Influence of Montmorillonite Nanocomposite on Tissue Levels of Lead and Blood Biochemical Parameters in Pigs Exposed to Lead

作     者：D.Y. Yu W.Rao B.Zhou. W.H.Song 

作者机构：College of Animal Science Institute of Feed Science Zhejiang University Hangzhou Zhejiang310029 China 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2010年第1卷第1期

页      面：44-48页

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 08[工学] 09[农学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Supported by National Natural Science Foundation of China (Grant Agreement No:30972121) 

主　　题：δ-amino levulinic acid dehydratase lead montmorillonite zinc protoporphyrin 

摘      要：ABSTRACT： Eighteen （Duroc x Landrace x Yorkshire） castrated boars, 55 days of age and weig- hing approximately 19 kg, were used to investigate the effects of montmorillonite nanocomposite on tissue levels of lead as well as changes in blood biochemical parameters in pigs fed lead contaminated diets. The barrows were randomly assigned to one of three treat- ments （n = 6） including a control which were fed a basal diet based on corn and soybean meal. The re- maining two groups were fed the basal diet supple- mented with 10 mg/kg lead either with or without 0.5% montmorillonite nanocomposite for 50 days. Pigs treated with lead had significantly increased lev- els of lead in their tissues. Lead accumulated in all tis- sues of the body with the highest accumulation found in the hair. When montmorillonite nanocomposite was given along with lead, tissue concentrations of lead did not differ from the control. Fecal excretion of leadincreased significantly in lead-exposed pigs treated with montmorillonite nanocomposite. A progressive and appreciable accumulation of lead was seen in blood with a concomitant increase in zinc protopor- phyrin levels during the course of treatment. Howev- er, zinc protoporphyrin levels did not differ from the control when montmorillonite nanocomposite was ad- ministered along with lead. The activity of ^-amino le- vulinic acid dehydratase in blood was significantly in- creased in lead treated pigs compared with the con- trol. However, in pigs treated with lead and montmo- riltonite nanocomposite in combination, the activity of δ-amino levulinic acid dehydratase was similar to con- trol pigs. Our results indicate that montmorillonite nanocomposite treatment of pigs exposed to lead re- suited in reduced lead concentrations in body tissues. It appears that montmorillonite nanocomposite func- tions by increasing fecal excretion of lead.