Stem Cells and Exosomes-associated Therapeutic Applications

作     者：Usama Ahmed Muhammad Abubakar Rooma Ayyoub Baqaur Rehman 

作者机构：Department of MedicineSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of BiosciencesCOMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan 

出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)

年 卷 期：2024年第8卷第6期

页      面：232-246页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Stem cells Exosomes Therapeutic Cancer Parkinson Diabetes 

摘      要：Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate the transport of multiple intracellular biological molecules including proteins,nucleic acids,lipids,and *** regulate a large number of cells and are involved in different pathological and physiological activities including carcinogenesis,viral infection,cell-cell communication and immune responses as *** cell-derived exosomes carry many benefits over simple stem cells in the form of easy access,freedom from tumourigenic capabilities,non-infusion toxicity,effortless preservation,and *** have almost the same properties and perform functions effectively in the same way as their parental cells do like adult stem cells and embryonic stem *** to their pluripotent or multipotent abilities,stem cells(SCs)transform into several types of *** addition to other secretions,SC also give exosomes,which in turn shows therapeutic significance for many disorders,including cancer,diabetes mellitus,skin allergies and regenerative *** originating from mesenchymal stem cells(MSCs)have miRNAs,lipids,and proteins that trigger diabetes and cancer situations in *** from SCs(sc-exos)are preferred to SC as there are fewer side effects and other challenges,including effectiveness,drug delivery,lower immunogenicity and *** the current review,we summarize the data from the last 5 years articles about exosomes and stem cell-derived microvesicles for the therapeutic potential of various diseases such as cancer,Alzheimer s disease,diabetes,and Parkinson s disease with clinical challenges and future aspects.