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Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury

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Neural Regeneration Research 2023年第7期18卷 1457-1462页

作者： Hannah MMcCoy Rachel Polcyn Naren LBanik azizul.haque Department of Microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Administration Medical Center CharlestonSCUSA

Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no *** and Drug Administration-approved ***,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in *** is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway ***-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in *** surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated *** here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following ***,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase *** combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following *** role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neu

关键词： cathepsin X ENOblock enolase glia mitogen-activated protein kinase/extracellular signal-regulated kinase neurodegeneration neuroinflammation phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B Rho-associated protein kinase spinal cord injury

Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury

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Neural Regeneration Research 2023年第5期18卷 940-946页

作者： Ali Myatich azizul.haque Christopher Sole Naren L.Banik Department of Microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Administration Medical Center CharlestonSCUSA Department of Health and Human Performance The CitadelCharlestonSCUSA

Spinal cord injuries affect nearly five to ten individuals per million every year. Spinal cord injury causes damage to the nerves, muscles, and the tissue surrounding the spinal cord. Depending on the severity, spinal injuries are linked to degeneration of axons and myelin, resulting in neuronal impairment and skeletal muscle weakness and atrophy. The protection of neurons and promotion of myelin regeneration during spinal cord injury is important for recovery of function following spinal cord injury. Current treatments have little to no effect on spinal cord injury and neurogenic muscle loss. Clemastine, an Food and Drug Administration-approved antihistamine drug, reduces inflammation, protects cells, promotes remyelination, and preserves myelin integrity. Recent clinical evidence suggests that clemastine can decrease the loss of axons after spinal cord injury, stimulating the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes that are capable of myelination. While clemastine can aid not only in the remyelination and preservation of myelin sheath integrity, it also protects neurons. However, its role in neurogenic muscle loss remains unclear. This review discusses the pathophysiology of spinal cord injury, and the role of clemastine in the protection of neurons, myelin, and axons as well as attenuation of skeletal muscle loss following spinal cord injury.

关键词： axonal damage clemastine myelination neuronal death oligodendrocytes skeletal muscle spinal cord injury

Bioelectricity generation and remediation of sulfide contaminated tidal flat sediment

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International Journal of Sediment Research 2020年第1期35卷 91-96页

作者： M.azizul Moqsud Department of Civil and Environmental Engineering University of California

A dramatic decrease in the catch of shellfish has been observed due to the high amount of Acid Volatile Sulfide(AVS) in the tidal flats in *** the current study,an evaluation of simultaneous bioelectricity generation and remediation of sulfide contaminated tidal flat sediment has been *** sediment samples collected from Tokyo Bay and Yamaguchi Bay,Japan,have been used in the laboratory test.A 2 L cylindrical shaped Sediment Microbial Fuel Cell(SMFC) has been used to evaluate the remediation of both sediment samples in the *** different electrode materials carbon felt,carbon fiber and bamboo charcoal were used in the experiments to compare their efficiency to reduce the AVS from the sediment and generate *** was observed that the AVS reduction was higher at 5 cm depths for the Tokyo Bay sediment(100%) compared to the Yamaguchi Bay sediment(60%).The larger grain size for the Tokyo Bay sediment was the probable reason for *** maximum voltage was around 100 and80 mV for Tokyo Bay and Yamaguchi Bay,respectively.

关键词： Acid volatile sulfide Bioelectricity Remediation Tidal flat Sediment microbial fuel cell Sediment

Monkeypox virus(MPXV):A Brief account of global spread,epidemiology,virology,clinical features,pathogenesis,and therapeutic interventions

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Infectious Medicine 2023年第4期2卷 262-272页

作者： Md Aminul Islam Jubayer Mumin Md Masudul haque Mdazizul.haque Ahrar Khan Prosun Bhattacharya Md Atiqul haque Advanced Molecular Lab Department of MicrobiologyPresident Abdul Hamid Medical CollegeKarimganj 2310Bangladesh COVID-19 Diagnostic Lab Department of MicrobiologyNoakhali Science and Technology UniversityNoakhali 3814Bangladesh Department of Global Public Health Karolinska InstitutetSE-17177 StockholmSweden Department of Public Health North South UniversityDhaka 1229Bangladesh Department of Biochemistry and Molecular Biology Faculty of AgricultureHajee Mohammad Danesh Science and Technology UniversityDinajpur 5200Bangladesh Shandong Vocational Animal Science and Veterinary College Weifang 261061China COVID-19 Research@KTH Department of Sustainable DevelopmentEnvironmental Science and EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden Key Laboratory of Animal Epidemiology and Zoonoses of Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijing 100019China Department of Microbiology Faculty of Veterinary and Animal ScienceHajee Mohammad Danesh Science and Technology UniversityDinajpur 5200Bangladesh

The largest monkeypox virus(MPXV)outbreak of the 21st century occurred in 2022,which caused epidemics in many *** to WHO,physical contact with infected persons,contaminated surfaces,or affected animals might be a source of this virus transmission.A febrile sickness including few symptoms found in MPX *** rash,lesions,fever,headache,fatigue,and muscle aches symptoms were observed commonly for this *** and in vitro,studies have shown that the antiviral medications cidofovir and brincidofovir are effective against *** first-generation vaccinia virus vaccine was developed in 1960,and it helped to protect against MPXV with its side effects.A second-generation vaccination with limitations was launched in ***,the CDC advised vaccinations for risk groups in endemic countries,including positive patients and hospital *** JYNNEOS vaccine,administered in 2 doses,also provides protection from *** article presents concisely the most recent findings regarding epidemiology,genomic transmission,signs and symptoms,pathogenesis,diagnosis,and therapeutic interventions for MPXV,which may be helpful to researchers and *** declared that MPX was no longer a global health emergency due to its declining case rate,and a number of countries have reported new *** research-based investigations must be carried out based on the 2022 outbreak.

关键词： Monkeypox(MPX) Monkeypox virus(MPXV) Epidemiology Zoonotic diseases Re-emerging viruses Genomic dissemination Vaccination and Treatment

Mean Opinion Score Estimation for Mobile Broadband Networks Using Bayesian Networks

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Computers, Materials & Continua 2022年第9期72卷 4571-4587页

作者： Ayman A.El-Saleh Abdulraqeb Alhammadi Ibraheem Shayea azizul Azizan Wan Haslina Hassan College of Engineering A’Sharqiyah University(ASU)Ibra400Oman Communication Systems and Networks Research Lab Malaysia-Japan International Institute of TechnologyUniversiti Teknologi MalaysiaKuala Lumpur54100Malaysia Department of Electronics and Communication Engineering Faculty of Electrical and Electronics EngineeringIstanbul Technical University(ITU)Istanbul34467Turkey Advanced Informatics Department Razak Faculty of Technology and InformaticsUniversiti Teknologi MalaysiaKuala Lumpur54100Malaysia

Mobile broadband(MBB)networks are expanding rapidly to deliver higher data *** fifth-generation cellular network promises enhanced-MBB with high-speed data rates,low power connectivity,and ultralow latency video ***,existing cellular networks are unable to perform well due to high latency and low bandwidth,which degrades the performance of various *** a result,monitoring and evaluation of the performance of these network-supported services is *** network providers optimize and monitor their network performance to ensure the highest quality of service to their *** paper proposes a Bayesian model to estimate the minimum opinion score(MOS)of video streaming services for any particular cellular *** MOS is the most commonly used metric to assess the quality of *** proposed Bayesian model consists of several input data,namely,round-trip time,stalling load,and bite *** was examined and evaluated using several test data sizes with various performance *** results show the proposed Bayesian network achieved higher accuracy overall test data sizes than a neural *** proposed Bayesian network obtained a remarkable overall accuracy of 90.36%and outperformed the neural network.

关键词： Quality of experience quality of service bayesian networks minimum opinion score artificial intelligence prediction mobile broadband

Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration

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Neuroimmunology and Neuroinflammation 2017年第12期4卷 254-257页

作者： Rachel Polcyn Mollie Capone Azim Hossain Denise Matzelle Naren L.Banik azizul.haque Department of Microbiology and Immunology Hollings Cancer CenterMedical University of South CarolinaCharlestonSC 29425USA Department of Neurosurgery Medical University of South CarolinaCharlestonSC 29425USA Ralph H.Johnson Veterans Administration Medical Center CharlestonSC 29401USA.

Enolase is a multifunctional enzyme primarily involved in catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis[1-4].Though typically ... 详细信息

关键词： Neuron specific enolase potential target regulating neuronal cell survival

Generalized Normalized Euclidean Distance Based Fuzzy Soft Set Similarity for Data Classification

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Computer Systems Science & Engineering 2021年第7期38卷 119-130页

作者： Rahmat Hidayat Iwan Tri Riyadi Yanto azizul Azhar Ramli Mohd Farhan Md.Fudzee Ansari Saleh Ahmar Faculty of Computer and Information Technology Universiti Tun Hussein Onn MalaysiaBatu PahatMalaysia Department of Information Technology Politeknik Negeri PadangPadangIndonesia Department of Information System Universitas Ahmad DahlanYogyakartaIndonesia Department of Statistics Universitas Negeri MakassarMakassarIndonesia

Classification is one of the data mining processes used to predict predetermined target classes with data learning *** study discusses data classification using a fuzzy soft set method to predict target classes *** study aims to form a data classification algorithm using the fuzzy soft set *** this study,the fuzzy soft set was calculated based on the normalized Hamming *** parameter in this method is mapped to a power set from a subset of the fuzzy set using a fuzzy approximation *** the classification step,a generalized normalized Euclidean distance is used to determine the similarity between two sets of fuzzy soft *** experiments used the University of California(UCI)Machine Learning dataset to assess the accuracy of the proposed data classification *** dataset samples were divided into training(75%of samples)and test(25%of samples)*** were performed in MATLAB R2010a *** experiments showed that:(1)The fastest sequence is matching function,distance measure,similarity,normalized Euclidean distance,(2)the proposed approach can improve accuracy and recall by up to 10.3436%and 6.9723%,respectively,compared with baseline ***,the fuzzy soft set method is appropriate for classifying data.

关键词： Soft set fuzzy soft set classification normalized euclidean distance similarity

Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance

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Journal of Integrative Agriculture 2020年第3期19卷 643-655页

作者： Md azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101P.R.China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049P.R.China Department of Biotechnology and Genetic Engineering Faculty of Applied Science and TechnologyIslamic UniversityKushtia 7003Bangladesh

Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental *** this study,the effects of PAs on rice salt tolerance were *** stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was ***-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly *** Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt *** rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt *** stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) *** findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance.

关键词： rice polyamines NaCl polyamine oxidase guazatine

Antioxidant, antimicrobial and cytotoxic potential of condensed tannins from Leucaena leucocephala hybrid-Rendang

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Food Science and Human Wellness 2016年第2期5卷 65-75页

作者： Mazni Abu Zarin Ho Yin Wan azizul Isha Nurdin Armania Laboratory of Vaccines and Immunotherapeutics Institute of BioscienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Laboratory of Natural Products Institute of BioscienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia

Condensed tannins(CTs)are one of the promising compounds due to their potentially health-promoting *** this study,CTs were extracted from a Leucaena leucocephala hybrid-Rendang and subjected to various biological studies including antioxidant(using Ferric reducing antioxidant power(FRAP),DPPH and ABTS radical scavenging assay),anti-microbial(against different pathogens)and cytotoxic activities(toward human breast adenocarcinoma(MCF-7),human colon carcinoma(HT29),human cervical carcinoma(HeLa)and human liver carcinoma(HepG2)cell lines)in cancer cells through in vitro *** structural characteristics and purity of CTs extract were determined using 13C *** results showed that CTs exhibited higher in vitro antioxidant activities(2257.12±80.55 mg TEAC/g extract,605.3±1.82 mg TEAC/g extract and 1014.03±1.20 mg TEAC/g extract in FRAP,ABTS and DPPH assay,respectively)and demonstrated anti-microbial activities toward selected Gram’s positive and Gram’s negative bacteria tested with MIC and MBC value at 6.25–50 mg/***,among other selected cancer cells,CTs also demonstrated cytotoxic activity toward human breast cancer cells(MCF-7)(IC50=38.33±2.08mg/mL).Characteristic of apoptosis such as cell shrinkage,nuclear condensation and apoptotic bodies were shown in *** preliminary investigations have provided scientific rationale to use CTs as an alternative therapy for various oxidative and inflammatory associated diseases.©2016 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Antioxidant Anti-microbial Condensed tannins Cytotoxic Leucaena leucocephala