Thiopurines in inflammatory bowel disease revisited

作     者：Florian Br Christian Sina Klaus Fellermann 

作者机构：Medical Department 1University Hospital Schleswig Holstein23538 LübeckGermany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第11期

页      面：1699-1706页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Thiopurines Mercaptopurine Tioguanine Azathioprine Ulcerative colitis Crohn’s disease 

摘      要：Although a great variety of new drugs have been introduced for the therapy of inflammatory bowel diseases so far,a definite cure of the disease is still out of *** anti-inflammatory approach to induce remission followed by maintenance therapy with immunosupressants is still the mainstay of *** comprising azathioprine and its active metabolite mercaptopurine as well as tioguanine,are widely used in the therapy of chronic active inflammatory bowel disease(IBD).Their steroid sparing potential and efficacy in remission maintenance are out of ***,untoward adverse events are frequently observed and may preclude further administration or be life *** review will focus on new aspects of thiopurine therapy in IBD,its efficacy and safety.