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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad bachar El baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Efficient Algorithm forMany-Electron Angular Momentum and Spin Diagonalization on Atomic Subshells

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Communications in Computational Physics 2016年第1期19卷 192-204页

作者： christian b.Mendl Zentrum Mathematik Technische Universitat MunchenBoltzmannstraße 385748 Garching bei MunchenGermany

We devise an efficient algorithm for the symbolic calculation of irreducible angular momentum and spin(LS)eigenspaces within the n-fold antisymmetrized tensor product∧^(n)V_(u),where n is the number of electrons and u=s,p,d,…denotes the atomic *** is an essential step for dimension reduction in configurationinteraction(CI)methods applied to atomic many-electron quantum *** algorithm relies on the observation that each Lz eigenstate with maximal eigenvalue is also an L2 eigenstate(equivalently for Sz and S2),as well as the traversal of LS eigenstates using the lowering operators L−and S−.Iterative application to the remaining states in∧^(n)V_(u)leads to an implicit simultaneous diagonalization.A detailed complexity analysis for fixed n and increasing subshell number u yields run time O(u^(3n−2)).A symbolic computer algebra implementation is available online.

关键词： Angular momentum and spin symmetry atomic many-electron quantum systems symbolic computation

Pollination interactions reveal direct costs and indirect benefits of plant-plant facilitation for ecosystem engineers

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Journal of Plant Ecology 2020年第1期13卷 107-113页

作者： Gianalberto Losapio christian Schöb Department of Evolutionary biology and Environmental Studies University of ZurichZurichSwitzerland Department of Environmental Systems Science ETH ZurichZurichSwitzerland

Aims Ecosystem engineers substantially modify the environment via their impact on abiotic conditions and the biota,resulting in facilitation of associated species that would not otherwise ***,reciprocal effects are poorly understood as studies of plant–plant interactions usually estimate only benefits for associated species,while how another trophic level may mediate direct and indirect feedback effects for ecosystem engineers is hardly *** We ran a field experiment with two ecosystem engineers(Arenaria tetraquetra and Hormathophylla spinosa)blooming either alone or with associated plants to decompose net effects and to test the hypothesis that pollinator-mediated interactions provide benefits that balance costs of facilitation by ecosystem *** Findings We found that net costs of facilitation are accompanied by pollinator-mediated *** ecosystem engineers producing fewer flowers per plant,they were visited by more and more diverse pollinators per flower when blooming with associated plants than when blooming *** seed production per plant was higher when ecosystem engineers bloomed alone,fruit set and seed set varied between *** one case(***),fruit and seed sets were negatively affected by the presence of associated plants,whereas,in another case(***),fruit set and seed set were higher and unaffected when ecosystem engineers bloomed with associated plants,*** findings suggest that besides experiencing direct costs,ecosystem engineers can also benefit from facilitating other species via increasing their own visibility to ***,we highlight that pollination interactions can compensate for costs of facilitation depending on ecosystem engineer *** study illuminates how the outcome of direct plant–plant interactions might be mediated by indirect interactions including third players.

关键词： biodiversity commensalism ecosystem engineering mutualism niche construction three-way interactions

COVID-19:Insights into long-term manifestations and lockdown impacts

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Journal of Sport and Health Science 2023年第4期12卷 438-463页

作者： Erika Hilbold christian bär Thomas Thum Institute of Molecular and Translational Therapeutic Strategies(IMTTS) Hannover Medical SchoolHannover 30625Germany Fraunhofer Cluster of Excellence Immune-Mediated Diseases(CIMD) Hannover 30625Germany Fraunhofer Institute for Toxicology and Experimental Medicine(ITEM) Hannover 30625Germany

Coronaviruses are pathogens thought to primarily affect the respiratory tracts of *** outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 was also marked mainly by its symptoms of respiratory illness,which were named coronavirus disease 2019(COVID-19).Since its initial discovery,many other symptoms have been linked to acute SARS-CoV-2 infections as well as to the long-term outcomes of COVID-19 *** these symptoms are different categories of cardiovascular diseases(CVDs),which continue to be the main cause of death *** World Health Organization estimates that 17.9 million people die from CVDs each year,accounting for~32%of all deaths *** inactivity is one of the most important behavioral risk factors for *** COVID-19 pandemic has affected CVDs as well as the physical activity in different ***,we provide an overview of the current status as well as future challenges and possible solutions.

关键词： Cardiovascular disease COVID-19 Long COVID Physical activity Return to play

Ecological intensification of agriculture through biodiversity management:introduction

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Journal of Plant Ecology 2023年第6期16卷 1-4页

作者： bernhard Schmid christian Schöb Department of Geography Remote Sensing LaboratoriesUniversity of ZurichWinterthurerstrasse 1908057 ZürichSwitzerland Universidad Rey Juan Carlos Calle Tulipán s/n28933 MóstolesSpain

A major feature of humans is that they can attain much higher population densities than any non-domestic animal species of similar body size(Damuth 1987).This is most likely due to the invention of agriculture(Herrera and Garcia-bertrand 2018),which allowed humans to manage ecosystems in such a way that as much biomass as possible is converted into food(Vitousek et al.1986).

关键词： Ecological likely agriculture

Three-Dimensional Sub-100 nm Super-Resolution Imaging of biological Samples Using a Phase Ramp in the Objective Pupil

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Nano Research 2011年第6期4卷 589-598页

作者： David baddeley Mark b. Cannell christian Soeller Department of Physiology University of Auckland Private Bag 92019 Auckland 1142 New Zealand

Localisation microscopy overcomes the diffraction limit by measuring the position of individual molecules to obtain optical images with a lateral resolution better than 30 nm. Single molecule localisation microscopy was originally demonstrated only in two dimensions but has recently been extended to three dimensions. Here we develop a new approach to three-dimensional （3D） localisation microscopy by engineering of the point-spread function （PSF） of a fluorescence microscope. by introducing a linear phase gradient between the two halves of the objective pupil plane the PSF is split into two lateral lobes whose relative position depends on defocus. Calculations suggested that the phase gradient resulting from the very small tolerances in parallelism of conventional slides made from float glass would be sufficient to generate a two-lobed PSF. We demonstrate that insertion of a suitably chosen microscope slide that occupies half the objective aperture combined with a novel fast fitting algorithm for 3D localisation estimation allows nanoscopic imaging with detail resolution well below 100 nm in all three dimensions （standard deviations of 20, 16, and 42 nm in x, y, and z directions, respectively）. The utility of the approach is shown by imaging the complex 3D distribution of microtubules in cardiac muscle cells that were stained with conventional near infrared fluorochromes. The straightforward optical setup, minimal hardware requirements and large axial localisation range make this approach suitable for many nanoscopic imaging applications.

关键词： Single molecules nanoscopy point-spread function engineering immunocytochemistry localisation microscopy

Thiopurines in inflammatory bowel disease revisited

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World Journal of Gastroenterology 2013年第11期19卷 1699-1706页

作者： Florian br christian Sina Klaus Fellermann Medical Department 1 University Hospital Schleswig Holstein23538 LübeckGermany

Although a great variety of new drugs have been introduced for the therapy of inflammatory bowel diseases so far,a definite cure of the disease is still out of *** anti-inflammatory approach to induce remission followed by maintenance therapy with immunosupressants is still the mainstay of *** comprising azathioprine and its active metabolite mercaptopurine as well as tioguanine,are widely used in the therapy of chronic active inflammatory bowel disease(IbD).Their steroid sparing potential and efficacy in remission maintenance are out of ***,untoward adverse events are frequently observed and may preclude further administration or be life *** review will focus on new aspects of thiopurine therapy in IbD,its efficacy and safety.

关键词： Thiopurines Mercaptopurine Tioguanine Azathioprine Ulcerative colitis Crohn’s disease