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Stem Cells and Exosomes-associated Therapeutic Applications

Journal of Clinical and Nursing Research 2024年第6期8卷 232-246页

作者： Usama Ahmed Muhammad Abubakar Rooma Ayyoub Baqaur rehman Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan

Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate the transport of multiple intracellular biological molecules including proteins,nucleic acids,lipids,and *** regulate a large number of cells and are involved in different pathological and physiological activities including carcinogenesis,viral infection,cell-cell communication and immune responses as *** cell-derived exosomes carry many benefits over simple stem cells in the form of easy access,freedom from tumourigenic capabilities,non-infusion toxicity,effortless preservation,and *** have almost the same properties and perform functions effectively in the same way as their parental cells do like adult stem cells and embryonic stem *** to their pluripotent or multipotent abilities,stem cells(SCs)transform into several types of *** addition to other secretions,SC also give exosomes,which in turn shows therapeutic significance for many disorders,including cancer,diabetes mellitus,skin allergies and regenerative *** originating from mesenchymal stem cells(MSCs)have miRNAs,lipids,and proteins that trigger diabetes and cancer situations in *** from SCs(sc-exos)are preferred to SC as there are fewer side effects and other challenges,including effectiveness,drug delivery,lower immunogenicity and *** the current review,we summarize the data from the last 5 years'articles about exosomes and stem cell-derived microvesicles for the therapeutic potential of various diseases such as cancer,Alzheimer's disease,diabetes,and Parkinson's disease with clinical challenges and future aspects.

关键词： Stem cells Exosomes Therapeutic Cancer Parkinson Diabetes

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ULAM-HYERS-RASSIAS STABILITY AND EXISTENCE OF SOLUTIONS TO NONLINEAR FRACTIONAL DIFFERENCE EQUATIONS WITH MULTIPOINT SUMMATION BOUNDARY CONDITION

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Acta Mathematica Scientia 2020年第2期40卷 589-602页

作者： Syed Sabyel HAIDER Mujeeb ur rehman School of Natural Sciences National University of Sciences and TechnologyH-12 Islamabad44000Pakistan

The purpose of this study is to acquire some conditions that reveal existence and stability for solutions to a class of difference equations with non-integer orderμ∈(1,2].The required conditions are obtained by applying the technique of contraction principle for uniqueness and Schauder’s fixed point theorem for ***,we establish some conditions under which the solution of the considered class of difference equations is generalized Ulam-Hyers-Rassias *** for the illustration of results is given.

关键词： Fractional difference equation Green's function existence and uniqueness Ulam-Hyers-Rassias stability summation boundary condition

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Evaluating the Potential of Nitrofurantoin and Fosfomycin for *** UTIs: A Susceptibility Study

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Journal of Clinical and Nursing Research 2024年第6期8卷 351-358页

作者： Usama Ahmed Muhammad Zubair Baqaur rehman Hafiz Muhammad Sultan Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Institute of Biological Sciences Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Crop Diseases Research Institute(CDRI) National Agricultural Research Centre NARCIslamabadPakistan

This study was designed to find the susceptibility of Nitrofurantoin and Fosfomycin among urinary isolates of *** hundred(400)urine samples were collected for susceptibility of nitrofurantoin and fosfomycin among urinary isolates of *** indoor and outdoor patients'urinary samples yielded growth of ***-stream urine specimens were inoculated on blood agar and CLED agar and incubated at 35±2°*** was observed,and Escherichia coli was identified by Gram staining,Catalase,Motility test and API 20E(Bio murex)as per standard *** susceptibility testing of isolates for nitrofurantoin and fosfomycin was carried out by the modified Kirby-Bauer disc diffusion method according to CLSI guidelines ATCC *** was used as a quality control strain.A total of 400 samples were tested susceptibility of nitrofurantoin and fosfomycin among urinary isolates of *** during this period.A total of 400 samples yielded the growth of ***,out of which 178(44.5%)were male and 222(55.5%)were female *** males,18(10%)were tolerant to nitrofurantoin,and 2(1.1%)were tolerant to *** females,9(4.09%)were susceptible to nitrofurantoin while 6(2.72%)were susceptible to *** age groups below 45 years old,6(4.76%)were tolerant to nitrofurantoin,and 2(1.58%)were sensitive to *** 46-66 years old,4(2.81%)were sensitive to nitrofurantoin,and 3(2.11%)were sensitive to *** 67-90 years old,17(12.87%)were sensitive to nitrofurantoin,and 4(3.03%)were tolerant to *** and nitrofurantoin showed good susceptibility in urinary isolates of *** and can be used empirically in our setup.

关键词： E.coli Fosfomycin Nitrofurantoin Susceptibility urinary isolates

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一种膜结合生物探针可视化检测剪切应力引起的细胞膜张力非均匀变化

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科学新闻 2019年第2期 155-155页

作者： Wang Li Xinlei Yu Fei Xie Baohong Zhang Shuai Shao Chunyang Geng aziz ur rehman aziz Xiaoling Liao 刘波大连理工大学生物医学工程学院

文章简介细胞膜是细胞感受外界应力刺激并作出反应的第一介质,探讨细胞膜张力的变化有助于理解细胞受力作用下功能变化的应力信号转导机制。为此,本研究基于荧光共振能量转移技术,利用一对荧光蛋白和一个"分子

关键词：细胞膜可视化检测生物探针剪切应力非均匀

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Topology and ferroelectricity in group-V monolayers

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Chinese Physics B 2020年第5期29卷 1-12页

作者： Mutee ur rehman Chenqiang Hua Yunhao Lu State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China

The group-V monolayers(MLs)have been studied intensively after the experimental fabrication of two-dimensional(2D)graphene and black *** observation of novel quantum phenomena,such as quantum spin Hall effect and ferroelectricity in group-V elemental layers,has attracted tremendous attention because of the novel physics and promising applications for nanoelectronics in the 2D *** this review,we comprehensively review recent research progress in engineering of topology and ferroelectricity,and several effective methods to control the quantum phase transition are *** then introduce the coupling between topological orders and ferroelectric *** research directions and outlooks are discussed at the end of the *** is expected that the comprehensive overview of topology and ferroelectricity in 2D group-V materials can provide guidelines for researchers in the area and inspire further explorations of interplay between multiple quantum phenomena in low-dimensional systems.

关键词： topology ferroelectricity two-dimensional material group-V element

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Cardioembolic Stroke as a Sequela of General Ventricular Hypokinesia Secondary to Acute Myocarditis in a 16-Year-Old Male

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Open Journal of Emergency Medicine 2024年第3期12卷 85-94页

作者： Abdul Khattan rehman Renaldo Pavrey Nazir Juvale Murtaza Bagwala Department of Emergency Medicine Saifee Hospital Mumbai India Department of Emergency Medicine Nanavati Max Super Specialty Hospital Mumbai India Department of Cardiology Saifee Hospital Mumbai India

Paediatric cardiac disease is an established cause of ischemic stroke in the neonatal and infantile groups. These diseases may be congenital or acquired. However, clinical myocarditis is in itself, relatively uncommon in older children. The most common pathogen is Coxsackie virus B. The offending agent instigates an immune response, which causes myocardial oedema with eventual systolic and diastolic dysfunction. Cardioembolic stroke can occur secondary to an intra-mural thrombus in a dysfunctional atrium or ventricle. We describe the case of an adolescent male with acute myocarditis complicated by a thromboembolic stroke. After initial management of acute pulmonary oedema and heart failure with restricted ejection fraction (HFrEF), the child developed seizure-like symptoms on the 10th day of hospitalization, prompting urgent neuro-radio diagnosis, which revealed acute infarcts in the cerebellum and frontal lobe of the cerebrum. We believe this case to be of clinical relevance because;1) The diagnosis of an acute stroke in children is often delayed due to the atypical clinical presentation and often the absence of traditional stroke-like symptoms, and 2) There is a lack of sufficient high-quality evidence regarding the predictors and the immediate management of stroke in paediatric heart disease, as well as inadequate data on prevalence and incidence in paediatric cardioembolic strokes.

关键词： Paediatric Ischemic Stroke Adolescent Myocarditis Ventricular Hypokinesia Cardioembolic

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A Novel Parallel Computing Confidentiality Scheme Based on Hindmarsh-Rose Model

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Computers, Materials & Continua 2023年第8期76卷 1325-1341页

作者： Jawad Ahmad Mimonah Al Qathrady Mohammed SAlshehri Yazeed Yasin Ghadi Mujeeb ur rehman Syed aziz Shah School of Computing Engineering and the Built EnvironmentEdinburgh Napier UniversityEdinburghEH105DTUK Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi112612United Arab Emirates School of Science Technology and HealthYork St John UniversityYorkYO317EXUK Research Centre for Intelligent Healthcare Coventry UniversityCoventryCV15FBUK

Due to the inherent insecure nature of the Internet,it is crucial to ensure the secure transmission of image data over this ***,given the limitations of computers,it becomes evenmore important to employ efficient and fast image encryption *** 1D chaotic maps offer a practical approach to real-time image encryption,their limited flexibility and increased vulnerability restrict their practical *** this research,we have utilized a 3DHindmarsh-Rosemodel to construct a secure *** randomness of the chaotic map is assessed through standard *** proposed system enhances security by incorporating an increased number of system parameters and a wide range of chaotic parameters,as well as ensuring a uniformdistribution of chaotic signals across the entire value ***,a fast image encryption technique utilizing the new chaotic system is *** novelty of the approach is confirmed through time complexity *** further strengthen the resistance against cryptanalysis attacks and differential attacks,the SHA-256 algorithm is employed for secure key *** results through a number of parameters demonstrate the strong cryptographic performance of the proposed image encryption approach,highlighting its exceptional suitability for secure ***,the security of the proposed scheme has been compared with stateof-the-art image encryption schemes,and all comparison metrics indicate the superior performance of the proposed scheme.

关键词： Hindmarsh-rose model image encryption SHA-256 parallel computing

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Analysis of Genetic Alterations in TP53 Gene in Breast Cancer - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 25-35页

作者： Baqaur rehman Muhammad Abubakar Muhammad Naeem Kiani Rooma Ayyoub Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China

Tumor protein p53 (TP53) mediates DNA repair and cell proliferation in growing cells. The TP53 gene is a tumor suppressor that regulates the expression of target genes in response to multiple cellular stress factors. Key target genes are involved in crucial cellular events such as DNA repair, cell cycle regulation, apoptosis, metabolism, and senescence. TP53 genetic variants and the activity of the wild-type p53 protein (WT-p53) have been linked to a wide range of tumorigenesis. Various genetic and epigenetic alterations, including germline and somatic mutations, loss of heterozygosity, and DNA methylation, can alter TP53 activity, potentially resulting in cancer initiation and progression. This study was designed to screen three reported mutations in the DNA-binding domain of the p53 protein in breast cancer, to evaluate the relative susceptibility and risk associated with breast cancer in the local population. Genomic DNA was isolated from 30 breast tumor tissues along with controls. Tetra and Tri ARMS PCR were performed to detect mutations in the TP53 coding region. For SNPs c.637C>T and c.733C>T, all analyzed cases were homozygous for the wild-type allele ‘C,’ while for SNP c.745A>G, all cases were homozygous for the wild-type allele ‘A.’ These results indicate no relevance of these three SNPs to cancer progression in our study cohort. Additionally, the findings from whole exon sequencing will help to predict more precise outcomes and assess the importance of TP53 gene mutations in breast cancer patients.

关键词： Breast cancer p53 Gene expression Mutation SNPs

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An Ontology-Based Framework for Semi-Automatic Schema Integration

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Journal of Computer Science & Technology 2005年第6期20卷 788-796页

作者： Zille Huma Muhammad Jaffar-ur rehman Nadeem Iftikhar Muhammad Ali dinnah University Islamabad Pakistan

Currently, schema integration frameworks use approaches like rule-based, machine learning, etc. This paper presents an ontology-based wrapper-mediator framework that uses both the rule-based and machine learning strategies at the same time. The proposed framework uses global and local ontologies for resolving syntactic and semantic heterogeneity, and XML for interoperability. The concepts in the candidate schemas are merged on the basis of the similarity coefficient, which is calculated using the defined rules and the prior mappings stored in the case-base.

关键词： heterogeneous databases database integration database semantics rule-based processing machine learning

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Advancing Cancer Stem Cell-Targeted Therapeutic Applications

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Proceedings of Anticancer Research 2024年第5期8卷 32-45页

作者： Muhammad Abubakar Rooma Ayyoub Baqaur rehman Muhammad Zubair Usama Ahmed Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan 2Institute of Biological SciencesKhwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan 3Department of MedicineSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China

Cancer stem cells(CSCs),first identified in blood cancers,are increasingly recognized as significant biomarkers and targets in tumor therapy due to their metastatic potential and role in cancer *** research has demonstrated the dedication of scientists in targeting CSCs to explore novel therapeutic *** types of cancer exhibit metastasis,heterogeneity,and resistance to treatment,all of which are influenced by *** cells utilize various transcription factors and signaling pathways to carry out these *** identifying and understanding these pathways,new therapeutic breakthroughs can be ***,targeting cancer stem cells holds great potential and importance in cancer ***,CSCs offer promising avenues for treating otherwise incurable ***,targeting CSCs presents challenges such as immunological rejection and disease *** research into CSCs may reveal new insights in the fight against cancer and ultimately improve human *** review explores the roles of CSCs in cancer development and treatment,aiming to uncover new therapeutic approaches.

关键词： Cancer stem cells Cancer Therapy

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