关键词：倍他米松呼吸窘迫综合征类固醇治疗视网膜病变胎膜早破无显著性差异保胎治疗超声结果发育不良日至

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Mechanisms involved in the Growth Promotion of Weaned Piglets by High-level Zinc Oxide

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Journal of Animal Science and biotechnology 2010年第1期1卷 59-67页

作者： X.L.Li. b.Dong D.F.Li J.D.Yin NationalKeyLaboratoryofAnimalNutrition CoUegeofAnimalScienceChinaAgriculturalUniversityBeijing100193China

Dietary supplementation with high lev- els of zinc oxide （ZnO） is an effective method to prevent diarrhea and promote growth in weaned pig- lets. However, the mechanisms behind these beneficial effects are not well understood. Recent advances in this field indicated that the effects of ZnO on piglet growth are achieved through multiple regulatory path- ways rather than a single pathway. This review focu- ses on recent advances in the effects of high level ZnO on： 1 ） Zn status in weaned piglets; 2 ） intestinal microbe flora regulation; 3 ） intestinal structure and function;4） ion secretion in the intestine epithelium;5） intestinal immunology; and 6） secretion of brain-in- testine peptides. ZnO appears to regulate the intestinal microflora and decreases the release of histamine to prevent diarrhea. ZnO also increases the expression of intestinal insulin-like growth factor-1 （ iGF-1 ） and the iGF-1 receptor to ameliorate intestinal injury associat- ed with weaning, and mediates secretion of brain-gut peptides to stimulate food intake, to promote the growth of piglets. better understanding of the underly-1 ing mechanisms should inspire us to supplement the diet for weaned piglets with ZnO and investigate new approaches to prevent diarrhea and enhance growth.

关键词： mechanism weaned piglets zinc oxide

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influence of Montmorillonite Nanocomposite on Tissue levels of Lead and blood biochemical Parameters in Pigs Exposed to Lead

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Journal of Animal Science and biotechnology 2010年第1期1卷 44-48页

作者： D.Y. Yu W.Rao b.Zhou. W.H.Song College of Animal Science Institute of Feed Science Zhejiang University Hangzhou Zhejiang310029 China

AbSTRACT： Eighteen （Duroc x Landrace x Yorkshire） castrated boars, 55 days of age and weig- hing approximately 19 kg, were used to investigate the effects of montmorillonite nanocomposite on tissue levels of lead as well as changes in blood biochemical parameters in pigs fed lead contaminated diets. The barrows were randomly assigned to one of three treat- ments （n = 6） including a control which were fed a basal diet based on corn and soybean meal. The re- maining two groups were fed the basal diet supple- mented with 10 mg/kg lead either with or without 0.5% montmorillonite nanocomposite for 50 days. Pigs treated with lead had significantly increased lev- els of lead in their tissues. Lead accumulated in all tis- sues of the body with the highest accumulation found in the hair. When montmorillonite nanocomposite was given along with lead, tissue concentrations of lead did not differ from the control. Fecal excretion of leadincreased significantly in lead-exposed pigs treated with montmorillonite nanocomposite. A progressive and appreciable accumulation of lead was seen in blood with a concomitant increase in zinc protopor- phyrin levels during the course of treatment. Howev- er, zinc protoporphyrin levels did not differ from the control when montmorillonite nanocomposite was ad- ministered along with lead. The activity of ^-amino le- vulinic acid dehydratase in blood was significantly in- creased in lead treated pigs compared with the con- trol. However, in pigs treated with lead and montmo- riltonite nanocomposite in combination, the activity of δ-amino levulinic acid dehydratase was similar to con- trol pigs. Our results indicate that montmorillonite nanocomposite treatment of pigs exposed to lead re- suited in reduced lead concentrations in body tissues. it appears that montmorillonite nanocomposite func- tions by increasing fecal excretion of lead.

关键词： δ-amino levulinic acid dehydratase lead montmorillonite zinc protoporphyrin

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江苏海门王浩钻孔全新世钙质超微化石的环境意义

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古生物学报 1996年第2期35卷 187-198,259页

作者：钟石兰刘金陵吴顺根周山富 William Y.b.Chang 中国科学院南京地质古生物研究所地质矿产部华东石油地质局地质研究所 CENTER FOR GREAT LUKES AND AQUATS SCiENCE AND SCHOOL OF NATURAL RESORCES AND ENViRONMENT

初步研究了海门王浩地区ＷＺＫ０１０、ＷＺＫ２１４、ＷＺＫ３００３钻孔中的全新世钙质超微化石组合，优势种Ｇ．ｏｃｅａｎｉｃａ组合中平均占９７％。依据化石的种数、丰度和保存状况，自下而上划分３个亚组合。第Ⅰ亚组合，深度７... 详细信息

初步研究了海门王浩地区ＷＺＫ０１０、ＷＺＫ２１４、ＷＺＫ３００３钻孔中的全新世钙质超微化石组合，优势种Ｇ．ｏｃｅａｎｉｃａ组合中平均占９７％。依据化石的种数、丰度和保存状况，自下而上划分３个亚组合。第Ⅰ亚组合，深度７４４７ｍ，由Ｇ．ｏｃｅａｎｉｃａ，Ｈ．ｃａｒｔｅｒｉｉ，Ｈ．ｗａｌｌｉｃｈｉｉ，Ｓ．ｌａｍｉｎａ，Ｕ．ｓｉｂｏｇａｅ组成，丰度较高，保存较好，代表前三角洲－浅海环境。第Ⅱ亚组合，深度４７—２５ｍ，成分有Ｇ．ｏｃｅａｎｉｃａ，Ｈ．ｃａｒｔｅｒｉｉ，Ｓ．ｌａｍｉｎａ，Ｕ．ｓｉｂｏｇａｅ，丰度低，种数少，保存较差，是三角洲前缘的产物。第Ⅲ亚组合，深度２５—２．０ｍ，种类计有Ｇ．ｃｏｅａｎｉｃａ，Ｅ．ｈｕｘｌｅｙｉ．Ｂ．ｂｉｇｅｌｏｗｉｉ，Ｈ．ｃａｒｔｅｒｉｉ，Ｈ．ｗａｌｉｃｈｉｉ，Ｈ．ｈｙａｌｉｎａ，Ｓ．ｈｉｓｔｒｉｃａ，Ｓ．ｌａｍｉｎａ，Ｕ．ｓｉｂｏｇａｅ，Ｃ．ｌｅｐｔｏｐｏｒｕｓ等，含量较高，种数较多，保存一般，反映海湾一渴湖环境。３个亚组合所在地层的岩胜分别为下部粘土、粉砂，中部粉细砂，上部粘土、粉砂。研究结果证实。

关键词：化石钙质超微化石长江三角洲全新世

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日粮中添加酵母硒对断奶仔猪生长性能及抗氧化性能的影响

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饲料工业 2015年第6期36卷 6-10页

作者：罗霄方俊刘刚 Myrlene Carine b.Tossou 李铁军邓近平湖南农业大学动物科学技术学院动物营养研究所湖南长沙410128 湖南农业大学动物科学技术学院湖南长沙410128 中国科学院亚热带农业生态研究所湖南长沙410125

饲养断奶仔猪时添加一定量的硒,可以降低仔猪死亡率、增加进食量和体重、降低料肉比,这种方法已得到了较为普遍的应用,但是对于硒的最佳添加量争论不一。文中试验研究酵母硒的添加量对仔猪生长性能的影响,筛选出三元杂交仔猪酵母硒的最... 详细信息

饲养断奶仔猪时添加一定量的硒,可以降低仔猪死亡率、增加进食量和体重、降低料肉比,这种方法已得到了较为普遍的应用,但是对于硒的最佳添加量争论不一。文中试验研究酵母硒的添加量对仔猪生长性能的影响,筛选出三元杂交仔猪酵母硒的最适添加量。选取21日龄、初生重相近、杜洛克×长白×约克夏三元杂交断奶仔猪192头,随机分为4个处理,每个处理8栏,每栏6头,对照组仔猪饲喂基础日粮,处理组仔猪在基础日粮中分别添加0.15、0.30、0.60 mg/kg的酵母硒,试验期为4周(28 d)。结果表明,添加酵母硒各组仔猪的平均日增重比对照组高,饲料利用率有所提高,且试验组仔猪腹泻率低、健康状况良好,其中0.30 mg/kg的添加量的料肉比最低,且抗氧化性最好、最稳定。3%的酵母硒,添加量可作为首选添加比例。

关键词：酵母硒仔猪料肉比

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对接受维生素A治疗的视网膜色素变性患者加用二十二碳六烯酸效果的进一步分析:亚群分析

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 17-18页

作者： berson E.L. Rosner b. Sandberg M.A. 张磊 berman-Gund Labo ratory 243 Charles St Boston MA 02114 United States Dr.

Objective: To determine whether docosahexaenoic acid will slow the course of r etinal degeneration in subgroups of patients with retinitis pigmentosa who are r eceiving vitamin A. Design: Acohort of 208 patients with retinitis pigmentosa, a ged 18 to 55 years, were randomly assigned to 1200 mg of docosahexaenoic acid pl us 15000 iU/d of vitamin A given as retinyl palmitate (DHA +A group) or control fatty acid plus 15000 iU/d of vitamin A (control +A group) and followed up ove r 4 years. Seventy percent of the patients in each group were taking vitamin A, 15000 iU/d, prior to entry. We compared rates of decline in ocular function in t he DHA +A vs control +A groups among the subgroups defined by use or nonuse of vitamin A prior to entry. We also determined whether decline in ocular function was related to red blood cell phosphatidylethanolamine docosahexaenoic acid lev el, dietary ω-3 fatty acid intake, or duration of vitamin A use. Main outcome measures were Humphrey Field Analyzer visual field sensitivity, 30-Hz electrore tinogram amplitude, and visual acuity. Results: Among patients not taking vitami n A prior to entry, those in the DHA +A group had a slower decline in field sen sitivity and electroretinogram amplitude than those in the control +A group ove r the first 2 years (P=.01 and P=.03, respectively); these differences were not observed in years 3 and 4 of follow-up or among patients taking vitamin A prior to entry. in the entire cohort, red blood cell phosphatidylethanolamine docosah exaenoic acid level was inversely related to rate of decline in total field sens itivity over 4 years (test for trend, P=0.05). This was particularly evident ove r the first 2 years among those not on vitamin A prior to entry (test for trend, P=0.003). in the entire control +A group, dietary ω-3 fatty acid intake was inversely related to loss of total field sensitivity over 4 years (intake,ion of vitamin A supplementation prior to ent r

关键词：视网膜色素变性二十二碳六烯酸群分析视网膜电图视功能棕榈酸视黄酯磷脂酰乙醇胺负相关趋势检验队列研究

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一个临界性的排除诊断

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 4-5页

作者： Clarke P. Glick S. Reilly b.M. 郭俊 Department of Medicine Cook County Hospital 1900W. Polk St. 1501-A Chicago IL 60612 United States Dr.

A 48-year-old airline mechanic from belize presented to the emergency depart ment with fever and altered mental status. Two weeks earlier, fever, myalgias, a nd dry cough had developed. His maximal daily temperature reached as high as 41. 1°C, and one week before coming to the emergency department, the patient awaken ed unable to speak. At a hospital in belize, he was febrile and aphasic without other focal neurologic findings. The results of computed tomography (CT) of the brain were normal. Examination of the cerebrospinal fluid revealed a protein lev el of 157 mg per deciliter and a glucose level of 44 mg per deciliter (2.4 mmol per liter) but no cells or microorganisms. The patient rec eived treatment with chloroquine and acyclovir for the next five days but did no t improve and was flown to Chicago for further care. On examination, the patient was agitated and unable to speak or follow verbal commands. The blood pressure was 132/74 mm Hg, the pulse 82 beats per minute, and the respiratory rate 20 bre aths per minute. The temperature was 39.5°C. The results of the general examina tion were normal, without meningismus. A neurologic examination revealed global aphasia but was otherwise normal except for an equivocal extensor plantar respon se on the right. The optic fundi appeared normal.

关键词：排除诊断临界性局灶性神经症状急诊科焦虑不安眼底检查肌痛周前呼吸频率完全性

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Prevalence and Associated Risk Factors of Porcine Echinococcosis at the ivorian Pig Slaughter Company (SiVAC), Yopougon Abidjan: A Cross Sectional Study

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Journal of biosciences and Medicines 2020年第11期8卷 1-8页

作者： Touré Lisette Koné Naférima Toure Alassane Emmanuel K. Mebourou Senin C. b. Valery Sevidzem S. Lendzele Mavoungou J. François Acapovi-Yao G. Lydie UFR biosciences Université Félix Houphou&euml t-boigny Abidjan C&ocirc te d’ivoire Laboratoire National d’Appui au Développement Agricole Laboratoire Central Vétérinaire de Bingerville Bingerville C&ocirc te d’ivoire Département des Sciences de la Vie Faculté de Sciences Université de Bangui Bangui République de Centrafrique Département Hygiène et Santé Animale Société Ivoirienne d’Abattage et de Charcuterie Abidjan C&ocirc te d’ivoire Laboratoire d’Ecologie Vectorielle (lev-iRET) Ecole Doctorale des Grandes Ecoles (EDGE) Libreville Gabon institut de Recherche en Ecologie Tropicale (iRET-CENAREST) Libreville Gabon

background: Parasitic diseases are threat to the development of ivorian Pig industry. Zoonotic diseases such as Echinococcosis have a significant impact on animal health and production. Little is known about Echinococcosis in Cô te d’ivoire. Aim: For these reasons, a cross section study was conducted at SiVAC in Yopougon, on pigs (Sus scrofa domesticus), in order to determine the prevalence and associated risk factors of Echinococcosis. Method: Paraclinical examinations of pig organs (kidneys, lungs, and liver) were conducted from 5th September to 30th December 2019 in order to report infection with this parasite. Results: Out of the 2425 slaughtered pigs, 63 of them were Echi-nococcosis positive, resulting in overall infection prevalence of 2.6% (95% Ci: 1.9% - 3.22%). The kidneys (2.35%) were most infected, followed by lungs (0.21%), and liver (0.04%). Recommendations: A more in-depth study on the molecular epidemiology of Echinococcosis in the different regions of Cô te d’ivoire is underway. Also, capacity building of community livestock actors (Veterinarians, health inspectors, breeders and butchers) and sensitization of the population on this disease is necessary in order to improve its diagnosis at the abattoir level and to set up strategies to combat it.

关键词： Echinococcosis Prevalence Pig SiVAC Abidjan

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抗病毒治疗适应证变化对提高慢性乙型肝炎治疗率的影响

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临床肝胆病杂志 2022年第6期38卷 1269-1274页

作者：王皓单姗尤红徐小元魏来侯金林庄辉孔媛媛贾继东中国消除乙肝临床研究平台(CR-Hepb)研究组首都医科大学附属北京友谊医院临床流行病学与循证医学研究室北京100050 首都医科大学附属北京友谊医院肝病中心北京100050 北京大学第一医院感染疾病科北京100034 北京清华长庚医院肝胆胰内科北京100044 南方医科大学南方医院感染内科广州510515 北京大学医学部病原生物学系北京100191 不详

目的探讨抗HbV治疗适应证变化对治疗率和需要治疗人群特征的影响。方法研究对象来自于中国消除乙肝临床研究平台(CR-Hepb)数据库中未经治慢性乙型肝炎患者,收集其人口学、病毒学、血液学及血生化信息。不符合正态分布的定量资料在两组... 详细信息

目的探讨抗HbV治疗适应证变化对治疗率和需要治疗人群特征的影响。方法研究对象来自于中国消除乙肝临床研究平台(CR-Hepb)数据库中未经治慢性乙型肝炎患者,收集其人口学、病毒学、血液学及血生化信息。不符合正态分布的定量资料在两组间比较采用Mann-Whitney U检验,多组间比较采用Kruskal-Wallis H检验,定性资料组间比较采用χ^(2)检验或Fisher确切概率检验。结果本研究共纳入3640例未经治慢性乙型肝炎患者,64.4%为男性,68.7%年龄为30~59岁,46.8%临床分期不确定。根据2015年版、2019年版慢性乙型肝炎防治指南和2022年版专家共识,分别有625例(17.2%)、1333例(36.6%)、和2890例(79.4%)符合抗病毒治疗适应证。2022年版共识新增需治疗患者1557例,其中1424例(91.5%)符合男性ALT>30 U/L、女性ALT>19 U/L的治疗阈值。2022年版专家共识新增需治疗患者的ALT、HbV DNA水平、APRi和Fib-4评分显著低于2019年版指南新增需治疗患者(P值均<0.05)。结论随着慢性乙型肝炎抗病毒治疗的适应证扩展,将显著提高患者的治疗比例,有利于更多有疾病进展风险的轻症患者得到及时治疗并改善长期预后。

关键词：乙型肝炎,慢性抗病毒药适应证

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急性卒中影像学研究路径图Ⅱ

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国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. Albers Joseph P. broderick Andrew M. Demchuk Jochen b. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard i. Aviv Roland bammer Jean-Claude baron Fernando Calamante bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair bijoy iC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeimagingResearchGroup，STiR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeimagingResearchGroup，STiR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy industry Roundtable，STAiR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国

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